Digital Commons Network^™

Screening For Medical Referral: Determining Variables That Influence Accuracy, Heather Ellis Mount

All ETDs from UAB

SCREENING FOR MEDICAL REFERRAL: DETERMINING VARIABLES THAT INFLUENCE ACCURACY HEATHER E. MOUNT DOCTOR OF SCIENCE IN PHYSICAL THERAPY ABSTRACT Background: Screening for medical referral is essential to autonomous practice; however, no studies have examined the medical screening abilities of physical therapists in various settings. Objective: The purpose of this study was to determine if physical therapists in various practice settings could appropriately screen for medical referral, given brief clinical vignettes. Methods: A Delphi study was performed to enhance the content validity of the vignettes. After reviewing the vignettes, survey participants determined if they would provide intervention, provide intervention and refer, …

Innate Immune Mechanisms Against The Atypical Fungal Pathogen Pneumocystis Murina, Michael Paul Nelson

All ETDs from UAB

Pneumonia caused by the fungal pathogen Pneumocystis continues to be the leading cause of morbidity and mortality in AIDS patients. In addition, there are a number of other non-HIV-associated diseases that render an individual susceptible to Pneumocystis infection, including chronic obstructive pulmonary disease. Innate immune mechanisms are important for controlling Pneumocystis lung infection. As alveolar macrophages serve the front lines of lung host defense, our goal was to elucidate their responses during lung Pneumocystis infection. Here, we established a role for Src family kinases in the lung immune response to Pneumocystis, which uncovered a role for alternatively activated alveolar macrophages. …

Electrophysiological Investigation Of Rabbit Retinal Ganglion Cells, Przemyslaw Nowak

All ETDs from UAB

The retina is the first stage of the visual system, responsible for transducing light into the neural signal and for subsequent processing of this signal before sending it to the higher visual centers in the brain. The output to the higher visual centers is mediated by retinal ganglion cells, which not only relay the signal, but also substantially contribute to its processing. Depending on what computations they perform, they are subdivided into different types. These cells have been extensively studied in various spices, one prominent example being the rabbit. In rabbits, one characteristic type comprises On-Off directionally selective retinal ganglion …

Association Between Cc Chemokine Ligand 3-Like-1 (Ccl3l1) Gene Copy Number And Rheumatoid Arthritis In African Americans, Mawuli Kwame Nyaku

All ETDs from UAB

Gene copy number of the CC Chemokine ligand 3-Like-1 (CCL3L1) located on chromosome 17 position q12 varies between ethnicities. Previously, gene copy number of CCL3L1 greater than the ethnic median copy has been associated with an increased risk of Rheumatoid Arthritis. Three later studies found no association between CCL3L1 and RA. All studies were conducted in non-African Americans and an objective of this study was to determine this association in an African American cohort. CCL3L1 shares significant homology with three other genes within the same cluster; CC Chemokine ligand 3 (CCL3), CC Chemokine ligand 3-Like-2 (CCL3L2) and CC Chemokine ligand …

Male Hypogonadism At A Tertiary Care Hospital In Karachi, Pakistan, Nanik Ram, Ali Asghar, Fauzan Hashmi, Najmul Islam

Section of Diabetes, Endocrinology and Metabolism

Background: Male hypogonadism is defined as 'inadequate gonadal function, manifested by deficiency in gametogenesis and/or secretion of gonadal hormones'. Signs and symptoms of hypogonadism depend primarily on the age of onset. It can be classified according to the site primarily involved: the gonads, the hypothalamus, or the pituitary gland. The objective this study was to determine the presentation and aetiology of male hypogonadism seen in a tertiary care hospital.

