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Evolutionary Relationships In Some Northern Groups Of The Direct-Developing Frog Genus Craugastor (Anura: Craugastoridae), Jeffrey W. Streicher

Biology Dissertations - Archive

Comparing phylogeographic patterns among vertebrates can give insight into the landscape and ecological determinants of phylogenetic diversity. However, in certain taxonomic groups (e.g., birds and mammals) natural history traits can be more influential in structuring phylogeographic patterns than historical interactions with the landscape. In contrast, groups like anurans (6132+ species) with poor dispersal capability and strict ecological requirements often display patterns of genetic diversification consonant with the geological and climatic characteristics of a landscape. The patterns resulting from these interactions can be used to elucidate the temporal dynamics of ecological differentiation, historical biogeography, and morphological evolution. The study of anurans …

Phylogenetic Systematics Of Dispholidine Colubrids (Serpentes: Colubridae), Thomas Gernot Eimermacher

Biology Dissertations - Archive

Dispholidine colubrids are a group of arboreal African snakes that are distributed throughout sub-Saharan Africa. Despite their vast distribution and medical significance, the systematic relationships of this group remain poorly understood. I used molecular and morphological data in both a phylogenetic and a multivariate framework to study the evolutionary relationships and external morphology of these snakes. The results of the phylogeographic investigation based on two mitochondrial markers indicated the presence of two distinct evolutionary lineages of Dispholidus sp. in southern Africa that are largely geographically separated by the Great Escarpment and associated habitat. A study of the molecular systematics of …

Prescribed Grazing On Pasturelands, Lynn E. Sollenberger, Carmen T. Agouridis, Eric S. Vanzant, Alan J. Franzluebbers, Lloyd B. Owens

Biosystems and Agricultural Engineering Faculty Publications

No abstract provided.

Multimodal Imaging Evidence For Axonal And Myelin Deterioration In Amnestic Mild Cognitive Impairment, Brian T. Gold, Yang Jiang, David K. Powell, Charles D. Smith

Neuroscience Faculty Publications

White matter (WM) microstructural declines have been demonstrated in Alzheimer's disease and amnestic mild cognitive impairment (aMCI). However, the pattern of WM microstructural changes in aMCI after controlling for WM atrophy is unknown. Here, we address this issue through joint consideration of aMCI alterations in fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity, as well as macrostructural volume in WM and gray matter compartments. Participants were 18 individuals with aMCI and 24 healthy seniors. Voxelwise analyses of diffusion tensor imaging data was carried out using tract-based spatial statistics (TBSS) and voxelwise analyses of high-resolution structural data was conducted using …

Complete Genome Sequence Of Clostridium Clariflavum Dsm 19732, Javier A. Izquierdo, Lynne Goodwin, Karen W. Davenport, Hazuki Teshima

Dartmouth Scholarship

Clostridium clariflavum is a Cluster III Clostridium within the family Clostridiaceae isolated from thermophilic anaerobic sludge (Shiratori et al, 2009). This species is of interest because of its similarity to the model cellulolytic organism Clostridium thermocellum and for the ability of environmental isolates to break down cellulose and hemicellulose. Here we describe features of the 4,897,678 bp long genome and its annotation, consisting of 4,131 protein-coding and 98 RNA genes, for the type strain DSM 19732.

Structural Characterization Of A Conserved, Calcium-Dependent Periplasmic Protease From Legionella Pneumophila, Debashree Chatterjee, Chelsea D. Boyd, George A. O'Toole, Holger Sondermann

Dartmouth Scholarship

The bacterial dinucleotide second messenger c-di-GMP has emerged as a central molecule in regulating bacterial behavior, including motility and biofilm formation. Proteins for the synthesis and degradation of c-di-GMP and effectors for its signal transmission are widely used in the bacterial domain. Previous work established the GGDEF-EAL domain-containing receptor LapD as a central switch in Pseudomonas fluorescens cell adhesion. LapD senses c-di-GMP inside the cytosol and relays this signal to the outside by the differential recruitment of the periplasmic protease LapG. Here we identify the core components of an orthologous system in Legionella pneumophila. Despite only moderate sequence conservation at …

Minimum Cost Of Transport In Asian Elephants: Do We Really Need A Bigger Elephant?, V. A. Langman, M. F. Rowe, T. J. Roberts, N. V. Langman, C. R. Taylor

