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Muc1 Mucin Stabilizes And Activates Hypoxia-Inducible Factor 1 Alpha To Regulate Metabolism In Pancreatic Cancer, Nina V. Chaika, Teklab Gebregiworgis, Michelle E. Lewallen, Vinee Purohit, Prakash Radhakrishnan, Xiang Liu, Bo Zhang, Kamiya Mehla, Roger B. Brown, Thomas Caffrey, Fang Yu, Keith R. Johnson, Robert Powers, Michael A. Hollingsworth, Pankaj K. Singh

Robert Powers Publications

Aberrant glucose metabolism is one of the hallmarks of cancer that facilitates cancer cell survival and proliferation. Here, we demonstrate that MUC1, a large, type I transmembrane protein that is overexpressed in several carcinomas including pancreatic adenocarcinoma, modulates cancer cell metabolism to facilitate growth properties of cancer cells. MUC1 occupies the promoter elements of multiple genes directly involved in glucose metabolism and regulates their expression. Furthermore, MUC1 expression enhances glycolytic activity in pancreatic cancer cells. We also demonstrate that MUC1 expression enhances in vivo glucose uptake and expression of genes involved in glucose uptake and metabolism in orthotopic implantation models …

Lymph Node Ratio Is An Important And Independent Prognostic Factor For Patients With Stage Iii Melanoma, Adam C. Berger, Michael Fierro, John C. Kairys, David Berd, Takami Sato, Jocelyn Andrel, Terry Hyslop, Michael J. Mastrangelo

Kimmel Cancer Center Faculty Papers

INTRODUCTION:

The incidence of melanoma is dramatically increasing worldwide. We hypothesized that the ratio of metastatic to examined lymph node ratio (LNR) would be the most important prognostic factor for stage III patients.

METHODS:

We retrospectively reviewed our institutional database of melanoma patients and identified 168 patients who underwent lymph node dissection (LND) for stage III disease between 1993 and 2007. Patients were divided into three groups based on LNR (≤10%, n = 93; 10-≤25%, n = 45; and >25%, n = 30). Univariate and multivariate analysis was performed using Cox proportional hazards model.

RESULTS:

The median survival time of …

Evolutionary History Of Caribbean Species Of Myotis, With Evidence Of A Third Lesser Antillean Endemic, Roxanne J. Larsen, Peter A. Larsen, Hugh H. Genoways, Francois M. Catzeflis, Keith Geluso, Gary G. Kwiecinski, Scott C. Pedersen, Fernando Simal

University of Nebraska State Museum: Mammalogy Papers

Currently, four species of Myotis are known from the islands of the Caribbean (Myotis dominicensis, M. martiniquensis, M. nesopolus, and M. nigricans). Myotis dominicensis and M. martiniquensis are endemic to the Lesser Antilles, whereas M. nesopolus and M. nigricans are considered conspecific with mainland populations. Recent phylogenetic and phylogeographic studies provided hypotheses regarding the origin and diversification of M. dominicensis and M. martiniquensis. However, these studies focused primarily on convergent morphology or distribution patterns of this genus and not on the evolutionary history of Caribbean Myotis. Here, we explore variation across multiple datasets …

Bats Of Barbados, Hugh H. Genoways, Roxanne J. Larsen, Scott C. Pedersen, Gary G. Kwiecinski, Peter A. Larsen

University of Nebraska State Museum: Mammalogy Papers

The chiropteran fauna of Barbados includes representatives of four families — Noctilionidae, Phyllostomidae, Vespertilionidae, and Molossidae — including 1 piscivore (Noctilio leporinus), 1 omnivore (Brachyphylla cavernarum), 1 pollenivore/nectarivore (Monophyllus plethodon), 1 frugivore (Artibeus jamaicensis), and 2 insectivorous species (Myotis nyctor and Molossus molossus). Despite an early report, we believe that preponderance of the evidence available at this time is that E. fuscus is not part of the fauna of Barbados. The Barbadian chiropteran fauna of 6 species is much smaller than those on the four neighboring Lesser Antillean islands to …

Examination Of Annual Variation In The Adult Sex Ratio Of Pronghorn (Antilocapra Americana), Justin D. Hoffman, Hugh H. Genoways

