Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2012

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 181 - 210 of 22907

Full-Text Articles in Entire DC Network

Large Scale Matrix Degradation By Stromal Cells Independent Of Invadopodia, Hong Cao, Robbin Eppinga, Eugene W. Krueger, Jing Chen, Mark A. Mcniven Dec 2012

Large Scale Matrix Degradation By Stromal Cells Independent Of Invadopodia, Hong Cao, Robbin Eppinga, Eugene W. Krueger, Jing Chen, Mark A. Mcniven

Faculty Work Comprehensive List

Invadopodia are actin-rich structures at the base of many neoplastic cells that sequester matrix metalloproteases that act to degrade the surrounding stroma to facilitate the invasive process. Conventional invadopodia are dependent upon Src kinase and the large GTPase dynamin 2 (Dyn 2). Whether invadopodia are the only mechanism by which cells degrade matrix is unclear. We have observed that cells of mesenchymal origin degrade matrix in an unique way different from tumor cells. The HYPOTHESIS of this study is that fibroblasts, and other cells of mesenchymal origin, degrade matrix by a mechanism distinct from that of epithelial-based tumor cells. The …

Go to article

Internet Gambling: An Overview Of Psychosocial Impacts, Mark D. Griffiths, Adrian Parke, Richard Wood, Jonathan Parke Dec 2012

Internet Gambling: An Overview Of Psychosocial Impacts, Mark D. Griffiths, Adrian Parke, Richard Wood, Jonathan Parke

UNLV Gaming Research & Review Journal

Technological innovation has always played a role in the development of gambling behaviour, primarily through providing new market opportunities. Early prevalence studies of Internet gambling in the UK, Canada and the US have shown that Internet gambling is not a cause for concern at present However, this seems likely to change as more people start to use the Internet for leisure activities. After a brief overview of gambling technologies and deregulation issues, this paper examines the impact of technology on gambling by highlighting salient factors in the rise of Internet gambling (i.e., accessibility, affordability, anonymity, convenience, escape immersion/dissociation, disinhibition, event …

Go to article

Earning The Right To Lead In Defining Moments: The Act Of Taking Leadership, Tom Karp, Jon-Arild Johannessen Dec 2012

Earning The Right To Lead In Defining Moments: The Act Of Taking Leadership, Tom Karp, Jon-Arild Johannessen

The Journal of Values-Based Leadership

True leaders emerge and earn their right to lead — not as a result of an organization’s day-to-day activities — but through courageous acts exhibited during the organization’s defining moments, whether such moments be characterized as stable or disastrous. Remaining strong and steadfast in testy situations while demonstrating the ability to bond to earn the trust of others are the predominant emotional and interpersonal characteristics on display when a leader earns his or her right to lead.

Go to article

Senate Executive Committee Minutes December 17, 2012, Bronx Community College Senate Executive Committee Dec 2012

Senate Executive Committee Minutes December 17, 2012, Bronx Community College Senate Executive Committee

BCC Governance Archives

Minutes for the meeting of the Senate Executive Committee on December 17, 2012.

Go to article

Phosphotyrosine Recognition Domains: The Typical, The Atypical And The Versatile, Tomonori Kaneko, Rakesh Joshi, Stephan M. Feller, Shawn S.C. Li Dec 2012

Phosphotyrosine Recognition Domains: The Typical, The Atypical And The Versatile, Tomonori Kaneko, Rakesh Joshi, Stephan M. Feller, Shawn S.C. Li

Paediatrics Publications

SH2 domains are long known prominent players in the field of phosphotyrosine recognition within signaling protein networks. However, over the years they have been joined by an increasing number of other protein domain families that can, at least with some of their members, also recognise pTyr residues in a sequence-specific context. This superfamily of pTyr recognition modules, which includes substantial fractions of the PTB domains, as well as much smaller, or even single member fractions like the HYB domain, the PKC and PKC C2 domains and RKIP, represents a fascinating, medically relevant and hence intensely studied part of the cellular …

Go to article

Senate Executive Committee Minutes December 17, 2012, Bronx Community College Senate Executive Committee Dec 2012

Senate Executive Committee Minutes December 17, 2012, Bronx Community College Senate Executive Committee

BCC Governance Archives

Minutes for the meeting of the Senate Executive Committee on December 17, 2013.

