Digital Commons Network^™

Regulation Of System Xc- And Its Contribution To Cell Death, Xiaoqian Liu

Dissertations (1934 -)

The main focus of the studies in this thesis involves examining the role of cystine/glutamate exchange (system xC-) in neuronal death in primary cortical cell culture, with an emphasis on how glial function affects neuronal cell death. System xC- is a sodium-independent transporter that mediates cystine uptake and glutamate release. It accounts for most of the cystine uptake in astrocytes in mature cultures, providing the rate limiting substrate for synthesis of the main endogenous antioxidant glutathione. The glutamate released by system xC- may lead to excessive extracellular glutamate and cause excitotoxicity.

β-N-methylamino-L-alanine (BMAA) is a non-protein amino acid that may …

Myosin Isoforms And Regulation Of Tonic And Phasic Contraction In Smooth Muscle, Qian Huang

Dissertations (1934 -)

The contractile properties of smooth muscle (SM) are broadly classified as tonic and phasic. Among the hypothesized underlying regulatory mechanisms for this difference is the different actomyosin ATPase kinetic properties of SM SMA/SMB myosin heavy chain (MHC) isoforms and the preferential expression of SMA and SMB MHC isoforms in tonic and phasic SM respectively. Thus, we hypothesized that SM SMA/B MHC expression determines tonic and phasic contractile patterns in SM.

To test the this hypothesis, the role of SMA and SMB MHC isoforms in tonic and phasic contractions was studied in phasic (longitudinal ileum and stomach circular antrum) and tonic …

Spectral Characterization Of Cytochromes P450 Active Site And Catalytic Intermediates, Daniel Kaluka

Dissertations (1934 -)

Cytochromes P450 (P450s) have been the subject of intense research for over six decades. Though it is widely accepted that a highly reactive Fe(IV)=O π-cation radical, or the so called compound I, facilitates the oxidation of relatively inert hydrocarbons, spectroscopic characterization of this putative intermediate has eluded detection under turnover conditions, presumably due to its very short lifetime. In this work, chemically inert substrates of P450s have been utilized in a new approach to capture and stabilize this transient intermediate and characterize it with resonance Raman (RR) spectroscopy, which is a well established tool for studying heme proteins. Specifically, perfluorodecanoic …

Lateral-Mode Vibration Of Microcantilever-Based Sensors In Viscous Fluids Using Timoshenko Beam Theory, Joshua Schultz

Dissertations (1934 -)

Dynamic-mode microcantilever-based devices are well suited to biological and chemical sensing applications. However, these applications often necessitate liquid-phase sensing, introducing significant fluid-induced dissipative forces and reducing device quality factors (Q). Recent experimental and analytical research has shown that higher in- fluidQis achieved by exciting microcantilevers in the lateral flexural mode. However, the experimental results show that, for microcantilevers having larger width-to-length (b/L) ratios, the behaviors predicted by current analytical models differ from measurements.

To more accurately model microcantilever resonant behavior in viscous fluids and to improve understanding of lateral-mode sensor performance, a new analytical model is developed, incorporating both viscous …

Photochemical Eilmination Reactions Via Zwitterionic Intermediates Generated By Electrocyclic Ring Closures, Majher Ibna Mannan Sarker

Dissertations (1934 -)

The research focuses on the design of photoremovable protecting groups that can be used to deprotect biological substrates of an organic compound by photolysis. The deprotection of the protecting group via photolysis requires heterolysis of a bond to the substrate. Heterolysis of a C-O or C-S σ-bonds in a zwitterionic intermediate is proposed. The photochemical electrocyclic reactions studied involve acrylanilides, benzothiophene carboxanilides, and N-(9-oxothioxanthenyl) benzothiophene carboxamides. α,β-Unsaturated anilides bearing leaving groups at the allylic position of the α-methylacrylamide group undergo photochemical electrocyclic ring closure with release of leaving group which could occur directly from a photochemically produced zwitterionic intermediate or …

Corticosterone-Induced Potentiation Of Cocaine Seeking: A Potential Role For Organic Cation Transporter 3, Evan N. Graf

Dissertations (1934 -)

While it is known that stress plays a role in the relapse of cocaine-seeking behavior, recent studies demonstrate that stress may be acting as a "stage setter" rather than directly triggering further cocaine use. This model suggests stimuli that do not normally evoke relapse under stress-free conditions may result in drug seeking when the exposure occurs under stressful conditions. In this study, we examined the corticosterone-dependent potentiation of cocaine-induced reinstatement by a stressor, electric footshock (EFS), in rats following cocaine self-administration and extinction. We found that in rats with a history of drug exposure under low intake conditions, footshock alone …

Finding A Better Confidence Interval For A Single Regression Changepoint Using Different Bootstrap Confidence Interval Procedures, Bodhipaksha Thilakarathne

College of Graduate Studies: Theses & Dissertations

Recently a number of papers have been published in the area of regression changepoints but there is not much literature concerning confidence intervals for regression changepoints. The purpose of this paper is to find a better bootstrap confidence interval for a single regression changepoint. ("Better" confidence interval means having a minimum length and coverage probability which is close to a chosen significance level). Several methods will be used to find bootstrap confidence intervals. Among those methods a better confidence interval will be presented.

