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Full-Text Articles in Entire DC Network
Reconstructing Comprehensive Sex Education Curriculum From Fifth To Tenth Grade In California : A Focus On Body Image, Kenzie Brand
Reconstructing Comprehensive Sex Education Curriculum From Fifth To Tenth Grade In California : A Focus On Body Image, Kenzie Brand
Capstone Projects and Master's Theses
This capstone examines the rationale why comprehensive sex education curriculum from ï¬fth to tenth grade in California needs to be reconstructed. This study discusses and compares the teen pregnancy rate and the sexually transmitted infection rate in teenagers. In addition, this capstone further examines how positive image can be encouraged at a young age through sex education through the perspectives of six health education teachers in California. This capstone is most valuable to educators, curricula writers, parents with children from ï¬fth to tenth grade, and school districts.
Seeds Of Hope : Improving The Nutritional Environment Of Seaside Middle School, Emily Abrahams
Seeds Of Hope : Improving The Nutritional Environment Of Seaside Middle School, Emily Abrahams
Capstone Projects and Master's Theses
Schools play a crucial role in the development of children. One way schools can be utilized is by positively influencing the eating habits of students. Poor diet has caused many detrimental effects within our society. In order to address the issue of poor nutritional environments in schools, Harvest of the Month (HOTM), a nutritional program provided through Community Alliance with Family Farmers (CAFF), was implemented in a 6th grade class as a pilot program. The program then expanded to 3 more 6th grade classes. Along with implementing the HOTM program, steps to begin a fruit tree orchard were also taken. …
Preparing Relative And Near Kin Caregivers : Evaluation Of Roots, Betsaida Macias Gonzalez
Preparing Relative And Near Kin Caregivers : Evaluation Of Roots, Betsaida Macias Gonzalez
Capstone Projects and Master's Theses
Family and Children’s Services at the Monterey County Department of Social and Employment Services, MCDSES, strive for children’s stability and safety. In Monterey County, there are too many unsuccessful relative and near kin placements. Relatives and near kin caregivers are mandated to complete ROOTS training, Relative Offering Ongoing Ties and Support. ROOTS' curriculum intends to increase caregiver's knowledge to prepare and guide them in becoming a stable home for a child in need. The evaluation of ROOTS, a knowledge based pre/posttest, demonstrated the caregivers' appreciation of support and it gave a broad understanding of the knowledge gained by the caregivers.
Building Strong Women : Addressing The Needs Of At-Risk Pre-Teen Girls, Sarah Walton
Building Strong Women : Addressing The Needs Of At-Risk Pre-Teen Girls, Sarah Walton
Capstone Projects and Master's Theses
Too many young, pre-teen girls are at risk of consequences including teenage pregnancy, juvenile delinquency, substance abuse, low education levels and more. Many girls find themselves in these situations due to at-risk factors such as the absence of parents, low family income, having disabilities, being retained in school, etc. During my senior year internship at Community Solutions, a non-profit organization in Gilroy, California, I addressed self-esteem issues and lack of life skills and social skills that 10-12 year old girls face on a daily basis. My goal was to reach out and empower them, hoping to build self-esteem and teach …
Food, Nutrition, And Packaging Science, Clemson University
Food, Nutrition, And Packaging Science, Clemson University
Billing Rates
No abstract provided.
Supplemental Schedules For The Year Ended June 30, 2012, Clemson University Controller's Office
Supplemental Schedules For The Year Ended June 30, 2012, Clemson University Controller's Office
Supplemental Schedules
No abstract provided.