Go to article

Expansin Synergy With Cellulases: Development Of A Transgenic Maize System For Expansin Production And Evaluation Of Synergistic Activity On Lignocellulosic Substrates, Sangwoong Yoon Dec 2012

Expansin Synergy With Cellulases: Development Of A Transgenic Maize System For Expansin Production And Evaluation Of Synergistic Activity On Lignocellulosic Substrates, Sangwoong Yoon

Student Theses and Dissertations

One of the greatest barriers to produce biofuels from lignocellulosic material is efficient cellulose depolymerization by cellulase activity. Expansin is a protein that is active in cell wall expansion in growing regions of most plants. Because of this unique activity, expansin synergistic activity with cellulase is believed to lower the depolymerization barrier. Over-expression of expansin in the maize production system is designed to produce sufficient protein 1) to study its physiological effects, and 2) to assess its ability to serve as an industrial enzyme for applications, particularly in biomass conversion. Transgenic lines of maize that express the cucumber expansin gene …

Go to article

Module-Based Subnetwork Alignments Reveal Novel Transcriptional Regulators In Malaria Parasite Plasmodium Falciparum, Hong Cai, Changjin Hong, Jianying Gu, Timothy G. Lilburn, Rui Kuang, Yufeng Wang Dec 2012

Module-Based Subnetwork Alignments Reveal Novel Transcriptional Regulators In Malaria Parasite Plasmodium Falciparum, Hong Cai, Changjin Hong, Jianying Gu, Timothy G. Lilburn, Rui Kuang, Yufeng Wang

Publications and Research

Background Malaria causes over one million deaths annually, posing an enormous health and economic burden in endemic regions. The completion of genome sequencing of the causative agents, a group of parasites in the genus Plasmodium, revealed potential drug and vaccine candidates. However, genomics-driven target discovery has been significantly hampered by our limited knowledge of the cellular networks associated with parasite development and pathogenesis. In this paper, we propose an approach based on aligning neighborhood PPI subnetworks across species to identify network components in the malaria parasite P. falciparum. Results Instead of only relying on sequence similarities to detect functional orthologs, …

Go to article

Global Profiling Of Alternative Splicing Events And Gene Expression Regulated By Hnrnph/F, Erming Wang, Vahid Aslanzadeh, Filomena Papa, Haiyan Zhu, Pierre De La Grange, Franca Cambi Dec 2012

Global Profiling Of Alternative Splicing Events And Gene Expression Regulated By Hnrnph/F, Erming Wang, Vahid Aslanzadeh, Filomena Papa, Haiyan Zhu, Pierre De La Grange, Franca Cambi

Neurology Faculty Publications

In this study, we have investigated the global impact of heterogeneous nuclear Ribonuclear Protein (hnRNP) H/F-mediated regulation of splicing events and gene expression in oligodendrocytes. We have performed a genome-wide transcriptomic analysis at the gene and exon levels in Oli-neu cells treated with siRNA that targets hnRNPH/F compared to untreated cells using Affymetrix Exon Array. Gene expression levels and regulated exons were identified with the GenoSplice EASANA algorithm. Bioinformatics analyses were performed to determine the structural properties of G tracts that correlate with the function of hnRNPH/F as enhancers vs. repressors of exon inclusion. Different types of alternatively spliced events …

Go to article

Psychology Award Given To, Then Named For, Neuroscience Major, Jim Bakken Dec 2012

Psychology Award Given To, Then Named For, Neuroscience Major, Jim Bakken

Browse All News

No abstract provided.

