Digital Commons Network^™

Sap Is Required For The Development Of Innate Phenotype In H2-M3-Restricted Cd8+ T Cells, Yaw Bediako, Yao Bian, Hong Zhang, Hoonsik Cho

University Faculty Publications and Creative Works

H2-M3-restricted T cells have a preactivated surface phenotype, rapidly expand, and produce cytokines upon stimulation, and, as such, are classified as innate T cells. Unlike most innate T cells, M3-restricted T cells also express CD8ab coreceptors and a diverse TCR repertoire: hallmarks of conventional MHC Ia-restricted CD8+ T cells. Although invariant NKT cells are also innate T cells, they are selected exclusively on hematopoietic cells (HC), whereas M3-restricted T cells can be selected on either hematopoietic or thymic epithelial cells. Moreover, their phenotypes differ depending on what cells mediate their selection. Although there is a clear correlation between selection on …

Building A Statistical Model For Predicting Cancer Genes, Ivan P. Gorlov, Christopher J. Logothetis, Shenying Fang, Olga Y. Gorlova, Christopher Amos

Dartmouth Scholarship

More than 400 cancer genes have been identified in the human genome. The list is not yet complete. Statistical models predicting cancer genes may help with identification of novel cancer gene candidates. We used known prostate cancer (PCa) genes (identified through KnowledgeNet) as a training set to build a binary logistic regression model identifying PCa genes. Internal and external validation of the model was conducted using a validation set (also from KnowledgeNet), permutations, and external data on genes with recurrent prostate tumor mutations. We evaluated a set of 33 gene characteristics as predictors. Sixteen of the original 33 predictors were …

Soybean Allergy: Effect Of Genetic Modification (Gm), Heat And Enzymatic Treatment On Overall Allergenicity, Rakhi Panda

Department of Food Science and Technology: Dissertations, Theses, and Student Research

Soybean allergy affects approximately 0.4% of children worldwide. At least 16 proteins in soybean bind IgE from some soybean allergic subjects. Although the relative allergenic importance and abundance of individual proteins in soybean varieties is not understood, the allergenicity assessment guideline for the safety of genetically modified (GM) food crops (Codex, 2003) includes assessing potential increases in expression of endogenous allergens in an allergenic crop like soybeans that might be due to insertion of the new DNA. The studies described in this dissertation included comparison of binding of IgE from individual soybean allergic subjects to proteins in three transgenic soybean …

The Parthenon, November 15, 2012, Shane Arrington

The Parthenon

The Parthenon, Marshall University’s student newspaper, is published by students Monday through Friday during the regular semester and weekly Thursday during the summer. The editorial staff is responsible for the news and the editorial content.

Wesleyan Honored For Student Activities, Leadership Programs, Shea Felde '14

News and Events (Discontinued Series)

No abstract provided.

Office Of Student Activities And Leadership Programs Wins Award, Shea Felde

News and Events (Discontinued Series)

No abstract provided.

The Inkwell, Armstrong Atlantic State University

The Inkwell

No abstract provided.

Lanthorn, Vol. 47, No. 26, November 15, 2012, Grand Valley State University

Volume 47, July 2, 2012 - June 3, 2013

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

Escherichia Coli-Mediated Impairment Of Ureteric Contractility Is Uropathogenic E. Coli Specific., Rachel V. Floyd, Mathew Upton, Scott J. Hultgren, Susan Wray, Theodor V. Burdyga, Craig Winstanley

School of Biomedical Sciences

BACKGROUND: Ureters are fundamental for keeping kidneys free from uropathogenic Escherichia coli (UPEC), but we have shown that 2 strains (J96 and 536) can subvert this role and reduce ureteric contractility. To determine whether this is (1) a widespread feature of UPEC, (2) exhibited only by UPEC, and (3) dependent upon type 1 fimbriae, we analyzed strains representing epidemiologically important multilocus sequence types ST131, ST73, and ST95 and non-UPEC E. coli. METHODS: Contractility and calcium transients in intact rat ureters were compared between strains. Mannose and fim mutants were used to investigate the role of type 1 fimbriae. RESULTS: Non-UPEC …