Phosphate-Solubilizing Microbes And Their Occurrence In The Rhizospheres Of Piper Betel In Karnataka, India, Padmavathi Tallapragada, Usha Seshachala
Phosphate-Solubilizing Microbes And Their Occurrence In The Rhizospheres Of Piper Betel In Karnataka, India, Padmavathi Tallapragada, Usha Seshachala
Turkish Journal of Biology
Low phosphate solubility is one of the most important factors limiting the plant growth in Indian soils. Many microorganisms can enhance phosphate solubility, but little is known about the magnitude of their phosphorus-solubilizing ability. The native populations of phosphate-solubilizing bacteria and fungi were studied in different rhizospheric soil samples obtained from betel vine plants (Piper betel L.) in order to compare the results. The present study focuses on the phosphate-solubilizing capacity of bacteria and fungi in rhizospheric soil samples obtained from betel vine plants, revealing the dominance of Aspergillus species (26.1 mm) as major phosphate solubilizers, along with Bacillus subtilis …
The Effects Of Seasonal Variation On The Fatty Acid Composition Of Total Lipid, Phospholipid, And Triacylglycerol In The Dorsal Muscle Of Capoeta Trutta Found In The Tigris River (Turkey), Eli̇f İpek Satar, Ersi̇n Uysal, Erhan Ünlü, Mehmet Başhan, Ali̇ Satar
The Effects Of Seasonal Variation On The Fatty Acid Composition Of Total Lipid, Phospholipid, And Triacylglycerol In The Dorsal Muscle Of Capoeta Trutta Found In The Tigris River (Turkey), Eli̇f İpek Satar, Ersi̇n Uysal, Erhan Ünlü, Mehmet Başhan, Ali̇ Satar
Turkish Journal of Biology
The effects of seasonal variation on the fatty acid composition of total lipid, triacylglycerol, and phospholipid in the dorsal muscle of Capoeta trutta were assessed by gas chromatographic method. A total of 18 different fatty acids were determined in the composition of C. trutta. The variations in fatty acid composition of total lipid, triacylglycerol, and phospholipid were recorded throughout the seasons. The total polyunsaturated fatty acids (PUFA) and monounsaturated fatty acids (MUFA) were the most important groups of total lipid. Total saturated fatty acid (SFA) and total MUFA were seen to increase from spring to summer while total PUFA decreased …
Abundance And Dynamics Of Filamentous Fungi In The Complex Ambrosia Gardens Of The Primitively Eusocial Beetle Xyleborinus Saxesenii Ratzeburg (Coleoptera: Curculionidae, Scolytinae), Peter H.W. Biedermann, Kier D. Klepzig, Michael Taborsky, Diana L. Six
Abundance And Dynamics Of Filamentous Fungi In The Complex Ambrosia Gardens Of The Primitively Eusocial Beetle Xyleborinus Saxesenii Ratzeburg (Coleoptera: Curculionidae, Scolytinae), Peter H.W. Biedermann, Kier D. Klepzig, Michael Taborsky, Diana L. Six
United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications
Insect fungus gardens consist of a community of interacting microorganisms that can have either beneficial or detrimental effects to the farmers. In contrast to fungus-farming ants and termites, the fungal communities of ambrosia beetles and the effects of particular fungal species on the farmers are largely unknown. Here, we used a laboratory rearing technique for studying the filamentous fungal garden community of the ambrosia beetle, Xyleborinus saxesenii, which cultivates fungi in tunnels excavated within dead trees. Raffaelea sulfurea and Fusicolla acetilerea were transmitted in spore-carrying organs by gallery founding females and established first in new gardens. Raffaelea sulfurea had …
Families With Hungry Children And The Transition From Preschool To Kindergarten, Colleen Heflin, Irma Arteaga, Sara Gable
Families With Hungry Children And The Transition From Preschool To Kindergarten, Colleen Heflin, Irma Arteaga, Sara Gable
University of Kentucky Center for Poverty Research Discussion Paper Series
This paper exploits a source of variation in the eligibility for federal nutrition programs to identify the program effects on food insecurity. Children are eligible for the WIC program until the day before they turn 61 months old. The result is an age discontinuity in program participation at the 61-month cutoff. Using the Early Childhood Longitudinal Study Birth-cohort dataset, we find strong evidence of a sizeable increase in household food insecurity at the 61- month cutoff. Our findings are robust to different model specifications, datasets, and various bandwidth choices using various non-parametric estimations.
