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A Yeast Gsk-3 Kinase Mck1 Promotes Cdc6 Degradation To Inhibit Dna Re-Replication, Amy E. Ikui, Valentina Rossio, Lea Schroeder, Satoshi Yoshida

Publications and Research

Cdc6p is an essential component of the pre-replicative complex (pre-RC), which binds to DNA replication origins to promote initiation of DNA replication. Only once per cell cycle does DNA replication take place. After initiation, the pre-RC components are disassembled in order to prevent re-replication. It has been shown that the N-terminal region of Cdc6p is targeted for degradation after phosphorylation by Cyclin Dependent Kinase (CDK). Here we show that Mck1p, a yeast homologue of GSK-3 kinase, is also required for Cdc6 degradation through a distinct mechanism. Cdc6 is an unstable protein and is accumulated in the nucleus only during G1 …

The Daily Egyptian, December 06, 2012, Daily Egyptian Staff

December 2012

No abstract provided.

Modernization, Sexual Risk-Taking, And Gynecological Morbidity Among Bolivian Forager-Horticulturalists, Jonathan Stieglitz, Aaron D. Blackwell, Raúl Quispe Gutierrez, Edhitt Cortez Linares, Michael Gurven, Hillard Kaplan

ESI Publications

Sexual risk-taking and reproductive morbidity are common among rapidly modernizing populations with little material wealth, limited schooling, minimal access to modern contraception and healthcare, and gendered inequalities in resource access that limit female autonomy in cohabiting relationships. Few studies have examined how modernization influences sexual risk-taking and reproductive health early in demographic transition. Tsimane are a natural fertility population of Bolivian forager-farmers; they are not urbanized, reside in small-scale villages, and lack public health infrastructure. We test whether modernization is associated with greater sexual risk-taking, report prevalence of gynecological morbidity (GM), and test whether modernization, sexual risk-taking and parity are …

Curriculum Subcommittee Agenda, December 6, 2012, Utah State University

Educational Policies Committee

Department of Nutrition, Dietetics and Food Sciences

• Add University Studies Request
• Prerequisite Change

School of Applied Sciences, Technology and Education

• New Course
• Prerequisite Change
• Delete Course

Department of Art and Design

• Add University Studies Request

Department of Theatre Arts

• Credit Hour Change
• Course Description Change
• Course Number Change

Department of Management

• Prerequisite Change

School of Teacher Education and Leadership

• New Course

Department of Family, Consumer, and Human Development

• Credit Hour Change, Prerequisite Change, Course Description Change

Department of Psychology

• Course Number Change, Credit Hour Change, Course Description Change
• Title Change, Course Description Change

Department of Special Education and Rehabilitation

• Course …

Vista: December 6, 2012, University Of San Diego

USD Vista (1965-)

No abstract provided.

Quantum Trade-Off Coding For Bosonic Communication, Mark M. Wilde, Patrick Hayden, Saikat Guha

Faculty Publications

The trade-off capacity region of a quantum channel characterizes the optimal net rates at which a sender can communicate classical, quantum, and entangled bits to a receiver by exploiting many independent uses of the channel, along with the help of the same resources. Similarly, one can consider a trade-off capacity region when the noiseless resources are public, private, and secret-key bits. We identified [see Wilde, Hayden, and Guha, Phys. Rev. Lett.PRLTAO0031-900710.1103/PhysRevLett.108.140501 108, 140501 (2012)] these trade-off rate regions for the pure-loss bosonic channel and proved that they are optimal provided that a long-standing minimum-output entropy conjecture is true. Additionally, we …

The Comment, December 6, 2012, Bridgewater State University

The Comment

No abstract provided.

Comparison Of 3-D Friction Stir Welding Viscoplastic Finite Element Model With Weld Data And Physically-Simulated Data, Maria Posada

Theses and Dissertations

Models (both physical and numerical) of the friction stir (FS) welding process are used to develop a greater understanding of the influence of independent process parameters on dependent process output variables, such as torque, power, specific weld energy, peak temperature, cooling rates and various metallurgical factors (e.g., grain size and precipitates). An understanding of how the independent process parameters influence output variables and ultimately their effect on resultant properties (e.g., strength, hardness, etc..) is desirable. Most models developed have been validated primarily for aluminum alloys with relatively small amounts of experimental data. Fewer models have been validated for steels or …