Go to article

Transient Spatiotemporal Chaos In A Morris-Lecar Neuronal Ring Network Collapses To Either The Rest State Or A Traveling Pulse, Keegan Keplinger Dec 2012

Transient Spatiotemporal Chaos In A Morris-Lecar Neuronal Ring Network Collapses To Either The Rest State Or A Traveling Pulse, Keegan Keplinger

Physics

Transient spatiotemporal dynamics exists in an electrically coupled Morris-Lecar neuronal ring network, a theoretical model of an axo-axonic gap junction network. The lifetime of spatiotemporal chaos was found to grow exponentially with network size. Transient dynamics regularly collapses from a chaotic state to either the resting potential or a traveling pulse, indicating the existence of a chaotic saddle. For special conditions, a chaotic attractor can arise in the Morris-Lecar network to which transient chaos can collapse. The short-term outcome of a Morris-Lecar ring network is determined as a function of perturbation configuration. Perturbing small clusters of nearby neurons in the …

Go to article

Arctic Fox Winter Movement And Diet In Relation To Industrial Development On Alaska's North Slope, Neil S. Lehner Dec 2012

Arctic Fox Winter Movement And Diet In Relation To Industrial Development On Alaska's North Slope, Neil S. Lehner

Biological Sciences

I examined winter movement and diet of Arctic foxes (Vulpes lagopus) in the Prudhoe Bay oilfields and an adjacent undeveloped area (National Petroleum Reserve-Alaska (NPR-A)). Movement metrics were compared between these areas using data from satellite collars. Daily travel rate was approximately 5 times greater in the undeveloped area than in Prudhoe Bay. Four adult foxes collared in NPR-A used the sea ice for extensive time periods. One of these foxes traveled 338 km in three days while another traveled to Banks Island (Northwest Territories, Canada), over 1050 km from its capture location. Prudhoe Bay foxes did not make these …

Go to article

Acclimation And Migration Potential Of A Boreal Forest Tree, Balsam Poplar (Populus Balsamifera L.) In A Changing Climate, Amanda L. Robertson Dec 2012

Acclimation And Migration Potential Of A Boreal Forest Tree, Balsam Poplar (Populus Balsamifera L.) In A Changing Climate, Amanda L. Robertson

Biological Sciences

In the North American boreal forest, 21st century climate change is projected to result in longer growing seasons, increased forest productivity, and northward expansions or shifts in species ranges. These projected impacts are largely based on observations across natural temperature gradients, e.g., latitude or altitude, or correlations between current species' distributions and modern climate envelopes. These approaches, although valuable, do not consider biological capacities important in a species' ability to cope with novel environments through physiological or phenological acclimation. Within a single species, adaptation to local environments may cause some populations to respond differently to climate change than others. Acclimation …

Go to article

Gardner-Webb University Awards Over 300 Degrees In Fall Commencement Ceremony, Office Of University Communications Dec 2012

Gardner-Webb University Awards Over 300 Degrees In Fall Commencement Ceremony, Office Of University Communications

Gardner-Webb NewsCenter Archive

Hundreds of supporters gathered at the Lutz-Yelton Convocation Center on Monday to celebrate the accomplishments of over 300 students as part of the fall commencement ceremony. The University also awarded three honorary doctorates to Randy Marion, Harvey Rogers, and Jack Hunt. The ceremony for 311 graduates featured commencement speeches by Elisabeth Ann Edmonson of Mooresboro, N.C. (Master of Divinity in Christian Education) and Gary Hudson Smith, IV of Aiken, S.C. (Bachelor of Science in Business Administration). Melinda Lauren McNeely of Charlotte, N.C. (Bachelor of Arts in Missiology) offered the traditional scripture reading.

