Digital Commons Network^™

Middle-Class Crisis In The Colonization Transition: Comparing Catalysts And Consequences In Taiwan, 1988-2008, Jui-Chang Jao

Theses and Dissertations--Sociology

The Taiwanese middle class has experienced two waves of crisis over the past three decades in the context of a colonization transition involving globalization and democratization as primary catalysts. On the economic front, Taiwan’s economy has become increasingly integrated into the Chinese market, resulting approximately one million of the Taiwanese middle class relocating to China. Moreover, neoliberal economic reforms have led to a downsized state sector of the Taiwanese economy. These economic changes affect the growth and stability of the Taiwanese middle class. Meanwhile, on the political front, an ongoing democratic consolidation and decolonization efforts have brought about significant political …

Stability Of Antibiotic Resistance Patterns In Agricultural Pastures: Lessons From Kentucky, Usa, Sloane Ritchey, Siva Gandhapudi, Mark Coyne

Plant and Soil Sciences Faculty Publications

No abstract provided.

Multiple Health Behavior Risks: Redefining Co-Action And Investigating Multiple Health Behavior Change Using The Transtheoretical Model, Jayson Spas

Open Access Dissertations

Despite considerable evidence to support efficacious and effective intervention for single health behaviors, relatively little is known about simultaneous multiple health behavior change. This research analyzed multiple health behavior change for three very different health risk behaviors. The sample (N=9,461) was predominantly White (93.8%), middle-aged (X= 43.9 years-old, SD=10.74) adults who met criteria for smoking, unhealthy diet, and unprotected sun exposure. Specifically, when sun protection and diet, smoking and diet, and smoking and sun protection were analyzed as three sets of behavior pairs from baseline to 24-month follow-up, results consistently demonstrated that simultaneous intervention on multiple health behavior risks increased …

Proteasome Regulation Of Caspase-8: Significance In Cancer, Michael Vincent Fiandalo

Theses and Dissertations--Molecular and Cellular Biochemistry

Anti-tumor therapeutic strategies based on combinations of chemotherapeutic agents with a death inducing ligand such as TNF-α Related Apoptosis Inducing Ligand (TRAIL), are directed towards selective and effective cancer cell apoptosis and enhanced therapeutic response. We previously demonstrated that proteasome inhibition sensitizes TRAIL resistant prostate cancer cells to TRAIL-mediated apoptosis via stabilization of the active p18 subunit of initiator caspase-8. The present study investigated the functional link between caspase-8 and the proteasome, by analyzing the impact of caspase-8 ubiquitination and proteasomal degradation on the outcomes of the extrinsic apoptosis pathway in cancer cells. Caspase-8 ubiquitination status was assessed by polyubiquitin …

The Cellular Nucleic Acid Binding Protein Regulates The Alzheimer’S Disease Β-Secretase Protein Bace1, Christopher J. Holler

Theses and Dissertations--Molecular and Cellular Biochemistry

Alzheimer’s disease (AD) is the most common neurodegenerative disease affecting the elderly population and is believed to be caused by the overproduction and accumulation of the toxic amyloid beta (Aβ) peptide in the brain. Aβ is produced by two separate enzymatic cleavage events of the larger membrane bound amyloid precursor protein, APP. The first, and rate-limiting, cleavage event is made by beta-secretase, or BACE1, and is thus an attractive therapeutic target. Our lab, as well as many others, has shown that BACE1 protein and activity are increased in late-stage sporadic AD. We have extended these findings to show that BACE1 …

Biochemical Actions Of A Novel Cis-Terpenone, Lin Zhang

Theses and Dissertations

Abstract BIOCHEMICAL ACTIONS OF A NOVEL CIS-TERPENONE By Lin Zhang, Ph.D. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. Virginia Commonwealth University, 2012 Director: Qibing Zhou, Ph.D Assistant Professor Department of Chemistry

Quinone methides are reactive species due to their electrophilicity, and natural quinone methide analogs have broad biological activities. Based on known actions of cytochrome P450 enzymes, we hypothesized that trans-terpenones can be metabolized in cells to form a cascade of metabolite products, which may be biologically active due to the generation of quinine and quinone methide …