Student Service Corps, Bryant Sheppard

Honors Projects

This Honors Project consists of two parts: an applied part and written interpretation of the author's experience. The main focus throughout the semester has been on the applied part, which has consisted of creating and leading a student organization focused on social justice, which has been named the Student Service Corps. In this document, the author covers the models that were used to facilitate the organization, the implementation of these models, and the impact of the author's Honors Project. The main purpose of the author's project was to research the necessary strategies to create a service organization focused on social …

The Alestle - Vol. 65 No. 15 - 12/06/2012, Southern Illinois University Edwardsville

The Alestle

Vol. 65 No. 15

The Parthenon, December 6, 2012, Shane Arrington

The Parthenon

The Parthenon, Marshall University’s student newspaper, is published by students Monday through Friday during the regular semester and weekly Thursday during the summer. The editorial staff is responsible for the news and the editorial content.

The Value Of Removing Daily Obstacles Via Everyday Problem-Solving Theory: Developing An Applied Novel Procedure To Increase Self-Efficacy For Exercise, Daniele Artistico, Angela Marinilli Pinto, Jill Douek, Justin Black, Lina Pezzuti

Publications and Research

The objective of the study was to develop a novel procedure to increase self-efficacy for exercise. Gains in one’s ability to resolve day-to-day obstacles for entering an exercise routine were expected to cause an increase in self-efficacy for exercise. Fifty-five sedentary participants (did not exercise regularly for at least 4 months prior to the study) who expressed an intention to exercise in the near future were selected for the study. Participants were randomly assigned to one of three conditions: (1) an Experimental Group in which they received a problem-solving training session to learn new strategies for solving day-to-day obstacles that …

Centers Of Cultural Gravity: Cultural Translation In Nublares, William Foster Carr

Theses and Dissertations

In the novel Nublares, Antonio Pérez Henares presents a caveman who typifies the modern, fragmented subject. The protagonist, Ojo Largo, a hybrid child of various cultures, crosses the boundaries between those cultures and negotiates the in-between space as a cultural translator. The concept of the fragmented, hybrid self reflects modern cognitive science. Daniel Dennett's Multiple Drafts model of consciousness presents a fragmented self characterized by "disaggregated agency," a subject consisting of the center of gravity between disparate mental processes and accumulated "narratives." Taking this model as point of departure, this thesis finds a consensus between three novels of prehistory, …

Two-Refinement By Pillowing For Structured Hexahedral Meshes, J. Bruce Malone

Theses and Dissertations

A number of methods for adaptation of existing all-hexahedral grids by localized refinement have been developed; however, none ideally fit all refinement needs. This thesis presents the structure to a method of two-refinement developed for conformal, structured, all-hexahedral grids that offers flexibility beyond what has been offered to date. The method is fundamentally based on pillowing pairs of sheets of hexes. This thesis also suggests an implementation of the method, shows the results of examples refined using it and compares these results to results from implementing three-refinement on the same examples.

A Study Of The Effect Of Heat-Treatment On The Morphology Of Nafion Ionomer Dispersion For Use In The Passive Direct Methanol Fuel Cell (Dmfc), Ting Yuan, Haifeng Zhang, Zhiqing Zou, Sufia Khatun, Daniel Akins, Yara Adam, Sophia Suarez

Publications and Research

Aggregation in heat-treated Nafion ionomer dispersion and 117 membrane are investigated by 1H and 19F Nuclear Magnetic Resonance (NMR) spectra, spin-lattice relaxation time, and self-diffusion coefficient measurements. Results demonstrate that heat-treatment affects the average Nafion particle size in aqueous dispersions. Measurements on heat-treated Nafion 117 membrane show changes in the 1H isotropic chemical shift and no significant changes in ionic conductivity. Scanning electron microscopy (SEM) analysis of prepared cathode catalyst layer containing the heat-treated dispersions reveals that the surface of the electrode with the catalyst ink that has been pretreated at ca. 80 °C exhibits a compact and uniform morphology. …

Kenyon Collegian - December 6, 2012

The Kenyon Collegian

No abstract provided.