A Study Of Emergency Room Utilization Related To Poorly Controlled Asthma In Pediatrics, Leistey T. Wortman
A Study Of Emergency Room Utilization Related To Poorly Controlled Asthma In Pediatrics, Leistey T. Wortman
Nursing Theses and Capstone Projects
Asthma is a disease of the respiratory system, which causes swelling and narrowing of the airways. Asthma is commonly seen in children. It is the leading cause of hospital stays and school absences. Hospitalization accounts for the single largest portion of the direct health care costs for asthma, estimated at nearly $18 billion a year (Everage, et al, 2010). Children with asthma may be able to breathe normally most of the time but when they encounter a substance that can cause problems (a "trigger"); an asthma attack (exacerbation) can occur (PubMed Health, 2011). The purpose of this study is to …
Neurological Outcomes In Induced Hypothermic States (Post Cardiac Arrest Resuscitation), Shonna Lee Bible
Neurological Outcomes In Induced Hypothermic States (Post Cardiac Arrest Resuscitation), Shonna Lee Bible
Nursing Theses and Capstone Projects
International studies indicate that induced hypothermia in successful Post Cardiac Arrest Resuscitation improves cerebral perfusion resulting in improved neurological function. Patients undergoing a neurological exam prior to induction of hypothermia may indicate potential mortality prognosis in this population. Literature Review indicated the use of the Glasgow-Pittsburg Cerebral Performance Categories for evaluation of neurological status in this population, but most institutions seem to utilize Glasgow Coma Scoring (GCS) in all patient populations for neurological examination. The purpose of this study was to determine if a neurological evaluation prior to and during the Induced Hypothermia state would affect the mortality outcomes in …
Introducing Telehealth To Nursing Students In A Pre-Licensure Program, Dwayne F. More
Introducing Telehealth To Nursing Students In A Pre-Licensure Program, Dwayne F. More
Nursing Theses and Capstone Projects
Telehealth has emerged as an enhancement to health care, giving clients greater access to care providers than ever before. It has benefited persons living in remote areas who cannot readily access health services and it has helped clients who have chronic disease conditions that require frequent monitoring, saving themselves and hospitals thousands of dollars. Nurses are an important part of delivering telehealth, yet it is not currently being taught in many nursing courses. The purpose of this project is to introduce telehealth into a pre-licensure nursing program via a learning module and to assess the students' understanding of the material …
The Use Of Peppermint Oil To Reduce The Nausea Of The Palliative Care And Hospice Patient, Mary Seale
The Use Of Peppermint Oil To Reduce The Nausea Of The Palliative Care And Hospice Patient, Mary Seale
Nursing Theses and Capstone Projects
A descriptive study was initiated to investigate the use of peppermint oil to reduce the nausea of the palliative care and hospice patient. Two local palliative care and hospice programs were used as sites for the study. Patients eighteen and older complaining of nausea were invited to participate in the study. The study was conducted for one and a half months. A total of eight patients consented to participate in the study with a mean age of seventy one years. The Bieri Scale, a visual-numeric analog, was used as the measurement instrument for the patients to evaluate their nausea. Results …
Barriers To Diabetes Self-Management In African American Women, Christine Little-Gregory
Barriers To Diabetes Self-Management In African American Women, Christine Little-Gregory
Nursing Theses and Capstone Projects
Diabetes is a global epidemic and is a leading cause of disease-related death. In the United States, diabetes is the most common chronic disease affecting 23.6 million Americans or 7.8% of the population (Centers for Disease Control, 2010a). African American women have the highest prevalence of diabetes. Health promotion in the form of diabetes self-management is the key to reducing this urgent disparity. This descriptive study sought to identify barriers to diabetes self-management and identify relationships associated with self-management in this population. This study was conducted using a convenience sampling of African American women with diabetes who were surveyed to …