Hiv Rna Suppression And Immune Restoration: Can We Do Better?, Marilia Rita Pinzone, Michelino Di Rosa, Bruno Cacopardo, Giuseppe Nunnari

Department of Microbiology and Immunology Faculty Papers

HAART has significantly changed the natural history of HIV infection: patients receiving antiretrovirals are usually able to control viremia, even though not all virological responders adequately recover their CD4+ count. The reasons for poor immune restoration are only partially known and they include genetic, demographic and immunologic factors. A crucial element affecting immune recovery is immune activation, related to residual viremia; indeed, a suboptimal virological control (i.e., low levels of plasma HIV RNA) has been related with higher levels of chronic inflammation and all-cause mortality. The sources of residual viremia are not yet completely known, even though the most important …

Evidence That The Density Of Self Peptide-Mhc Ligands Regulates T-Cell Receptor Signaling., Nadia Anikeeva, Dimitry Gakamsky, Jørgen Schøller, Yuri Sykulev

Department of Microbiology and Immunology Faculty Papers

Noncognate or self peptide-MHC (pMHC) ligands productively interact with T-cell receptor (TCR) and are always in a large access over the cognate pMHC on the surface of antigen presenting cells. We assembled soluble cognate and noncognate pMHC class I (pMHC-I) ligands at designated ratios on various scaffolds into oligomers that mimic pMHC clustering and examined how multivalency and density of the pMHCs in model clusters influences the binding to live CD8 T cells and the kinetics of TCR signaling. Our data demonstrate that the density of self pMHC-I proteins promotes their interaction with CD8 co-receptor, which plays a critical role …

The Career Support Network (Csn): Workforce Programming Through A New Lens, Rickie Brawer, Mph, Phd, James D. Plumb Md, Mph, Stephen Kern, Phd, Otr/L, Faota

Department of Family & Community Medicine Faculty Papers

Challenges:

Loss of Earn center as referral source

Multiple IRB submissions

Training/orientation at Philadelphia Prison System for working with pre-release prisoners

Service team organization/scheduling

Coordinating of cohorts at various stages of enrollment

Sepa-Reads: Cardiovascular Health Literacy Coalition, Rickie Brawer, Mph, Phd, James D. Plumb Md, Mph, Rob Simmons Drph,Mph,Ches, Martha Romney Rn,Ms,Jd,Mph, Patricia Yurchick, Rn, Mba, Cphq, Leslie Stearns

Department of Family & Community Medicine Faculty Papers

Poster includes:

Health literacy definition

Factors that contribute to health literacy

Extent of the literacy problem

What do we know from a decade of research?

Readmission rates

Evaluation: long and short term outcomes

And much more.

Passive Stretching And Its Effect On Spasticity And Range Of Motion In Children With Cerebral Palsy: A Systematic Review, Mallory Groppe, Katrin Baxter, Todd E. Davenport

School of Pharmacy Faculty Articles

Study Design: Only research studies published in peer-reviewed journals in the last two decades and published in the English language were included. Studies centered on surgical or pharmacological interventions were not included. To examine the strengths and weaknesses of these studies, the Physiotherapy Evidence Database (PEDro) scale and Sackett’s levels of evidence were used. Objectives: The aim of this paper is to analyze literature published in the past two decades, which explores the effects of stretching when used to reduce spasticity and increase range of motion in children with spastic cerebral palsy (CP), as well as to address the effects …

Attentional Bias And Alcohol Abuse, Jessica Jane Weafer

Theses and Dissertations--Psychology

Selective attention towards alcohol-related cues (i.e., “attentional bias”) is thought to reflect increased incentive motivational value of alcohol and alcohol cues acquired through a history of heavy alcohol use, and as such attentional bias is considered to be a clinically relevant factor contributing to alcohol use disorders. This dissertation consists of two studies that investigated specific mechanisms through which attentional bias might serve to promote alcohol abuse. Study 1 compared magnitude of attentional bias in heavy (n = 20) and light (n = 20) drinkers following placebo and two doses of alcohol (0.45 g/kg and 0.65 g/kg). Heavy drinkers displayed …

The “Ethical” Surplus Of The War On Illegal Immigration, Francis J. Mootz Iii, Leticia Saucedo

McGeorge School of Law Scholarly Articles

No abstract provided.

