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2012

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Efficacy Of Multifunctionalized Saccharide Constructs For The Attenuation Of Amyloid-Beta Toxicity, Dhruva Dilip Dhavale Jan 2012

Efficacy Of Multifunctionalized Saccharide Constructs For The Attenuation Of Amyloid-Beta Toxicity, Dhruva Dilip Dhavale

LSU Doctoral Dissertations

There is evidence that amyloid-beta (Aβ) toxicity is mediated through interactions and binding with neuronal surface sialic acids in Alzheimer’s disease (AD). The binding affinity is higher if the sialic acids are clustered and toxicity of Aβ was attenuated by removal of neuronal sialic acids. Thus, interfering with cell membrane-Aβ binding using biomimetics that could reproduce the clustered sialic acid structure could present us with a potential target for therapeutic intervention in AD. Based on this hypothesis, we developed several multifunctionalized sialic acid labeled chitosan compounds of different valency, or number of sialic acid per chitosan molecule, to attenuate Aβ …

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Factors Affecting University Stem Faculty Job Satisfaction, Lisa Babin Verret Jan 2012

Factors Affecting University Stem Faculty Job Satisfaction, Lisa Babin Verret

LSU Doctoral Dissertations

Many job satisfaction studies have been done on faculty in higher education, but very little research has focused on science, technology, engineering, and mathematics (STEM) faculty. Through these studies, very little consensus has been reached on the satisfaction levels of male and female faculty. The purpose of this quantitative study was to examine the job satisfaction of tenured and tenure-track male and female STEM faculty at research institutions in six states. Moreover, the study sought to examine the relationship between STEM faculty job satisfaction and potential explanatory factors: gender, rank, tenure, salary, family status, whether or not there are children …

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Role Of Herpes Simplex Type I Glycoproteins In Entry And Cell-Cell Fusion, Sona Chowdhury Jan 2012

Role Of Herpes Simplex Type I Glycoproteins In Entry And Cell-Cell Fusion, Sona Chowdhury

LSU Doctoral Dissertations

Herpes simplex virus type I (HSV-1) is a neurotropic virus that infects primarily mucocutaneous epithelial cells and nervous tissue. Membrane fusion is an important aspect of the HSV-1 lifecycle, that occurs during viral entry (virus-cell fusion), viral spread (cell-to-cell fusion), as well as, during virion morphogenesis (assembly and egress). These membrane fusion steps involve complex interactions between multiple viral glycoproteins and cellular receptors. HSV-1 glycoprotein B (gB) is necessary but not sufficient for membrane fusion events. Despite the fact, that the majority of known hypermorphic mutations which cause extensive virus-induced cell fusion occur within glycoprotein K (gK); yet the role …

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Controller Reduction For Linear Systems, Lili Kong Jan 2012

Controller Reduction For Linear Systems, Lili Kong

LSU Doctoral Dissertations

This dissertation proposes some H-infinity and H2 performance preserving controller reduction methods for linear systems. The proposed methods can guarantee robust stability and performance for the closed-loop system with the reduced order controllers. Several H-infinity stability and performance preserving controller reduction methods are proposed in this dissertation. It is shown that the weighting functions used in the proposed controller reduction methods can be directly obtained from the parametrization of the H-infinity controllers. Hence, comparing with the most existing controller reduction approaches, the proposed controller reduction methods require less computation and are easy to apply. At the same time, several algorithms …

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Extending Social Cognitive Career Theory Into The Entrepreneurship Domain: Entrepreneurial Self-Efficacy's Mediating Role Between Inputs, Outcome Expectations, And Intentions, Eric William Liguori Jan 2012

Extending Social Cognitive Career Theory Into The Entrepreneurship Domain: Entrepreneurial Self-Efficacy's Mediating Role Between Inputs, Outcome Expectations, And Intentions, Eric William Liguori

LSU Doctoral Dissertations

Self-efficacy is among the most important constructs in recent entrepreneurship literature (Forbes, 2005), and is central to our understanding of entrepreneurial phenomena. Accordingly, it often captures the attention of policy makers, community leaders, educators and entrepreneurship advocates (e.g., Shook & Bratianu, 2010; Descant, 2010; McCollister, 2011; Chapman, 2011). In this dissertation, I seek to expand upon the extant knowledge of self-efficacy research by undertaking three specific objectives. First, I apply a social cognitive career theory (Lent, Brown, & Hackett, 1994) to entrepreneurship, and posit that this is a more robust theoretical framework to study individual entrepreneurial activity. Second, I explore …