Self-Care Agency And Self-Care Practice Of Adult African Americans With Type 2 Diabetes, Martha Eddings
Self-Care Agency And Self-Care Practice Of Adult African Americans With Type 2 Diabetes, Martha Eddings
Nursing Theses and Capstone Projects
The purpose of the study was to identify and examine the concepts of self-care agency and self-care practice of African American adults diagnosed with type 2 diabetes, living in the local community. The research questions addressed were: 1) What is the self-care agency of adult African Americans diagnosed with type 2 diabetes? 2) What is the self-care practice of adult African Americans diagnosed with type 2 diabetes? 3) Is there a relationship between self-care agency and self-care practice in adult African Americans diagnosed with type 2 diabetes? The Denyes Self-Care Agency Instrument (DSCAI-90) and the Denyes Self-Care Practice Instrument (DSCPI-90) …
Guide To The Mary Jo Moriarty Collection, 1915-1998, Caitlin Gette-King, Orson Kingsley
Guide To The Mary Jo Moriarty Collection, 1915-1998, Caitlin Gette-King, Orson Kingsley
Archives & Special Collections Finding Aids
Brief Biographical Sketch
Mary Jo Moriarty was born in Boston and received her bachelor’s degree in history from Villa Maria College and her master’s and doctoral degrees from the Boston University School of Education. Moriarty worked as a health and physical education teacher at Hyannis State Teachers College from 1937 until the school’s closing in 1944. She moved with the college’s health and physical education program to Bridgewater State Teachers College when the two merged. She taught as a professor in the Physical Education Department, and later served as chairwoman of the Physical Education Major and the Department of Health …
Sullivan County, New Hampshire Annual Report Of The Board Of Commisioners, And Other Elected Officials And Department Heads Fiscal Year 2012., Sullivan County Representatives
Sullivan County, New Hampshire Annual Report Of The Board Of Commisioners, And Other Elected Officials And Department Heads Fiscal Year 2012., Sullivan County Representatives
Sullivan County, NH Annual Reports
This is an annual report containing vital statistics for a county in the state of New Hampshire.
2013 Ole Miss Women's Golf Media Guide, Ole Miss Athletics. Women's Golf
2013 Ole Miss Women's Golf Media Guide, Ole Miss Athletics. Women's Golf
Women's Golf
No abstract provided.
Markers Of Sleep-Disordered Breathing And Prediabetes In Us Adults, Omayma Alshaarawy, Srinivas Teppala, Anoop Shankar
Markers Of Sleep-Disordered Breathing And Prediabetes In Us Adults, Omayma Alshaarawy, Srinivas Teppala, Anoop Shankar
Faculty & Staff Scholarship
Background. Prediabetes is a preclinical stage in the hyperglycemia continuum where subjects are at increased risk of developing diabetes. Several studies reported a positive association between markers of sleep-disordered breathing (SDB) and diabetes. However, few studies investigated the relationship between SDB markers and prediabetes. Methods. We examined 5,685 participants ≥20 years from the National Health and Nutrition Examination Survey (NHANES) 2005–2008. The exposure of interest was SDB markers including sleep duration, snoring, snorting, and daytime sleepiness. The outcome was prediabetes (), among subjects free of diabetes. Results. SDB markers were associated with prediabetes. Compared to those without any sleep disturbance, …
Hyperglycemia Increases Muscle Blood Flow And Alters Endothelial Function In Adolescents With Type 1 Diabetes, Amanda S. Dye, Hong Huang, John A. Bauer, Robert P. Hoffman
Hyperglycemia Increases Muscle Blood Flow And Alters Endothelial Function In Adolescents With Type 1 Diabetes, Amanda S. Dye, Hong Huang, John A. Bauer, Robert P. Hoffman
Faculty & Staff Scholarship