Dartmouth Scholarship

Body mass is the primary determinant of an animal’s energy requirements. At their optimum walking speed, large animals have lower mass-specific energy requirements for locomotion than small ones. In animals ranging in size from 0.8 g (roach) to 260 kg (zebu steer), the minimum cost of transport (COT_min) decreases with increasing body size roughly as COT_min∝body mass (M_b)^{–0.316±0.023} (95% CI). Typically, the variation of COT_min with body mass is weaker at the intraspecific level as a result of physiological and geometric similarity within closely related species. The interspecific relationship estimates that …

Towards Colombian Small-Scale Marine Fisheries Management: Hacia Un Manejo De La Pesca Marina Artesanal En Colombia, Lina Maria Saavedra-Diaz

Doctoral Dissertations

Small-scale fisheries are an important economic and social foundation for the livelihood of coastal communities in Colombia. Yet artisanal fishing communities are characterized by a low quality of life and a struggle for the basic components of well being, in part because of inadequate marine resource management. As a consequence of inadequate management, some resources are already overexploited and depletion threatens the food security of these fishing villages. Lack of information on fisheries resources, open access artisanal fisheries, and poor socio-economic conditions, coupled with the high diversity and low abundance characteristic of tropical environments, place these fisheries resources at risk. …

Sterol Lipid Metabolism In Down Syndrome Revisited: Down Syndrome Is Associated With A Selective Reduction In Serum Brassicasterol Levels, Gavin Tansley, Daniel T. Holmes, Dieter Lütjohann, Elizabeth Head, Cheryl L. Wellington

Pharmacology and Nutritional Sciences Faculty Publications

Over the past 15 years, insights into sterol metabolism have improved our understanding of the relationship between lipids and common conditions such as atherosclerosis and Alzheimer's Disease (AD). A better understanding of sterol lipid metabolism in individuals with Down Syndrome (DS) may help elucidate how this population's unique metabolic characteristics influence their risks for atherosclerosis and AD. To revisit the question of whether sterol lipid parameters may be altered in DS subjects, we performed a pilot study to assess traditional serum sterol lipids and lipoproteins, as well as markers of sterol biosynthesis, metabolites, and plant sterols in 20 subjects with …

Aging And Down Syndrome, Elizabeth Head, Wayne Silverman, David Patterson, Ira T. Lott

Pharmacology and Nutritional Sciences Faculty Publications

No abstract provided.

Sexually Transmitted Diseases In Adolescence, Donald E. Greydanus, Jane Seyler, Hatim A. Omar, Colleen B. Dodich

Pediatrics Faculty Publications

High rates of unprotected sexual behavior in adolescents result in millions of sexually transmitted diseases (STDs) in the world. This paper reviews factors inducing high STD rates, specific STDs, and their management based on 2010 US Centers for Disease and Prevention (CDC) STD guidelines. Clinicians should screen all their sexually active adolescent patients for STDs and provide preventive education as well as treatment measures.

Purification And Applications Of A Bacteriophage-Derived Enzyme Chapk Against Problematic Staphylococci., Niamh Marie O'Shea

Theses

The bacteriophage K-derived peptidase CHAPk (Cysteine/Histidine-dependant amidohydrolase peptidase) can be produced from E. coli XL 1-Blue. Standard operating procedures for the production, purification and quality assessment of the peptidase were developed and set out in detail in this thesis. CHAPk exhibits strong antistaphylococcal properties and the purified enzyme was evaluated for its potential to eliminate S. aureus from the bovine udder and from human skin. As a teat dip CHAPk reduced the levels of S. aureus by three to five log cycles on both animal and human surfaces. CHAPk activity in milk was evaluated using challenge assays against the bovine …

Phylogenetic Analysis Of Rotavirus Strains Gl, G3 5g9 5p[8] And P[4] Using Both Neighbour-Joining And Maximum Parsimony, Jenny Cotter

Theses

Globally rotavirus is one of the most important causes of gastroenteritis in children and affects nearly all children by the age of 5 years. It also infects adults with most severe symptoms in the elderly or immune compromised. The most common strains associated with human rotavirus gastroenteritis are G1-G4 and G9 along with P[8],[6]and [4].All previous studies used only neighbour-joining method in the phylogenetic analysis of rotavirus genes. In this study rotavirus genes VP7 and VP4 for rotavirus strains G1 .G3 ,G9 , P[8] and P[4] were analysed in MEGA4.0 using both neighbour-joining and maximum parsimony. The main difference in …