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Thermal Field Investigations And Applications To Integral Abutment Bridges With Frp Panels, Bo Kong Jan 2012

Thermal Field Investigations And Applications To Integral Abutment Bridges With Frp Panels, Bo Kong

LSU Doctoral Dissertations

Expansion joints are often considered as one of the most vulnerable elements affecting the sustainability of traditional jointed bridges. Over the past several decades, a new type of integral abutment bridge (IAB) has been proposed, where the joints are eliminated at the abutments and/or along the length of the bridges. Although with wide acceptances, the IABs have not been largely applied in practice. Many arguments are unsettled and there are no national design guidelines currently. Among all, the thermal behavior is one of the most concerned issues, and that, to a large extent, limits the maximum length of IABs that …

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Two Sides Of The Ancient Vase: Eastern And Western Principles In The Works Of Keiko Abe, Christopher K. Hoefer Jan 2012

Two Sides Of The Ancient Vase: Eastern And Western Principles In The Works Of Keiko Abe, Christopher K. Hoefer

LSU Doctoral Dissertations

Keiko Abe is recognized as one of the leading marimba virtuosos of the Twentieth century. As a composer, she has been writing for solo marimba since the early 1960s and continues composing for the medium today. Her music became popular with Western percussionists after the publishing of Works for Marimba in 1987. This was her first compilation of works for the five-octave marimba. These pieces have become a constant source of repertoire for collegiate and professional performers. Despite Abe’s popularity and influence, little research has examined her compositions. This document features analysis and background of Abe and her music and …

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Thermal Stress Analysis Of Jointed Plain Concrete Pavements Containing Fly Ash And Slag, Yoonseok Chung Jan 2012

Thermal Stress Analysis Of Jointed Plain Concrete Pavements Containing Fly Ash And Slag, Yoonseok Chung

LSU Doctoral Dissertations

With the current demand for Portland cement concrete (PCC) sustainability, supplementary cementitious materials (SCMs) are used in concrete mixtures. The SCMs positively impact the environmental and economic aspects of concrete mixtures and improve the mixture properties in both fresh and hardened concrete. In this research, one control and twenty-four ternary mixtures, with various combinations of fly ashes (Class C and F), slags (Grade 100 and 120), and Portland cement were fabricated. The thermal properties (coefficient of thermal expansion (CTE), thermal conductivity, and heat capacity) and mechanical properties of the selected ternary mixtures were measured at various ages. Temperature gradients were …

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Biomass Energy Production In Louisiana: A Gis Study On The Supply Chain, Anil Raj Kizhakkepurakkal Jan 2012

Biomass Energy Production In Louisiana: A Gis Study On The Supply Chain, Anil Raj Kizhakkepurakkal

LSU Doctoral Dissertations

One major drawback of biomass fuel is its bulky nature and the resulting high cost of transporting the fuel to the facility where the energy is being produced. Hence, supply chain of biomass residues plays a crucial role in determining the financial viability of bioenergy production. Transporting biomass for energy purposes more than 50 miles (80 km) is not considered economically feasible in most conditions. In the wood energy scenario, the maximum distance is more often restricted to distances of less than 200 km between production and consumption (via road). A study was done to determine logging residues and agricultural …

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Beta-Diketone And Beta-Ketoenamine Based Molecular Squares, Jackson Kiplagat Cherutoi Jan 2012

Beta-Diketone And Beta-Ketoenamine Based Molecular Squares, Jackson Kiplagat Cherutoi

LSU Doctoral Dissertations

Abstract This dissertation focuses on synthesis of β-diketone and β-ketoenamine ligands for molecular polygons. Previous work with the bis(β-diketone) m-pbaH2 showed that it can be converted to a copper molecular square, Cu4(m-pba)4, but its use in host-guest reactions was limited by its low solubility in most organic solvents. Accordingly, in the present work, the m-pbhxH2 ligand, with pentyl chains replacing the methyl groups in the β-diketone moieties of m-pbaH2, was successfully prepared beginning with 6-dodecyne. This ligand reacts with Cu2+ to make the molecular square Cu4(m-pbhx)4, which is soluble in a wider range of solvents. Host-guest reactions of Cu4(m-pbhx)4 with …

