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The Epigenetic Regulation Of Cubilin And The Physiological Role Of This Receptor In Maintaining The Homeostasis Of Serum Albumin And Hdl, Sayed Obaidullah Aseem

MUSC Theses and Dissertations

Cubilin is an endocytic receptor capable of mediating the endocytosis of multiple ligands including High Density Lipoprotein apolipoprotein A-I (apoA-1) and albumin. It is highly expressed on the epithelium of intestinal villi and renal proximal tubules. In the kidney, endocytosis mediated by cubilin and its co-receptor megalin is the principal mechanism for proximal tubule reabsorption of filtered proteins, such as albumin and apoA-1. Yet, the consequences of cubilin deficiency on the blood levels of albumin and apoA-1 have not been studied. Furthermore, cubilin is downregulated in chronic diseases such as diabetes. However, little is known about the regulation of cubilin …

Does The Use Of Intravenous Zoledronic Acid, In Combination With Chemotherapy Regimens, Arrest The Development And Spread Of Cancer Cells To Increase Disease-Free Survival In Breast Cancer Patients?, Dara Colasurdo

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not “Does the use of intravenous zoledronic acid, in combination with chemotherapy regimens, arrest the development and spread of cancer cells to increase disease-free survival in breast cancer patients.“

STUDY DESIGN: Review of three English language primary randomized controlled trials published between 2009 and 2010.

DATA SOURCES: Randomized controlled trials and open label, randomized, phase 2 trial comparing the use of zoledronic acid in combination with chemotherapy to the use of chemotherapy alone were found using Medline/PubMed and Cochrane Databases

OUTCOMES MEASURED: The outcomes measured were incidence …

The Ecological Validity Of The Self-Explanation Effect: The Deleterious Effect Of Music On Self-Explanations, Jason Geller, Robert J. Calin-Jageman

Modern Psychological Studies

One of the most powerful ways to boost learning is to require students to self-explain—to generate written or verbal explanations of their study material as they are studying. Although self-explaining is known to enhance learning across a wide range of ages and study materials, this empirical work has focused almost exclusively on optimal study conditions. Here we explore if selfexplaining is similarly effective in the presence of background music, a distraction students commonly elect to incorporate into their study routines. In the first study, 32 university students were asked to learn about neuronal action potentials while we varied both self-explaining …

The Effect Of Music Genre On A Memory Task, Darragh Bugter, Randy Carden

Modern Psychological Studies

This study examined the effects of two different music genres and silence on a memory task Sixty participants were randomly assigned to three groups which were exposed to rap music, classical music or silence while playing the Concentration game. The number of flips needed to complete the Concentration game was measured and served as the memory score. Results of a one-way analysis of variance detected a significant difference between the groups. A planned post hoc analysis found that the classical music group completed the Concentration game in significantly fewer flips than the rap group.

Psychosocial Interventions For Adults Who Were Sexually Abused As Children (Protocol For A Cochrane Review), Jessica Shaffner Wilen, Julia H. Littell, Georgia Salanti

Graduate School of Social Work and Social Research Faculty Research and Scholarship

No abstract provided.

2012 Annual Reports And Resolutions, American Dental Association

ADA Transactions

This item is part of the Annual Reports and Resolutions subtitle of the ADA Transactions, a serial publication of the annual activities of the ADA House of Delegates (HOD)/Board of Trustees (BOT) made up of three separate subtitles: Annual Reports and Resolutions, Supplements, and Transactions. Generally, the ADA Transactions are published in multiple volumes throughout the year. Older versions include reports from all departments as subsections, while more recent versions include only those of councils, commissions, and committees.

Graduate Catalog And Student Handbook 2012-2013, Nova Southeastern University

Abraham S. Fischler College of Education and School of Criminal Justice Graduate Course Catalogs

No abstract provided.

Population And Public Policy: Essays In Honor Of Paul Demeny, Geoffrey Mcnicoll, John Bongaarts, Ethel P. Churchill

Population Policy and Demographic Analysis

Paul Demeny, founding editor of Population and Development Review, retired following the publication of Volume 38 in 2012. This collection of essays on population and public policy marks the occasion and celebrates his scholarly career.

The opening essays in this supplement to Population and Development Review cover population renewal in affluent societies, the management of intergenerational relations throughout history, and the sustainability issues confronting the modern welfare state. Another set of contributions is concerned with the historical experience with low fertility; the puzzles that ultra-low fertility and natural population decrease pose for theorists of human behavior; the relationship between …

Penile Enhancement Procedures With Simultaneous Penile Prosthesis Placement, Tariq S. Hakky, Jessica Suber, Gerard Henry, David Smith, Paul Bradley, Daniel Martinez, Rafael E. Carrion

Surgery Faculty Publications

Here we present an overview of various techniques performed concomitantly during penile prosthesis surgery to enhance penile length and girth. We report on the technique of ventral phalloplasty and its outcomes along with augmentation corporoplasty, suprapubic lipectomy, suspensory ligament release, and girth enhancement procedures. For the serious implanter, outcomes can be improved by combining the use of techniques for each scar incision. These adjuvant procedures are a key addition in the armamentarium for the serious implant surgeon

