Digital Commons Network^™

Stamp Out Stigma : Putting A Face To Mental Illness : Increasing Mental Health Knowledge For Local High School Students, Danielle Pacheco

Capstone Projects and Master's Theses

Adolescence is a critical time for mental, social, and emotional development. Untreated mental health problems among adolescents often result in negative outcomes. Mental illness can decrease an individual’s ability to function in the community, with consequences such as suicide, delinquency, truancy, and substance abuse. Adolescents face these determinate costs when they do not receive treatment; consequently, they may increase as the problem of untreated illnesses expands. The lack of resources, deficiency of mental health education, and fear of stigma discourages individuals and their families from seeking the help they need. The Stamp Out Stigma workshop provides information and education about …

Reclaiming Our Purpose: Becoming A Missionary Movement Again, Mike Cauley

Journal of Adventist Mission Studies

No abstract provided.

The Development Of The Spiritual Life As The Foundation For Mission, Michael R. Cauley

Journal of Adventist Mission Studies

No abstract provided.

The Muslim Spiritual Progress Scale: Aiding Muslims In Coming To Christ, Marc Coleman

Journal of Adventist Mission Studies

No abstract provided.

"Don't Drop The Soap": Organizing Sexualities In The Repeal Of The Us Military's "Don't Ask, Don't Tell" Policy, Craig Rich, Julie Kalil Schutten, Richard A. Rogers

Communication Studies Faculty Works

Guided by critical, feminist, and queer approaches to organizational communication, this paper critically analyzes the United States military's "Don't Ask, Don't Tell" (DADT) policy and the Department of Defense's (2010) report recommending DADT's repeal. Rather than fostering genuine integration, the repeal report reproduces the conditions that marginalize queer soldiers under DADT, relegating gays and lesbians to the hyper-private (closet) while constructing an asexual veneer for the military organization. Such closeting remains necessary due to the threat that "openly" gay men pose to the image of the soldier as an impenetrable predator. Finally, the recommendation to deny sexual orientation the status …

Assessing The Efficacy Of Wildlife Ordinances As A Management Tool For Reducing Human-Bear Conflicts In New Hampshire, Jaclyn Virginia Comeau

Master's Theses and Capstones

This study evaluated the effectiveness of wildlife ordinances to address human-bear conflicts in New Hampshire by assessing their ability to reduce reported conflicts, achieve public support, and reduce the availability of anthropogenic attractants, ultimately reducing conflicts. Six towns in northern New Hampshire were used to make these evaluations; 3 with ordinances (Lincoln, Franconia, and Gorham) and 3 without (Bartlett, Lancaster, and Whitefield). The number of reported human-bear conflicts were compared between pre- and post-ordinance years in ordinance towns, a mail/online survey was sent to landowners in the 6 towns to assess and compare attitudes towards bears and ordinances, and the …

Myricetin Inhibits Islet Amyloid Polypeptide (Iapp) Aggregation And Rescues Living Mammalian Cells From Iapp Toxicity, Casey Zelus, Ayano Fox, Anastasia Calciano, Bianca S. Faridian, Luiza A. Nogaj, David A. Moffet

Chemistry and Biochemistry Faculty Works

The aggregation of the amyloidogenic polypeptide IAPP (Islet Amyloid Polypeptide, amylin) is believed to play a direct role in the death of pancreatic β-islet cells in type II diabetes. Preventing the initial aggregation event of IAPP is one strategy for slowing, and possibly preventing, the progression of this disease. Here, we investigate myricetin’s potential as an inhibitor of IAPP aggregation. We show that myricetin prevented thioflavin T binding in a concentration dependent manner. Atomic force microscopy revealed that myricetin prevented fiber formation under rigorous conditions conducive to forming IAPP aggregates. Using an IAPP-EGFP (Enhanced Green Fluorescent Protein) protein construct, we …

Metals And Bacteria Partitioning To Various Size Particles In Ballona Creek Storm Water Runoff, John Dorsey, Jeffrey S. Brown, Eric D. Stein, Drew Ackerman, Jessica Lyon, Patrick M. Carter

Civil and Environmental Engineering Faculty Works

Many storm water best management practice (BMP) devices function primarily by capturing particulate matter to take advantage of the well-documented association between storm water particles and pollutants. The hydrodynamic separation or settling methods used by most BMP devices are most effective at capturing medium to large particles; however, these may not be the most predominant particles associated with urban runoff. The present study examined particle size distribution in storm water runoff from an urban watershed in southern California and investigated the pollutant-particle associations of metals (Cu, Pb, Ni, and Zn) and bacteria (enterococci and Escherichia coli). During small storm events …