Ontology Management For Universities, Roland Böving

Theses

What is the 'knowledge' of a university? It is the sum of all experiences and all contributions of students and staff. Knowledge ultimately exists, among other things, in the form of theses, articles, lectures and research reports. The largest knowledge pool of a university is made up, however, of the knowledge and expertise of every single member of the university. As a result of the high rate of turnover of people, knowledge and expertise are on the one hand constantly being lost, but this is replaced by a fresh intake of upcoming young students and lecturers reflecting the spirit of …

Settlement Of Municipal Solid Waste, Emmet Burke

Theses

The mechanical properties of waste (compression index, elastic modulus, stresses) are an important aspect for the design, operation and post-closure uses of landfills. In recent years the requirement to utilise the acreage that the landfill occupies to its maximum potential has necessitated the landfill structure to accommodate a greater volume of waste over a smaller plan area. This pushes the boundaries of design relating to side-slope and infrastructural elements of landfill structures.

The objectives of this research were identified from significant gaps in the knowledge relating to the settlement and mechanical properties of municipal solid waste. The main objectives are …

Characterisation Of Crataegus Monogyna Fractions And Assessment Of Their Functional Properties, Eilish Shortle

Theses

Hawthorn {Crataegus monogyna) is a herb that has been used medicinally since ancient times. In modern medicine it is known for its cardiotonic properties and is used as a cardiovascular protective, hypotensive and hypocholesterolemic agent. In recent years supercritical fluid extraction (SFE) has become more popular as an extraction method for botanical material as it is an environmentally-friendly method that can produce toxic-free extracts. The optimal SFE extraction conditions for the extraction of antioxidant compounds from both, hawthorn leaf & dower and hawthorn berries, using carbon dioxide, were determined in this study. The optimized extracts were then compared to pre-prepared …

New Thinking On "Shareholder Primacy", Lynn A. Stout

Cornell Law Faculty Publications

By the beginning of the twenty-first century, many observers had come to believe that U.S. corporate law should, and does, embrace a "shareholder primacy" rule that requires corporate directors to maximize shareholder wealth as measured by share price. This Essay argues that such a view is mistaken.

As a positive matter, U.S. corporate law and practice does not require directors to maximize "shareholder value" but instead grants them a wide range of discretion, constrained only at the margin by market forces, to sacrifice shareholder wealth in order to benefit other constituencies and the firm itself. Although recent "reforms" designed to …

The New Illegitimacy: Children Of Cohabiting Couples And Stepchildren, Cynthia Grant Bowman

Cornell Law Faculty Publications

The legal treatment of children of unmarried parents and stepchildren must be changed if they are not to be disadvantaged in comparison with children of married parents. With respect to the areas of law discussed in this Article, legal reform is necessary in a variety of situations in which legitimate children receive what is the functional equivalent of posthumous support-that is, inheritance in the absence of a will, social security survivors benefits, workers' compensation, and tort suits for wrongful death and loss of consortium. Cohabitants and stepchildren of both married and unmarried parents should be added to the persons listed …

Tp53 Codon 72 Polymorphism Affects Accumulation Of Mtdna Damage In Human Cells, Serena Altilia, Aurelia Santoro, Davide Malagoli, Catia Lanzarini, Josué Adolfo Ballesteros Álvarez, Gianluca Galazzo, Donald Carl Porter, Paolina Crocco, Giuseppina Rose, Giuseppe Passarino, Igor Roninson, Claudio Franceschi, Stefano Salvioli

Faculty Publications

Human TP53 gene is characterised by a polymorphism at codon 72 leading to an Arginine-to-Proline (R/P) substitution. The two resulting p53 isoforms have a different subcellular localisation after stress (more nuclear or more mitochondrial for the P or R isoform, respectively). p53P72 variant is more efficient than p53R72 in inducing the expression of genes involved in nuclear DNA repair. Since p53 is involved also in mitochondrial DNA (mtDNA) maintenance, we wondered whether these p53 isoforms are associated with different accumulation of mtDNA damage. We observed that cells bearing p53R72 accumulate lower amount of mtDNA damage upon rotenone stress with respect …