University of Nebraska State Museum: Mammalogy Papers

The adult sex ratio (ASR) is an important component of a population’s demographics and can be used as an indicator of a population’s status. However, the causes of annual variation in ASRs are unknown for many species. Fluctuations in ASR can arise through demographic stochasticity and intense selective harvesting. In this study we investigate the longterm patterns of variation in the ASRs (bucks: 100 does) for four populations of pronghorn (Antilocapra americana) in western Nebraska. We used multiple variables in a model selection process to predict annual fluctuation of pronghorn ASRs. We found that the number of bucks: 100 does …

Genetic Diversity Of Neotropical Myotis (Chiroptera: Vespertilionidae) With An Emphasis On South American Species, Roxanne J. Larsen, Michelle C. Knapp, Hugh H. Genoways, Faisal Ali Anwarali Khan, Peter A. Larsen, Don E. Wilson, Robert J. Baker

University of Nebraska State Museum: Mammalogy Papers

Background: Cryptic morphological variation in the Chiropteran genus Myotis limits the understanding of species boundaries and species richness within the genus. Several authors have suggested that it is likely there are unrecognized species-level lineages of Myotis in the Neotropics. This study provides an assessment of the diversity in New World Myotis by analyzing cytochrome-b gene variation from an expansive sample ranging throughout North, Central, and South America. We provide baseline genetic data for researchers investigating phylogeographic and phylogenetic patterns of Myotis in these regions, with an emphasis on South America.

Methodology and Principal Findings: Cytochrome-b sequences were …

Structural Alterations Induced By Botulinum Toxin Injection In Juvenile Versus Adult Rat Muscle, Sherif M. Hassan, Mohammed H. Badawoud, Abdulmonem A. Al-Hayani

Saudi Medical Journal

OBJECTIVE: To investigate whether botulinum neurotoxin type A (BoNT-A) injections produce the same structural changes in juvenile and adult muscle. METHODS: The present study was carried out in the Department of Anatomy, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia from October 2010 to May 2011. A total of 32 adult and 32 juvenile rats were used. Electron microscopy and immuno-histochemical techniques were used to conduct the morphological study. Neurofilament immunohistochemistry method was used. RESULTS: The results indicate that the use of BoNT-A injections induced morphological changes in the form of muscle fiber atrophy, disorganization of the …

Down-Regulation Of Fecal Mir-143 And Mir-145 As Potential Markers For Colorectal Cancer, Jin-Ming Li, Rong-Hua Zhao, Shao-Tang Li, Cai-Xia Xie, Hong-Hua Jiang, Wen-Jun Ding, Peng Du, Wei Chen, Ming Yang, Long Cui

Saudi Medical Journal

OBJECTIVE: To detect 4 MicroRNA (miRNA) in the stool samples of colorectal cancer (CRC) patients to determine whether these miRNAs could be biomarkers in CRC screening or treatment. METHODS: A retrospective comparison study was carried out in the Department of Colorectal Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China from September 2009 to March 2011. We detected 4 miRNAs (miR-143, miR-145, miR-21, and miR-106a) in the stool samples of 38 CRC patients and 13 healthy individuals. Total RNA from the stool samples was extracted using the EZNA TM stool RNA kit R6828-01. The miRNA quantification was carried …

Effect Of Daidzein-Low-Calorie Diet On Body Weight, Serum Levels Of Glucose, Resistin, And High Sensitive C-Reactive Protein In High Fat, High Calorie Diet Induced Rats, Majid Mohamad-Shahi, Majid Karandish, Fatemeh Haidari, Kosar Omidian, Seyed-Reza Fatemi-Tabatabayei, Hossein Rafiei

Saudi Medical Journal

OBJECTIVE: To assess the effect of restricting calories with or without daidzein on weight, serum levels of glucose, and inflammatory markers in obese rats. METHODS: This experimental study was carried out in Jundishapur University, Ahvaz, Iran, from September 2010 to January 2011. Obesity was induced in 30 male Wistar rats (140-160, 6-8 weeks age) after 6 weeks by feeding them a high-fat diet. Then, the rats were divided into 3 groups: obese rats treated with low-calorie diet containing 50 mg/kg daidzein (n=10); obese rats treated with low-calorie diet containing dimethyl sulfoxide (n=10); and obese rats that were given ad libitum …

