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Effects Of L-2-Oxоthiazolidine-4-Carboxylic Acid On The Lung Antioxidant Defense System In An Asthma Mouse Model, Lyudmil Georgiev Terziev, Veneta Lyubenova Shopova, Violeta Yordanova Dancheva, Galya Tzvetanova Stavreva, Angelina Milcheva Stoyanova

Turkish Journal of Medical Sciences

We aim ed to study the effect of a glutathione precursor, L-2-oxothiazolidine-4-carboxylic acid (OTCA), on the lung antioxidant defense system in an animal asthma model. Materials and methods: The study was carried out on 24 female C57BL/6 mice. The mice were divided into 4 treatment groups: group 1 - control group; group 2 - injected with ovalbumin (OVA) and given an OVA inhalant; group 3 - treated with OTCA and phosphate-buffered saline inhalant; and group 4 -injected with OVA and OTCA and given an OVA inhalant. Under sodium pentobarbital anesthesia the animals were killed by exsanguination 48 h after the …

Hyaluronidase-1 Expression Is Not A Predictor Of Biochemical Recurrence In Radical Prostatectomy Specimens, Bayram Güner, Sidika Şeyma Özkanli, Turhan Çaşkurlu, Asif Yildirim, Mehmet Cenk Gürbüz, Itir Ebru Zemheri̇

Turkish Journal of Medical Sciences

The purposes of this study were to evaluate the rate of biochemical recurrence among patients who underwent radical prostatectomy due to localized prostate cancer, assess the risk factors of biochemical recurrence, and investigate its relation with hyaluronidase-1 (HYAL-1). Materials and methods: We retrospectively evaluated the data of 112 patients who underwent radical retropubic prostatectomy. HYAL-1 expression was evaluated immunohistochemically and staining was graded as mild, moderate, and severe. Two blinded pathologists evaluated the specimens. The relation among preoperative pathologic findings that were detected in transrectal ultrasound (TRUS) guided biopsy, specimens of radical prostatectomy in the final stage, and biochemical recurrence …

Tularemia As A Result Of Outdoor Activities For Children In The Countryside, Şaban Gürcan, Gamze Varol Saraçoğlu, Aynur Karadeni̇zli̇, Emi̇ne Neşe Özkayin, Şemsi̇ Zafer Öztürk, Cemal Çi̇çek, Bi̇nay Vatansever

Turkish Journal of Medical Sciences

To investigate the features of a new tularemia outbreak that occurred in the Thrace region. Materials and methods: The research team visited the village after the identification of the index case. Serum and throat samples were taken from 41 villagers who were examined, and environmental samples were taken in order to identify the source of the outbreak. Culture, serology, and molecular methods were used to search for Francisella tularensis in these samples. Results: A total of 8 children were diagnosed with tularemia. The adults and all of the other children were seronegative for tularemia. All of the patients had a …

Efficacy Of Azithromycin For Prevention Of Bronchopulmonary Dysplasia (Bpd), Manizheh Mostafa Gharehbaghi, Ali Peirovifar, Mortaza Ghojazadeh, Majid Mahallei

Turkish Journal of Medical Sciences

Bronchopulmonary dysplasia (BPD) remains one of the most serious and challenging complications in premature infants. This study was conducted to evaluate the efficacy of azithromycin in the prevention of BPD in very low birth weight preterm infants Materials and methods: Preterm neonates with birth weight less than 1500 g were enrolled in a prospective randomized controlled clinical trial. One hundred eight neonates were randomly allocated to the intervention group (n = 56) or control group (n = 52). The intervention group received oral azithromycin 10 mg/kg for 1 week followed by 5 mg/kg for another week. The outcome measures were …

The Levels Of Serum Chemokines In Patients With Behçet's Disease, İbrahi̇m Kökçam, Di̇lara Turgut, Nafi̇ye Fulya İlhan, Demet Çi̇çek