Go to article

Ecological Development Of A Management Plan For Reindeer (Rangifer Tarandus) On St. George Island, Alaska, Michelle L. St. Martin Dec 2012

Ecological Development Of A Management Plan For Reindeer (Rangifer Tarandus) On St. George Island, Alaska, Michelle L. St. Martin

Agriculture and Horticulture

Management of an herbivore production system requires a working knowledge of the components and processes of the targeted grazing system. Land owners and stakeholders wish to develop a management plan for reindeer on St. George Island, Alaska. The foci of this study were to determine seasonal diet composition (including forage preference); evaluate nutritional content of Angelica lucid, a potential alternative winter forage; estimate lichen biomass; and estimate reindeer abundance, annual production, and sustainable stocking density. Lichens were the preferred reindeer forage throughout the year, however significant seasonal dietary shifts occurred across the seasons. Fortis and grasses were consumed in significantly …

Go to article

Quantity And Quality Of Freshwater Rearing Habitat In Relation To Juvenile Pacific Salmon Abundance In The Kulukak River, Alaska, Jesse M. Coleman Dec 2012

Quantity And Quality Of Freshwater Rearing Habitat In Relation To Juvenile Pacific Salmon Abundance In The Kulukak River, Alaska, Jesse M. Coleman

Fisheries

Monitoring of freshwater habitat and its influence on stream-rearing fish is essential for recognizing and mitigating the impacts of human- and climate-induced changes. For the purposes of developing a monitoring program in the U.S. Fish and Wildlife Service Togiak National Wildlife Refuge, densities and habitat relationships of juvenile coho salmon Oncorhynchus kisutch and sockeye salmon O. nerka were estimated in two tributaries of the Kulukak River, Alaska, in July 2010. Multiple-pass depletion electrofishing was used to estimate density in a random sample of habitat units belonging to one of four categorical habitat classes. Regression methods were also used to quantify …

Go to article

Subsistence Salmon Fishing In Beaufort Sea Communities, Shelley S.D. Cotton Dec 2012

Subsistence Salmon Fishing In Beaufort Sea Communities, Shelley S.D. Cotton

Fisheries

Environmental change, combined with observations of increasing numbers of salmon in subsistence fisheries, has generated a need for more information about salmon use, abundance, and distribution in the Arctic. Ethnographic research was conducted in Barrow and Nuiqsut, Alaska, in 2010 and 2011 with 41 active fishermen and elders. Salmon catches were perceived to be increasing; however, perceptions about changing salmon abundance were mixed. While pink salmon (Oncorhynchus gorbuscha) and chum salmon (O. keta) have been observed in subsistence fisheries in the central North Slope region for over 50 years, only within the last 10 to 20 years has local use …

Go to article

Characterizing The Fish Community In Turbid Alaskan Rivers To Assess Potential Interactions With Hydrokinetic Devices, Parker T. Bradley Dec 2012

Characterizing The Fish Community In Turbid Alaskan Rivers To Assess Potential Interactions With Hydrokinetic Devices, Parker T. Bradley

Fisheries

The Yukon and Tanana rivers are two large, glacially turbid rivers in Alaska, where hydrokinetic projects are being explored for feasibility of electricity production. Downstream migration behavior of fishes in these rivers is poorly understood; as a result, the potential impacts of hydrokinetic devices, which will be placed in the deepest and fastest part of the river, on fishes are unknown. Downstream migrating fishes were sampled during the ice-free season along the river margins of the Yukon River in 2010 and the river margins and mid-channel of the Tanana River in 2011. Results suggest that the river margins in the …

Go to article

Impacts Of Sea Otter Predation On Commercially Important Sea Cucumbers (Parastichopus Californicus) In Southeast Alaska, Sean D. Larson Dec 2012

Impacts Of Sea Otter Predation On Commercially Important Sea Cucumbers (Parastichopus Californicus) In Southeast Alaska, Sean D. Larson

