Digital Commons Network^™

Genome-Wide Association Studies Of Asthma In Population-Based Cohorts Confirm Known And Suggested Loci And Identify An Additional Association Near Hla, Andrew C. Heath, Pamela A. F. Madden, Et Al

Open Access Publications

No abstract provided.

Intermuscular Adipose Tissue Is Muscle Specific And Associated With Poor Functional Performance, Lori J. Tuttle, David R. Sinacore, Michael J. Mueller

Open Access Publications

No abstract provided.

Postprandial Leucine And Insulin Responses And Toxicological Effects Of A Novel Whey Protein Hydrolysate-Based Supplement In Rats, Ryan G. Toedebusch, Thomas E. Childs, Shari R. Hamilton, Jan R. Crowley, Frank W. Booth, Michael D. Roberts

Open Access Publications

No abstract provided.

Measurement Of Apolipoprotein E And Amyloid Β Clearance Rates In The Mouse Brain Using Bolus Stable Isotope Labeling, Jacob M. Basak, Jungsu Kim, Yuriy Pyatkivskyy, Kristin R. Wildsmith, Hong Jiang, Maia Parsadanian, Bruce W. Patterson, Randall J. Bateman, David M. Holtzman

Open Access Publications

No abstract provided.

A Multicenter Evaluation Of Diagnostic Tools To Define Endpoints For Programs To Eliminate Bancroftian Filariasis, Peter U. Fischer, Ramakrishna U. Rao, Et Al

Open Access Publications

No abstract provided.

Large-Scale Pathway-Based Analysis Of Bladder Cancer Genome-Wide Association Data From Five Studies Of European Background, Gerald Andriole Jr., Et Al

Open Access Publications

No abstract provided.

In Vivo Human Apolipoprotein E Isoform Fractional Turnover Rates In The Cns, Kristin R. Wildsmith, Jacob M. Basak, Bruce W. Patterson, Yuriy Pyatkivskyy, Jungsu Kim, Kevin E. Yarasheski, Jennifer X. Wang, Kwasi G. Mawuenyega, Hong Jiang, Maia Parsadanian, Hyejin Yoon, Tom Kasten, Wendy C. Sigurdson, Chengjie Xiong, Alison Goate, David M. Holtzman, Randall J. Bateman

Open Access Publications

No abstract provided.

Incorporating Patient Preference Into The Management Of Infertility In Women With Polycystic Ovary Syndrome, Ugochi C. Okoroafor, Emily S. Jungheim

Open Access Publications

No abstract provided.

Hospital Flood Preparedness: A Survey Of 15 Provinces In Central Thailand, Anucha Apisarnthanarak, Thana Khawcharoenporn, Keith F. Woeltje, David K. Warren

Open Access Publications

No abstract provided.

Adverse Metabolic Response To Regular Exercise: Is It A Rare Or Common Occurrence?, Claude Bouchard, Steven N. Blair, Timothy S. Church, Conrad P. Earnest, James M. Hagberg, Keijo Hakkinen, Nathan T. Jenkins, Laura Karavirta, William E. Kraus, Arthur S. Leon, D. C. Rao, Mark A. Sarzynski, James S. Skinner, Cris A. Slentz, Tuomo Rankinen

Open Access Publications

No abstract provided.

Moderate-Intensity Exercise Improves Body Composition And Improves Physiological Markers Of Stress In Hiv-Infected Men, Wesley Dudgeon, Jason R. Jaggers, Kenneth D. Phillips, Larry Durstine, Stephanie Burgess, George William Lyerly, John Mark Davis, Gregory Alan Hand

Faculty and Staff Scholarship

HIV/AIDS and its treatment often alter body composition and result in poorer physical functioning. The aim of this study was to determine the effects of a moderate-intensity exercise program on body composition and the hormones and cytokines associated with adverse health outcomes. HIV-infected males (N = 111) were randomized to an exercise group (EX) who completed 6 weeks of moderate-intensity exercise training, or to a nonintervention control group (CON). In pre- and postintervention, body composition was estimated via DXA, peak strength was assessed, and resting blood samples were obtained. There was a decrease in salivary cortisol at wake (P = …

An Educational Intervention To Increase Fruit And Vegetable Consumption In Parents Of Obese And Overweight Children, Zenesha R. Barkley

UNF Graduate Theses and Dissertations

The incidence and prevalence of overweight and obese children in the United States is a serious health concern since the complications of childhood obesity can have serious and long-term effects: cardiovascular disease, sleep apnea, type 2 diabetes, neurological disease, and pulmonary disease. Parental modeling and nutritional education focusing on the obese/overweight child’s parents has been shown as an effective strategy for improving nutritional outcomes of the recommended servings of fruits and vegetables in children from five to ten years of age. Outcomes of this study and targeted nutritional modeling included increasing vegetable and fruit consumption of the parent by at …

Advocacy And Human Rights, Evangelical Advocacy: A Response To Global Poverty

Syllabi

This course is designed to prepare Christian leaders to identify entry points for engagement in social justice advocacy in the context of the global struggle for human rights/justice. In order to approach such advocacy from a uniquely Christian perspective, participants will examine the Christian witness to the state (at all levels) and evaluate the role followers of Jesus have in walking with the oppressed to seek justice for them. Case studies from a variety of Christian and secular organizations will highlight the various levels at which advocacy can occur.