Calpain-1 Knockout Reveals Broad Effects On Erythrocyte Deformability And Physiology, Adam Wieschhaus, Anwar Khan, Asma Zaidi, Henry Rogalin, Toshihiko Hanada, Fei Liu, Lucia De Franceschi, Carlo Brugnara, Alicia Rivera, Athar H. Chishti

Faculty and Staff Publications

Pharmacological inhibitors of cysteine proteases have provided useful insights into the regulation of calpain activity in erythrocytes. However, the precise biological function of calpain activity in erythrocytes remains poorly understood. Erythrocytes express calpain-1, an isoform regulated by calpastatin, the endogenous inhibitor of calpains. In the present study, we investigated the function of calpain-1 in mature erythrocytes using our calpain-1-null [KO (knockout)] mouse model. The calpain-1 gene deletion results in improved erythrocyte deformability without any measurable effect on erythrocyte lifespan in vivo. The calcium-induced sphero-echinocyte shape transition is compromised in the KO erythrocytes. Erythrocyte membrane proteins ankyrin, band 3, protein 4.1R, …

Customizing Bibliographic Databases For The End User, Ann Farren

Proceedings of the IATUL Conferences

No abstract provided.

Development And Evaluation Of New Algorithms For The Retrieval Of Wind And Internal Wave Parameters From Shipborne Marine Radar Data, Björn Lund

Open Access Dissertations

The goal of this work is to develop and evaluate techniques for the retrieval of wind and internal wave (IW) information from marine X-band radar data. While ocean wind measurements are crucial for the transfer of energy and momentum across the air-sea interface, IWs play an important role in tidal energy transport. Marine radars work by transmitting microwave energy from a rotating antenna that also measures the backscatter. The radar backscatter from the sea surface is controlled by the wind-generated small ripple waves through the Bragg-scattering mechanism. Surface winds are thus the dominant factor for generating the radar backscatter. The …

Agenda And Attachments, November 14, 2012

Agendas and Minutes

No abstract provided.

Immune Correlates Of Aging In Outdoor-Housed Captive Rhesus Macaques (Macaca Mulatta), Elizabeth S. Didier, Chie Sugimoto, Lisa C. Bowers, Imtiaz A. Khan, Marcelo J. Kuroda

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Background

Questions remain about whether inflammation is a cause, consequence, or coincidence of aging. The purpose of this study was to define baseline immunological characteristics from blood to develop a model in rhesus macaques that could be used to address the relationship between inflammation and aging. Hematology, flow cytometry, clinical chemistry, and multiplex cytokine/chemokine analyses were performed on a group of 101 outdoor-housed captive rhesus macaques ranging from 2 to 24 years of age, approximately equivalent to 8 to 77 years of age in humans.

Results

These results extend earlier reports correlating changes in lymphocyte subpopulations and cytokines/chemokines with increasing …

Campus Assembly Minutes 10/02/2012, Campus Assembly

Campus Assembly

No abstract provided.

Minutes Of The Faculty Senate Meeting, November 14, 2012, University Of Arkansas, Fayetteville. Faculty Senate

Faculty Senate Minutes

No abstract provided.

Blog Post, Undergraduate Open House Underscores Growing Interest In Usfsp, 'Burg Blogs, November 14, 2012, Bill Hogarth

USF St. Petersburg Campus News and Press Releases

A blog post by Interim Regional Chancellor Bill Hogarth of the University of South Florida St. Petersburg about an open house for prospective students and increased interest in the university.

November 14, 2012 Cal Poly Report, Public Affairs Office

Cal Poly Report

No abstract provided.

Sex Differences In Normal Fetuses And Infants: A Commentary, David S. Moore

Pitzer Faculty Publications and Research

Sex differences in infants warrant attention, not because they clarify the extent to which such differences reflect nature or nurture, but because studying them is likely to illuminate the origins of sex differences later in life and thereby yield manipulations that could influence the development of important competences. It is not yet clear how male and female infants come to differ. Testosterone is influential, but because of the complexity of the developmental systems in which it operates, its effects are not straightforward: Testosterone does different things in different contexts. Simple explanations invoking hormone exposure should not be expected to satisfactorily …

Minutes, Presentation To College Of Arts And Sciences Chairs, University Of South Florida St. Petersburg General Education Committee Meeting, November 14, 2012, University Of South Florida St. Petersburg. Faculty Senate. General Education Committee

USF St. Petersburg General Education Committee Meetings

Minutes from the November 14, 2012, meeting of the General Education Committee of the University of South Florida St. Petersburg's Faculty Senate to the College of Arts and Sciences (CAS) chairs.