Turkish Journal of Medical Sciences

As chemokines are involved in the regulation of immune responses and inflammatory reactions, this study aimed to investigate the serum levels of some chemokines to determine whether they play roles in the pathogenesis of Behçet's disease (BD). Materials and methods: The study comprised 64 cases, allocated to active or inactive patient groups. The levels of serum macrophage inflammatory protein-1\alpha (MIP-1\alpha), epithelial neutrophil-activating protein-78 (ENA-78), and neutrophil-activating peptide-2 (NAP-2) were measured. Results: The serum levels of MIP-1\alpha and ENA-78 were statistically higher in BD patients than controls (P = 0.032 and P = 0.023, respectively). However, NAP-2 levels did not differ …

Investigation Of Serum Paraoxonase-1 Activity And Lipid Levels In Patients With Hyperthyroidism, Gülden Başkol, Kiymet Dolbun Seçki̇n, Fahri̇ Bayram, Fati̇h Tanriverdi̇

Turkish Journal of Medical Sciences

The present study was designed to investigate the relationship among the serum paraoxonase-1 (PON-1) activity, lipid levels, and thyroid hormone status in patients with hyperthyroidism. Materials and methods: The study group comprised 30 patients with primary hyperthyroidism and 18 normal healthy controls who were matched for age and sex. Serum PON-1 activity was determined by spectrophotometric methods. Results: Serum PON-1 activity was found to be lower in patients compared to controls (P < 0.05). Free triiodothyronine (T3) and free thyroxine (T4) levels were significantly higher in the patient group compared to the control group (P < 0.001 and P < 0.001 respectively). Thyroid-stimulating hormone (TSH) and total cholesterol values were found to be lower in patients than in the controls (P < 0.001 and P < 0.001 respectively). Low-density lipoprotein cholesterol levels were found to be decreased in patients compared to controls (P < 0.005). Triglyceride and high-density lipoprotein cholesterol levels were not significantly different between the 2 groups (P > 0.05). Serum PON-1 activity was found to be negatively correlated with free T4 levels (r = -0.324, P < 0.05) and positively correlated with total cholesterol (r = 0.330, P < 0.05) and TSH levels (r = 0.577, P < 0.001). Conclusion: Our PON-1 results show that there is decreased antioxidant defense in patients with hyperthyroidism. Therefore, we think that effective antioxidant therapy to increase PON-1 activity may be a therapeutic option in patients with hyperthyroidism.

Histopathological Effects Of The Food Contaminant Furan On Some Endocrine Glands Of Prepubertal Male Rats, Eli̇f Karacaoğlu, Güldeni̇z Selmanoğlu, Aysun Kiliç

Turkish Journal of Medical Sciences

To evaluate the toxicity of furan on the thyroid gland, adrenal gland, and pancreas of prepubertal male rats. Materials and methods: Furan was administered orally to 3-4-week-old male rats at doses of 2, 4, and 8 mg kg^{-1} day^{-1} by dissolving in corn oil for 90 days. The rats were sacrificed by cervical dislocation at the end of the experiment. Their endocrine glands including the thyroid gland, adrenal gland, and pancreas were removed and weighed. Tissues were examined morphologically and histopathologically under a light microscope. Results: Organ and relative organ weights of rats did not change with furan administration. Histopathological …

Genotyping Of Giardia Intestinalis Isolated From People Living In Sivas, Turkey, Serpi̇l Değerli̇, Naci̇ Değerli̇, Ali̇ Çeli̇ksöz, Semra Özçeli̇k

Turkish Journal of Medical Sciences

The technique of polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) genotyping was used to characterise morphologically identical isolates of Giardia intestinalis from human stool samples. Materials and methods: In this study a total of 17 trophozoite samples, obtained either directly from stool samples or after excystation, or by duodenal aspiration, were used. A set of primers was chosen to amplify the different regions of triose phosphate isomerase (tpi) and a segment of the glutamate dehydrogenase (gdh) genes. A single-stranded conformational polymorphism technique was also used in an attempt to discriminate among some subgroups. Results: Only primers of the 683-bp segment …