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Subgradient Formulas For Optimal Control Problems With Constant Dynamics, Lingyan Huang Jan 2012

Subgradient Formulas For Optimal Control Problems With Constant Dynamics, Lingyan Huang

LSU Doctoral Dissertations

In this thesis our fi_x000C_rst concern is the study of the minimal time function corresponding to control problems with constant convex dynamics and closed target sets. Unlike previous work in this area, we do not make any nonempty interior or calmness assumptions and the minimal time functions is generally non-Lipschitzian. We show that the Proximal and Fréchet subgradients of the minimal time function are computed in terms of normal vectors to level sets. And we also computed the subgradients of the minimal time function in terms of the F-projection. Secondly, we consider the value function for Bolza Problem in optimal …

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Law Student Knowledge Of Legal Interviewing: A Case Study Of Self-Evaluation Using Video Annotation, William Taggart Monroe Jan 2012

Law Student Knowledge Of Legal Interviewing: A Case Study Of Self-Evaluation Using Video Annotation, William Taggart Monroe

LSU Doctoral Dissertations

Video has long been used to support learner reflection in professional education programs in law, health, and education. Emerging video analysis tools offer learners the ability to highlight segments of video and focus their attention to specific moments or aspects of performance. These emerging tools afford opportunities for more systematic observation, analysis, and deliberate reflection on learner performance than was available previously. Expertise research has found that representative, rigorous tasks followed by immediate feedback and error correction constitute deliberate practice. Training environments that incorporate deliberate practice and emerging video annotation and analysis tools provide opportunities for learners pinpoint strengths and …

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Fatigue Performance Of Existing Bridges Under Dynamic Loads From Winds And Vehicles, Wei Zhang Jan 2012

Fatigue Performance Of Existing Bridges Under Dynamic Loads From Winds And Vehicles, Wei Zhang

LSU Doctoral Dissertations

During the life cycle of bridges, varied amplitude of stress ranges on structural details are induced by the random traffic and wind loads. The progressive deteriorated road surface conditions might accelerate the fatigue damage accumulations. Micro-cracks in structural details might be initiated. An effective structural modeling scheme and a reasonable fatigue damage accumulation rule are essential for stress range acquisitions and fatigue life estimation. The present research targets at the development of a fatigue life and reliability prediction methodology for existing steel bridges under real wind and traffic environment with the capability of including multiple random parameters and variables in …

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Early Voting In The 2004 Presidential Election, James Michael Siira Jan 2012

Early Voting In The 2004 Presidential Election, James Michael Siira

LSU Doctoral Dissertations

The addition of early voting laws has led to the many changes in the US political system. In this dissertation I examine early voting early voting in a number of different contexts. First, how early voting fits in with the larger issue of voter turnout in the U.S. Second, why some states have early voting policies and other states choose to not have those policies. Third, how state-level political parties view the option to cast an early vote. Fourth, the differences between early voters, election day voters, and non-voters. Fifth, what are the determents of casting an early ballot. Sixth, …

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Synthesis And Characterization Of Geopolymers For Infrastructural Applications, Jian He Jan 2012

Synthesis And Characterization Of Geopolymers For Infrastructural Applications, Jian He

LSU Doctoral Dissertations

In this study, the synthesis process, composition, and microstructure as well as mechanical properties of geopolymers generated by 3 different kinds of raw materials (i.e., metakaolin, mixture of red mud and fly ash, mixture of red mud and rice husk ash) was explored. For geopolymers from identical raw materials, variable parameters involved in the synthesis were examined to investigate the extent and degree of geopolymerization. Uniaxial compression testing was used to examine the mechanical properties (i.e. compressive strength, stiffness, and failure strain). Then the composition and microstructure were characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM) as well …

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Comparison Of Alumni Donors And Alumni Nondonors On Selected Demographic, Educational And Involvement Factors, Arlette Barbara Rodriguez Rodrigue Jan 2012

Comparison Of Alumni Donors And Alumni Nondonors On Selected Demographic, Educational And Involvement Factors, Arlette Barbara Rodriguez Rodrigue