Methods: This cross-sectional study was conducted at Endocrine Clinics, Aga Khan University Hospital Karachi. Data of male patients with hypogonadism who attended clinics during January 2009 to August 2011 were …

Thomas Jefferson University, Department Of Pathology, Anatomy And Cell Biology, Oral Administration Of Apigenin Inhibits Metastasis Through Akt/P70s6k1/Mmp-9 Pathway In Orthotopic Ovarian Tumor Model., Jun He, Qing Xu, Min Wang, Chongyong Li, Xu Qian, Zhumei Shi, Ling-Zhi Liu, Bing-Hua Jiang

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Apigenin, a flavonoid commonly present in the daily diet, is known for its potential anti-tumor properties. However, the effect of apigenin via oral administration on tumor growth and metastasis remains unknown. In this study we developed an orthotopic ovarian tumor model in nude mice to test the effect of apigenin oral administration, and showed that apigenin inhibited the micrometastasis of cancer cells in the animal tumor model. To understand the mechanism of apigenin in inhibiting metastasis, we found that apigenin greatly inhibited MMP-9 expression and p-AKT and p-p70S6K1 levels in the tumor tissues compared to the control group. We further …

Transition To Democracy In Post-Soviet States: Success Or Failure. Case Study Analysis, Ceyhun Valiyev

Khazar Journal of Humanities and Social Sciences

The democratization of Post-Soviet states in past two decades is the subject of this academic study. The main question of this research is that why most of the PostSoviet states haven’t gone through successful transition to democracy. Five countries; Azerbaijan, Belorussia, Georgia, Lithuania and Uzbekistan are the cases of this study to analyze and evaluate as empirical part of this work. I haven’t chosen the countries that have standard and equal level of success or failure. For instance, Lithuania is among those countries that have gone through quite successful process of democratization, whereas others have similar or different problems hindering …

Vitamin D: Implications Of The Institute Of Medicine Report For Clinical Practice, Dorothy Grasso, Margaret A. Rafferty

Publications and Research

In November 2010, the Institute of Medicine (IOM) released Dietary Reference Intakes for Calcium and Vitamin D, a radical departure from previous advice given regarding these two nutrients that have been reported in respected health journals. The 14-member expert committee found clear and convincing evidence to support the association between adequate levels of vitamin D and bone health. The IOM committee did not find enough evidence to support claims that inadequate levels of vitamin D are linked to increased risks for cancer, cardiovascular disease, or diabetes. In this article, the authors discuss the controversy surrounding vitamin D and provide guidance …

Encyclopedia Of Wellness: From Açai Berry To Yo-Yo Dieting, Elisabeth Tappeiner

Publications and Research

No abstract provided.

Virtualization And Shared Infrastructure Data Storage For It In Kosovo Institutions, Gani Zogaj

Theses

This capstone project addressed the need to strengthen the centralization and security of the electronic data from various national institutions in Kosovo. Most of the electronic data in Kosovo Institutions are separated in so many server rooms in different institutions and different locations. The Republic of Kosovo institutions have different systems of data stored in different physical spaces. Most of these data should be exchangeable in different systems and different data bases. The country lacks physical security in the current system of data security and professional staff for maintaining such data (databases, applications, and other electronic data). The budget of …

Necessity Defense To Felon-In-Possession Charges: The Third Circuit Justifies A Federal Justification Defense In Virgin Islands V. Lewis, Kathryn Maza

Villanova Law Review (1956 - )

The article presents information on the conceptions of morality and justice and the maximization of social welfare. The defense of necessity, its common law justification and the recognition of federal justification defense are discussed. The decisions made by the Third Circuit of the U.S. Court of Appeals in the trial of Virgin Islands v. Lewis, the judicial duty and the justification doctrine are also discussed.

Shoulder-And Back-Muscle Activation During Shoulder Abduction And Flexion Using A Bodyblade Pro Versus Dumbbells, Joseph S. Parry, Rachel Straub, Daniel Cipriani

Physical Therapy Faculty Articles and Research

Context: The Bodyblade Pro is used for shoulder rehabilitation after injury. Resistance is provided by blade oscillations—faster oscillations or higher speeds correspond to greater resistance. However, research supporting the Bodyblade Pro’s use is scarce, particularly in comparison with dumbbell training. Objective: To compare muscle activity, using electromyography (EMG), in the back and shoulder regions during shoulder exercises with the Bodyblade Pro vs dumbbells. Design: Randomized crossover study. Setting: San Diego State University biomechanics laboratory. Participants: 11 healthy male subjects age 19–32 y. Intervention: Subjects performed shoulder-flexion and -abduction exercises using a Bodyblade Pro and …

