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2012

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Connectivity And Collaboration: The Use Of Blogs In First-Year Composition, Melissa Peterson Jan 2012

Connectivity And Collaboration: The Use Of Blogs In First-Year Composition, Melissa Peterson

All ETDs from UAB

In this thesis, I discuss the nature of digital communication at a very broad level, examine the evolution and definition of "blogs," and consider ways that blogs can be used in educational settings to improve the understanding and application of rhetorical principles. Although digital media have resulted in a dramatic shift in the way messages are created, transmitted, and consumed, digital technologies need not be viewed with skepticism and alarm. While these technologies present new challenges and opportunities for communication, the changes are more of a gradual evolution than a sudden overhaul. Within digital media, blogs are an incredibly difficult …

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Development Of Electrospun Bone-Mimetic Matrices For Bone Regenerative Applications, Matthew Christopher Phipps Jan 2012

Development Of Electrospun Bone-Mimetic Matrices For Bone Regenerative Applications, Matthew Christopher Phipps

All ETDs from UAB

Although bone has a dramatic capacity for regeneration, certain injuries and procedures present defects that are unable to heal properly, requiring surgical intervention to induce and support osteoregeneration. Our research group has hypothesized that the development of a biodegradable material that mimics the natural composition and architecture of bone extracellular matrix has the potential to provide therapeutic benefit to these patients. Utilizing a process known as electrospinning, our lab has developed a bone-mimetic matrix (BMM) consisting of composite nanofibers of the mechanically sta-ble polymer polycaprolactone (PCL), and the natural bone matrix molecules type-I colla-gen and hydroxyapatite nanocrystals (HA). We herein …

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Environmental And Organizational Characteristics Associated With A Critical Access Hospital Being Contract Managed Or Becoming Acquired, Virginia Anne Razo Jan 2012

Environmental And Organizational Characteristics Associated With A Critical Access Hospital Being Contract Managed Or Becoming Acquired, Virginia Anne Razo

All ETDs from UAB

The focus of this research is the relationship between environmental and organizational characteristics and critical access hospitals (CAHs) being contract managed or acquired. The resource dependence theory guided the methodology. Based on this theory, organizations prefer to remain autonomous until key resources become scarce. The scarcity of resources combined with a dynamic external environment causes environmental uncertainty that requires organizations to consider a variety of strategic responses in order to survive. Given the results of this study, contract managed CAHs were associated with markets that were less munificent and more dynamic with older facilities, relative to independent hospitals. Due to …

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Model System Using Controlled Receptor Expression For Molecular Ultrasound Imaging Applications, Reshu Saini Jan 2012

Model System Using Controlled Receptor Expression For Molecular Ultrasound Imaging Applications, Reshu Saini

All ETDs from UAB

Ultrasound is a noninvasive, inexpensive imaging modality used to characterize biological tissues. Targeted contrast-enhanced ultrasound imaging is an emerging preclinical strategy which uses contrast agents for characterization of biological processes on a molecular level. These microbubble agents are lipid shelled micron-sized particles that have the capability to be coated with ligands such as antibodies or small peptides in order to bind to their target receptors. Molecular ultrasound imaging, using these targeted contrast agents, allows for a quantitative assessment of molecular targets with a high sensitivity. Although this technique is in preclinical research, further advances in contrast agent design and potential …

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Regulation Of Alpha-Synuclein Accumulation By The Autophagy-Lysosome Pathway In A Preclinical Model Of Parkinson Disease, Leandra Rosa Mangieri Jan 2012

Regulation Of Alpha-Synuclein Accumulation By The Autophagy-Lysosome Pathway In A Preclinical Model Of Parkinson Disease, Leandra Rosa Mangieri