The Effect Of Vitamin E Supplementation On An Experimental Haemonchus Contortus Infection In Dorset Lambs, Brittany Marie De Wolf

Open Access Master's Theses

Gastrointestinal parasitism in sheep, particularly lambs, results in substantial economic losses to producers worldwide. Nutritional status has been shown to play an important role in host immune response to parasitic infections. The objective of this study was to investigate the effect of vitamin E supplementation on an artificial Haemonchus contortus (H. contortus) infection in immature lambs. Twenty Dorset lambs were stratified into two treatment groups according to parasite susceptibility. Worm-free lambs, 28 to 32 weeks of age, were supplemented with vitamin E (d-α-tocopherol) for twelve weeks following the recommendations of the National Research Council for minimal daily requirement …

Effect Of Silicon On Plant Growth And Drought Stress Tolerance, Kaerlek W. Janislampi

Publications

Silicon is not considered an essential nutrient, but it is typically abundant in soils and can be taken up in large amounts by plants. Silicon is known to have beneficial effects when added to rice and several other plants. These effects include disease and insect resistance, structural fortification, and regulation of the uptake of other ions. In this study, the effect of silicic acid fertilization on the growth and drought tolerance of four crop plants (corn, wheat, soybean, and rice) was analyzed. Plants were studied using three cultivation techniques: 1) hydroponic solution and subjected to salt stress, 2) low-silicon soil-less …

Building Interdisciplinary Qualitative Research Networks: Reflections On Qualitative Research Group (Qrg) At The University Of Manitoba, Kerstin Stieber Roger, Gayle Halas

The Qualitative Report

As qualitative research methodologies continue to evolve and develop, both students and experienced researchers are showing greater interest in learning about and developing new approaches. To meet this need, faculty at the University of Manitoba created the Qualitative Research Group (QRG), a community of practice that utilizes experiential learning in the context of social relationships to nurture social interaction, create opportunities to share knowledge, support knowledge creation, and build collaborations among all disciplines. While many other qualitative research networks such as the QRG may exist, little has been published on their early development or the activities that contribute to the …

Demanding Substance Or Form? The Sec's Plain English Handbook As A Basis For Securities Violations, J. Scott Colesanti

Hofstra Law Faculty Scholarship

In 1998, the United States Securities and Exchange Commission (“SEC” or “ “Commission”) released a style manual titled “The Plain English Handbook.” The culmination of a drive by its Chairman, Arthur Levitt, the Handbook drew upon the rules of grammar, best industry practice, and even the support of billionaire Warren Buffett in calling for a layman's translation of corporate disclosure documents.

To varying degrees, commentators noted the significance of the Handbook. Initial textual studies provided mixed results. The press marveled at its novelty but securities regulation experts were less sanguine, chiding Commission members for naming themselves “language czars of the …

The Characteristics Of Soft Tissue Following Root Coverage Procedures With Two Types Of Acellular Dermal Matrix Allografts, Ramzi Abou Arraj

All ETDs from UAB

Acellular dermal matrix allograft (ADMA) has emerged as a reliable substitute for autogenous soft tissue grafts in the treatment of gingival recessions and lack of keratinized gingiva (KG). ADMA has been hypothesized to create a zone of "immobile tissue" extending apical to the mucogingival junction (MGJ). This project aims to investigate the presence of this zone associated with the use of a coronally advanced flap in combination with either AlloDerm® (ADMA A) or Puros Dermis® (ADMA B) for root coverage procedures. Twenty patients, each presenting with one Miller Class I or II recession defect, were randomized to receive either ADMA …

Exploring Health Disparities For Children In The City Of Milwaukee, Mark Edwin Anderson

All ETDs from UAB

This study investigated whether school-based oral health programs as a public policy intervention increased dental sealant applications among children from low-income families and minorities in public schools in inner city Milwaukee. By using a difference-in-differences analysis, we examined pre-post time frames, 2001-2003 and 2008-2009, to determine sealant application usage in public schools in nine inner city Milwaukee zip codes after the intervention of a public policy initiative to expand school-based oral health programs with the expressed intent of increasing placement of dental sealants in children at high risk for dental decay and disease. Results of a binary logistic regression revealed …