The Effects Of Locomotor Posture On Kinematics, Performance And Behavior During Obstacle Negotiation In Lizards, Jessica Self

College of Graduate Studies: Theses & Dissertations

The ability to efficiently move over uneven terrain is critical for most terrestrial animals. Bipedal running is common in lizard species, however the biological advantage of a bipedal running posture remains uncertain. I examined the hypothesis that a bipedal posture is advantageous when crossing obstacles. Particularly, I determined whether kinematic adjustments differ among four focal species with contrasting body forms and ecology. I also examined how sprint speed changed when crossing obstacles with a quadrupedal versus a bipedal posture. I quantified kinematics from high-speed video (300 frames/second) of lizards running down a 3m runway both with and without the presence …

Bird Use Of Cumberland Island's Freshwater Wetlands, Lisa Dlugolecki

College of Graduate Studies: Theses & Dissertations

Cumberland Island is the southernmost barrier island off the coast of Georgia. Its freshwater wetlands are an important, rare habitat to have on a barrier island surrounded by saltmarsh and ocean. Many species of birds require freshwater wetlands as feeding, roosting and nesting grounds. However, the freshwater wetlands on Cumberland Island have been impacted by humans for centuries causing birds to abandon their historic nesting ground. Known land use histories of Cumberland Island's freshwater wetlands were gathered to try and determine how the wetlands changed over time Wetlands were analyzed for presence of wetland-dependent birds and recorded. Thirty-six species of …

Patterns Of Chemosensory Behavior In A Closed Population Of Wild African Elephants (Loxodonta Africana), Russell W. Blogg

College of Graduate Studies: Theses & Dissertations

Chemosensory behaviors are used by many mammalian species to assess chemical signals in the environment. These chemical signals may contain important information about reproductive state, identity, status, or location of conspecifics. Elephants are a long-lived species and males reproduce at a much later age than females, which provides a protracted developmental period for males. This study examined chemosensory behaviors in a population of African elephants living in Addo Elephant National Park, South Africa and demonstrated that patterns emerge as elephants develop and approach sexual maturity. Older pubescent males (15-19 year olds) performed more chemosensory behaviors than younger pubescent males (10-14 …

Spatial And Temporal Immune Response In House Flies In Response To Ingestion Of Bacillus Cereus And Eschericha Coli 0157-H7, Adam Fleming

College of Graduate Studies: Theses & Dissertations

House flies (Musca domestica L.) feed and breed on septic substrates, putting them in direct contact with a multitude of disease causing agents and can act as a bridge for those agents to humans. The house fly has previously been shown to carry many different species of bacteria that are pathogenic. Escherichia coli O157:H7 is a pathogenic enterohemorrhagic serotype of E. coli that can be vectored by the house fly. Bacillus cereus is a foodborne pathogen that has also been isolated from the house fly in previous studies. To examine vector potential for these pathogens, house flies were fed green …

Focus, 2012, Fall, Andrews University

Focus

FOCUS (ISSN 1077-9345) is published quarterly, free of charge, for alumni and friends of Andrews University, an institution owned and operated by the Seventh-day Adventist Church.

Stem Cell Based Tissue Engineering And Regenerative Medicine: A Review Focusing On Adult Stem Cells, Jordan Greenberg, Veronica R. Fortino, Daniel Pelaez, Herman S. Cheung

Biology Faculty Articles

Tissue engineering has emerged as a field that attempts to harness the bodies' own developmental and repair features to treat diseases and illnesses. Many of these illnesses are caused by necrosis or loss of functionality of complete organs or specific cell types. Early discoveries in embryonic stem cells fueled a wave of research that led to claims about possibly regenerating nonfunctioning organs. Although we are still far away from being able to grow functional organs in a Petri dish, the field continues to progress forward, and new clinical trials have been approved for using both embryonic and adult stem cell …

Accuracy Of Self-Reported Sun Exposure And Sun Protection Behavior, Joel J. Hillhouse, Robert Turrisi, James Jaccard, June K. Robinson