The Florida Melanoma Trial I: A Prospective Multicenter Phase I/Ii Trial Of Postoperative Hypofractionated Adjuvant Radiotherapy With Concurrent Interferon-Alfa-2b In The Treatment Of Advanced Stage Iii Melanoma With Long-Term Toxicity Follow-Up, Steven E. Finkelstein, Andy Trotti, Nikhil Rao, Douglas Reintgen, Wayne Cruse, Lynn Feun, Vernon Sondak, Daohai Yu, Weiwei Zhu, Clement Gwede, Ronald Deconti

Surgery Faculty Publications

Radiotherapy (RT) and interferon-alfa-2b (IFN α-2b) have individually been used for adjuvant therapy stage III melanoma with high-risk pathologic features. We hypothesized that concurrent adjuvant RT and IFN α-2b may decrease the risk of regional recurrence following surgery with acceptable toxicity. A prospective multicenter phase I/II study was conducted to evaluate hypofractionated RT with concurrent IFN. Induction IFN α-2b, 20 MU/m2/d, was administered IV ×5 consecutive days every week for 4 weeks. Next, RT 30 Gy in 5 fractions was given with concurrent IFN α-2b, 10 MU/m2 SQ 3 times per week on days alternating with …

Problems In Using Diagnosis In Child And Adolescent Mental Health Services Research, Leonard Bickman, Lynne G. Wighton, E. Warren Lambert, Marc Karver, Lindsey Steding

Psychology Faculty Publications

This paper presents results from a three-part study on diagnosis of children with affective and behavior disorders. We examined the reliability, discriminant, and predictive validity of common diagnoses used in mental health services research using a research diagnostic interview. Results suggest four problems: a) some diagnoses demonstrate internal consistency only slightly better than symptoms chosen at random; b) diagnosis did not add appreciably to a brief global functioning screen in predicting service use; c) low inter-rater reliability among informants and clinicians for six of the most common diagnoses; and d) clinician diagnoses differed between sites in ways that reflect different …

Missing The Trees For The Forest? Learning Environments Versus Learning Techniques In Simulations, Chad Raymond

Faculty and Staff - Articles & Papers

Institutions of higher learning are increasingly asked to defend curricular and pedagogical outcomes. Faculty must demonstrate that simulations are productive tools for learning, but a review of the literature shows that the evidence of their effectiveness is inconclusive, despite their popularity in the classroom. Simulations may in fact help students learn, but the pedagogical benefits of simulations may be being attributed too generally to the learning environments that they supposedly produce, rather than the specific learning modalities that occur within them. The paper concludes with a recommendation that educators choose particular learning techniques first, and then build simulations around these …

Twentieth Report Of The Florida Ornithological Society Records Committee: 2010, Andrew W. Kratter

Florida Field Naturalist

No abstract provided.

Front Cover, Florida Field Naturalist

Florida Field Naturalist

No abstract provided.

Honors And Awards Council Awards List, Faculty Senate

Faculty Senate Archives

No abstract provided.

Assassination Or Targeted Killings After 9/11, John Yoo

NYLS Law Review

No abstract provided.

Β-Secretases, Alzheimer's Disease, And Down Syndrome, Robin L. Webb, M. Paul Murphy

Molecular and Cellular Biochemistry Faculty Publications

Individuals with Down Syndrome (DS), or trisomy 21, develop Alzheimer's disease (AD) pathology by approximately 40 years of age. Chromosome 21 harbors several genes implicated in AD, including the amyloid precursor protein and one homologue of the β-site APP cleaving enzyme, BACE2. Processing of the amyloid precursor protein by β-secretase (BACE) is the rate-limiting step in the production of the pathogenic Aβ peptide. Increased amounts of APP in the DS brain result in increased amounts of Aβ and extracellular plaque formation beginning early in life. BACE dysregulation potentially represents an overlapping biological mechanism with sporadic AD …

Keratin 8/18 Filaments: Potential Modulators Of Death Signaling In Ovarian Granulosa Cells, Sarah E. Kinsman

Master's Theses and Capstones

Granulosa cell apoptosis is associated with follicular atresia; but the cellular mechanisms that drive this process, especially its cell specificity, are relatively unknown. Here, we determined that cultured granulosa cells abundantly express K8/K18 filaments and inhibition of protein synthesis enhances Fas-induced apoptosis. In this context, the roles of cFLIP, ERK1/2 and Akt are minimal but conversely, K8/K18 filaments have a prominent role in granulosa cell resistance to Fas-induced apoptosis. Keratin 8/18 filaments in granulosa cells provide a plausible mechanism to avoid Fas-induced apoptosis and this mechanism potentially involves the synthesis of labile proteins. The existence of K8/K18 filaments in granulosa …

The Influence Of Abiotic And Biotic Factors On Two Nudibranchs Feeding Upon Membranipora Membranacea In The Southern Gulf Of Maine, Megan I. Mcculler

Master's Theses and Capstones

The abiotic (temperature and flow rate) and biotic factors within fouling communities at three marinas located along the southern Gulf of Maine from June to December in 2010 and 2011 were surveyed. The goal of this study was to determine what is driving the recent population increase of the nudibranch, Corambe obscura, and whether the native nudibranch, Onchidoris muricata, is transitioning prey species. In addition, the affects of temperature on aspects of C. obscura's life history were determined by laboratory experiments.