LSU Doctoral Dissertations

This study compared College of Agriculture (COA) alumni of a research university (RU/VH) in the Southern U.S. on selected demographic characteristics and contact information by whether or not the alumni are donors to the university. The target population was COA graduates from 1862 Land Grant Universities located in the Southern portion of the United States. The accessible population was Louisiana State University (LSU) COA alumni graduates. The sample was alumni who completed their degree program from the years 1950 through 2000. The instrument used was the Tiger Advancement Information Lookup System (TAILS) database. Universities have become burdened by financial instability …

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The Effect Of Loving Kindness Meditation And Student Teachers Stress And Empathy, Imre Csaszar Jan 2012

The Effect Of Loving Kindness Meditation And Student Teachers Stress And Empathy, Imre Csaszar

LSU Doctoral Dissertations

Teachers face increasing demands in the twenty-first century as they engage with students, administrators, coworkers, staff, and parents. High demands and stressors may generate feelings of emotional exhaustion in educators. If left ignored or untreated the emotional exhaustion may eventually lead to burnout and impairment. This prospectus highlights a study designed to explore a preventative option to mitigate the experience of stress felt by student teachers through a structured, guided mindfulness training practice: loving kindness meditation.

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The Role Of Music-Making In The Identity Construction Of Members Of An Adult Community Concert Band, Pamela G. Taylor Jan 2012

The Role Of Music-Making In The Identity Construction Of Members Of An Adult Community Concert Band, Pamela G. Taylor

LSU Doctoral Dissertations

The purpose of this qualitative case study was to ascertain how music-making and band membership contributed to the identities of members of the New Orleans Concert Band and how their identities influenced their behaviors. The musician role identity of members of the New Orleans Concert Band, an adult community band, was examined through the lens of identity theory using ethnographic methods. Findings were based upon interviews with 37 band members, observations of rehearsals and concerts, and an examination of the organization’s documents. Results indicated that members valued individual and group music-making, literature played by the band, and social aspects of …

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Examination Of The Reliability And Validity Of A New Observation Measure For Autism Spectrum Disorders: The Autism Spectrum Disorder Observation For Children, Daniene Neal Jan 2012

Examination Of The Reliability And Validity Of A New Observation Measure For Autism Spectrum Disorders: The Autism Spectrum Disorder Observation For Children, Daniene Neal

LSU Doctoral Dissertations

With increasing attention being drawn to autism spectrum disorders (ASD), specifically with regard to early and accurate diagnosis and treatment, researchers and clinicians alike have placed emphasis on finding assessment tools that can aid in this goal. The purpose of this study is to examine the psychometric properties of a new observation measure for ASD, the Autism Spectrum Disorders-Observation for Children (ASD-OC). The ASD-OC was found to have good to excellent interrater reliability, and excellent internal consistency (ƒÑ = .96). As a result of these initial reliability analyses, nine items were removed from the scale. The resulting 45 item ASD-OC …

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Microfabrication Of Conductive Polymer Nanocomposite For Sensor Applications, Chaoxuan Liu Jan 2012

Microfabrication Of Conductive Polymer Nanocomposite For Sensor Applications, Chaoxuan Liu

LSU Doctoral Dissertations

This dissertation developed novel microfabrication techniques of conductive polymer nanocomposite and utilized this material as a functional element for various physical sensor applications. Microstructures of nanocomposite were realized through novel microcontact printing and laser ablation assisted micropatterning processes. Prototype devices including large-strain strain sensor and highly-sensitive pressure sensor were demonstrated showing distinct advantages over existing technologies. The polymer nanocomposite used in this work comprised elastomer poly(dimexylsiloxane) (PDMS) as polymer matrix and multi-walled carbon nananotubes (MWCNTs) as a conductive nanofiller. To achieve uniform distribution of carbon nanotubes within the polymer, an optimized dispersion process was developed, featuring a strong organic solvent—chloroform, …

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The Responsibility Of Clothing Slaves In The United States As Described In Slave Petitions, 1775 To 1867, Ryan Jerel Aldridge Jan 2012

The Responsibility Of Clothing Slaves In The United States As Described In Slave Petitions, 1775 To 1867, Ryan Jerel Aldridge