The Success And Continued Challenges Of The Yolo Bypass Wildlife Area: A Grassroots Restoration, Rachael E. Salcido

McGeorge School of Law Scholarly Articles

No abstract provided.

A “Lawyer For All Seasons”: The Lawyer As Conflict Manager, Michael T. Colatrella Jr.

McGeorge School of Law Scholarly Articles

This interdisciplinary Article explores why interpersonal conflict management principles and skills are essential to good lawyering and, thus, why law schools should teach these principles and skills to all their students. In demonstrating the immense practical value an understanding of interpersonal conflict management principles and skills have in the practice of law, this Article examines case studies involving organizations that have dramatically reduced legal costs, among other benefits, by abandoning a solely legalistic approach to conflict and embracing conflict management principles. The lessons learned from these studies and the interpersonal conflict management principles that underlie them support the idea that …

Supporting Informed Learners In The 21st Century, Christine S. Bruce, Hilary Hughes, Mary M. Somerville

University Libraries Librarian and Staff Articles and Papers

This article elaborates the concept of informed learning and locates it in educational, workplace, and community settings. Drawing on existing research into people’s experience of information literacy, it identifies critical experiences of informed learners in each of these three settings. It also explores the support required in educational, community, and workplace contexts, which makes informed learning possible. Recognizing strong implications for policy makers in different sectors, the article presents a set of guiding principles for developing informed learning and learners. The idea of informed learning represents and advances understandings of information literacy that incorporate the broader concept of using information …

Social Capital And Homeless Youth: Influence Of Residential Instability On College Access, William G. Tierney, Ronald E. Hallett

Benerd College Faculty Articles

This article examines the experiences homeless youth face and the influence of social networks on their education. Using a social capital framework, we analyze the experiences that are different for poor youth in general and those homeless. Data used include interviews with 123 homeless youth and more than 40 policymakers, school counselors, and after-school program coordinators. Youth identified three aspects of their lives that influence network development associated with college access: mobility and stability, meeting basic needs, and anonymity and shame. The temporary nature of their residential stability requires a systemic response by educational institutions.

Impact Of An Elective Course On Pharmacy Students’ Attitudes, Beliefs, And Competency Regarding Medicare Part D, Suzanne M. Galal, Rajul A. Patel, Huong K. Thai, Christine M. Phou, Mark P. Walberg, Joseph A. Woelfel, Sian M. Carr-Lopez, Emily K. Chan

School of Pharmacy Faculty Articles

Objective. To determine the impact of an elective course on pharmacy students’ perceptions, knowledge, and confidence regarding Medicare Part D, medication therapy management (MTM), and immunizations.

Design. Thirty-three pharmacy students were enrolled in a Medicare Part D elective course that included both classroom instruction and experiential training.

Assessment. Students’ self-reported confidence in and knowledge of Part D significantly improved upon course completion. End-of-course student perceptions about the relative importance of various aspects of MTM interventions and their confidence in performing MTM services significantly improved from those at the beginning of the course. Students’ confidence in performing immunizations also increased significantly …

American Society Of Interventional Pain Physicians (Asipp) Guidelines For Responsible Opioid Prescribing In Chronic Non-Cancer Pain: Part 2--Guidance., Laxmaiah Manchikanti, Salahadin Abdi, Sairam Atluri, Carl C. Balog, Ramsin M. Benyamin, Mark V. Boswell, Keith R. Brown, Brian M. Bruel, David A. Bryce, Patricia A. Burks, Allen W. Burton, Aaron K. Calodney, David L. Caraway, Kimberly A. Cash, Paul J. Christo, Kim S. Damron, Sukdeb Datta, Timothy R. Deer, Sudhir Diwan, Ike Eriator, Frank J.E. Falco, Bert Fellows, Stephanie Geffert, Christopher G. Gharibo, Scott E. Glaser, Jay S. Grider, Haroon Hameed, Mariam Hameed, Hans Hansen, Michael E. Harned, Salim M. Hayek, Adam M. Kaye