Type 2-Diabetes Is Associated With Elevated Levels Of Tnf-Alpha, Il-6 And Adiponectin And Low Levels Of Leptin In A Population Of Mexican American: A Cross-Sectional Study, S. Mirza, Monir Hossain, Christine Mathews, Perla Martinez, Paula Pino, Jennifer L. Gay, Anne R. Rentfro, Joseph B. Mccormick, Susan P. Fisher-Hoch

School of Nursing Faculty Publications

The goal of the study was to determine the association between diabetes and inflammation in clinically diagnosed diabetes patients. We hypothesized that low-grade inflammation in diabetes is associated with the level of glucose control. Using a cross-sectional design we compared pro and anti-inflammatory cytokines in a community recruited cohort of 367 Mexican Americans with type 2-diabetes having a wide range blood glucose levels. Cytokines (IL-6, TNF-α, IL-1β, IL-8) and adipokines (adiponectin, resistin and leptin) were measured using multiplex ELISA. Our data indicated that diabetes as whole was strongly associated with elevated levels of IL-6, leptin, CRP and TNF-α, whereas worsening …

Regulation Of The Transcription And Subcellular Localization Of The Tumor Suppressor Pten By Δnp63Α, Mary Kathryn Leonard

Browse all Theses and Dissertations

Non-melanoma skin cancers (NMSCs) are the most common form of cancer in the United States with an estimated 3.5 million new cases each year. Surgical excision is the main treatment for NMSC, but leaves the potential for disfiguring scars and does not fully reduce the risk of recurrence since the surrounding tissue is also sun damaged and may contain tumor-promoting mutations. By understanding the molecular etiology of NMSC we may be able to expand treatment options to more than just resection. Normal epidermal development is dependent upon the expression of the transcription factor p63. Amplification of the ΔNp63α isoform is …

Maturation Of The Carotid Body Oxygen-Sensor During Rat Development, Julia Paulet

Browse all Theses and Dissertations

Carotid bodies (CB) are paired, oxygen-sensing organs located in the bifurcation of the carotid artery that act as peripheral chemoreceptors in the detection of hypoxic, hypercapnic and acidotic levels in the arterial blood. CBs respond to these fluctuations in blood gases by initiating firing of the carotid sinus nerve. This ultimately results in the appropriate ventilatory change to restore blood gases to their physiological levels. Studies have shown that the hypoxic response of the carotid body in juvenile mammals is low, but as maturation occurs this response is strengthened and clearly exhibited in adults. One theory suggests mitochondria play a …

Experimental And Numerical Analysis Of Nano-Enhanced Polymer Coated Steel Plates Subjected To Ballistic Loading, Miles Coleman Fowler

Electronic Theses and Dissertations

The following is a summary of research for a portion of the project titled Nano-Enhanced and Bio-Inspired Composite Materials for Mitigation and Protection of TIH Railcars and Stationary Tanks Against High Power Impact. This research investigated several nano-enhanced polymers for their suitability in high-speed impact protection applications. The polymers were tested mechanically to find ideal nano-particle additive percentages then coated onto steel substrates. These coated substrates were impacted using 0.50-caliber projectiles in order to find the ballistic limit (V50) for each combination. Computer modeling in ANSYS AUTODYN was undertaken to calculate a numerical ballistic limit for each plate configuration. The …

Temporal And Spatial Assessment Of Pahs In Water, Sediment, And Oysters As A Result Of The Deepwater Horizon Oil Spill, Meghan Christina Dailey

Electronic Theses and Dissertations

On April 20, 2010, BP's Deepwater Horizon oil rig exploded leaking over 200 million gallons of crude oil into the Gulf of Mexico for 84 days. Exposure to oil-associated polycyclic aromatic hydrocarbons (PAHs) in the water and sediment could severely impact the aquatic organisms inhabiting the Gulf of Mexico (i.e. developmental defects, reproductive effects, death, etc.). Therefore, water, sediment and oyster, Crassostrea virginica, samples were collected approximately bimonthly between May 26 and November 30, 2010 from multiple sites along the Gulf Coast, namely, two sites in Mobile Bay (Denton and Sand Reefs at 1 or 0.1 m above the bay …