Loss Of Axonal Mitochondria Promotes Tau-Mediated Neurodegeneration And Alzheimer's Disease-Related Tau Phosphorylation Via Par-1., Kanae Iijima-Ando, Michiko Sekiya, Akiko Maruko-Otake, Yosuke Ohtake, Emiko Suzuki, Bingwei Lu, Koichi M Iijima

Farber Institute for Neuroscience Faculty Papers

Abnormal phosphorylation and toxicity of a microtubule-associated protein tau are involved in the pathogenesis of Alzheimer's disease (AD); however, what pathological conditions trigger tau abnormality in AD is not fully understood. A reduction in the number of mitochondria in the axon has been implicated in AD. In this study, we investigated whether and how loss of axonal mitochondria promotes tau phosphorylation and toxicity in vivo. Using transgenic Drosophila expressing human tau, we found that RNAi-mediated knockdown of milton or Miro, an adaptor protein essential for axonal transport of mitochondria, enhanced human tau-induced neurodegeneration. Tau phosphorylation at an AD-related site Ser262 …

Glucose Decouples Intracellular Ca2+ Activity From Glucagon Secretion In Mouse Pancreatic Islet Alpha-Cells., Sylvain J Le Marchand, David W Piston

Farber Institute for Neuroscience Faculty Papers

The mechanisms of glucagon secretion and its suppression by glucose are presently unknown. This study investigates the relationship between intracellular calcium levels ([Ca(2+)](i)) and hormone secretion under low and high glucose conditions. We examined the effects of modulating ion channel activities on [Ca(2+)](i) and hormone secretion from ex vivo mouse pancreatic islets. Glucagon-secreting α-cells were unambiguously identified by cell specific expression of fluorescent proteins. We found that activation of L-type voltage-gated calcium channels is critical for α-cell calcium oscillations and glucagon secretion at low glucose levels. Calcium channel activation depends on K(ATP) channel activity but not on tetrodotoxin-sensitive Na(+) channels. …

Accountable Care Organizations In The Affordable Care Act, Frank Pasquale

Seton Hall Law Review

No abstract provided.

Chronic Orofacial Pain Influences Self-Regulation In A Rodent Model, Tracey Christine Kniffin

Theses and Dissertations--Psychology

Self-regulation is the capacity to exert control over cognition, emotion, behavior, and physiology. Since chronic pain interferes with the ability to self-regulate, the primary goal of this study was to examine, in rodents, the effects of chronic pain on self-regulation processes. Sixteen male Sprague-Dawley rats were divided into two groups: (1) chronic constriction injury of the infraorbital nerve (CCI-ION) and (2) naïve. Testing confirmed that CCI-ION animals had significant mechanical allodynia compared to naïve animals (p<0.001). A two-part self-regulation behavioral paradigm consisting of a cued go/no-go task and a subsequent persistence task was developed based on human paradigms. In the cued task, both groups made fewer incorrect lever presses in post-surgery trials (p<0.001); naive animals had a greater decrease in number of incorrect presses than CCI-ION animals (p=0.06). Similarly, both groups had a larger correct to total lever presses ratio in post-surgery trials (p<0.001); naïve animals had a greater increase than CCI-ION animals (p=0.06). In the persistence task, naïve animals experienced a greater decrease in lever presses (p=0.08) than did CCI-ION animals (p=0.66). These results suggest that animals experiencing chronic pain were not able to learn as well as naïve animals, and may have difficulty responding to novel environmental demands.

Shifting Losses: The Impact Of Fannie's And Freddie's Conservatorships On Commercial Banks Articles, Essays, And Transcripts, Julie Andersen Hill

Essays, Reviews, and Shorter Works

No abstract provided.