All ETDs from UAB

Finding novel therapeutics that delay or halt the progression of Parkinson Disease (PD) is key to providing symptomatic relief of debilitating symptoms. A defining pathological feature of PD is characterized by the formation of Lewy bodies, intraneuronal inclusions comprised mainly of α-synuclein (ASYN) (4). Vacuolar ATPase (V-ATPase), an enzyme complex comprised of two multi-subunit-containing domains, critically regulates the acidification of vesicles such as lysosomes and thus proper function of the autophagy-lysosome pathway (ALP), which is critical for the degradation of ASYN. Compromises to V-ATPase have been shown to negatively affect lysosome function and its ability to clear toxic forms of …

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Real-Time Quantitative Pcr For Evaluation Of Mutans Streptococci And Dental Caries, Chanika Manmontri Jan 2012

Real-Time Quantitative Pcr For Evaluation Of Mutans Streptococci And Dental Caries, Chanika Manmontri

All ETDs from UAB

Mutans streptococci (MS), e.g., Streptococcus mutans (Sm) and Streptococcus sobrinus (Ss), are associated with dental caries. Quantification of MS has been shown to predict caries risk. A new technology using PCR may streamline quantification compared to traditional culture methods. Purpose: To use real-time quantitative PCR (qPCR) and standard plate counting (SPC) for detection and quantification of levels of Sm, Ss and total streptococci (TS) in clinical samples from high-caries-risk children with no regular access to dental care and to study correlation of these bacterial levels and ratios to caries prevalence. Methods: Saliva and plaque samples were collected from school-aged children …

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Localization Of Proteins Involved In Trafficking In Frog And Mouse Retina, Amie Marsh Jan 2012

Localization Of Proteins Involved In Trafficking In Frog And Mouse Retina, Amie Marsh

All ETDs from UAB

The connecting cilium serves as the major route for protein transport from the inner to outer segment of photoreceptor cells. The hypothesis that all Congenital Stationary Night Blindness (CSNB) rhodopsin mutants travel properly to the rod outer segment in Xenopus laevis will be tested by preparing transgenic X. laevis expressing a rhodopsin mutation found in human CSNB, A295V. In addition, probing for the existence of potential proteins involved in regulating rhodopsin trafficking and monitoring their localization will contribute to a better understanding of the underlying pathway of intracellular photoreceptor trafficking.

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Genome-Wide Dna Methylation Changes During Breast Tumorigenesis, Natalie E. Mitchell Jan 2012

Genome-Wide Dna Methylation Changes During Breast Tumorigenesis, Natalie E. Mitchell

All ETDs from UAB

Neoplastic reprogramming generates cancerous cells from normal derivatives, enabling researchers to create a model of the early stages of oncogenesis and analyze molecular changes in real-time. Aberrations in DNA methylation are considered a major mechanism contributing to the acquisition and maintenance of a cancerous phenotype; however, little research exists regarding gene-specific changes in DNA methylation during the transition from a normal to neoplastic cell. Human mammary epithelial cells (HMECs) underwent neoplastic transformation through the addition of three defined genetic elements to generate one line of semi-transformed, pre-malignant cells (SHMECs) and two separate lines of fully transformed, malignant cells (THMECs). We …

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A Phenomenological Study Of Obesity And Its Impact On Functional Status, Life-Space Mobility, And Physical Activity In Southern African American Older Women, Pamela G. Bowen Jan 2012

A Phenomenological Study Of Obesity And Its Impact On Functional Status, Life-Space Mobility, And Physical Activity In Southern African American Older Women, Pamela G. Bowen

All ETDs from UAB

The majority of work on health disparities has focused on public policy and identifying disparate conditions. Obesity is a significant public health problem that has reached epidemic proportions, considered the second leading cause of preventable death, encourages a sedentary lifestyle, and can lead to a higher prevalence of functional impairments. Moreover, obesity increases the risk that persons may develop one or more serious medical conditions, such as cardiovascular disease, hypertension, stroke, Type 2 diabetes, and osteoarthritis, especially among African Americans. In the United States, African American women are more likely to be classified as overweight or obese. In fact, approximately …

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The Role Of Cd11c+ Cells In Response To Ozone, Jeffrey David Brand Jan 2012