Evolution Of The Modern Ode Course, Beverly West, Robert Borrelli, Lawrence Moore

CODEE Journal

The rapid development of technology in the latter part of the twentieth century has revolutionized the teaching of differential equations. In this paper we will try to trace the evolution of this important change. We tried to include the most important efforts in this regard, but we apologize in advance if some efforts have slipped our attention.

The Lumberjack, November 14, 2012, The Lumberjack Staff

2012

The student newspaper of Humboldt State University

Undergraduate Curriculum And Academic Policy Committee Minutes, November 14, 2012

Undergraduate Curriculum and Academic Policy Committee Minutes

Minutes from the Wright State University Faculty Senate Undergraduate Curriculum and Academic Policy Committee meeting held on November 14, 2012.

Toward The Beginning Of Time: Circadian Rhythms In Metabolism Precede Rhythms In Clock Gene Expression In Mouse Embryonic Stem Cells, Jiffin K. Paulose, Edmund B. Rucker Iii, Vincent M. Cassone

Biology Faculty Publications

The appearance, progression, and potential role for circadian rhythms during early development have previously focused mainly on the suprachiasmatic nucleus (SCN) and peri- and postnatal expression of canonical clock genes. More recently, gene expression studies in embryonic stem cells have shown that some clock genes are expressed in undifferentiated cells; however rhythmicity was only established when cells are directed toward a neural fate. These studies also concluded that a functional clock is not present in ESCs, based solely on their gene expression. The null hypothesis underlying the present study is that embryonic stem cells become rhythmic in both clock gene …

The Spinnaker [Vol. 33 No. 108], University Of North Florida

Spinnaker

Student newspaper for the UNF community.

Daily Eastern News: November 14, 2012, Eastern Illinois University

November

No abstract provided.

Emu Today, November 14, 2012, Eastern Michigan University

EMU Today

No abstract provided.

Volume 104 Issue 10, Southwestern Oklahoma State University

The Southwestern - Archive

No abstract provided.

Targeting Astrocytes Ameliorates Neurologic Changes In A Mouse Model Of Alzheimer's Disease, Jennifer L. Furman, Diana M. Sama, John C. Gant, Tina L. Beckett, M. Paul Murphy, Adam D. Bachstetter, Linda J. Van Eldik, Christopher M. Norris

Pharmacology and Nutritional Sciences Faculty Publications

Astrocytes are the most abundant cell type in the brain and play a critical role in maintaining healthy nervous tissue. In Alzheimer's disease (AD) and most other neurodegenerative disorders, many astrocytes convert to a chronically "activated" phenotype characterized by morphologic and biochemical changes that appear to compromise protective properties and/or promote harmful neuroinflammatory processes. Activated astrocytes emerge early in the course of AD and become increasingly prominent as clinical and pathological symptoms progress, but few studies have tested the potential of astrocyte-targeted therapeutics in an intact animal model of AD. Here, we used adeno-associated virus (AAV) vectors containing the astrocyte-specific …

The Fghog1 Pathway Regulates Hyphal Growth, Stress Responses, And Plant Infection In Fusarium Graminearum., Dawei Zheng, Shijie Zhang, Xiaoying Zhou, Chenfang Wang, Ping Xiang, Qian Zheng, Jin-Rong Xu

Department of Botany and Plant Pathology Faculty Publications

Fusarium head blight (FHB) caused by Fusarium graminearum is a destructive disease of wheat and barley worldwide. In a previous study of systematic characterization of protein kinase genes in F. graminearum, mutants of three putative components of the osmoregulation MAP kinase pathway were found to have distinct colony morphology and hyphal growth defects on PDA plates. Because the osmoregulation pathway is not known to regulate aerial hyphal growth and branching, in this study we further characterized the functions of the FgHog1 pathway in growth, pathogenesis, and development. The Fghog1, Fgpbs2, and Fgssk2 mutants were all reduced in …