LSU Doctoral Dissertations

The content analysis of eighteenth and nineteenth century slave petitions identified slave dress terms and descriptors by type and frequency and a descriptive analysis of slave dress petitions revealed the following themes: the expense and burden attributed to clothing slaves, slave dress neglect, hiring contracts that included slave dress, the use of slave dress as a reflection of the slaveholders character, compensation for slave dress provided by an individual other than the slaveholder, the quality of slave dress, the distribution of slave dress, and slave dress terminology descriptors. The most frequent specific provision request for slave dress items consisted of …

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Identification And Incorporation Of Quantitative Indicators Of Ecosystem Function Into Single-Species Fishery Stock Assessment Models And The Associated Biological Reference Points, Melissa Hedges Monk Jan 2012

Identification And Incorporation Of Quantitative Indicators Of Ecosystem Function Into Single-Species Fishery Stock Assessment Models And The Associated Biological Reference Points, Melissa Hedges Monk

LSU Doctoral Dissertations

The move towards an ecosystem approach to fisheries management requires baseline information on the biotic communities and an understanding of the interactions among species. The two objectives of this study were to describe the demersal fish community (DFC) associated with the northwestern Gulf shrimp trawl fishery, and to utilize a multispecies Lotka-Volterra model to examine possible community level effects of fishing. Community level effects include predator-prey interactions and the responses of fish in the same community to fishing pressure. The summer and fall Southeast Area Monitoring and Assessment Program (SEAMAP) bottomfish trawl surveys were used to identify spatial and temporal …

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Chemical And Biological Evaluation Of Antibiotic-Based Ionic Liquids And Gumbos Against Pathogenic Bacteria, Marsha Rae Cole Jan 2012

Chemical And Biological Evaluation Of Antibiotic-Based Ionic Liquids And Gumbos Against Pathogenic Bacteria, Marsha Rae Cole

LSU Doctoral Dissertations

The research presented in this dissertation explores a novel pragmatic therapeutic approach for control, prevention, and treatment of infectious disease using Active-Pharmaceutical Ingredient-based Ionic Liquids (API-ILs) and Groups of Uniform Materials Based on Organic Salts (GUMBOS). Accordingly, several antiseptic- and antibiotic-based API-ILs and GUMBOS were synthesized and characterized using a combination of analytical and microbiological techniques. Overall, this research presents an advanced alternative to combination antibiotic therapy by using a novel group of ionic antimicrobial materials that have controlled pharmacokinetics, improved bioavailabilities, reduced toxicities, multi-modal properties, and potent antimicrobial spectrum of activity as a viable alternative to combating bacterial infections. …

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Hypercube Diagrams For Knots, Links, And Knotted Tori, Ben Mccarty Jan 2012

Hypercube Diagrams For Knots, Links, And Knotted Tori, Ben Mccarty

LSU Doctoral Dissertations

For a knot K the cube number is a knot invariant defined to be the smallest n for which there is a cube diagram of size n for K. Examples of knots for which the cube number detects chirality are presented. There is also a Legendrian version of this invariant called the Legendrian cube number. We will show that the Legendrian cube number distinguishes the Legendrian left hand torus knots with maximal Thurston-Bennequin number and maximal rotation number from the Legendrian left hand torus knots with maximal Thurston-Bennequin number and minimal rotation number. Finally, there is a generalization of cube …

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Entanglement, Uncertainty And Relativity In Fundamental Mechanics With An Application In Qkd, Christopher David Richardson Jan 2012

Entanglement, Uncertainty And Relativity In Fundamental Mechanics With An Application In Qkd, Christopher David Richardson

LSU Doctoral Dissertations

In this dissertation I will probe the innate uncertainty of quantum mechanics. After deriving the necessary tools I will tackle Popper's experiment, a long misunderstood thought experiment with recent experimental results. I will then discuss how uncertainty changes when making measurements from different relativistic reference frames and resolve some on the tension between quantum mechanics and relativity. Finally I utilize the practical aspect of quantum uncertainty and describe a practical quantum key distribution scheme.