ETSU Faculty Works

The objective of this study was to compare the accuracy of self-reported skin cancer risk outcome measures proposed as standards by prevention experts to aggregated estimates of behavior from weekly diaries. Weekly electronic diaries of ultraviolet radiation (UVR) behaviors, initially validated by comparison with daily electronic diaries, were used to assess the accuracy of commonly used end-of-summer self-reported measures among 250 adults. Results revealed low biases, and good correspondence between simple open-ended self-reported estimates of days outside, hours outside, sunbathing days and hours, and days outside when not protected by either sunscreen, long-sleeved shirts, hats, or shade. Rating scale measures …

Unmanned Signatures, Brian Macaskill

Reconstruction: Studies in Contemporary Culture

UNMANNED SIGNATURES? In addition to its more common significations, “unmanned” is used also in the ‘sport’ of falconry, where it means “not broken in”; the term will in falconry be applied to a hawk or kestrel not (yet?) broken into obedience. “Unwomanned” is similarly linked to deviation from control and controlled norms, but is more likely to appear as a reflexive verb (“to unwoman [herself]”) than as an adjective, and is more likely to be tightly tied in gendered fashion to ‘degeneracy.’ As phrase, title and incipit, “Unmanned Signatures” is in all sorts of ways an oddly descended, perhaps even …

Returning Counselor Education Doctoral Students: Issues Of Retention, Attrition, And Perceived Experiences, David Burkholder

Journal of Counselor Preparation and Supervision

A phenomenological research design was utilized to illuminate the experiences of counselor education doctoral students who had voluntarily departed from study and successfully returned. No studies exist in the counselor education literature examining this phenomenon. Themes derived from the data suggest a common experience across participants, including the salient nature of leaving and returning to study, the importance of faculty-student interactions, and that departure is informed by personal factors and academic culture. The findings have implications for student retention and attrition, as well as counseling departments, counseling faculty, and counselor education doctoral students.

The Journal Of Counselor Preparation And Supervision Volume 5, Number 2, Edina Renfro-Michel, Larry D. Burlew

Journal of Counselor Preparation and Supervision

No abstract provided.

A Value Assessment Of The Gordon Natural Area Of Environmental Studies At The West Chester University Of Pennsylvania, Brandon Nye, Ben Keller, Travis Decaro

Gordon Natural Area History & Strategic Plan Documents

No abstract provided.

A Perspective On Livestock–Wolf Interactions On Western Rangelands, Stewart W. Breck, Patrick Clark, Larry Howery, Douglas Johnson, Bryan Kluever, Samuel Smallidge, Andres Cibils

United States Department of Agriculture Wildlife Services: Staff Publications

The reintroduction of wolves into their historical ranges in the North American Rocky Mountains and areas of the southwestern United States is possibly one of the most ambitious ecosystem restoration efforts of the recent past. This initiative has been controversial and has stimulated considerable debate among concerned stakeholders about the feasibility of harmonizing multiple land-use demands when preservation of a large predator becomes a central management goal. In many areas, ranching has taken center stage of this debate as ranchers and land managers seek to develop sustainable ways to manage livestock on landscapes with wolves.

The challenges associated with wolf …

Resource Review: Breakout Edu, Rachel Bayer, Catherine Sorenson

Journal of Youth Development

Game-based learning is becoming an increasingly popular pedagogical technique for providing engaging learning experiences for youth. The Breakout EDU platform provides an opportunity to bring game-based learning into formal and non-formal learning environments using an escape-room-like approach while teaching specific subject areas and building life skills. There are more than 1,500 ready-made games for teaching a variety of topic areas, from science and math to team building, in any learning context. It also provides resources and tools to support youth development professionals in creating their own games. This review provides an overview of Breakout EDU and its kit and digital …

Mcquade Messenger- Fall 2012, Merrimack College

McQuade Messenger

Triannual newsletter outlining the activities, events, hours, features, and resources available at McQuade Library. Fall 2012, 4 pages.

“Indians, In A Jurisdictional Sense”: Tribal Citizenship And Other Forms Of Non-Indian Consent To Tribal Criminal Jurisdiction, Paul Spruhan

Faculty Scholarship

Can tribes exert criminal jurisdiction over non- Indians who consent, by whatever means, to adhere to tribal laws? Has federal Indian law, and tribes’ reaction to it, changed the universe of tribal jurisdiction so significantly that non-Indians can truly never be subject to tribal criminal law? This article explores the concept of consent as a still viable theory of tribal criminal jurisdiction. I first examine some historical examples of non-Indian consent through adoption or naturalization under tribal law, and reactions to such consent by federal officials. I then discuss modern examples of tribal law theories of consent, primarily through recent …

Genetic Characterization Of North American Populations Of The Wheat Curl Mite And Dry Bulb Mite, Gary L. Hein, Roy French, Benjawan Siriwetwiwat, James W. Amrine

