Digital Commons Network^™

Faculty Promotion And Tenure Recipients, 2012, University Of Arkansas, Fayetteville. Libraries, University Of Arkansas, Fayetteville. Provost And Vice Chancellor For Academic Affairs, University Of Arkansas, Fayetteville. Office Of The Chancellor

Faculty Promotion and Tenure Reception

Event was sponsored by Chancellor and Provost

University Of Arkansas Catalog Of Studies, 2011-2012, University Of Arkansas, Fayetteville

Undergraduate Catalog of Studies

No abstract provided.

Razorback Basketball Media Guide, 2011-2012, University Of Arkansas, Fayetteville. Athletics Media Relations

Arkansas Women's Basketball

No abstract provided.

The Colby Oracle 2012, Colby College

The Colby Oracle

Colby College’s yearbook for the Class of 2012.

Advancing Transgender Civil Rights And Equality In New York: The Need For Genda, New York Civil Liberties Union, Lincoln Square Legal Services, Inc.

Policy and Legislative Advocacy Clinic

Currently, no statewide law in New York explicitly prohibits discrimination against people whose appearance or identity does not conform to gender stereotypes. This means that people who are fired from their jobs, denied housing and services, and mistreated in the workplace, in stores and in restaurants merely because of their appearance or gender identity do not have clear legal protection. The Gender Expression Non-Discrimination Act (GENDA) would fix this problem by adding gender identity and gender expression to the categories currently included in New York State’s antidiscrimination laws, such as sex, sexual orientation, race, religion and disability. This report explains …

Genomic Instability Measured By Inter-(Simple Sequence Repeat) Pcr And High-Resolution Microsatellite Instability Are Prognostic Of Colorectal Carcinoma Survival After Surgical Resection, Bruce M. Brenner, Helen Swede

UCHC Articles - Research

Background

During the multiyear progression to colorectal cancer, numerous genomic alterations arise in events ranging from single base mutations to gains or losses of entire chromosomes. A single genetic change might not stand out as an independent predictor of outcome. The goal of this study was to determine if more comprehensive measurements of genomic instability provide clinically relevant prognostic information.

Methods

Our study included 65 sporadic colorectal cancer patients diagnosed from 1987 to 1991 with last follow-up ascertained in 2006. We estimated an overall tally of alterations using the genome-wide sampling technique of inter-(simple sequence repeat [SSR]) polymerase chain reaction …

Fabrication Of Immunosensor Microwell Arrays From Gold Compact Discs For Detection Of Cancer Biomarker Proteins, Chi K. Tang, Abhay Vaze, James F. Rusling

UCHC Articles - Research

A simple method is reported to fabricate gold arrays featuring microwells surrounding 8-electrodes from gold compact discs (CDs) for less than $0.2 per chip. Integration of these disposable gold CD array chips with microfluidics provided inexpensive immunoarrays that were used to measure a cancer biomarker protein quickly at high sensitivity. The gold CD sensor arrays were fabricated using thermal transfer of laserjet toner from a computer-printed pattern followed by selective chemical etching. Sensor elements had an electrochemically addressable surface area of 0.42 mm² with RSD <2%. For a proof-of-concept application, the arrays were integrated into a simple microfluidic device for electrochemical detection of cancer biomarker interleukin-6 (IL-6) in diluted serum. Capture antibodies of IL-6 were chemically linked onto the electrode arrays and a sandwich immunoassay protocol was developed. A biotinylated detection antibody with polymerized horseradish peroxidase labels was used for signal amplification. The detection limit of IL-6 in diluted serum was remarkably low at 10 fg mL ⁻¹ (385 aM) with a linear response with log of IL-6 concentration from 10 …

Of Ticks, Mice And Men: Understanding The Dual-Host Lifestyle Of Lyme Disease Spirochaetes, Justin D. Radolf, Melissa J. Caimano

UCHC Articles - Research

In little more than 30 years, Lyme disease, which is caused by the spirochaete Borrelia burgdorferi, has risen from relative obscurity to become a global public health problem and a prototype of an emerging infection. During this period, there has been an extraordinary accumulation of knowledge on the phylogenetic diversity, molecular biology, genetics and host interactions of B. burgdorferi. In this Review, we integrate this large body of information into a cohesive picture of the molecular and cellular events that transpire as Lyme disease spirochaetes transit between their arthropod and vertebrate hosts during the enzootic cycle.