The Effectiveness Of Blended Instruction In Core Postsecondary Mathematics Courses, Anna E. Bargagliotti, Fernanda Botelho, Jim Gleason, John Haddock, Alistair Windsor

Mathematics, Statistics and Data Science Faculty Works

Most students in U.S. universities are required to take a collection of core courses regardless of their degree or major. These courses are known as "general education" courses. The general education requirements typically include at least one mathematics course. Unfortunately each year hundreds of thousands of students in the US do not succeed in these general education mathematics courses causing them to act as a barrier to degree completion. Low student success rates in these courses are pervasive, and it is well documented that the U.S. needs to improve student success and retention in general education mathematics courses.

In this …

Substituting The End For The Whole: Why Voters Respond Primarily To The Election-Year Economy, Andrew Healy, Gabriel S. Lenz

Economics Faculty Works

According to numerous studies, the election-year economy influences presidential election results far more than cumulative growth throughout the term. Here we describe a series of surveys and experiments that point to an intriguing explanation for voter behavior that runs contrary to the standard explanations political science has offered, but one that accords with a large psychological literature. Voters, we find, actually intend to judge presidents on cumulative growth. However, since that characteristic is not readily available to them, voters inadvertently substitute election-year performance because it is more easily accessible. This “end-heuristic” explanation for voters’ election-year emphasis reflects a general tendency …

Role Of Twin Cys-Xaa9-Cys Motif Cysteines In Mitochondrial Import Of The Cytochrome C Oxidase Biogenesis Factor Cmc1, Deepa V. Dabir

Biology Faculty Works

The Mia40 import pathway facilitates the import and oxidative folding of cysteine-rich protein substrates into the mitochondrial intermembrane space. Here we describe the in vitro and in organello oxidative folding of Cmc1, a twin CX9C-containing substrate, which contains an unpaired cysteine. In vitro, Cmc1 can be oxidized by the import receptor Mia40 alone when in excess or at a lower rate by only the sulfhydryl oxidase Erv1. However, physiological and efficient Cmc1 oxidation requires Erv1 and Mia40. Cmc1 forms a stable intermediate with Mia40 and is released from this interaction in the presence of Erv1. The three proteins are shown …

Fragmented Ethnopolitical Social Representations Of A Territorial Peace Agreement: The Mindanao Peace Talks, Cristina Jayme Montiel, Ma. Elizabeth J. Macapagal, Judith M. De Guzman

Psychology Department Faculty Publications

This article examines fractures in the social representations of a contested peace agreement in the longstanding territorial conflict of Mindanao. We compared representational structures and discourses about the peace talks among Muslims and Christians. Study One used an open-ended survey of 420 Christians and Muslims from two Mindanao cities identified with different Islamised tribes, and employed the hierarchical evocation method to provide representational structures of the peace agreement. Study Two contrasted discourses about the Memorandum of Agreement between two Muslim liberation fronts identified with separate Islamised tribes in Mindanao. Findings show unified Christians’ social representations about the peace agreement. However, …

Franco-American Cultures In A New World Perspective, Jonathan Gosnell

French Studies: Faculty Publications

This article explores cultural traditions from a little-known corner of the francophone world, what specialists call Franco-America. It represents a fertile site for reexamination of francophone postcolonial cultures. Beginning in the nineteenth century, French Canadians traveled to New England mill towns in search of work, established ethnic communities, and progressively became Franco-Americans. Today, endogamous Franco enclaves have all but disappeared, but French cultural expressions persist. Jack Kerouac is the most well known representative of this obscure French life. Franco-American written cultures, the focus of this essay, shed light on a distinct immigrant experience in the United States.

From Baker V. Carr To Bush V. Gore, And Back, Nelson Lund

Case Western Reserve Law Review

No abstract provided.

Judicial Protection Of Popular Sovereignty: Redressing Voting Technology, Candice Hoke

Case Western Reserve Law Review

No abstract provided.

Tribute To Professor Bill Leatherberry, Louis Stokes

Case Western Reserve Law Review

No abstract provided.

Is Wikileaks A Hit Man Handbook: Why Wikileaks Cannot Claim First Amendment Immunity If The Afghan And Iraq War Logs Cause Physical Harm, Rachel Wolbers

Journal of Law, Technology, & the Internet

No abstract provided.

Mass File Sharing Lawsuits: Legalized Extortion Or Valid Defense Of Copyright, Tyler Tassone

Journal of Law, Technology, & the Internet

No abstract provided.