A Community Dietetics Intervention To Improve The Use Of Oral Nutritional Supplements In The Community Setting, Sharon Kennelly

Doctoral

Evaluation of a community dietetics intervention to improve oral nutritional supplement prescribing practices in the community. Background: Healthcare professionals working in the community do not always prescribe oral nutritional supplements (ONS) according to best practice guidelines and expenditure on ONS has increased. The aim of this study was to investigate ONS prescribing practices and to determine the impact of a community dietetics intervention on these practices and expenditure one year later. Methods: At baseline ONS prescribing practices were investigated by patient interview with a community dietitian. The intervention involved an education programme for general medical practitioners (GPs), practice nurses, nurses …

The Political Left Rolls With The Good And The Political Right Confronts The Bad: Connecting Physiology And Cognition To Preferences, Michael D. Dodd, Amanda Balzer, Carly M. Jacobs, Michael W. Gruszczynski, Kevin B. Smith, John R. Hibbing

Department of Psychology: Faculty Publications

We report evidence that individual-level variation in people’s physiological and attentional responses to aversive and appetitive stimuli are correlated with broad political orientations. Specifically, we find that greater orientation to aversive stimuli tends to be associated with right-of-centre and greater orientation to appetitive (pleasing) stimuli with left-of-centre political inclinations. These findings are consistent with recent evidence that political views are connected to physiological predispositions but are unique in incorporating findings on variation in directed attention that make it possible to understand additional aspects of the link between the physiological and the political.

Contributions Of Dynamic Systems Theory To Cognitive Development, John P. Spencer, Andrew Austin, Anne R. Schutte

Department of Psychology: Faculty Publications

This paper examines the contributions of dynamic systems theory to the field of cognitive development, focusing on modeling using dynamic neural fields. A brief overview highlights the contributions of dynamic systems theory and the central concepts of dynamic field theory (DFT). We then probe empirical predictions and findings generated by DFT around two examples—the DFT of infant perseverative reaching that explains the Piagetian A-not-B error, and the DFT of spatial memory that explain changes in spatial cognition in early development. A systematic review of the literature around these examples reveals that computational modeling is having an impact on empirical research …

Association Between The Serotonin Transporter Triallelic Genotype And Eating Problems Is Moderated By The Experience Of Childhood Trauma In Women, Scott F. Stoltenberg, Cynthia Anderson, Parthasarathi Nag, Cheryl Anagnopoulos

Department of Psychology: Faculty Publications

Objective—This study investigated a potential interaction between the triallelic polymorphism of the serotonin transporter gene (SLC6A4) promoter and the experience of childhood trauma on the number of problem eating behaviors.

Methods—The study sample was comprised of 439 (64.7% female) Caucasian college students (mean age = 22.49, SD = 6.12). Participants completed questionnaires that assessed eating problems and experience of trauma in childhood (ages 0-12) and donated cheek cells for 5- HTTLPR and rs25531 genotyping.

Results—Women carrying a lower expressing allele (i.e. LG or S) who were exposed to higher levels of childhood trauma reported significantly higher mean numbers of eating …

Neural Mechanisms Underlying Neurooptometric Rehabilitation Following Traumatic Brain Injury, Caitlin M. Hudac, Srinivas Kota, James L. Nedrow, Dennis L. Molfese

Department of Psychology: Faculty Publications

Mild to severe traumatic brain injuries have lasting effects on everyday functioning. Issues relating to sensory problems are often overlooked or not addressed until well after the onset of the injury. In particular, vision problems related to ambient vision and the magnocellular pathway often result in posttrauma vision syndrome or visual midline shift syndrome. Symptoms from these syndromes are not restricted to the visual domain. Patients commonly experience proprioceptive, kinesthetic, vestibular, cognitive, and language problems. Neurooptometric rehabilitation often entails the use of corrective lenses, prisms, and binasal occlusion to accommodate the unstable magnocellular system. However, little is known regarding the …

A Kinematic Description Of The Temporal Characteristics Of Jaw Motion For Early Chewing: Preliminary Findings, Erin M. Wilson, Jordan R. Green, Gary Weismer

Department of Special Education and Communication Disorders: Faculty Publications

Purpose: The purpose of this investigation was to describe age- and consistency-related changes in the temporal characteristics of chewing in typically developing children between the ages of 4 and 35 months and adults using high-resolution optically based motion capture technology.