Alterations of blood flow and endothelial function precede development of complications in type 1 diabetes. The effects of hyperglycemia on vascular function in early type 1 diabetes are poorly understood. To investigate the effect of hyperglycemia on forearm vascular resistance (FVR) and endothelial function in adolescents with type 1 diabetes, FVR was measured before and after 5 minutes of upper arm arterial occlusion using venous occlusion plethysmography in (1) fasted state, (2) euglycemic state (~90 mg/dL; using 40 mU/m2/min insulin infusion), and (3) hyperglycemic state (~200 mg/dL) in 11 adolescents with type 1 diabetes. Endothelial function was assessed by the …
Assessment Of The Dining Environment On And Near The Campuses Of Fifteen Post-Secondary Institutions, Tanya M. Horacek, Maria B. Edman, Carol Byrd-Bredbenner, Gale Carey, Sarah M. Colby, Geoffrey W. Greene, Wen Guo, Kendra K. Kattelmann, Melissa D. Olfert, Jennifer Walsh, Adrienne B. White
Assessment Of The Dining Environment On And Near The Campuses Of Fifteen Post-Secondary Institutions, Tanya M. Horacek, Maria B. Edman, Carol Byrd-Bredbenner, Gale Carey, Sarah M. Colby, Geoffrey W. Greene, Wen Guo, Kendra K. Kattelmann, Melissa D. Olfert, Jennifer Walsh, Adrienne B. White
Faculty & Staff Scholarship
Objective: The present study evaluated the restaurant and dining venues on and near post-secondary campuses varying in institution size. Design: The Nutrition Environment Measures Survey for Restaurants (NEMS-R) was modified to evaluate restaurants as fast food, sit down and fast casual; and campus dining venues as dining halls, student unions and snack bar/cafe ́s. ANOVA with post hoc Tukey’s B and T tests were used to distinguish differences between dining venues and associated institutions by size.
Setting: The study was conducted at fifteen US post-secondary institutions, 2009–2011. Subjects: Data presented are from a sample of 175 restaurants and sixty-eight on-campus …
Markers Of Sleep Disordered Breathing And Diabetes Mellitus In A Multiethnic Sample Of Us Adults: Results From The National Health And Nutrition Examination Survey (2005–2008), Charumathi Sabanayagam, Srinivas Teppala, Anoop Shankar
Markers Of Sleep Disordered Breathing And Diabetes Mellitus In A Multiethnic Sample Of Us Adults: Results From The National Health And Nutrition Examination Survey (2005–2008), Charumathi Sabanayagam, Srinivas Teppala, Anoop Shankar
Faculty & Staff Scholarship
We examined gender and ethnic differences in the association between sleep disordered breathing (SDB) and diabetes among 6,522 participants aged ≥20 years from the National Health and Nutrition Examination Survey 2005–08. SDB severity was defined based on an additive summary score including sleep duration, snoring, snorting, and daytime sleepiness. We found that the summary SDB score was significantly associated with diabetes after adjusting for potential confounders in the whole population. Compared to those without any sleep disturbance, the multivariable odds ratio (OR) (95% confidence interval (CI)) of diabetes among those with ≥3 sleep disturbances was 2.04 (1.46–2.87). In sex-specific analyses, …
Heritable Patterns Of Tooth Decay In The Permanent Dentition: Principal Components And Factor Analyses, John R. Shaffer, Eleanor Feingold, Xiaojing Wang, Karen Tcuenco, Daniel E. Weeks, Rebecca S. Desensi, Deborah E. Polk, Steve Wendell, Robert J. Weyant, Richard Crout, Daniel W. Mcneil, Mary L. Marazita
Heritable Patterns Of Tooth Decay In The Permanent Dentition: Principal Components And Factor Analyses, John R. Shaffer, Eleanor Feingold, Xiaojing Wang, Karen Tcuenco, Daniel E. Weeks, Rebecca S. Desensi, Deborah E. Polk, Steve Wendell, Robert J. Weyant, Richard Crout, Daniel W. Mcneil, Mary L. Marazita
Faculty & Staff Scholarship
Background
Dental caries is the result of a complex interplay among environmental, behavioral, and genetic factors, with distinct patterns of decay likely due to specific etiologies. Therefore, global measures of decay, such as the DMFS index, may not be optimal for identifying risk factors that manifest as specific decay patterns, especially if the risk factors such as genetic susceptibility loci have small individual effects. We used two methods to extract patterns of decay from surface-level caries data in order to generate novel phenotypes with which to explore the genetic regulation of caries.