Fisheries

Consequences from management actions, particularly those regarding species reintroductions, are not always immediately apparent. After sea otters were extirpated from Southeast Alaska in the 18th and 19th century fur trade, it is presumed that marine invertebrate stocks grew in the absence of sea otter predation. Since reintroduction in the 1960s, the Southeast Alaska sea otter population has grown, with great potential to deplete the commercially important sea cucumber, Parastichopus californicus. This study evaluates the interaction with and impacts of sea otters on sea cucumbers using foraging observations and sea cucumber density data collected for fishery management. Sea otter diets, in …

Go to article

Incorporating Stakeholder Input In Research Priorities For The Aleutian Islands, Rachael Margaret Wadsworth Dec 2012

Incorporating Stakeholder Input In Research Priorities For The Aleutian Islands, Rachael Margaret Wadsworth

Fisheries

Federal law requires that resource management agencies consider stakeholder input in the selection of preferred alternatives for proposed actions. Not only do stakeholders contribute unique perspectives on the impact of alternative actions and the desirability of various policy objectives, including stakeholders in the decision process adds to the perceived legitimacy of those decisions. Incorporating stakeholder input is legally required and advantageous to sustainable governance of the oceans and implementation of a National Ocean Policy such as ecosystem-based management. Agencies use a variety of formal and informal mechanisms to solicit and incorporate stakeholder input. In this study, we compare expert panel …

Go to article

A Test Of Local Adaptation In Seasonally Separate Subpopulations Of Pink Salmon (Oncorhynchus Gorbuscha), Christopher V. Manhard Dec 2012

A Test Of Local Adaptation In Seasonally Separate Subpopulations Of Pink Salmon (Oncorhynchus Gorbuscha), Christopher V. Manhard

Fisheries

Differences in fitness related traits were observed between first generation (F₁) hybrid and control lines of temporally distinct subpopulations of pink salmon (Oncorhynchus gorbuscha). The lines were cultured in a common freshwater environment, released to sea together, and collected at their natal stream as adults. Early-and late-run pink salmon, which are partially genetically isolated by the time at which they return to Auke Creek in Southeast Alaska to spawn, were crossed to create F₁ and F₂ hybrid groups in the even- and odd-year brood lines. Marine survival of controls exceeded that of F₁ hybrids of the even-year brood line, whereas …

Go to article

Co2 Flux From Tundra Lichen, Moss, And Tussock, Council, Alaska: Assessment Of Spatial Representativeness, Yongwon Kim, Namyi Chae, Bangyong Lee Dec 2012

Co2 Flux From Tundra Lichen, Moss, And Tussock, Council, Alaska: Assessment Of Spatial Representativeness, Yongwon Kim, Namyi Chae, Bangyong Lee

Research Posters

CO2 flux-measurement in dominant tundra vegetation on the Seward Peninsula of Alaska was examined for spatial representativeness, using a manual chamber system. In order to assess the representativeness of CO2 flux, a 40 m × 40 m (5-m interval; 81 total points) plot was used in June, August, and September of 2011. Average CO2 fluxes in lichen, moss, and tussock tundra were 3.4 ± 2.7, 4.5 ± 2.9, and 7.2 ± 5.7 mgCO2/m2/m during growing season, respectively, suggesting that tussock tundra is a significant CO2 source, especially considering the wide distribution of tussock tundra in the circumpolar region. Further, soil …

Go to article

Modeling The Thermal Balance Between Groundwater Springs And River Ice, Chas Jones, Knut Kielland, Larry Hinzman Dec 2012

Modeling The Thermal Balance Between Groundwater Springs And River Ice, Chas Jones, Knut Kielland, Larry Hinzman

Research Posters

We modeled the thermal balance between groundwater discharge and ice-free areas in the Tanana River near Fairbanks, Alaska, a region that is characterized by discontinuous permafrost. Under degrading permafrost conditions, these areas have been hypothesized to have increased winter discharge due to increasing contributions from groundwater flow. In the winter, interior Alaskan rivers are fed almost entirely by groundwater, which also serves as an external source of heat energy to the system. Several reaches of the river fed by groundwater springs remain ice-free or have dangerously thin ice throughout the winter despite air temperatures that dip below -40° C. These …