The Role Of Cd11c+ Cells In Response To Ozone, Jeffrey David Brand

All ETDs from UAB

Environmental ozone exposure remains a major public health concern with over one-third of the United States population experiencing unhealthful levels. Epidemiological studies indicate exposure increases morbidity in those with pre-existing disease such as asthma, though the biological mechanisms underlying this phenomenon remain elusive. CD11c+ cells within the respiratory tract include dendritic cells (DCs), which are the most efficient antigen presenters and play major roles controlling immune responses. In addition, DCs are thought necessary for asthma pathogenesis and exacerbation. Therefore the link between ozone associated asthma morbidity may be DCs. We hypothesize ozone exposure may site specifically alter DC phenotypes, numbers, …

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Development And Validation Of The Alumni Loyalty Scale, Jennifer Rogers Breland Jan 2012

Development And Validation Of The Alumni Loyalty Scale, Jennifer Rogers Breland

All ETDs from UAB

Developing and maintaining alumni support of higher education institutions is continuously an area of interest for institutional administrators. The role that alumni play in the overall picture has somewhat changed throughout the decades, but what encourages this support has remained the same. A graduate of a higher education institution must have a sense of loyalty, along with other contributing factors, that will create the necessary motivation in order for an alumnus to support his or her alma mater. The purpose of this study is to identify the psychometric properties of an instrument intended to assist institutions with determining the level …

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Effects Of Mobile Internet Use On College Student Pedestrian Injury Risk, Katherine Walker Byington Jan 2012

Effects Of Mobile Internet Use On College Student Pedestrian Injury Risk, Katherine Walker Byington

All ETDs from UAB

Unintentional pedestrian injury is a leading cause of death in the United States. Given the complexity of accurately judging the safety of a street crossing, the task likely becomes even more challenging when pedestrians become distracted by attempting to multitask. Newly introduced cell phone functionalities such as mobile internet may introduce distraction that goes beyond the basic cognitive demand of a phone conversation or even text messaging, both of which distract pedestrians and increase unsafe behavior. The present study examined participants' pedestrian behavior while distracted by mobile internet applications. In addition, we aimed to explore college students' perceptions of the …

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Analysis Of Abundance And Biodiversity Of Mosquitoes And Their Epidemiological Implications In Three Urban Neighborhoods In The Southeastern United States, Erick Xavier Caamano Jan 2012

Analysis Of Abundance And Biodiversity Of Mosquitoes And Their Epidemiological Implications In Three Urban Neighborhoods In The Southeastern United States, Erick Xavier Caamano

All ETDs from UAB

Birmingham, Alabama has experienced several mosquito-borne epidemics, including Saint Louis encephalitis (SLE) and West Nile virus (WNV). Despite the outbreak of these diseases, the city lacks a mosquito surveillance program that would assist in vector control efforts. In order to assess the possible advantages of implementing a surveillance system for the city, three neighborhoods were chosen for surveys based on the fact that past epidemics have been concentrated in these areas. During the two surveillance years, 2009 had more abundance of mosquitoes and more species variability than the 2010 season. Overall, as abundance of mosquitoes increased in a particular site, …

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Effect Of Different Percentages Of Silica Nanofibers Filler Loads On Mechanical And Physical Properties Of Flowable And Hybrid Composite Resins, Qinyue Cai Jan 2012

Effect Of Different Percentages Of Silica Nanofibers Filler Loads On Mechanical And Physical Properties Of Flowable And Hybrid Composite Resins, Qinyue Cai

All ETDs from UAB

Dental composites are used for a variety of applications in dentistry today. Dental composites are composed of a resin matrix containing a blend of Bis-GMA (bis-phenol A-glycidyldimethacrylate) or urethane dimethacrylate (UDMA) along with TEGDMA (tetraethylglycidylmethacrylate). Exhaustive researches has been conducted in recent years to improve physical and mechanical properties of resin-based dental composites, since the existing resin-filler systems may not be suitable for long term applications in large as well as high stress restorations. Nanofillers reinforced composite resins have shown promising results. Silica-based nanoparticles and clusters are blended with larger-sized fillers and are available commercially for restoring large posterior restorations. …