Department of Entomology: Faculty Publications

The wheat curl mite, Aceria tosichella Keifer, transmits at least three harmful viruses, wheat streak mosaic virus (WSMV), high plains virus (HPV), and Triticum mosaic virus (TriMV) to wheat (Triticum aestivum L.) throughout the Great Plains. This virus complex is considered to be the most serious disease of winter wheat in the western Great Plains. One component of managing this disease has been developing mite resistance in wheat; however, identification of mite biotypes has complicated deployment and stability of resistance. This biotypic variability in mites and differential virus transmission by different mite populations underscores the need to better understand …

Benefits And Barriers In Mining The Healthcare Industry Data, John Wang, Bin Zhou, Ruiliang Yan

Faculty Publications

The authors’ paper addresses the applications of data mining within the healthcare industry. Healthcare data are seen as one of the more rewarding and most difficult of all data to analyze. Proper data mining techniques provide the methodology and technology to transform the voluminous amounts of data into useful information for decision making. Data mining can be utilized to help find cures for existing diseases, uncovering patterns for genetic diseases and the causes of new diseases across the globe. By implementing data mining techniques the industry is finally gaining control over the inadequacy of readily available records. Data mining has …

Bard Free Press, Vol. 14, No. 2 (October 2012), Bard College

Bard Free Press - All Issues (2000-2018)

No abstract provided.

Analysis Of The Detection Of Organophosphate Pesticides In Aqueous Solutions Using Polymer-Coated Sh-Saw Sensor Arrays, Tian Newman

Master's Theses (2009 -)

The shear horizontal surface acoustic wave (SH-SAW) device was investigated as a micro-chemical sensor for the direct, rapid and in-situ monitoring of chemical contaminants in groundwater and wastewater. The chemical contaminants of interest are organo-phosphate-based compounds (parathion, parathion-methyl, and paraoxon). The polymers used as partially chemically selective coatings are 2,2’-diallylbisphenol A - 1,1,3,3,5,5-hexamethyltrisiloxane (BPA-HMTS), and 2,2’-diallylbisphenol A- polydimethylsiloxane (BPA-PDMS), polyepichlorohydrin (PECH). The experimental results indicate that the analyte/polymer interaction is a result of mass loading and viscoelastic changes in the polymer. BPA-HMTS, BPA-PDMS, and PECH have the highest to lowest sensitivity towards parathion, parathion-methyl, and paraoxon respectively. The polymers tested …

Development And Performance Of A Sparsity-Exploiting Algorithm For Few-View Single Photon Emission Computed Tomogrpahy (Spect) Reconstruction, Paul Arthur Wolf

Master's Theses (2009 -)

Single Photon Emission Computed Tomography (SPECT) provides noninvasive images of the distribution of radiotracer molecules. Dynamic Single Photon Emission Computed Tomography provides information about tracer uptake and washout from a series of time-sequence images. Stationary ring-like multi-camera systems are being developed to provide rapid dynamic acquisitions with high temporal sampling. Reducing the number of cameras reduces the cost of such systems but also reduces the number of views acquired, limiting the angular sampling of the system. Novel few-view image reconstruction methods may be beneficial and are being investigated for the application of dynamic SPECT. A sparsity-exploiting algorithm intended for few-view …

Manna From The Glossy Pulpit: Food Advertising In Women's Magazines, Kira-Lynn Reeves

Master's Theses (2009 -)

Women’s magazines reach millions of readers each month, and have been the subject of many academic inquires from media effects studies to feminist analyses. While many studies have investigated female readers’ experience with these texts, or examined the advertising content of women’s magazines, little research to date has focused on food advertising. This liberal feminist critique explores the experience of reading the 2011 issues of the three popular women’s magazines, Glamour, SELF, and Family Circle. Using Stern’s (1996) textual analysis method for advertisements, this study examines how food advertisements in women’s magazines encourage women to think about …

Quantitative Analysis Of Methangenic Community In Anaerobic Digesters And Its Response To Freeze Drying And Exposure To Oxygen, Keerthi Cherukuri

Master's Theses (2009 -)

Methanogens are integral to carbon cycling, catalyzing the production of methane and carbon dioxide, both potent greenhouse gases. Methane is produced in a wide variety of highly reduced anaerobic environments, as well as by degradation of organic compounds in industrial and municipal wastewater. This process is carried out by the concerted activity of an interdependent microbial community, composed of Bacteria and Archaea, the later including methanogens which complete the final step and produce methane and carbon dioxide. Methanogenesis is often the rate limiting step and is sensitive to processing imbalances. Therefore, an understanding of the microbial community structure and dynamics …

Panorama October 2012, Southern Adventist University

Panorama Parent Newsletter

This issue of the Panorama parent newsletter announces the new Parent Portal, contains a profile on Kari Schultz, and highlights Studio 4109 Live.