School of Pharmacy Faculty Articles

RESULTS: Part 2 of the guidelines on responsible opioid prescribing provides the following recommendations for initiating and maintaining chronic opioid therapy of 90 days or longer. 1. A) Comprehensive assessment and documentation is recommended before initiating opioid therapy, including documentation of comprehensive history, general medical condition, psychosocial history, psychiatric status, and substance use history. (Evidence: good) B) Despite limited evidence for reliability and accuracy, screening for opioid use is recommended, as it will identify opioid abusers and reduce opioid abuse. (Evidence: limited) C) Prescription monitoring programs must be implemented, as they provide data on patterns of prescription usage, reduce prescription …

Career Coaching Across The Curriculum: Enhancing The Career Competencies Of The 21st Century Learner, Mark W. Slomp, Kerry B. Bernes

Northwest Journal of Teacher Education

This article examines the effectiveness of a pilot project offered by members of the Faculty of Education at the University of Lethbridge entitled, ―Career Coaching Across the Curriculum: Integrating Career Development into Classroom Instruction‖. It explores whether this pilot project effectively prepares pre-service teachers to integrate career education into curriculum. It also explores whether this pilot project contributes to the attainment of important career development competencies for students in the Kindergarten-Grade 12 educational system.

The Efficacy Of Inquiry-Based Learning In Undergraduate Physiology, James Depaepe, Tracy Campion

Northwest Journal of Teacher Education

Lecture, where learning is passive, remains a prevalent instructional method of teaching content. Contextualized approaches like Inquiry-Based Learning (IBL) where students are more actively engaged remains less common. For 25 years the literature has supported contextualized approaches. Nevertheless, recent papers have claimed IBL to be an unguided approach that has produced content knowledge deficits. Therefore, we tested whether undergraduate physiology content could be learned using IBL. Four groups of undergraduates (mean ages=23, N=60) took a ten-week physiology course using IBL. A content valid pretest and posttest measured content knowledge. A one-way ANOVA indicated no significant differences within or between groups …

Installments, Issue 56, January/February 2012, Renee Montgomery

Libraries' Newsletters

No abstract provided.

Focused Brief Group Therapy Treatment Manual, Jennifer Elaine Lotz

Browse all Theses and Dissertations

Focused Brief Group Therapy (FBGT) was developed in a college counseling center in order to meet the mental health needs of the student population effectively within an 8 session limit. The model was developed to address pragmatic concerns by integrating best practice (AGPA, ASGW) and the local scientist model (practice based evidence). The goal of FBGT is measurable change in a focused area of interpersonal distress. The interpersonal circumplex, an empirically derived and scientifically validated model of interpersonal functioning, is used. Assessment is used to inform and guide treatment as well as to measure change. The model has been honed …

Development And Evaluation Of An Ecological Display For The Detection, Evaluation, And Treatment Of Cardiovascular Risk, Timothy Ryan Mcewen

Browse all Theses and Dissertations

Ecological interface design (EID; Vicente & Rasmussen, 1992) is a discipline that emphasizes the necessity of understanding the laws and constraints of a domain in order to make meaningful design decisions. We applied EID principles to create an ecological interface aimed at helping physicians with the detection, evaluation, and treatment of cardiovascular disease risk (specifically for hypertension and hyperlipidemia) and then evaluated it in two exploratory studies. In the first study, twenty-three internal medical residents participated viewed data from twelve patients (in six blocks) in a repeated measures study that measured which risk factors participant felt required follow-up and if …

Fire Losses And Conflicting Judicial Rulings Over Whether Property Insurers Must Indemnify Insureds And Pay Third-Party Claims - Some Implications For Wildfire Litigation In Texas's Courts, Willy E. Rice

Faculty Articles

Wildfires in Texas have generated two interrelated questions: (1) whether insurers have a duty to indemnify residential and commercial property owners if a wild forest, brush, grass, or prairie fire destroys homeowners' property in Texas, and (2) whether insurers have a duty to pay or settle third-party claims in Texas if a property owner starts a fire on her property, which evolves into a wildfire and destroys a third party's residential or commercial property.