Methods
The 128 tooth surfaces of the permanent …
The Effects Of A Gentle Yoga Program On Sleep, Mood, And Blood Pressure In Older Women With Restless Legs Syndrome (Rls): A Preliminary Randomized Controlled Trial, Kim E. Innes, Terry K. Selfe
The Effects Of A Gentle Yoga Program On Sleep, Mood, And Blood Pressure In Older Women With Restless Legs Syndrome (Rls): A Preliminary Randomized Controlled Trial, Kim E. Innes, Terry K. Selfe
Faculty & Staff Scholarship
Objective. To examine the effects of yoga versus an educational film program on sleep, mood, perceived stress, and sympathetic activation in older women with RLS. Methods. Participants were drawn from a larger trial regarding the effects of yoga on cardiovascular disease risk profiles in overweight, sedentary postmenopausal women. Seventy-five women were randomized to receive either an 8-week yoga () or educational film () program. All 75 participants completed an RLS screening questionnaire. The 20 women who met all four diagnostic criteria for RLS ( yoga, 10 film group) comprised the population for this nested study. Main outcomes assessed pre- and …
A Tailored Wellness Intervention For College Students Using Internet-Based Technology: A Pilot Study, Alessandro Quartiroli, Sam Zizzi
A Tailored Wellness Intervention For College Students Using Internet-Based Technology: A Pilot Study, Alessandro Quartiroli, Sam Zizzi
Faculty & Staff Scholarship
The purpose of this study was to develop and pilot a theory-based, computer-tailored feedback system for healthy behaviors for college students at a large, public university, aiming to enhance student wellness. A total of 1300 college students were contacted. Sixty–two students completed the eight week intervention. The participants were randomly assigned into two groups and received the survey three times, consistently receiving normative or personalized feedback. The participating sample was generally healthy and mainly comprised of freshman, Caucasian, and normal weight individuals. Repeated-measure ANOVAs were run and small significant interactions were found between the type of feedback received and some …
Bisphenol A And Metabolic Syndrome: Results From Nhanes, Srinivas Teppala, Suresh Madhavan, Anoop Shankar
Bisphenol A And Metabolic Syndrome: Results From Nhanes, Srinivas Teppala, Suresh Madhavan, Anoop Shankar
Faculty & Staff Scholarship
Background. Bisphenol A (BPA) is detected in the urine of 95% of US adults. Recent evidence from population-based studies suggests that BPA is associated with individual components for metabolic syndrome (MetS). However, no previous study has examined the direct association between BPA and MetS. Methods. We examined 2,104 participants from the National Health and Nutrition Examination Survey 2003–2008. The main outcome was the presence of MetS (). Results. Increasing levels of urinary BPA were positively associated with MetS, independent of confounders such as age, gender, race/ethnicity, smoking, alcohol intake, physical activity, and urinary creatinine. Compared to tertile 1 (referent), the …
Modeling Chemical Interaction Profiles: I. Spectral Data-Activity Relationship And Structure-Activity Relationship Models For Inhibitors And Non-Inhibitors Of Cytochrome P450 Cyp3a4 And Cyp2d6 Isozymes, Brooks Mcphail, Yunfeng Tie, Huixiao Hong, Bruce A. Pearce, Laura K. Schnackenberg, Weigong Ge, Luis G. Valerio, James C. Fuscoe, Weida Tong, Dan A. Buzatu, Jon G. Wilkes, Bruce A. Fowler, Eugene Demchuk, Richard D. Berger
Modeling Chemical Interaction Profiles: I. Spectral Data-Activity Relationship And Structure-Activity Relationship Models For Inhibitors And Non-Inhibitors Of Cytochrome P450 Cyp3a4 And Cyp2d6 Isozymes, Brooks Mcphail, Yunfeng Tie, Huixiao Hong, Bruce A. Pearce, Laura K. Schnackenberg, Weigong Ge, Luis G. Valerio, James C. Fuscoe, Weida Tong, Dan A. Buzatu, Jon G. Wilkes, Bruce A. Fowler, Eugene Demchuk, Richard D. Berger