Fabrication Of Lipospheres For Paclitaxel And Assessment Of In Vitro Cytotoxicity Against U373 Cancer Cell Lines, Nilakshi Nerkar, Amrita Bajaj, Shruti Shrikhande, Darshana Jain

The Thai Journal of Pharmaceutical Sciences

Paclitaxel is an antineoplastic drug, effective for various complex cancers especially ovarian and breast cancer. Due to its high hydrophobicity, an adjuvant such as polyethoxylated castor oil (Cremophor EL) has to be used in its clinical administration; however, it causes serious side-effects. Inclusion of paclitaxel in lipid matrix (lipospheres) has been proved to be a good approach to eliminate the need for Cremophor EL and to prolong the release of the drug. This paper describes the development of lipospheres as carriers for paclitaxel. Lipospheres constituted of bioacceptable and biodegradable lipids were fabricated and characterised. Scanning electron microscopy (SEM), differential scanning …

Thrombolytic Activity Of Some Spices And Plants Available In Bangladesh, Md. Rakib Ai-Manun, Nabiha Amrin, Jahura Begum, Md. Abdul Mazid

The Thai Journal of Pharmaceutical Sciences

Thrombolytic activities of some plants, namely Tamarindus indica (Fabaceae), Flemingia congesta (Fabaceae), Lawsonia inermis (Lythraceae), Mesua nagassarium (Clusiaceae, and spices, namely Coriandrum sativum (Apiaceae), Curcuma longa (Zingiberaceae), Cinnamomum tamala (Lauraceae), Nigella sativa (Ranunculaceae), Eugenia aromaticum (Myrtaceae), available in Bangladesh, were evaluated using an in vitro model. The thrombolytic activity in terms of percentage of weight loss of in vitro formed clots were found as C. sativum 43.25 ± 7.18%, C. longa 53.32 ± 4.96%, C. tamala 22.10 ± 3.18%, N. sativa 28.49 ± 3.72%, E. aromaticum 32.18 ± 3.10%, T. indica 28.91 ± 2.29%, F. congesta 35.27 ± 7.35%, L. …

Lactobacillus Plantarum T23/3 As A Potential Probiotic Strain Isolated From Faces, Titpawan Nakpheng, Rosainee Kha, Neelam Balekar, Sanae Kaewnopparat, Teerapol Srichana

The Thai Journal of Pharmaceutical Sciences

The present study was undertaken to evaluate the properties of Lactobacillus plantarum T23/3 isolated from the feces of healthy elderly volunteer. The L. plantarum T23/3 showed better tolerance property to bile acid, simulated gastric fluid (SGF) and simulated intestinal fluid (SIF), and exhibited antimicrobial activity against tested enteropathogens. It formed macroscopic granules with surface hydrophobicity and co-aggregated with tested microbial strain. It was resistant to some antibiotics used for treatment of diarrhea so there is possibility to co-administer L. plantarum as probiotic with antidiarrheal therapy. Furthermore, adhesion and significant potential for decreasing adhesion of pathogens (E. coli 2601 and V. …

Influences Of Habitual Diet, Ethnicity, And Age On Circulating Total Ghrelin, Amy Ellis

All ETDs from UAB

Ghrelin is a hormone known to stimulate appetite and food intake. Although certain macronutrients differentially suppress ghrelin on an acute basis, it is unknown whether habitual macronutrient intake affects circulating ghrelin. Thus, the first experimental aim was to determine whether 8-week habituation to diets differing in carbohydrate or fat would affect fasting ghrelin or ghrelin response to a mixed meal. Recent reports also suggest that ghrelin regulation may relate to propensity for obesity. Obesity is more prevalent among AA compared to EA, with the highest rates among AA females. This disparity becomes apparent before puberty, and childhood obesity tends to …

Sleep Quality, Stress, Caregiver Burden, And Quality Of Life In Maternal Caregivers Of Young Children With Bronchopulmonary Dysplasia, Christine A. Feeley

All ETDs from UAB

Mothers are usually the primary caregivers of young children with a chronic illness such as bronchopulmonary dysplasia (BPD), and may have no formal caregiver training. Children with BPD often require complex healthcare at home (complex medication regimens, oxygen via nasal cannula, Gastrostomy feedings, etc.), thus many maternal caregivers experience difficulty balancing the needs of their child with their own needs and other responsibilities. As such, maternal caregivers may report increased levels of stress and caregiver burden, as well as decreased quality of life (QOL). Additionally, a great number of maternal caregivers report poor sleep quality due to nighttime caregiving duties. …