Characterization Of Uropathogenic Escherichia Coli Strains Obtained From Urology Outpatient Clinic Of Ege Medical Faculty In İzmir, Betül Gi̇ray, Füsun Bahri̇ye Uçar, Sabi̇re Şöhret Aydemi̇r

Turkish Journal of Medical Sciences

To identify the papG gene and its allelic variation in uropathogenic Escherichia coli (UPEC) strains isolated from patients with acute pyelonephritis and cystitis. Materials and methods: Seventy-five E. coli strains isolated from patients admitted to the University of Ege Medical Faculty urology outpatient clinic were isolated and identified phenotypically. All of these strains were examined for the papG gene and allelic distribution of this gene with the multiplex polymerase chain reaction technique. Results: papG genes were found in 24 of 75 E. coli strains. Of these 24 strains, 7 (29%) had papG class II only, 8 (33%) had class III …

Minimum Inhibitory And Minimum Bactericidal Concentrations Of Boron Compounds Against Several Bacterial Strains, Murat Tolga Yilmaz

Turkish Journal of Medical Sciences

Boron compounds are essential micronutrients for many organisms. However, they negatively affect plant, soil, and water microflora if excessive amounts exist in irrigation water. Therefore, this study aimed to define the minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of boric acid and borax by selecting the bacteria that can survive in all environments. Materials and methods: The antibacterial efficacy of boric acid and borax against several bacterial strains was evaluated 3 times with the macrodilution broth method. Results: The MICs and MBCs of boric acid were obtained as 3.80 mg/mL, 3.80 mg/mL, 7.60 mg/mL, and 7.60 mg/mL against …

Circulating Levels Of Igf-I And Igfbp-3 In Gastric Cancer, Konca Altinkaynak, Mehmet Bi̇li̇ci̇, Nuri̇ Bakan, Fati̇h Akçay

Turkish Journal of Medical Sciences

To explore the causative mechanism of gastric carcinoma and to investigate the roles of circulating IGF-I and IGFBP-3 in gastric cancer. Materials and methods: Serum IGF-I and IGFBP-3 concentrations were measured using a 2-site coated tube immunoradiometric assay. Results: Serum IGF-I and IGFBP-3 values in gastric cancer patients were significantly lower compared to those in the control group. The difference between serum IGF-I/IGFBP-3 in patients and the control group was not significant. Conclusion: The low serum IGF-I and IGFBP-3 levels detected in patients with gastric cancer could be due to decreased synthesis or increased catabolism of IGF-I or both. It …

Investigation Of The Clinical And Hematological Significance Of The First Observed Hemoglobin Ernz Variant [Β123(H1) Thr>Asn] In The Turkish Population, Ramazan Güneşaçar, Muhammet Murat Çeli̇k, Oktay Hasan Öztürk, Mustafa Çeli̇k, Cemi̇l Tümer, Tanju Çeli̇k

Turkish Journal of Medical Sciences

In this report, we aimed to investigate the clinical and hematological significance of the first observed hemoglobin Ernz variant in the Turkish population. Materials and methods: We identified the Hb Ernz variant in 3 nonrelated females (Probands 1, 2, and 3). Proband 1’s family was also included the study. Hematological data were obtained with an automated cell counter and routine methodology. The beta-globin gene was sequenced by automatic sequencing. Results: Proband 1 was detected as a combination of Hb Ernz/Hb S without any clinical symptoms. Her sister and brother had to be an Hb Ernz/Hb S combination. Her mother and …

The Effect Of Intermittent Fasting And Water Restriction On Myocardial Ischemia/Reperfusion-Induced Arrhythmia In Rats, Sali̇h Tunç Kaya, Ömer Bozdoğan