Empty Protection And Meaningless Review—The Need To Reform California's Stagnant Capital Clemency System, Brittney Cunningham

Loyola of Los Angeles Law Review

This Note examines California’s stagnant capital clemency system and its ability to properly function as a fail safe against miscarriages of justice. Finding that the state’s clemency system lacks transparency, appears arbitrary, and is strained by political pressure, this Note argues that California’s system of wide discretion fails to provide a meaningful review of clemency petitions. To restore clemency’s failsafe function, this Note urges California to create a clemency board and provide procedural guidelines for the board to follow when addressing petitions. This Note asserts that by enacting these reforms, California will invigorate its stagnant clemency system and ensure that …

Confronting Forensics: Bullcoming V. New Mexico And The Sixth Amendment, Megan Weisgerber

Loyola of Los Angeles Law Review

The U.S. Supreme Court’s 2004 Crawford v. Washington decision drastically altered the long-standing Confrontation Clause jurisprudence, refocusing the constitutional inquiry on the testimonial nature of a witness’s statement but leaving for another day any effort to spell out a comprehensive definition of the term “testimonial.” Thus began the current line of Confrontation Clause cases, each of which sought to clarify the Sixth Amendment’s confrontation protections but arguably clouded any clarity that the case before it brought. In 2009, the Court decided Melendez-Diaz v. Massachusetts, in which it held that a forensic laboratory report prepared for a criminal trial is …

Reproduksi Stereotip Dan Resistensi Orang Katobengke Dalam Struktur Masyarakat Buton, Tasrifin Tahara

Antropologi Indonesia

Buton manuscripts indicated that Buton Kingdom appeared in 14th Century. In the periods of the 17 th, 18th, and 19th centuries, Buton Kingdom initiated to be the free kingdom. In the begining of 20th , dutch colonial goverment incorporated that the Buton kingdom and placed it under their rule. The principles were laid down based on the social cultural in eceonomic development. Relation to be governed especially are in the field of education, health, and economy. In 1960, Buton kingdom was dissolved following the death of Sultan Laode Muhammad Falihi as the last sultan. During the kingdom era, Buton social …

Growth And Photochemical Responses Of Three Crop Species Treated With Textile Azo Dyes, Nuran Çi̇çek, Banu Efeoğlu, Deni̇z Tanyolaç, Yasemi̇n Ekmekçi̇, Reto Jörg Strasser

Turkish Journal of Botany

The present study was conducted to investigate the impact of textile dye on the early seedling stage of 3 crops: barley, maize, and wheat. Seeds were imbibed in different concentrations of textile dye for 12 h and were then grown in a controlled growth room for 8 days with a related dye solution. Some growth and polyphasic chlorophyll fluorescence parameters were measured and analysed to appraise the effect of textile dye on the 3 crops. Although different crop species showed differences in response to different concentrations, textile dye generally affected almost all radicle growth parameters more adversely than coleoptile growth …

Three New Records For Turkey: Allium Giganteum (Liliaceae), Grammosciadium Scabridum, And Ferulago Angulata Subsp. Carduchorum (Apiaceae), Lütfi̇ Behçet, İdri̇s Kaval, Mustafa Rüstemoğlu

Turkish Journal of Botany

Allium giganteum Regel (Liliaceae), Grammosciadium scabridum Boiss., and Ferulago angulata (Schlecht.) Boiss. subsp. carduchorum (Boiss. & Hausskn.) D.F.Chamb. (Apiaceae) are reported as new records for the Turkish flora. They have been identified using the collected specimens and Flora Iranica. The taxa's diagnostic characters, habitats, photos, and a distribution map of the new records in Turkey are given.

Larynx-Sparing Techniques Using Intensity-Modulated Radiation Therapy For Oropharyngeal Cancer., Voichita Bar-Ad, Haibo Lin, Wei-Ting Hwang, Curtiland Deville, Pinaki R Dutta, Zelig Tochner, Stefan Both

Department of Radiation Oncology Faculty Papers

The purpose of the current study was to explore whether the laryngeal dose can be reduced by using 2 intensity-modulated radiation therapy (IMRT) techniques: whole-neck field IMRT technique (WF-IMRT) vs. junctioned IMRT (J-IMRT). The effect on planning target volumes (PTVs) coverage and laryngeal sparing was evaluated. WF-IMRT technique consisted of a single IMRT plan, including the primary tumor and the superior and inferior neck to the level of the clavicular heads. The larynx was defined as an organ at risk extending superiorly to cover the arytenoid cartilages and inferiorly to include the cricoid cartilage. The J-IMRT technique consisted of an …