High Sensitivity Carbon Nanotube Based Electrochemiluminescence Sensor Array, James F. Rusling

UCHC Articles - Research

Ink jet printed carbon nanotube forest arrays capable of detecting picomolar concentrations of immunoglobulin G (IgG) using electrochemiluminescence (ECL) are described. Patterned arrays of vertically aligned single walled carbon nanotube (SWCNT) forests were printed on indium tin oxide (ITO) electrodes. Capture anti-IgG antibodies were then coupled through peptide bond formation to acidic functional groups on the vertical nanotubes. IgG immunoassays were performed using silica nano particles (Si NP) functionalized with the ECL luminophore [Ru(bpy)₂ PICH₂]²⁺], and IgG labelled G1.5 acid terminated PAMAM dendrimers. PAMAM is poly(amido amine), bpy is 2,2′-bipyridyl and PICH₂ is (2-(4-carboxyphenyl)imidazo[4,5-f][1,10]phenanthroline). …

Are Baby Boomers Who Care For Their Older Parents Planning For Their Own Future Long-Term Care Needs?, Alison Kleppinger, Julie T. Robison

UCHC Articles - Research

A rapidly expanding number of baby boomers provide care to aging parents. This study examines associations between caregiver status and outcomes related to awareness and anticipation of future long-term care (LTC) needs using 2007 Connecticut Long-Term Care Needs Assessment survey data. Baby boomers who were adult child caregivers (n = 353) vs. baby boomers who were not (n = 1242) were more likely to anticipate some future LTC needs and to have considered certain financing strategies. Although baby boomer adult child caregivers more readily anticipate some future LTC needs, they are not taking specific actions. It is important to address …

Bone Tissue Engineering: Recent Advances And Challenges, Ami R. Amini, Cato T. Laurencin, Syam P. Nukavarapu

UCHC Articles - Research

The worldwide incidence of bone disorders and conditions has trended steeply upward and is expected to double by 2020, especially in populations where aging is coupled with increased obesity and poor physical activity. Engineered bone tissue has been viewed as a potential alternative to the conventional use of bone grafts, due to their limitless supply and no disease transmission. However, bone tissue engineering practices have not proceeded to clinical practice due to several limitations or challenges. Bone tissue engineering aims to induce new functional bone regeneration via the synergistic combination of biomaterials, cells, and factor therapy. In this review, we …

An Open-Source Sandbox For Increasing The Accessibility Of Functional Programming To The Bioinformatics And Scientific Communities, Matthew Fenwick, Colbert Sesanker, Jay Vyas, Michael R. Gryk

UCHC Articles - Research

Scientists are continually faced with the need to express complex mathematical notions in code. The renaissance of functional languages such as LISP and Haskell is often credited to their ability to implement complex data operations and mathematical constructs in an expressive and natural idiom. The slow adoption of functional computing in the scientific community does not, however, reflect the congeniality of these fields. Unfortunately, the learning curve for adoption of functional programming techniques is steeper than that for more traditional languages in the scientific community, such as Python and Java, and this is partially due to the relative sparseness of …

Undergraduate Scholarship At Winthrop University 2012 Book Of Abstracts, Winthrop University, Undergraduate Research Office, Winthrop University

Abstract Books

Winthrop University proudly presents the first Undergraduate Scholarship at Winthrop University Book of Abstracts. Building off the nine-year tradition of producing abstract books for students in the College of Arts and Sciences, University College is now creating this book to present the scholarship occurring throughout all five academic colleges in the university: College of Arts and Sciences (CAS), College of Business Administration (CBA), College of Education (COE), the College of Visual and Performing Arts (CVPA) and University College (UC). In addition to the research abstracts, we are using the book to document the students who have completed Honors Theses, applied …

Making Sense Of Intellectual Property Law, Christopher J. Buccafusco

All Faculty Scholarship

Intellectual property (IP) scholars have long struggled to explain the boundaries of and differences between copyright and patent law. This Article proposes a novel explanation: copyright and patent can be fruitfully understood as establishing a dichotomy between the different human senses. Copyright has bracketed works addressed to the senses of sight and hearing, and it treats products appealing to touch, taste, and smell as functional and, thus, uncopyrightable. To the extent the latter receive IP protection, it is through the utility patent regime. The Article begins by establishing this descriptive proposition, and it shows how some of the most contested …

Incentivizing The Utilization Of Pharmacogenomics In Drug Development, Valerie Gutmann Koch

All Faculty Scholarship

Pharmacogenomics, the study and development of compounds according to how an individual’s genes affects the body’s response to drugs, holds enormous promise for increasing the safety and efficiency of drug development while decreasing adverse reactions and the trial-and-error nature of drug prescription. However, pharmacogenomics may not be the panacea for all development and prescription problems. This article explores some of the obstacles to pharmacogenomic advancement including industry reluctance to pursue research because of potentially prohibitive costs associated with developing products and legal liability concerns. The implications pharmacogenomics has for drug research and development as well as various areas of law …

Pgtandme: Social Networking-Based Genetic Testing And The Evolving Research Model, Valerie Gutmann Koch