Results suggest that abiotic factors influence basic community members such as the kelp host, Saccharina latissima, and the invasive …

Throughfall Chemistry In Deciduous And Coniferous Forest Stands At Thompson Farm, New Hampshire, Musa Dinc

Master's Theses and Capstones

In this study, I compare the chemical composition of throughfall in deciduous and coniferous forest stands to the chemistry of wet deposition. The study was conducted at Thompson Farm, Durham NH, which is owned and managed by the University of New Hampshire. Thompson Farm (43.11N, 70.95W) is at an altitude of 23 m and about 24 km from the Gulf of Maine. Throughfall samples were obtained from two forest stands using wet-dry Aerochem Metrics 301 collectors and rainfall samples were collected in a wet-only precipitation collector (N-CON Atmospheric Deposition Samples Model 00-120) from 14 April 2009 to 14 November 2009.The …

Investigation Of Chromophoric Dissolved Organic Matter As A Freshwater Tracer In The Kennebec River Estuary, Alison Barner

Master's Theses and Capstones

In an attempt to explore the feasibility of using chromophoric dissolved organic matter (CDOM) as a freshwater tracer in the Kennebec Estuary of Maine, potential causes of the variability of the CDOM absorption coefficient (ag412) in relation to salinity were investigated. A predictable relationship between CDOM variability and factors such as river discharge and season was sought to explain CDOM variability for use in remote sensing. To accomplish these objectives, ag412 was calibrated to continuous underway FDOM measurements using linear regressions from 14 cruises. USGS daily discharge rates were checked for possible relationships with ag412 values. Although no trends were …

Analysis Of Bisphenol A (Bpa) In Local Waters And In Pvc Pond Liner, Brandon Bills

Undergraduate Honors Theses

Concentrations of the endocrine disrupter bisphenol A (BPA) were determined for three water samples from the watershed of Charleston, IL, USA. The analytical approach employed solid phase extraction in conjunction with GC/MS-SIM analysis and yielded a limit of detection of 30 ppt (parts per trillion). The local waterways Town Branch. Cassel Creek and Embarras River showed concentrations of 58(11) ppt, 89(3) ppt, and 32(9) ppt respectively. Additional measurements of BPA availability from aqueous laboratory extractions of a commercial PVC pond liner have been initiated. Preliminary results indicate significant BPA release from the pond liner, dependent upon extraction conditions.

The Crossover Phenomenon In Young Adult Literature, Keri Jo Carroll

Undergraduate Honors Theses

No abstract provided.

Lassa: Emotion Detection Via Information Fusion, Ning Yu, Sandra Kübler, Joshua Herring, Yu-Yin Hsu, Ross Israel, Charese Smiley

Information Science Faculty Publications

Due to the complexity of emotions in suicide notes and the subtle nature of sentiments, this study proposes a fusion approach to tackle the challenge of sentiment classification in suicide notes: leveraging WordNet-based lexicons, manually created rules, character-based n-grams, and other linguistic features. Although our results are not satisfying, some valuable lessons are learned and promising future directions are identified.

2b: "Copy Of Carbon Dioxide Data Illinois Natural Gas", U.S. Energy Information Administration

Ecosystem Disruption & Climate Change

No abstract provided.

2b: "Copy Of Carbon Dioxide Data Illinois Totals", U.S. Energy Information Administration

Ecosystem Disruption & Climate Change

No abstract provided.

2b: "Copy Of Carbon Dioxide Data Illinois Petroleum Products", U.S. Energy Information Administration

Ecosystem Disruption & Climate Change

No abstract provided.

2012 Georgia Southern University Softball Roster, Georgia Southern University

Women's Softball Records

• 2012 Softball Roster

2012 Georgia Southern University Softball Media Guide, Georgia Southern University

Women's Softball Records

• Table of Contents

Music Therapy Within The Context Of Psychotherapeutic Models, Mary Scovel, Susan Gardstrom

Department of Music Faculty Publications

Music therapy clinical practice occurs at various levels. Wheeler (1983) has classified the treatment of adults with mental disorders into three types: music therapy as an activity therapy; insight music therapy with re-educative goals; and insight music therapy with reconstructive goals.

Activity-based therapy is aimed at helping the client reach observable, measurable goals through various forms of music experiences. In contrast, the two remaining levels focus on facilitation of change through personal insight gained via musical experiences and verbalization about those experiences. Insight-based music therapy processes are ordinarily more intense and prolonged, in that deep emotions are evoked, and in …