Turkish Journal of Medical Sciences

To investigate the effect of intermittent fasting and water restriction on ischemia/reperfusion-induced arrhythmias. Materials and methods: Six minutes of ischemia followed by 6 min of reperfusion was produced by the ligation and then releasing of the left coronary artery. Intermittent fasting and water restriction were applied during 1 month for 12 h/day. The duration, type, and incidence of arrhythmias during reperfusion and the survival rate at the end of reperfusion were determined and compared. Results: The score of arrhythmia that was determined using the type and duration of arrhythmia did not show significant differences among groups. The arrhythmic period was …

Effects Of Combined Oral Contraceptives On The Skin Of Mice, Nibras Hatim Khamees, Insaf Jasim Mahmoud, Amal Al Khateeb

Turkish Journal of Medical Sciences

To find the effects of a combination of 2 widely used contraceptives, ethinyl estradiol and cyproterone acetate (ECPA), on skin and sebaceous gland morphology and dermal vascularity of mice. Materials and methods: Female mice were divided into groups: treatment with ECPA for 1 month (T) and its control (C); and cessation of treatment for an additional month (recovery, R) and its control (CR). Body weight, skin histology and morphometry, and vaginal smears were performed and analyzed. Results: In the T and R groups, there was a significant increase in epidermal and dermal thickness and dermal vascularity. In group T, the …

Structural Properties Of Thermoresponsive Poly(N-Isopropylacrylamide)-Poly(Ethyleneglycol) Microgels, J. Clara-Rahola, A. Fernandez-Nieves, B. Sierra-Martin, A. B. South, L. Andrew Lyon, J. Kohlbrecher, A. F. Barbero

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

The application of RNA interference to treat disease is an important yet challenging concept in modern medicine. In particular, small interfering RNA (siRNA) have shown tremendous promise in the treatment of cancer. However, siRNA show poor pharmacological properties, which presents a major hurdle for effective disease treatment especially through intravenous delivery routes. In response to these shortcomings, a variety of nanoparticle carriers have emerged, which are designed to encapsulate, protect, and transport siRNA into diseased cells. To be effective as carrier vehicles, nanoparticles must overcome a series of biological hurdles throughout the course of delivery. As a result, one promising …

Media Portrayals Of Political Spouse's Communication On The Campaign Trail: A Content Analysis, Anita Lynn Herold

Theses and Dissertations

A good public image is important to everyone, but it is vital to political

candidates. Media content has been the focus of much research, but most centers on the candidate as an individual. This research explores media portrayals of the communication that occurs between a candidate and their spouse.

A content analysis of newsmagazine articles from September 1, 2010 to November 1, 2010 was conducted exploring concepts relating to candidate status, spouse's sex, gender roles and stereotypes, acceptance, and media ideology.

Only 8.82% of the articles contained instances of spousal communication. All of these communication events portrayed in the article …

Dirhodium-Induced Intramolecular C-H Insertion On Diazosulfones/Sulfonates And Its Synthetic Applications, Christian Suhngwa Jungong

Theses and Dissertations

This works explores the use of rhodium-catalyzed intramolecular C-H insertion on diazosulfones and sulfonates as a tool to simplify the synthesis of organic molecules. Dirhodium-induced intramolecular C-H insertion on diazo carbonyl compounds is a relatively well-studied reaction. It occurs with an overwhelming bias for the formation of five-membered carbocycles or heterocycles, with the order of reactivity of C-H bonds being methine > methylene >> methyl. This intrinsic preference can be overridden by dissimilar factors such as substrate conformation, insertion site electronic effects and the reactivity of the dirhodium catalyst.

This study has disclosed that when diazo- sulfones and sulfonates are employed, dirhodium-induced …

Native American Secondary Female Students' Perspectives On School Success, Frances Ann Rodenburg

Theses and Dissertations

The purpose of this qualitative study was twofold: (a) to gain an understanding of how students perceive their own academic successes, learning experiences, and factors that contribute to their success; and (b) to document oral stories students shared about their experiences through transcribed interviews. The information gathered was intended to support educators in understanding factors contributing to school success for Native American students. Students interviewed were eight female, Native American students in Grades 8 through 10, living in poverty, and scoring at proficient or advanced levels on their 2009-2010 state assessment in both reading and math.