Gene Expression Signatures Modulated By Epidermal Growth Factor Receptor Activation And Their Relationship To Cetuximab Resistance In Head And Neck Squamous Cell Carcinoma., Elana J Fertig, Qing Ren, Haixia Cheng, Hiromitsu Hatakeyama, Adam Dicker Md, Phd, Ulrich Rodeck, Michael Considine, Michael F Ochs, Christine H Chung

Department of Radiation Oncology Faculty Papers

BACKGROUND: Aberrant activation of signaling pathways downstream of epidermal growth factor receptor (EGFR) has been hypothesized to be one of the mechanisms of cetuximab (a monoclonal antibody against EGFR) resistance in head and neck squamous cell carcinoma (HNSCC). To infer relevant and specific pathway activation downstream of EGFR from gene expression in HNSCC, we generated gene expression signatures using immortalized keratinocytes (HaCaT) subjected to ligand stimulation and transfected with EGFR, RELA/p65, or HRASVal12D.

RESULTS: The gene expression patterns that distinguished the HaCaT variants and conditions were inferred using the Markov chain Monte Carlo (MCMC) matrix factorization algorithm Coordinated Gene Activity …

The Global Impact And Implementation Of Human Rights Norms: Introduction, Linda Carter

McGeorge School of Law Scholarly Articles

No abstract provided.

Medical Marijuana: A Study Of Unintended Consequences, Gerald Caplan

McGeorge School of Law Scholarly Articles

No abstract provided.

Even Moe Dalitz Would Blush: Why The District Attorney Has No Business Collecting Unpaid Casino Markers, Francis J. Mootz Iii

McGeorge School of Law Scholarly Articles

No abstract provided.

Health Equity, Healthy People 2020, And Coercive Legal Mechanisms As Necessary For The Achievement Of Both, Emily Whelan Parento

McGeorge School of Law Scholarly Articles

Principles of health equity require that all people have equal opportunity to develop and maintain their health, yet in the face of widespread and presumptively inequitable health disparities, the law has done little. This paper argues that health equity demands the use of coercive legal mechanisms in certain circumstances given the existence of current disparities and the evidence of effectiveness of direct regulation as compared to its alternatives. Moreover, the paper argues that Healthy People 2020, which is the nation's “master blueprint for health” and explicitly seeks to achieve health equity, has not fully incorporated the principles of health equity …

The Status Of Clinical Faculty In The Legal Academy: Report Of The Task Force On The Status Of Clinicians And The Legal Academy, Bryan L. Adamson, Bradford Colbert, Kathy Hessler, Katherine R. Kruse, Robert R. Kuehn, Mary Helen Mcneal, Calvin G. C. Pang, David A. Santacroce

Other Publications

In the midst of ongoing debates within the legal academy and the American Bar Association on the need for 'practice-ready" law school graduates through enhanced attention to law clinics and externships and on the status of faculty teaching in those courses, this report identifies and evaluates the most appropriate modes for clinical faculty appointments. Drawing on data collected through a survey of clinical program directors and faculty, the report analyzes the five most identifiable clinical faculty models: unitary tenure track; clinical tenure track; long-term contract; short-term contract; and clinical fellowships. It determines that, despite great strides in the growth of …

Will Contests: From Start To Finish., Joyce Moore

St. Mary's Law Journal

This Article primarily focuses on the practical problems facing attorneys and courts when evaluating and proving up a will or trust in contested cases. The focus extends further into the special procedural and evidentiary rules applicable to these actions, the use and misuse of summary judgment proceedings in these cases, and some observations regarding developing trends and strategies in will and trust contest litigation. Admittedly, this area of practice is a melting pot of presumptions, exceptions, threshold hurdles, capacity qualms, evidentiary issues, strategic clauses, and countless other headache-inducing legal issues. Yet, attorneys must diligently juggle all of them while also …