Method: Data were collected from 60 participants (48 children, 12 adults) across 5 age ranges (beginners, 7 months, 12 months, 35 months, and adults); each age group included 12 participants. Three different food consistencies were trialed as appropriate. The data were analyzed to assess changes in chewing rate, chewing sequence duration, and estimated number of chewing cycles.

Results: The results …

Simulating School Closure Policies For Cost Effective Pandemic Decision Making, Ozgur M. Araz, Paul Damien, David A. Paltiel, Sean Burke, Bryce Van De Geijn, Alison Galvani, Lauren Ancel Meyers

Department of Supply Chain Management and Analytics: Faculty Publications

Background: Around the globe, school closures were used sporadically to mitigate the 2009 H1N1 influenza pandemic. However, such closures can detrimentally impact economic and social life.

Methods: Here, we couple a decision analytic approach with a mathematical model of influenza transmission to estimate the impact of school closures in terms of epidemiological and cost effectiveness. Our method assumes that the transmissibility and the severity of the disease are uncertain, and evaluates several closure and reopening strategies that cover a range of thresholds in school-aged prevalence (SAP) and closure durations.

Results: Assuming a willingness to pay per quality adjusted life-year (QALY) …

Ccpa Regulates Arginine Biosynthesis In Staphylococcus Aureus Through Repression Of Proline Catabolism, Austin S. Nuxoll, Steven M. Halouska, Marat R. Sadykov, Mark L. Hanke, Kenneth W. Bayles, Tammy Kielian, Robert Powers, Paul D. Fey

Department of Chemistry: Faculty Publications

Staphylococcus aureus is a leading cause of community-associated and nosocomial infections. Imperative to the success of S. aureus is the ability to adapt and utilize nutrients that are readily available. Genomic sequencing suggests that S. aureus has the genes required for synthesis of all twenty amino acids. However, in vitro experimentation demonstrates that staphylococci have multiple amino acid auxotrophies, including arginine. Although S. aureus possesses the highly conserved anabolic pathway that synthesizes arginine via glutamate, we demonstrate here that inactivation of ccpA facilitates the synthesis of arginine via the urea cycle utilizing proline as a substrate. Mutations within putA, rocD, …

Unraveling The Structural Complexity In A Single-Stranded Rna Tail: Implications For Efficient Ligand Binding In The Prequeuosine Riboswitch, Catherine D. Eichhorn, Jun Feng, Krishna C. Suddala, Nils G. Walter, Charles L. Brooks Iii, Hashim M. Al-Hashimi

Department of Chemistry: Faculty Publications

Single-stranded RNAs (ssRNAs) are ubiquitous RNA elements that serve diverse functional roles. Much of our understanding of ssRNA conformational behavior is limited to structures in which ssRNA directly engages in tertiary interactions or is recognized by proteins. Little is known about the structural and dynamic behavior of free ssRNAs at atomic resolution. Here, we report the collaborative application of nuclear magnetic resonance (NMR) and replica exchange molecular dynamics (REMD) simulations to characterize the 12 nt ssRNA tail derived from the prequeuosine riboswitch. NMR carbon spin relaxation data and residual dipolar coupling measurements reveal a flexible yet stacked core adopting an …

Energy Issues Affecting Corn/Soybean Systems: Challenges For Sustainable Production, Douglas L. Karlen, David Archer, Adam Liska, Seth Meyer

Adam Liska Papers

Quantifying energy issues associated with agricultural systems, even for a two-crop corn (Zea mays L.) and soybean (Glycine max [L.] Merr.) rotation, is not a simple task. It becomes even more complicated if the goal is to include all aspects of sustainability (i.e., economic, environmental, and social). This Issue Paper examines energy issues associated with and affecting corn/soybean rotations by first defining the size of the system from both a U.S. and global perspective and then establishing boundaries based on the Farm Bill definition of sustainability. This structured approach is essential to help quantify energy issues within corn/soybean …

Mononuclear Phagocyte Intercellular Crosstalk Facilitates Transmission Of Cell-Targeted Nanoformulated Antiretroviral Drugs To Human Brain Endothelial Cells, Georgette D. Kanmogne, Sangya Singh, Upal Roy, Xinming Liu, Joellyn Mcmillan, Santhi Gorantla, Shantanu Balkundi, Nathan Smith, Yazen Alnouti, Nagsen Gautam, You Zhou, Larisa Poluektova, Alexander Kabanov, Tatiana Bronich, Howard Gendelman