Empty Creditor Syndrome And Vivisepulture: Preventing Credit-Default-Swap Holders From Pushing Companies Into Premature Graves By Refusing To Negotiate Restructurings, Dante Alteri Marinucci

Case Western Reserve Law Review

No abstract provided.

School, Family, And Faith: Social Influences On Educational Outcomes Of Nonmetropolitan Sexual Minority Students, Christopher J. Stapel

Theses and Dissertations--Sociology

Social institutions in rural communities tend to be highly interrelated and social ties tend to be dense and multiplex. Human ecological theoretical models posit that all institutions in which an individual is embedded interact in complex ways. As such, this dissertation examines the influences of school, faith, family, and risk contexts on the grade point averages of students who attended school in nonmetropolitan counties in Appalachian Kentucky. Using data disaggregated by gender from nearly 5,000 adolescents, I identified risk and protective factors on grade point averages by attraction type (exclusively opposite-sex attracted, same-sex attracted, and unsure of attraction), identified differences …

Graduate Employees’ Work And Organizing In Today’S University: A New Social Movement Theory Approach To Internal And External Struggles, Michael Carl Ide

Theses and Dissertations--Sociology

This is a mixed-methods comparative study of union and non-union graduate employees’ work experiences, following Wicken’s (2008) call for additional research into the graduate union movement. I used focus group interviews, finding that nonunionized participants had significantly more negative views of their work and faculty members than unionized participants. Non-unionized participants were also more likely to display greater internalization of neoliberal views and neoliberal subjectivity, and were more likely to see their problems in fatalistic terms. I found increased activity with the union to be associated with both decreased fear and anxiety as well as an increased sense of personal …

Proteasome Regulation Of Caspase-8: Significance In Cancer, Michael Vincent Fiandalo

Theses and Dissertations--Molecular and Cellular Biochemistry

Anti-tumor therapeutic strategies based on combinations of chemotherapeutic agents with a death inducing ligand such as TNF-α Related Apoptosis Inducing Ligand (TRAIL), are directed towards selective and effective cancer cell apoptosis and enhanced therapeutic response. We previously demonstrated that proteasome inhibition sensitizes TRAIL resistant prostate cancer cells to TRAIL-mediated apoptosis via stabilization of the active p18 subunit of initiator caspase-8. The present study investigated the functional link between caspase-8 and the proteasome, by analyzing the impact of caspase-8 ubiquitination and proteasomal degradation on the outcomes of the extrinsic apoptosis pathway in cancer cells. Caspase-8 ubiquitination status was assessed by polyubiquitin …

Structural Basis Of Substrate Recognition In Thimet Oligopeptidase And Development Of Nanoparticles For Therapeutic Enzyme Delivery, Jonathan Mark Wagner

Theses and Dissertations--Molecular and Cellular Biochemistry

Neuropeptidases are responsible for degradation of signaling peptides in the central nervous system and periphery. Some neuropeptidases have also been shown to play a role as part of the cell’s hydrolytic machinery responsible for breaking down proteins and peptides into amino acids, and these enzymes therefore influence small peptide availability for antigen presentation. A better understanding of how neuropeptidases recognize their substrates could lead to therapeutics that modulate the activity of these important enzymes. Alternatively, re-engineering these enzymes to selectively hydrolyze undesirable peptides could make them attractive as therapeutics themselves. A key question in understanding the activity of these enzymes …

Biochemical Actions Of A Novel Cis-Terpenone, Lin Zhang

Theses and Dissertations

Abstract BIOCHEMICAL ACTIONS OF A NOVEL CIS-TERPENONE By Lin Zhang, Ph.D. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. Virginia Commonwealth University, 2012 Director: Qibing Zhou, Ph.D Assistant Professor Department of Chemistry

Quinone methides are reactive species due to their electrophilicity, and natural quinone methide analogs have broad biological activities. Based on known actions of cytochrome P450 enzymes, we hypothesized that trans-terpenones can be metabolized in cells to form a cascade of metabolite products, which may be biologically active due to the generation of quinine and quinone methide …

Supporting Informed Learners In The 21st Century, Christine S. Bruce, Hilary Hughes, Mary M. Somerville

University Libraries Librarian and Staff Articles and Papers

This article elaborates the concept of informed learning and locates it in educational, workplace, and community settings. Drawing on existing research into people’s experience of information literacy, it identifies critical experiences of informed learners in each of these three settings. It also explores the support required in educational, community, and workplace contexts, which makes informed learning possible. Recognizing strong implications for policy makers in different sectors, the article presents a set of guiding principles for developing informed learning and learners. The idea of informed learning represents and advances understandings of information literacy that incorporate the broader concept of using information …

Impact Of An Elective Course On Pharmacy Students’ Attitudes, Beliefs, And Competency Regarding Medicare Part D, Suzanne M. Galal, Rajul A. Patel, Huong K. Thai, Christine M. Phou, Mark P. Walberg, Joseph A. Woelfel, Sian M. Carr-Lopez, Emily K. Chan

School of Pharmacy Faculty Articles

Objective. To determine the impact of an elective course on pharmacy students’ perceptions, knowledge, and confidence regarding Medicare Part D, medication therapy management (MTM), and immunizations.