Embedding Affective Learning Outcomes In Library Instruction, Ellysa Stern Cahoy, Robert Schroeder

Communications in Information Literacy

While information literacy in higher education has long been focused on cognitive learning outcomes, attention must be paid to students' affective, emotional needs throughout the research process. This article identifies models for embedding affective learning outcomes within information literacy instruction, and provides strategies to help librarians discover, articulate, and address students' self-efficacy, motivation, emotions and attitudes. Worksheets to assist in creating affective learning outcomes are included to bring structure to an area of learning that is often challenging to articulate and measure. Also included in the article are the results of a recent survey of instruction librarians' familiarity and inclusion …

Considering Information Literacy Skills And Needs: Designing Library Instruction For The Online Learner, Swapna Kumar, Marilyn Ochoa, Mary Edwards

Communications in Information Literacy

This paper reports on a library instruction needs assessment conducted with incoming doctoral students (n=34) in two online programs in education. The differences in the prior skills and experiences of the two groups highlighted the importance of both needs assessments and learner analysis as well as course- or program-specific instructional design in information literacy instruction for online students. Based on students' reported skills, education librarians structured both the content and format of instruction to help students succeed in online activities in the doctoral program.

Predictors Of Student's Attitudes Toward Science Literacy, Irina I. Holden

Communications in Information Literacy

Being information and science literate are crucial in an age when scientific developments influence the political arena and vice versa. In order to become active and responsible citizens, students must understand such issues as global warming and stem cell research. Furthermore, they must be lifelong learners, capable of researching and educating themselves about new scientific developments. These are some of the complex issues that information literacy educators must address. This article reports on the results of a survey of student's attitudes towards science literacy and lifelong learning, and on variables associated with their attitudes. Most of the students' attitudes were …

Notes From The Field: 10 Short Lessons On One-Shot Instruction, Megan Oakleaf, Steven Hoover, Beth Woodard, Jennifer Corbin, Randy Hensley, Diana Wakimoto, Christopher V. Hollister, Debra Gilchrist, Michelle Millet, Patty Iannuzzi

Communications in Information Literacy

Librarians teach. It might not be what they planned to do when they entered the profession, or it may have been a secret hope all along. Either way, librarians teach, and one teaching scenario remains quintessential: the one-shot library instruction session. In recognition of the centrality of the "one-shot," this article shares several authors' "notes from the field." The notes provide a range of strategies for developing pedagogically sound one-shot library instruction sessions, grouped loosely into three categories: planning, delivery, and integration. The authors offer these insights in their own words in hopes that other teaching librarians may benefit from …

Binding Of An Indenoisoquinoline To The Topoisomerase-Dna Complex Induces Reduction Of Linker Mobility And Strengthening Of Protein-Dna Interaction., Giordano Mancini, Ilda D'Annessa, Andrea Coletta, Giovanni Chillemi, Yves Pommier, Mark S. Cushman, Alessandro Desideri

Borch Department of Medicinal Chemistry and Molecular Pharmacology Faculty Publications

Long-duration comparative molecular dynamics simulations of the DNA-topoisomerase binary and DNA-topoisomerase-indenoisoquinoline ternary complexes have been carried out. The analyses demonstrated the role of the drug in conformationally stabilizing the protein-DNA interaction. In detail, the protein lips, clamping the DNA substrate, interact more tightly in the ternary complex than in the binary one. The drug also reduces the conformational space sampled by the protein linker domain through an increased interaction with the helix bundle proximal to the active site. A similar alteration of linker domain dynamics has been observed in a precedent work for topotecan but the molecular mechanisms were different …

Diverse Lifestyles And Strategies Of Plant Pathogenesis Encoded In The Genomes Of Eighteen Dothideomycetes Fungi., Robin A. Ohm, Nicolas Feau, Bernard Henrissat, Conrad L. Schoch, Benjamin A. Horwitz, Kerry W. Barry, Bradford J. Condon, Alex C. Copeland, Braham Dhillon, Fabian Glaser, Cedar N. Hesse, Idit Kosti, Kurt Labutti, Erika A. Lindquist, Susan Lucas, Asaf A. Salamov, Rosie E. Bradshaw, Lynda Ciuffetti, Richard C. Hamelin, Gert H.J. Kema, Christopher Lawrence, James A. Scott, Joseph W. Spatafora, B Gillian Turgeon, Pierre J.G.M. De Wit, Shaobin Zhong, Stephen B. Goodwin, Igor V. Grigoriev

Department of Botany and Plant Pathology Faculty Publications

The class Dothideomycetes is one of the largest groups of fungi with a high level of ecological diversity including many plant pathogens infecting a broad range of hosts. Here, we compare genome features of 18 members of this class, including 6 necrotrophs, 9 (hemi)biotrophs and 3 saprotrophs, to analyze genome structure, evolution, and the diverse strategies of pathogenesis. The Dothideomycetes most likely evolved from a common ancestor more than 280 million years ago. The 18 genome sequences differ dramatically in size due to variation in repetitive content, but show much less variation in number of (core) genes. Gene order appears …