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Developing A Geospatial Protocol For Coral Epizootiology, Jennifer Anne Lentz Jan 2012

Developing A Geospatial Protocol For Coral Epizootiology, Jennifer Anne Lentz

LSU Doctoral Dissertations

This dissertation explores how geographic information systems (GIS) and spatial statistics, specifically the techniques used to map, detect, and spatially analyze disease epidemics, could be used to advance our understanding of coral reef health. Given that different types of spatial analysis, as well as different parameter settings within each analysis, can produce noticeably different results, poor selection or improper use of a given technique would likely lead to inaccurate representations of the spatial distribution and false interpretations of the disease. For this reason, I performed a comprehensive review of the following types of exploratory spatial data analysis (ESDA): mapping and …

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Tackling Gravity Wave Confusion Noise With Template Optimizers, A. S. Stroeer, Matthew Benacquista Jan 2012

Tackling Gravity Wave Confusion Noise With Template Optimizers, A. S. Stroeer, Matthew Benacquista

Physics & Astronomy Faculty Publications

The Mock LISA Data Challenge 4.0 simulated the joint two-year recording of gravitational wave signals from mergers of spinning black holes, extreme mass ratio inspirals, Galactic white dwarf binaries, bursts from cosmic strings, and a stochastic background—all over LISA instrument noise. We analysed this data using a global multi-start box and bound optimization scheme, incorporating multi-dimensional Nelder Mead simplex 2 optimization. Our scheme identified 2658 binaries. Of these, 2246 were found to systematically decompose the power in a strong spinning black hole merger into a "white dwarf binary transform". The remaining 416 binaries were identified with a false alarm rate …

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Controlling Calibration Errors In Gravitational-Wave Detectors By Precise Location Of Calibration Forces, Hernan P. Daveloza, M Afrin Badhan, Mario C. Diaz, K. Kawabe, P. N. Konverski, M. Landry, R. L. Savage Jan 2012

Controlling Calibration Errors In Gravitational-Wave Detectors By Precise Location Of Calibration Forces, Hernan P. Daveloza, M Afrin Badhan, Mario C. Diaz, K. Kawabe, P. N. Konverski, M. Landry, R. L. Savage

Physics & Astronomy Faculty Publications

We present results of finite element analysis simulations which could lead to more accurate calibration of interferometric gravitational wave detectors. Calibration and actuation forces applied to the interferometer test masses cause elastic deformation, inducing errors in the calibration. These errors increase with actuation frequency, and can be greater than 50% at frequencies above a few kilohertz. We show that they can be reduced significantly by optimizing the position at which the forces are applied. The Advanced LIGO [1] photon calibrators use a two-beam configuration to reduce the impact of local deformations of the test mass surface. The position of the …

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The Characterization Of Virgo Data And Its Impact On Gravitational-Wave Searches, J. Aasi, J. Abadie, Matthew Benacquista, G. Cagnoli, Teviet Creighton, Mario C. Diaz, Soma Mukherjee, Volker Quetschke, Malik Rakhmanov, Joseph D. Romano, Cristina V. Torres Jan 2012

The Characterization Of Virgo Data And Its Impact On Gravitational-Wave Searches, J. Aasi, J. Abadie, Matthew Benacquista, G. Cagnoli, Teviet Creighton, Mario C. Diaz, Soma Mukherjee, Volker Quetschke, Malik Rakhmanov, Joseph D. Romano, Cristina V. Torres

Physics & Astronomy Faculty Publications

Between 2007 and 2010 Virgo collected data in coincidence with the LIGO and GEO gravitational-wave (GW) detectors. These data have been searched for GWs emitted by cataclysmic phenomena in the universe, by non-axisymmetric rotating neutron stars or from a stochastic background in the frequency band of the detectors. The sensitivity of GW searches is limited by noise produced by the detector or its environment. It is therefore crucial to characterize the various noise sources in a GW detector. This paper reviews the Virgo detector noise sources, noise propagation, and conversion mechanisms which were identified in the three first Virgo observing …

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The Political Ontology Of Race, Michael James Jan 2012

The Political Ontology Of Race, Michael James

Faculty Journal Articles

Race theory is dominated by two camps. Eliminativists rely on a biological ontology, which contends that the concept of race must be biologically grounded, in order to repudiate the very term, on grounds that it is epistemologically vacuous and normatively pernicious. Conservationists use a social ontology, in which race is based on social practices, in order to retain racial categories in remedial social policies, such as affirmative action and race-based political representation. This article attempts to reorient this debate in two ways. First, it challenges the idea that racial identity is entirely unchosen by defending a political ontology of race …

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