Students attended various schools …

Vapor-Liquid Phase Equilibria Using Monte Carlo Wang-Landau Simulations, Tsvetan Aleksandrov

Theses and Dissertations

The experimental determination of the critical point of metals is inherently connected with difficulties of measuring large temperatures and pressures. On the other hand, that of straight alkane chains larger than ten carbon atoms and branched chains larger than eight atoms is burdensome due to decomposition of the molecules while in the vapor phase. Therefore molecular simulations stand as an appropriate alternative for determining the critical point and phase coexistence properties of these fluids. Most simulation methods that are apt for this task rely on particles insertion and deletion moves that can significantly complicate the simulation, since high density in …

Examining The Likelihood Of Readmission To Inpatient Pulmonary Rehabilitation Using A Variety Of Predictors, Allison Jean Neil

Theses and Dissertations

This study involved examining 5 years of existing medical records for patients previously in pulmonary rehabilitation, producing 333 subjects (180 female). The purpose of this study was to determine if any variables could significantly predict readmission, so a better pulmonary rehabilitation programs could be designed. Thus reducing the cost for the health care system as well as the patients themselves, and for in the patients future it would reduced illness, pain, and human suffering. A discriminant analysis was conducted in order to determine the likelihood of readmission into pulmonary rehabilitation using the independent variables of 6MWT difference, PEFR difference, BMI …

Introducing Astronomy Into High School Physics Curriculum Through The Use Of The University Of North Dakota Observatory, Caitlin Marie Nolby

Theses and Dissertations

Astronomy education is currently lacking in the secondary level classroom. Many programs have been created to remedy this, including research opportunities for students and training workshops for educators. These reach only a small fraction of the population however, while remaining students still lack the opportunity to learn astronomy at the secondary level. This research addresses the creation of a program that will make astronomy education a recurring option for students across North Dakota through implementation of a two-week astronomy course at Grand Forks Central High School (GFCHS) in a class of 19 physics students. During ten class periods from April …

Post-Traumatic Stress Disorder, Nicole Smith

A with Honors Projects

This research paper examines post-traumatic stress disorder and its effects, symptoms and cures.

Disease-Branding And Drug-Mongering: Could Pharmaceutical Industry Promotional Practices Result In Tort Liability?, Jason S. Cetel

Seton Hall Law Review

No abstract provided.

Higher Il-6 And Il6:Igf Ratio In Patients With Barth Syndrome, Lori D. Wilson, Sadeeka Al-Majid, Cyril Rakovski, Christina D. Schwindt

Mathematics, Physics, and Computer Science Faculty Articles and Research

Background: Barth Syndrome (BTHS) is a serious X-linked genetic disorder associated with mutations in the tafazzin gene (TAZ, also called G4.5). The multi-system disorder is primarily characterized by the following pathologies: cardiac and skeletal myopathies, neutropenia, growth delay, and exercise intolerance. Although growth anomalies have been widely reported in BTHS, there is a paucity of research on the role of inflammation and the potential link to alterations in growth factors levels in BTHS patients.

Methods: Plasma from 36 subjects, 22 patients with Barth Syndrome (0.5 - 24 yrs) and 14 healthy control males (8 - 21 yrs) was …

40_1_Insidefrontcover.Pdf, Marine Ornithology

Marine Ornithology

No abstract provided.

40_1_Contents.Pdf, Marine Ornithology

Marine Ornithology

No abstract provided.

Eiu 4118g : The Biological Origins Of Social Practices, Biological Sciences

Approved Course Proposals

No abstract provided.

Geo 5830 : Gis: Building Geodatabases, Geology/Geography

Approved Course Proposals

No abstract provided.

Esc/Geg 5830 : Building Geodatabases, Geology/Geography

Approved Course Proposals

No abstract provided.

Cancer And You, Diah-Aldeen Judeh

A with Honors Projects

This project discusses ways a person can identify cancer and what to do if cancer is present.