Go to article

Dynamic Interactions Of Snow And Plants In The Boreal Forest, Winter 2011-2012 Revealed By Time-Lapse Photography And Lidar, Simon Filhol, Matthew Sturm Dec 2012

Dynamic Interactions Of Snow And Plants In The Boreal Forest, Winter 2011-2012 Revealed By Time-Lapse Photography And Lidar, Simon Filhol, Matthew Sturm

Research Posters

As winter progresses, snow accumulates on the ground and plants of the boreal forest. On their passage to the ground, the falling snowflakes encounter physical obstacles like the complex structure of tree branches and shrubs. These cause the fall trajectories to deviate, and in some cases even stop, before a snowflake reaches the forest floor. After deposition, wind and gravitational settlement further affect the snow distribution. Because of these snow-vegetation interactions, snow gets distributed in the forest along vertical and the horizontal directions in a complex way. To better understand these interactions between snow and plants, we designed an experiment, …

Go to article

Evaluation Of Prey Composition And Nutritional Value Of Diets Of Free-Ranging Harbor Seals (Phoca Vitulina) From Tugidak Island, Gretchen L. Geiger Dec 2012

Evaluation Of Prey Composition And Nutritional Value Of Diets Of Free-Ranging Harbor Seals (Phoca Vitulina) From Tugidak Island, Gretchen L. Geiger

Marine Biology

Changes in climate can cause shifts in ecosystem structure that can affect quantity or quality of prey available to predator populations. Due to sex or age-specific behaviors of predators, certain classes within a population may be more severely impacted by changes in their diet. This study evaluated prey composition and nutritional value of summer diets of harbor seals (Phoca vitulina richardii) from Tugidak Island, Alaska from 2001-2009. The MIXIT-WIN program was used to estimate the nutritional value of average harbor seal diets. Changes in relative abundance of certain prey species were correlated to sea surface temperature anomalies. Despite changes in …

Go to article

Kelp Forests And Barren Grounds: Phlorotannin Production And Holdfast Community Structure In The Aleutian Dragon Kelp, Eualaria Fistulosa, Martin D. Schuster Dec 2012

Kelp Forests And Barren Grounds: Phlorotannin Production And Holdfast Community Structure In The Aleutian Dragon Kelp, Eualaria Fistulosa, Martin D. Schuster

Marine Biology

The canopy forming kelp Eualaria fistulosa inhabits two organizational states throughout the Aleutian archipelago, kelp forests and barren grounds. Urchin abundance and behavior determines which state dominates in any given area. Sporophyll phlorotannin content and holdfast epibiont fauna were investigated at multiple islands along the Aleutian archipelago to determine how the organizational state affects the production of secondary metabolites and the taxon richness, abundance and biomass of holdfast communities. Barren ground sporophylls had higher phlorotannin content than kelp forest sporophylls, although grazing rates on sporophylls from each state did not differ during in situ grazing experiments. The taxon richness, abundance …

Go to article

Multiple Regulatory Mechanisms Control B-1 B Cell Activation, Vishal Sindhava, Subbarao Bondada Dec 2012

Multiple Regulatory Mechanisms Control B-1 B Cell Activation, Vishal Sindhava, Subbarao Bondada

Microbiology, Immunology, and Molecular Genetics Faculty Publications

B-1 cells constitute a unique subset of B cells identified in several species including mice and humans. B-1 cells are further subdivided into B-1a and B-1b subsets as the former but not the later express CD5.The B-1a subset contributes to innate type of immune responses while the B-1b B cell subset contributes to adaptive responses. B-1 cell responses to B cell receptor (BCR) as well as Toll-like receptor (TLR) ligation are tightly regulated due to the cross-reactivity of antigen specific receptors on B-1 cells to self-antigens. B-1 cells are elevated in several autoimmune diseases. CD5 plays a major role in …