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When Concerted Conduct Leads To Misuse: An Examination Of The Federal Circuit's En Banc Holding In Princo, Jerrad T. Howard Jan 2012

When Concerted Conduct Leads To Misuse: An Examination Of The Federal Circuit's En Banc Holding In Princo, Jerrad T. Howard

Kentucky Law Journal

No abstract provided.

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Common Sense And The Commerce Clause: Why Elimination Of The Physical Presence Test For Taxation Defies Both, Lucas Humble Jan 2012

Common Sense And The Commerce Clause: Why Elimination Of The Physical Presence Test For Taxation Defies Both, Lucas Humble

Kentucky Law Journal

No abstract provided.

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Restoring Luster To The Palladium Of Freedom, Wm. T. Robinson Iii Jan 2012

Restoring Luster To The Palladium Of Freedom, Wm. T. Robinson Iii

Kentucky Law Journal

No abstract provided.

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No Exit: The Financial Crisis Facing State Courts, G. Alan Tarr Jan 2012

No Exit: The Financial Crisis Facing State Courts, G. Alan Tarr

Kentucky Law Journal

No abstract provided.

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The Invisible Branch: Funding Resilient Courts Through Public Relations, Institutional Identity, And A Place On The "Public Radar", Paul J. De Muniz Jan 2012

The Invisible Branch: Funding Resilient Courts Through Public Relations, Institutional Identity, And A Place On The "Public Radar", Paul J. De Muniz

Kentucky Law Journal

No abstract provided.

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State Courts And Public Justice: New Challenges, New Choices, John T. Broderick, Lawrence Friedman Jan 2012

State Courts And Public Justice: New Challenges, New Choices, John T. Broderick, Lawrence Friedman

Kentucky Law Journal

No abstract provided.

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Do We Have 18th Century Courts For The 21st Century?, Michael L. Buenger Jan 2012

Do We Have 18th Century Courts For The 21st Century?, Michael L. Buenger

Kentucky Law Journal

No abstract provided.

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Debt And Discipline: Neoliberal Political Economy And The Working Classes, Tayyab Mahmud Jan 2012

Debt And Discipline: Neoliberal Political Economy And The Working Classes, Tayyab Mahmud

Kentucky Law Journal

Over the last three decades, neoliberal restructuring of the economy created a symbiosis of debt and discipline. New legal regimes and strategic use of monetary policy displaced Keynesian welfare, facilitated financialization of the economy, broke the power of organized labor, and expanded debt to sustain aggregate demand. Public laws and policies created afield of possibility within which financial markets extended their reach and brought ever-increasing sections of the working classes and the marginalized within the ambit of the credit economy. Reordered public policies and new norms of personal responsibility demarcated the horizon within which the economically vulnerable pursued strategies of …

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At Risk Patients And Doctors: Why Increased Agency Enforcement And Private Causes Of Action Under The Supremacy Clause Are Needed To Protect Medicaid Providers And Beneficiaries, Steven Clark Jan 2012

At Risk Patients And Doctors: Why Increased Agency Enforcement And Private Causes Of Action Under The Supremacy Clause Are Needed To Protect Medicaid Providers And Beneficiaries, Steven Clark

Kentucky Law Journal

No abstract provided.

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Love's Labor's Lost: Marry For Love, Copyright Work Made-For-Hire, And Alienate At Your Leisure, Llewellyn Joseph Gibbons Jan 2012

Love's Labor's Lost: Marry For Love, Copyright Work Made-For-Hire, And Alienate At Your Leisure, Llewellyn Joseph Gibbons

Kentucky Law Journal

No abstract provided.