Nebraska Center for Biotechnology: Faculty and Staff Publications

Despite the successes of antiretroviral therapy (ART), HIV-associated neurocognitive disorders remain prevalent in infected people. This is due, in part, to incomplete ART penetration across the blood–brain barrier (BBB) and lymph nodes and to the establishment of viral sanctuaries within the central nervous system. In efforts to improve ART delivery, our laboratories developed a macrophage-carriage system for nanoformulated crystalline ART (nanoART) (atazanavir, ritonavir, indinavir, and efavirenz). We demonstrate that nanoART transfer from mononuclear phagocytes (MP) to human brain microvascular endothelial cells (HBMEC) can be realized through cell-to-cell contacts, which can facilitate drug passage across the BBB. Coculturing of donor MP …

The Epigenetics Of Emerging And Nonmodel Organisms, Vett K. Lloyd, Jennifer A. Brisson, Kathleen A. Fitzpatrick, Lori A. Mceachern, Eveline C. Verhulst

School of Biological Sciences: Faculty Publications

Genetic model organisms have gifted researchers with a breathtakingly detailed understanding of the most intimate aspects of their genomes, cells, and development. And yet there is a problem—model organisms have been selected because they have simple life histories and happily inhabit laboratories. In short, they make a virtue of being boring. But the diversity of the natural world is not fully captured by yeast, flies, or mice. To truly appreciate the variety of biological mechanisms underlying this remarkable diversity, one must study the often inconvenient but fascinating non model organism. Experimental and descriptive approaches in non model organisms have become …

Divergent Functions Of The Myotubularin (Mtm) Homologs Atmtm1 And Atmtm2 In Arabidopsis Thaliana: Evolution Of The Plant Mtm Family, Yong Ding, Ivan Ndamukong, Yang Zhao, Yuannan Xia, Jean-Jack Riethoven, David R. Jones, Nullin Divecha, Zoya Avramova

School of Biological Sciences: Faculty Publications

Myotubularin and myotubularin-related proteins are evolutionarily conserved in eukaryotes. Defects in their function result in muscular dystrophy, neuronal diseases and leukemia in humans. In contrast to the animal lineage, where genes encoding both active and inactive myotubularins (phosphoinositide 3-phosphatases) have appeared and proliferated in the basal metazoan group, myotubularin genes are not found in the unicellular relatives of green plants. However, they are present in land plants encoding proteins highly similar to the active metazoan enzymes. Despite their remarkable structural conservation, plant and animal myotubularins have significantly diverged in their functions. While loss of myotubularin function causes severe disease phenotypes …

Are Ascaris Lumbricoides And Ascaris Suum A Single Species?, Daniela Leles, Scott L. Gardner, Karl Reinhard, Alena Iñiguez, Adauto Araujo

Karl Reinhard Publications

Since the original description and naming of Ascaris lumbricoides from humans by Linnaeus in 1758 and later of Ascaris suum from pigs by Goeze 1782, these species have been considered to be valid. Four hypotheses relative to the conspecificity or lack thereof (and thus origin of these species) are possible: 1) Ascaris lumbricoides (usually infecting humans) and Ascaris suum (recorded mostly from pigs) are both valid species, with the two species originating via a speciation event from a common ancestor sometime before the domestication of pigs by humans, or 2) Ascaris lumbricoides in humans is derived directly from the species …

Synthesizing Parasitology With Archaeology In Paleopathology, Karl Reinhard, Adauto Araujo

Karl Reinhard Publications

Parasitology is the study of organisms that are symbiotic with other organisms. In this form of symbiosis, the parasite species by definition benefits from the interaction while the host is harmed to some degree. In actuality, some parasites benefit their hosts. The animals traditionally studied by parasitologists range from protozoa to arthropods, and include all types of internal and external worms. Ticks, fleas, lice, and a variety of insects that transmit parasites are also studied by parasitologists. Recently, a more holistic view of parasitism appeared, including bacteria and viruses. In essence, parasitology is the study of a certain kind of …