Can Public Education Be Saved? An Argument For Educational Reform, Kathrine Hyatt

Honors Theses

Education, a key to later success, needs to be the number one priority. However, the American of public education has many systemic problems that are inhibiting children from reaching their full potential. This literature review first examines the colonial roots of American education and briefly tracks the development. Then, four major systemic problems are addressed: the over reliance on standardized testing, teaching methods and curriculum, lack of creativity, and how the cycle of poverty impacts learning. Finally solutions are discussed, with the ultimate recommendation being to adapt the Montessori Method.

Dissolved Organic Matter Composition And Bioavailability Reflect Ecosystem Productivity In The Western Arctic Ocean, Yuan Shen, Cedric Fichot, Ronald Benner

Faculty Publications

Dissolved organic carbon (DOC) and total dissolved amino acids (TDAA) were measured in high (Chukchi Sea) and low (Beaufort Sea) productivity regions of the western Arctic Ocean to investigate the composition and bioavailability of dissolved organic matter (DOM). Concentrations and DOC-normalized yields of TDAA in Chukchi surface waters were relatively high, indicating an accumulation of bioavailable DOM. High concentrations and yields of TDAA were also observed in the upper halocline of slope and basin waters, indicating off-shelf transport of bioavailable DOM from the Chukchi Sea. In contrast, concentrations and yields of TDAA in Beaufort surface waters were relatively low, indicting …

2012-12-06, Morehead State University. Board Of Regents.

Morehead State Board of Regents Agenda Books and Meeting Minutes

No abstract provided.

My Beautiful, Jacquetta Harvey

Theses and Dissertations

In creating my work I use bold, bright colors and fundamental shapes and patterns. My images reflect how I view the world and genuinely express my imagination, feelings, and thinking. Working this way allows me to apply a symbolic face to personal concerns, beliefs, fears, ideologies, and philosophies. I see a world where life and art blend to create images of triumph and tragedy, joy and pain, or growth and change. My ideas have grown from the desire to understand myself as a woman, as a Christian, and as a unique individual. Dealing with personal questions, I explore the varying …

Collaboration And Problem-Based Learning: Integrating Information Literacy Into A Political Science Course, Peg Cook, Mary Barbara Walsh

Communications in Information Literacy

This paper details the collaborative efforts of a reference librarian and a political science professor to seamlessly meld the study of politics with the acquisition of information literacy skills using a problem-based learning approach. Students in an introductory American Government class were engaged in a group project in which they acted as media consultants for the political candidate of their choice. Two information literacy sessions were embedded into the project. ACRL Information Literacy Standards were used to generate and assess performance outcomes. Student feedback, as well as pre-test and post-test results, indicate that a problem-based approach to enhancing information literacy …

Microfluidic Devices With Integrated Sample Preparation For Improved Analysis Of Protein Biomarkers, Pamela Nsang Nge

Theses and Dissertations

Biomarkers present a non-invasive means of detecting cancer because they can be obtained from body fluids. They can also be used for prognosis and assessing response to treatment. To limit interferences it is essential to pretreat biological samples before analysis. Sample preparation methods include extraction of analyte from an unsuitable matrix, purification, concentration or dilution and labeling. The many advantages offered by microfluidics include portability, speed, automation and integration. Because of the difficulties encountered in integrating this step in microfluidic devices most sample preparation methods are often carried out off-chip. In the fabrication of micro-total analysis systems it is important …

A Tangle Net Study On Relative Abundance And Habitat Preference Of Elasmobranchs In North Inlet Estuary, South Carolina, Moriah Heather Moore

Electronic Theses and Dissertations

Although habitat selection is relatively well studied in some elasmobranchs, no field or lab studies have focused on sediment preference, which is important to other benthic marine vertebrates. To determine the relative abundance and sediment preference of shallow water benthic elasmobranch inhabitants of North Inlet, SC, we employed 187 30 minute tangle net sets over two sediment types (mud and sand). The majority of our capture consisted of 41 Dasyatis sayi (tagged 37) and 31 Sphyrna tiburo (tagged 14). Although D. sayi had been recorded in North Inlet, previous studies found greater numbers of congeners D. americana and D. sabina. …

Westerner, December 6, 2012, Western New England University

Student Newspapers

The official student newspaper of Western New England University