Faculty & Staff Scholarship
An interagency collaboration was established to model chemical interactions that may cause adverse health effects when an exposure to a mixture of chemicals occurs. Many of these chemicals—drugs, pesticides, and environmental pollutants—interact at the level of metabolic biotransformations mediated by cytochrome P450 (CYP) enzymes. In the present work, spectral data-activity relationship (SDAR) and structure-activity relationship (SAR) approaches were used to develop machine-learning classifiers of inhibitors and non-inhibitors of the CYP3A4 and CYP2D6 isozymes. The models were built upon 602 reference pharmaceutical compounds whose interactions have been deduced from clinical data, and 100 additional chemicals that were used to evaluate model …
Modeling Chemical Interaction Profiles: Ii. Molecular Docking, Spectral Data-Activity Relationship, And Structure-Activity Relationship Models For Potent And Weak Inhibitors Of Cytochrome P450 Cyp3a4 Isozyme, Yunfeng Tie, Brooks Mcphail, Huixiao Hong, Bruce A. Pearce, Laura K. Schnackenberg, Weigong Ge, Dan A. Buzatu, Jon G. Wilkes, James C. Fuscoe, Weida Tong, Bruce A. Fowler, Richard D. Beger, Eugene Demchuk
Modeling Chemical Interaction Profiles: Ii. Molecular Docking, Spectral Data-Activity Relationship, And Structure-Activity Relationship Models For Potent And Weak Inhibitors Of Cytochrome P450 Cyp3a4 Isozyme, Yunfeng Tie, Brooks Mcphail, Huixiao Hong, Bruce A. Pearce, Laura K. Schnackenberg, Weigong Ge, Dan A. Buzatu, Jon G. Wilkes, James C. Fuscoe, Weida Tong, Bruce A. Fowler, Richard D. Beger, Eugene Demchuk
Faculty & Staff Scholarship
Polypharmacy increasingly has become a topic of public health concern, particularly as the U.S. population ages. Drug labels often contain insufficient information to enable the clinician to safely use multiple drugs. Because many of the drugs are bio-transformed by cytochrome P450 (CYP) enzymes, inhibition of CYP activity has long been associated with potentially adverse health effects. In an attempt to reduce the uncertainty pertaining to CYP-mediated drug-drug/chemical interactions, an interagency collaborative group developed a consensus approach to prioritizing information concerning CYP inhibition. The consensus involved computational molecular docking, spectral data-activity relationship (SDAR), and structure-activity relationship (SAR) models that addressed the …
Insight Into The Transmission Biology And Species-Specific Functional Capabilities Of Tsetse (Diptera: Glossinidae) Obligate Symbiont Wigglesworthia, Rita V M Rio, Rebecca E. Symula, Jinhwen Wang, Claudia Lohs, Yi-Neng Wu, Anna K. Snyder, Robert D. Bjornson, Kenshiro Oshima, Bryan S. Biehl, Nicole T. Perna, Masahira Hattori, Serap Aksoy
Insight Into The Transmission Biology And Species-Specific Functional Capabilities Of Tsetse (Diptera: Glossinidae) Obligate Symbiont Wigglesworthia, Rita V M Rio, Rebecca E. Symula, Jinhwen Wang, Claudia Lohs, Yi-Neng Wu, Anna K. Snyder, Robert D. Bjornson, Kenshiro Oshima, Bryan S. Biehl, Nicole T. Perna, Masahira Hattori, Serap Aksoy
Faculty & Staff Scholarship
Ancient endosymbionts have been associated with extreme genome structural stability with little differentiation in gene inventory between sister species. Tsetse flies (Diptera: Glossinidae) harbor an obligate endosymbiont, Wigglesworthia, which has coevolved with the Glossina radiation. We report on the ~720-kb Wigglesworthia genome and its associated plasmid from Glossina morsitans morsitans and compare them to those of the symbiont from Glossina brevipalpis. While there was overall high synteny between the two genomes, a large inversion was noted. Furthermore, symbiont transcriptional analyses demonstrated host tissue and development-specific gene expression supporting robust transcriptional regulation in Wigglesworthia, an unprecedented observation in other obligate mutualist …