When Coercion Lacks Care: Competency To Make Medical Treatment Decisions And Parens Patriae Civil Commitments, Dora W. Klein

Faculty Articles

The subject of this Article is people who have been civilly committed under a state’s parens patriae authority to care for those who are unable to care for themselves. These are people who, because of a mental illness, are a danger to themselves. Even after they have been determined to be so disabled by their mental illness that they cannot care for themselves, many are nonetheless found to be competent to refuse medical treatment. Competency to make medical treatment decisions generally requires only a capacity to understand a proposed treatment, not an actual or rational understanding of that treatment. This …

Allegedly “Biased,” “Intimidating,” And “Incompetent” State Court Judges And The Questionable Removal Of State Law Class Actions To Purportedly “Impartial” And “Competent” Federal Courts—A Historical Perspective And An Empirical Analysis Of Class Action Dispositions In Federal And State Courts, 1925-2011, Willy E. Rice

Faculty Articles

Judges as well as members of plaintiffs’ and defense bars agree: a class action is a superior, efficient, and inexpensive procedural tool to litigate disputes that present similar questions of fact and law. To be sure, corporations and insurers have a long history of filing successful class actions against each other in state courts. Yet those corporate entities convinced Congress to embrace an uncommon view: continuing to allow allegedly “hostile” and “biased” state judges and juries to hear and decide everyday consumers’ “purely substantive state law class actions” is unfair and inefficient. Responding to the plea, Congress enacted the Class …

Cns Neural/Glial Progenitors As Targets Of Hiv-1 And Opiates: Effects On Proliferation And Population Dynamics May Alter Behavior Outcomes., Yun Kyung Hahn

Theses and Dissertations

Human immunodeficiency virus (HIV) infected patients with a history of injection opiate abuse have higher incidences of acquired immunodeficiency syndrome (AIDS) and neurological dysfunction. The use of combined anti-retroviral therapy has significantly reduced the prevalence of mortality and progression to AIDS. Due to extended life expectancy, these patients are still at a great risk for HIV-associated neurological disorders and impairment in their later life. Neural progenitor cells (NPCs) play critical roles in brain growth and repair after injury and insult. Pediatric HIV patients whose glial populations are still developing are especially at risk for central nervous system (CNS) damage. Our …

Adam10: A Novel Regulator Of Mast Cell Function And Activation, Travis Faber

Theses and Dissertations

In this study we show, to our knowledge, the first description of the role ADAM10 plays on mast cells. ADAM10 is abundantly expressed on mast cells both in vitro and in vivo. Its expression is inhibited by IL-10, a suppressive cytokine. siRNA depletion of ADAM10 on bone marrow-derived mast cells (BMMC) caused decreased IL-6 production following IgE cross-linking and also impaired BMMC stem cell factor (SCF)-induced migration through collagen IV. Mast cells and T helper cells (Th cells) in the peritoneum were reduced in ADAM10 KO mice. In addition, ADAM10 KO BMMC produced significantly less of all cytokines measured following …

A Unified Nonlinear Adaptive Approach For The Fault Diagnosis Of Aircraft Engines, Remus C. Avram

Browse all Theses and Dissertations

In this thesis, a fault detection and isolation (FDI) method is developed for aircraft engines by utilizing nonlinear adaptive estimation techniques. Engine sensor faults, actuator faults and component faults are considered under one unified framework. The fault diagnosis architecture consists of a bank of nonlinear adaptive estimators. One of them is the fault detection estimator used for fault detection, and the remaining ones are fault isolation estimators employed to determine the particular fault type/location after fault detection. Each isolation estimator is designed based on the functional structure of a particular fault type under consideration. The FDI architecture has been integrated …