Electron Attachment To Molecules In A Cluster Environment, Ilya I. Fabrikant, S. Caprasecca, Gordon A. Gallup, J. D. Gorfinkiel

Gordon Gallup Publications

Low-energy dissociative electron attachment (DEA) to the CF₂Cl₂ and CF₃Cl molecules in a water cluster environment is investigated theoretically. Calculations are performed for the water trimer and water hexamer. It is shown that the DEA cross section is strongly enhanced when the attaching molecule is embedded in a water cluster, and that this cross section grows as the number of water molecules in the cluster increases. This growth is explained by a trapping effect that is due to multiple scattering by water molecules while the electron is trapped in the cluster environment. The trapping increases …

Effect Of Archer Density On Elk Pregnancy Rates And Conception Dates, Gregory A. Davidson, Bruce K. Johnson, James H. Noyes, Brian L. Dick, Michael J. Wisdom

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

Archery hunting in Oregon has increased dramatically over the past 2 decades. At the same time, spring juvenile to adult female ratios of Rocky Mountain elk (Cervus elaphus) have been declining. This has raised concern that archery seasons may be disrupting elk breeding and contributing to the decline in recruitment. Two mechanisms could contribute to reduced juvenile:female ratios: 1) reduced pregnancy rates, and 2) delayed conception dates because of human disturbance during the rut. We varied the number of archery hunters at the Starkey Experimental Forest and Range over 13 years to evaluate effects of archer density on …

Modelling Approaches For Relating Effects Of Change In River Flow To Populations Of Atlantic Salmon And Brown Trout, J. D. Armstrong, K. H. Nislow

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

Modelling approaches for relating discharge to the biology of Atlantic salmon, Salmo salar L., and brown trout, Salmo trutta L., growing in rivers are reviewed. Process-based and empirical models are set within a common framework of input of water flow and output of characteristics of fish, such as growth and survival, which relate directly to population dynamics. A continuum is envisaged incorporating various contributions of process and empirical structure as practical and appropriate to specific goals. This framework is compared with, and shown to differ from, approaches whose output is in the form of quantity and form of habitat (or …

The Relationship Between Male Moth Density And Female Mating Success In Invading Populations Of Lymantria Dispar, Patrick C. Tobin, Ksenia S. Onufrieva, Kevin W. Thorpe

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

The successful establishment of non-native species in new areas can be affected by many factors including the initial size of the founder population. Populations comprised of fewer individuals tend to be subject to stochastic forces and Allee effects (positive-density dependence), which can challenge the ability of small founder populations to establish in a new area. Although the conceptual relationship between initial colony size and establishment success has been previously documented, it is not trivial to estimate precisely the colony size needed to ensure colony persistence. Over the last 40 years, there have been many studies on the probability of mating …

A Detrimental Soil Disturbance Prediction Model For Ground-Based Timber Harvesting, Derrick A. Reeves, Matthew C. Reeves, Ann M. Abbott, Deborah S. Page-Dumroese, Mark D. Coleman

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

Soil properties and forest productivity can be affected during ground-based harvest operations and site preparation. The degree of impact varies widely depending on topographic features and soil properties. Forest managers who understand site-specific limits to ground-based harvesting can alter harvest method or season to limit soil disturbance. To determine the potential areal extent of detrimental (potentially plant growth limiting) soil disturbance based on site characteristics and season of harvest, we developed a predictive model based on soil monitoring data collected from 167 groundbased harvest units. Data collected included dominant site parameters (e.g., slope, aspect, soil texture, and landtype), harvest season, …

A Synoptic Review Of U.S. Rangelands A Technical Document Supporting The Forest Service 2010 Rpa Assessment, Matthew Clark Reeves, John E. Mitchell

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

The Renewable Resources Planning Act of 1974 requires the USDA Forest Service to conduct assessments of resource conditions. This report fulfills that need and focuses on quantifying extent, productivity, and health of U.S. rangelands. Since 1982, the area of U.S. rangelands has decreased at an average rate of 350,000 acres per year owed mostly to conversion to agricultural and residential land uses. Nationally, rangeland productivity has been steady over the last decade, but the Rocky Mountain Assessment Region appears to have moderately increased productivity since 2000. The forage situation is positive and, from a national perspective, U.S. rangelands can probably …