All Faculty Scholarship

The opportunity to use extensive genetic data, personal information, and family medical history for research purposes may be naturally appealing to the personal genetic testing (PGT) industry, which is already coupling its direct-to-consumer (DTC) products with social networking technologies, as well as to potential industry or institutional partners. This article evaluates the transformation in research that the hybrid of PGT and social networking will bring about, and – highlighting the challenges associated with a new paradigm of “patient-driven” genomic research – focuses on the consequences of shifting the structure, locus, timing, and scope of research through genetic crowd-sourcing. This article …

2012 Celebration Of Inquiry Program, Coastal Carolina University

Celebration of Inquiry

10th Celebration of Inquiry, March 29-31, 2012. Theme: From Curiosity to Exploration: Linking Knowing and Doing. 4th Annual Undergraduate Research Competition abstracts and schedule are included in the program.

Review Of Civil-Military Coordination In Local Disaster Response, Wilfredo J. Nieves

Master of Public Health Program Student Publications

Background: Globally, disasters affect over 200 million people annually. Governments at all levels attempt to mitigate the effects of disasters by providing training and resources to responders in the event of a disaster. When the disaster is of sufficient magnitude, those that respond will require additional resources to adequately attend to disaster victims. County emergency managers assist in making needed additional resources available. Department of Defense (DoD) installations are sources where emergency management agency (EMA) directors may request assistance. The purpose of this research is to understand the resources legal authority available to civilian emergency managers of Ohio Counties in …

Preclinical Determinants Of Drug Choice Under Concurrent Schedules Of Drug Self-Administration, Matthew L. Banks, S. Stevens Negus

Pharmacology and Toxicology Publications

Drug self-administration procedures have played a critical role in the experimental analysis of psychoactive compounds, such as cocaine, for over 50 years. While there are numerous permutations of this procedure, this paper will specifically focus on choice procedures using concurrent schedules of intravenous drug self-administration. The aims of this paper are to first highlight the evolution of drug choice procedures and then review the subsequent preclinical body of literature utilizing these choice procedures to understand the environmental, pharmacological, and biological determinants of the reinforcing stimulus effects of drugs. A main rationale for this paper is our proposition that choice schedules …

Processing Of Damaged Dna Ends For Double-Strand Break Repair In Mammalian Cells, Lawrence F. Povirk

Pharmacology and Toxicology Publications

Most DNA double-strand breaks (DSBs) formed in a natural environment have chemical modifications at or near the ends that preclude direct religation and require removal or other processing so that rejoining can proceed. Free radical-mediated DSBs typically bear unligatable 3′-phosphate or 3′-phosphoglycolate termini and often have oxidized bases and/or abasic sites near the break. Topoisomerase-mediated DSBs are blocked by covalently bound peptide fragments of the topoisomerase. Enzymes capable of resolving damaged ends include polynucleotide kinase/phosphatase, which restores missing 5′-phosphates and removes 3′-phosphates; tyrosyl-DNA phosphodiesterases I and II (TDP1 and TDP2), which remove peptide fragments of topoisomerases I and II, respectively; …

Mice Deficient In Gem Gtpase Show Abnormal Glucose Homeostasis Due To Defects In Beta-Cell Calcium Handling, Jenny E. Gunton, Mary Sisavanh, Rebecca A. Stokes, Jon Satin, Leslie S. Satin, Min Zhang, Sue M. Liu, Weikang Cai, Kim Cheng, Gregory J. Cooney, D. Ross Laybutt, Trina So, Juan-Carlos Molero, Shane T. Grey, Douglas A. Andres, Michael S. Rolph, Charles R. Mackay

Pharmacology and Toxicology Publications

Aims and Hypothesis

Glucose-stimulated insulin secretion from beta-cells is a tightly regulated process that requires calcium flux to trigger exocytosis of insulin-containing vesicles. Regulation of calcium handling in beta-cells remains incompletely understood. Gem, a member of the RGK (Rad/Gem/Kir) family regulates calcium channel handling in other cell types, and Gem over-expression inhibits insulin release in insulin-secreting Min6 cells. The aim of this study was to explore the role of Gem in insulin secretion. We hypothesised that Gem may regulate insulin secretion and thus affect glucose tolerance in vivo.