Go to article

Meg Coherence Imaging In Dyslexia: Activation Of Working Memory Pathways, Alfred Mansour Dec 2012

Meg Coherence Imaging In Dyslexia: Activation Of Working Memory Pathways, Alfred Mansour

Master's Theses and Doctoral Dissertations

The aims of this dissertation are to 1) review the genetic, neurodevelopmental, structural, and functional brain imaging studies that are the foundations of our understanding of dyslexia and 2) investigate the pattern of activation and functional connectivity of neuronal networks critical in working memory in dyslexics by means of magnetoenchephalographic (MEG) coherence imaging. Dyslexics showed an early onset of activation in the precentral gyrus and the superior frontal gyrus, which differed from controls where activation was initiated in posterior cortical regions (supramarginal gyrus and superior temporal gyrus). Further, dyslexics showed lower normalized amplitudes of activation in the right superior temporal …

Go to article

Gene, Pathway And Network Frameworks To Identify Epistatic Interactions Of Single Nucleotide Polymorphisms Derived From Gwas Data, Yu Liu, Sean Maxwell, Tao Feng, Xiaofeng Zhu, Robert C. Elston, Mehmet Koyutürk, Mark R. Chance Dec 2012

Gene, Pathway And Network Frameworks To Identify Epistatic Interactions Of Single Nucleotide Polymorphisms Derived From Gwas Data, Yu Liu, Sean Maxwell, Tao Feng, Xiaofeng Zhu, Robert C. Elston, Mehmet Koyutürk, Mark R. Chance

Faculty Scholarship

Background: Interactions among genomic loci (also known as epistasis) have been suggested as one of the potential sources of missing heritability in single locus analysis of genome-wide association studies (GWAS). The computational burden of searching for interactions is compounded by the extremely low threshold for identifying significant p-values due to multiple hypothesis testing corrections. Utilizing prior biological knowledge to restrict the set of candidate SNP pairs to be tested can alleviate this problem, but systematic studies that investigate the relative merits of integrating different biological frameworks and GWAS data have not been conducted.Results: We developed four biologically based frameworks to …

Go to article

Vegf And Angiopoietin-1 Exert Opposing Effects On Cell Junctions By Regulating The Rho Gef Syx, Siu P. Ngok, Rory Geyer, Miaoliang Liu, Antonis Kourtidis, Sudesh Agrawal, Chuanshen Wu, Himabindu Reddy Seerapu, Laura J. Lewis-Tuffin, Karen L. Moodie, Deborah Huveldt, Ruth Marx, Jay M. Baraban, Peter Storz, Arie Horowitz, Panos Z. Anastasiadis Dec 2012

Vegf And Angiopoietin-1 Exert Opposing Effects On Cell Junctions By Regulating The Rho Gef Syx, Siu P. Ngok, Rory Geyer, Miaoliang Liu, Antonis Kourtidis, Sudesh Agrawal, Chuanshen Wu, Himabindu Reddy Seerapu, Laura J. Lewis-Tuffin, Karen L. Moodie, Deborah Huveldt, Ruth Marx, Jay M. Baraban, Peter Storz, Arie Horowitz, Panos Z. Anastasiadis

Dartmouth Scholarship

Vascular endothelial growth factor (VEGF) and Ang1 (Angiopoietin-1) have opposing effects on vascular permeability, but the molecular basis of these effects is not fully known. We report in this paper that VEGF and Ang1 regulate endothelial cell (EC) junctions by determining the localization of the RhoA-specific guanine nucleotide exchange factor Syx. Syx was recruited to junctions by members of the Crumbs polarity complex and promoted junction integrity by activating Diaphanous. VEGF caused translocation of Syx from cell junctions, promoting junction disassembly, whereas Ang1 maintained Syx at the junctions, inducing junction stabilization. The VEGF-induced translocation of Syx from EC junctions was …

Go to article

First Prev Next Last