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Health Care Reform, Wellness Programs And The Erosion Of Informed Consent, Matt Lamkin Jan 2012

Health Care Reform, Wellness Programs And The Erosion Of Informed Consent, Matt Lamkin

Kentucky Law Journal

No abstract provided.

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"A Matter Of Grace": Alternatives To Billing Insurance For Sexual Assault Forensic Examinations, Jessica C. Harvey Jan 2012

"A Matter Of Grace": Alternatives To Billing Insurance For Sexual Assault Forensic Examinations, Jessica C. Harvey

Kentucky Law Journal

No abstract provided.

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Judge Bernard S. Meyer: First Merit Appointee To The New York Court Of Appeals, Vincent R. Johnson Jan 2012

Judge Bernard S. Meyer: First Merit Appointee To The New York Court Of Appeals, Vincent R. Johnson

Faculty Articles

This is the story of Judge Bernard S. Meyer’s exhilarating, exhausting, and highly productive first year on the New York Court of Appeals. Based on a reputation for integrity and a record of professional accomplishment, Judge Meyer was chosen to the New York Court of Appeals in 1979, and the following seven-and-a-half years he spent there were highly productive. While on the Court of Appeals, Judge Meyer was a progressive reformer, and it was clear he intended to use his office to make the world a better place and, whenever possible, remedy injustice. He looked for ways in which the …

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Transcriptional Regulation Of Gfap, Sujeong Yeo Jan 2012

Transcriptional Regulation Of Gfap, Sujeong Yeo

All ETDs from UAB

Glial fibrillary acidic protein (GFAP) is an astrocytic intermediate filament protein whose levels are increased in response to CNS injuries. Aim one of my thesis is to find the regulatory elements of the GFAP promoter responsible for its expression properties using a transgenic approach, since previous studies showed inconsistent results between in vitro and in vivo approaches. Two contiguous DNA segments previously implicated in transcriptional control of the GFAP gene, the B region (bp -1612 to -1489), and the C1.1 and C1.2 regions (bp -1488 to -1399), were analyzed. Block mutation of each of 4 contiguous sequences together spanning the …

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Serotonin Signaling In Angiogenesis, Ali Zamani Jan 2012

Serotonin Signaling In Angiogenesis, Ali Zamani

All ETDs from UAB

Serotonin (5-hydroxytryptamine, 5-HT) is a well-known "happy" neurotransmitter. Selective serotonin reuptake inhibitors (SSRIs) are the most prescribed class of antidepressant medications to raise the serotonin level in the brain. However, the majority of serotonin in the human body is present outside of the brain and stored in platelets in blood circulation. Blood coagulation is a common feature of malignant solid tumors and leads to significant serotonin release from activated platelets into tumor environment. Due to the unique feature of platelet in lacking nucleus, the impact of platelet and serotonin on cancer progression has been overlooked by studies focusing on cancer …

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Evaluating The Efficacy Of Radiofrequency Amplitude-Modulated Electromagnetic Fields As A Novel Treatment For Hepatocellular Carcinoma, Jacquelyn Winifred Zimmerman Jan 2012

Evaluating The Efficacy Of Radiofrequency Amplitude-Modulated Electromagnetic Fields As A Novel Treatment For Hepatocellular Carcinoma, Jacquelyn Winifred Zimmerman

All ETDs from UAB

Hepatocellular carcinoma (HCC) incidence in the US is dramatically increasing. Five-year survival has remained 3-5% for the past several decades, demonstrating urgent need for additional therapies. Intrabuccal administration of amplitude-modulated radiofrequency electromagnetic fields (RF EMF) is a novel, minimally invasive treatment modality. Clinical evidence demonstrates this treatment approach elicits therapeutic responses in cancer patients. In vitro we have described a phenotype in HCC cells following RF EMF exposure that included proliferative inhibition, modulation of gene expression, and disruption of the mitotic spindle. This phenotype was specific for HCC cells exposed to HCC-specific RF EMF. We have demonstrated similar efficacy in …

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