Fat Distribution And Metabolic Health: The Effects Of Macronutrient Manipulation On Fat Distribution, Weight Loss, And Glucose Metabolism, Amy Miskimon Goss

All ETDs from UAB

Fat distribution pattern may contribute to risk of development of metabolic diseases such and type 2 diabetes and cardiovascular disease. However, the precise nature of the relationships between adipose tissue depots and metabolic health remains controversial. Additionally, further research is needed to identify optimal dietary approaches to reduce disease risk and visceral adiposity among overweight and obese individuals, who may already be on a trajectory for development of metabolic disease. Therefore, the goal of this project was to examine relationships of adipose tissue depots with insulin sensitivity, and then to determine if diets differing in CHO and fat content can …

Effects Of Stress On Growth Hormone Receptor Signaling, Ryan Marshall Corrick

All ETDs from UAB

Growth hormone (GH) regulates body composition via stimulation of protein synthesis and catabolism of adipose tissue, generally promoting maintenance of lean body mass. Following severe injury, GH resistance contributes to muscle protein wasting, adversely impacting morbidity and mortality. In this dissertation research, we sought to determine the mechanisms of GH resistance following injury. To accomplish this, we evaluated GH signaling in a mouse model of severe injury. In the first section of this thesis, we demonstrate severe impairments in hepatic GH signaling occurring in association with an apparent, hemorrhage-dependent cleavage of the GH receptor (GHR). In the second section, we …

How Older Adults With Age-Related Macular Degeneration Living In A Southeastern Metropolitan Area Develop Physical Activity Self-Efficacy, A Grounded Theory Study, Elizabeth Anne Barstow

All ETDs from UAB

HOW OLDER ADULTS WITH AGE-RELATED MACULAR DEGENERATION LIVING IN A SOUTHEASTERN METROPOLITAN AREA DEVELOP PHYSICAL ACTIVITY SELF-EFFICACY, A GROUNDED THEORY STUDY ABSTRACT This qualitative grounded theory study explored the process of Physical Activity Self-Efficacy development among older adults with age-related macular degeneration in a southeastern metropolitan area. According to the United States Administration on Aging, the population of individuals over 65 will be 88.5 million by the year 2050, doubling its 2010 estimates. As our population ages, so does the prevalence of chronic conditions. One of these chronic conditions, age-related macular degeneration, is the leading cause of vision loss in …

Evaluation Of The Association Of Low-Level Prenatal Blood Lead Exposure And Auditory Brainstem Response Among Infants, Timothy A. Dignam

All ETDs from UAB

Hearing loss is one of the most common major abnormalities present among infants. Two to four infants per 1,000 are born in the United States with severe-to-profound newborn hearing loss (Chu 2003). Undetected, hearing loss delays speech, language, and cognitive development. Numerous studies have shown that prenatal lead exposure is associated with a variety of neurobehavioral and electrophysiological abnormalities (Abbate 1995, Bellinger 2004, Koller 2004). Studies focusing on hearing have primarily described pediatric cases or occupationally exposed adults where blood lead levels (BLLs) are much higher than currently seen in the United States (Otto 1985; Bleecker 2003; Schwartz 1987). Hearing …

The Impact Of The State Children's Health Insurance Program's Unborn Child Ruling On Foreign-Born Latina Prenatal Care Utilization And Birth Outcomes, 2000-2007, Jonathan Hawthorne Drewry

All ETDs from UAB

In 2002 the State Children's Health Insurance Program (SCHIP) "unborn child ruling" was established to provide prenatal care (PNC) to low income women otherwise without health insurance. The majority of foreign-born (FB) Latinas otherwise ineligible for PNC should have benefited most from the ruling. In late 2003 six states incorporated the UCR into their state plan amendments, providing a natural experiment for policy analysis. This study used cross-sectional pooled natality data from 2000-2007 to estimate the effect of the UCR on prenatal care utilization (PNCU) and birth outcomes. A differences-in-differences econometrics model was employed using policy enacting and non-enacting states, …

Soy And Breast Cancer, Mandeep K. Virk-Baker

All ETDs from UAB

The incidence of breast cancer is lower in Asia as compared to Western countries. However, the breast cancer risk among Asian immigrants living in Western countries reaches nearly as high as the Western country, suggesting environmental factors (e.g. diet and lifestyle) may be important for this geographical disparity. One dietary change of Asian immigrants is a reduction in soy consumption. Soy is rich in isoflavones, which compete with estrogen for receptor (ER) binding, and may protect against breast cancer. S-(-)equol, a metabolite of the soy isoflavone daidzein (DZ) has a higher bioavailability and greater affinity for ER than DZ. The …