Design. Thirty-three pharmacy students were enrolled in a Medicare Part D elective course that included both classroom instruction and experiential training.

Assessment. Students’ self-reported confidence in and knowledge of Part D significantly improved upon course completion. End-of-course student perceptions about the relative importance of various aspects of MTM interventions and their confidence in performing MTM services significantly improved from those at the beginning of the course. Students’ confidence in performing immunizations also increased significantly …

American Society Of Interventional Pain Physicians (Asipp) Guidelines For Responsible Opioid Prescribing In Chronic Non-Cancer Pain: Part 2--Guidance., Laxmaiah Manchikanti, Salahadin Abdi, Sairam Atluri, Carl C. Balog, Ramsin M. Benyamin, Mark V. Boswell, Keith R. Brown, Brian M. Bruel, David A. Bryce, Patricia A. Burks, Allen W. Burton, Aaron K. Calodney, David L. Caraway, Kimberly A. Cash, Paul J. Christo, Kim S. Damron, Sukdeb Datta, Timothy R. Deer, Sudhir Diwan, Ike Eriator, Frank J.E. Falco, Bert Fellows, Stephanie Geffert, Christopher G. Gharibo, Scott E. Glaser, Jay S. Grider, Haroon Hameed, Mariam Hameed, Hans Hansen, Michael E. Harned, Salim M. Hayek, Adam M. Kaye

School of Pharmacy Faculty Articles

RESULTS: Part 2 of the guidelines on responsible opioid prescribing provides the following recommendations for initiating and maintaining chronic opioid therapy of 90 days or longer. 1. A) Comprehensive assessment and documentation is recommended before initiating opioid therapy, including documentation of comprehensive history, general medical condition, psychosocial history, psychiatric status, and substance use history. (Evidence: good) B) Despite limited evidence for reliability and accuracy, screening for opioid use is recommended, as it will identify opioid abusers and reduce opioid abuse. (Evidence: limited) C) Prescription monitoring programs must be implemented, as they provide data on patterns of prescription usage, reduce prescription …

Career Coaching Across The Curriculum: Enhancing The Career Competencies Of The 21st Century Learner, Mark W. Slomp, Kerry B. Bernes

Northwest Journal of Teacher Education

This article examines the effectiveness of a pilot project offered by members of the Faculty of Education at the University of Lethbridge entitled, ―Career Coaching Across the Curriculum: Integrating Career Development into Classroom Instruction‖. It explores whether this pilot project effectively prepares pre-service teachers to integrate career education into curriculum. It also explores whether this pilot project contributes to the attainment of important career development competencies for students in the Kindergarten-Grade 12 educational system.

The Importance Of Using Technology-Enhanced 21st Century Literacy Skills To Support Culture And Diversity In The Classroom, Sonia Isabel Lopez-Lopez, Ibtesam Hussein, Maysoun Ali

Northwest Journal of Teacher Education

Teaching in today‘s classrooms is not the same as it has been in the past; that is what teachers claim. There is a new generation of students, with new expectations and capacities, coming into the classroom. The Internet and technology in general are used everywhere to communicate and interact with others. Today, students are looking for different interactions and ways of learning in the classroom. Therefore, technology should be used not only because students are using new technologies ubiquitously outside of the classroom, but also because the use of technology can enrich students‘ understandings of diversity and culture, which can …

Lipase-Kinase Associations Involving Pld2, Jak3 And Fes That Underlie Cancer Cell Proliferation And Invasion, Qing Ye

Browse all Theses and Dissertations

Phospholipase D (PLD) is an enzyme that breaks down phospholipids in the cell membrane. It has been suggested that PLD may play a role during cell proliferation and cell invasion of cancer cells. The objective of this thesis was to define new molecular signaling pathways in which PLD2 might be involved in terms of cell proliferation (first part) and cell invasion (second part). To this, I compared molecular and biochemical aspects between untransformed cell lines with highly invasive, transformed breast cancer cells. In the first part, I investigated the interaction of two tyrosine kinases with PLD2 and the effect of …