Journey, Hosik Kim

Electronic Theses and Dissertations

My ceramic sculptures are about my story as well as the stories of all of us. Through these children that were born from clay, I find myself remembering and returning to the long journey that I have been walking all along. Memories are often the inspiration for my work, whether they are good or bad. In Korean, we call this [Special characters omitted]. I preserve these memories by carving into the surface of the clay, revealing a tattoo-like effect. I tried to make my own tattoos through my artwork because tattoos have a story and stay forever. My thesis speaks …

Donor-Sigma-Acceptor (D-Sigma-A) Molecules With Perylenebisimide Acceptors Having Alkyl Or Peg Swallowtails With Sulfur Or Hydroxyl Anchors: Synthesis And Applications In Langmuir-Blodgett Films, Single Molecule Spectroscopy (Sms), G-Quadruplex Studies And Passivation Of Gold Nanoparticles, Rajesh Kota

Electronic Theses and Dissertations

Use of single molecules as electronic devices is presently considered a potential alternative to semiconductor-based nanoscale electronics. The ability to study a single molecule or a small group of molecules provides a great opportunity to build electronic devices at the molecular level. It is vital to understand the parameters that control the device properties such as molecular structure, conformation and arrangement at the surface. Ari Aviram and Mark A. Ratner proposed the construction of a single organic molecule as an organic rectifier. Donor-Sigma-Acceptor (D-?-A ) molecules, when arranged with a proper orientation as Langmuir-Blodgett (LB) films and fixed between two …

Mixing It Up: Multiple Symbiont Acquisition Strategies As An Adaptive Mechanism In The Coral Stylophora Pistillata, Kristen A. Byler

Electronic Theses and Dissertations

In obligate symbioses, the host's survival relies on the successful acquisition and maintenance of symbionts, which can be transferred from parent to offspring via direct inheritance (vertical transmission) or acquired anew each generation from the environment (horizontal transmission). Vertical transmission ensures progeny acquire their obligate symbionts, but progeny encountering an environment that differs from that of their parent may be disadvantaged by hosting a suboptimal symbiont. Conversely, horizontal symbiont acquisition provides hosts the benefit of acquiring symbionts well suited to the prevailing environment, but progeny may fail to acquire their obligate symbionts. Here I show that the coral Stylophora pistillata …

The Legal Relationship Between Cohabitants And Their Partners' Children, Cynthia Grant Bowman

Cornell Law Faculty Publications

This Article argues that U.S. law should give protection to relationships between cohabitants and their partners 'children when necessary to avoid the economic and emotional trauma that may be caused by separation of the child from a member of his or her household if the cohabitation ends. After examining the social science literature about the welfare of both stepchildren and children of cohabitants and the inadequate legal treatment of custody, visitation, and child support issues under current law, the author recommends that cohabiting stepparents (1) be given standing to seek custody if they have acted as de facto parents, with …

Cognitive Profiles And The Impact Of Medication On Children With Attention Deficit Hyperactivity Disorder, Lucy J. Wimpenny

PCOM Psychology Dissertations

Attention Deficit Hyperactivity Disorder (ADHD) is one of the most frequently diagnosed disorders in children and adolescents. Individuals with ADHD often display behavioral symptoms, including inattention and/or impulsivity, which can also lead to struggles in the school setting. Current research has suggested that deficits in processing speed and working memory are common in individuals diagnosed with ADHD and are often seen on measures of cognitive ability. Positive outcomes have been associated with the use of psychostimulant medication to treat the symptoms of ADHD, although little research has supported this form of treatment to improve cognitive functioning in individuals diagnosed with …

The Relationship Between Parental Stress, Cognitive Distortions, And Child Psychopathology, Daniel Kennedy

PCOM Psychology Dissertations

While there are a number of factors that may contribute to maladaptive parenting behaviors, parental stress has consistently been related to the increased risk of child maltreatment and, ultimately, the development of childhood. The question then is what drives parental stress and what are those key factors? Based on previous research, there are multiple parental, child, and environmental factors that lead to parental stress, but there is not a clear understanding of what initially drives parental stress. Based on cognitive behavioral models of stress and Abidin’s theory of parental stress, it is theorized that parental cognitions play an important role …