Methods

Gem-deficient mice were generated and their metabolic phenotype characterised by …

Evaluation Of Δd And Δ18o As Natural Markers Of Invertebrate Source Environment And Dispersal In The Middle Mississippi River-Floodplain Ecosystem, David J. Myers, Gregory Whitledge, Matt R. Whiles

Publications

Movement of invertebrates among large rivers, tributaries, and floodplain lakes or dispersal of adult aquatic insects from riverine or floodplain habitats may provide important subsidies to food webs in receiving habitats. Intensive sampling at habitat interfaces and artificial labeling are two approaches to assess freshwater invertebrate dispersal, but these are difficult to implement at a landscape scale. Natural chemical tracers have been used to track dispersal of fishes and marine invertebrates, but the potential applicability of stable isotope ratios as natural tracers of invertebrate dispersal in freshwater environments has not been assessed. We evaluated stable hydrogen and oxygen isotopes (δD …

A Doubling Method For The Generalized Lambda Distribution, Todd C. Headrick, Mohan Dev Pant

Publications

This paper introduces a new family of generalized lambda distributions GLDs based on a method of doubling symmetric GLDs. The focus of the development is in the context of L-moments and L-correlation theory. As such, included is the development of a procedure for specifying double GLDs with controlled degrees of L-skew, L-kurtosis, and L-correlations. The procedure can be applied in a variety of settings such as modeling events and Monte Carlo or simulation studies. Further, it is demonstrated that estimates of L-skew, L-kurtosis, and L-correlation are substantially superior to conventional product-moment estimates …

Atrazine Exposure In Public Drinking Water And Preterm Birth, Jessica L. Rinsky, Claudia Hopenhayn, Vijay Golla, Steven R. Browning, Heather M. Bush

Epidemiology and Environmental Health Faculty Publications

Objectives

Approximately 13% of all births occur prior to 37 weeks gestation in the U.S. Some established risk factors exist for preterm birth, but the etiology remains largely unknown. Recent studies have suggested an association with environmental exposures. We examined the relationship between preterm birth and exposure to a commonly used herbicide, atrazine, in drinking water.

Methods

We reviewed Kentucky birth certificate data for 2004–2006 to collect duration of pregnancy and other individual-level covariates. We assessed existing data sources for atrazine levels in public drinking water for the years 2000–2008, classifying maternal county of residence into three atrazine exposure groups. …

Developmentally-Based Scaling Of Leaf Venation Architecture Explains Global Ecological Patterns, L. Sack, C. Scoffoni, A. D. Mckown, K. Frole, M. Rawls, J. C. Havran, H. Tran, T. Tran

Biology

No abstract provided.

Exposure To Ozone Modulates Human Airway Protease/Antiprotease Balance Contributing To Increased Influenza A Infection, M. J. Kesic, M. Myer, R. Bauer, I. Jaspers

Physician Assistant Program

No abstract provided.

Conference Program, David Elad

Computational Fluid Dynamics (CFD) in Medicine And Biology in Conjunction With the Seventh International Biofluid Mechanics Symposium

No abstract provided.

A Generalized Birkhoff-Rott Equation For Two-Dimensional Active Scalar Problems, Hui Sun, David Uminsky, Andrea L. Bertozzi

Mathematics

In this paper we derive evolution equations for the two-dimensional active scalar problem when the solution is supported on one-dimensional curves. These equations are a generalization of the Birkhoff–Rott equation when vorticity is the active scalar. The formulation is Lagrangian and it is valid for nonlocal kernels K that may include both a gradient and an incompressible term. We develop a numerical method for implementing the model which achieves second order convergence in space and fourth order in time. We verify the model by simulating classic active scalar problems such as the vortex sheet problem (in the case of inviscid, …

Network-Based Criterion For The Success Of Cooperation In An Evolutionary Prisoner's Dilemma, Stephen Devlin, T Treloar

Mathematics

We consider an evolutionary prisoner's dilemma on a random network. We introduce a simple quantitative network-based parameter and show that it effectively predicts the success of cooperation in simulations on the network. The criterion is shown to be accurate on a variety of networks with degree distributions ranging from regular to Poisson to scale free. The parameter allows for comparisons of random networks regardless of their underlying topology. Finally, we draw analogies between the criterion for the success of cooperation introduced here and existing criteria in other contexts.

Bioharness Multivariable Monitoring Device. Part I: Validity, James A. Johnstone, Paul A. Ford, Gerwyn Hughes, Tim Watson, Andrew T. Garrett

Kinesiology (Formerly Exercise and Sport Science)

The BioharnessTM monitoring system may provide physiological information on human performance but there is limited information on its validity. The objective of this study was to assess the validity of all 5 BioharnessTM variables using a laboratory based treadmill protocol. 22 healthy males participated. Heart rate (HR), Breathing Frequency (BF) and Accelerometry (ACC) precision were assessed during a discontinuous incremental (0- 12 km·h-1) treadmill protocol. Infra-red skin temperature (ST) was assessed during a 45 min-1 sub-maximal cycle ergometer test, completed twice, with environmental temperature controlled at 20 ±0.1 °C and 30 ± 0.1 °C. Posture (P) was assessed using a …