Digital Commons Network^™

Understanding Carbohydrate Recognition By Antiviral Lectins: Applying Computational Methods To Protein-Carbohydrate Complexes, Yukiji Karen Fujimoto

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Human immunodeficiency virus (HIV) infection of T-cells begins when the viral envelope glycoprotein, gp120, binds to CD4 receptors on the target cell surface. Over the past several years, proteins isolated from various prokaryotes have been shown to inhibit HIV cell entry by binding to gp120 and thus blocking the association with CD4. Lectins that bind to high-mannose oligosaccharides on gp120 are an attractive class of antiviral agents. While several of these have been quite well characterized both structurally and biochemically, there remain many open questions regarding their mechanism of inhibition. Among the best studied is cyanovirin-N (CVN), which is currently …

Screening For Steroid-Derived Immunomodulatory Metabolites Biosynthesized By Mycobacterium Tuberculosis (M. Tuberculosis), Xiaoqian Jin

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Tuberculosis (Tb) is a serious worldwide threat to human health killing 1.4 million people every year. Mycobacterium tuberculosis (M. tuberculosis), the causative agent for Tb, has infected 30% of the world's population. The emergence of multidrug, extensively drug, and total drug resistant organisms (MDR/XDR/TDR TB) creates an urgent demand to develop new drugs with novel mechanisms to be effective against both sensitive and drug-resistant strains of M. tuberculosis. The cholesterol metabolism pathway in M. tuberculosis is important for mycobacterial survival in the host macrophage. We proposed that cholesterol serves as a starting material for biosynthesis of steroid-derived immunomodulators that down-regulate …

Understanding The Effects Of Multivalent Glycopolymer Structure On Molecular Recognition, Eunjung Lee

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Carbohydrate-protein interactions are involved in a large number of important physiological and pathological processes. The weak binding affinity of a monovalent carbohydrate is compensated by multivalency in which multimeric recognition elements interact with a cell surface display of two or more receptors. In order to study lectin-carbohydrate interactions and find analytical and diagnostic applications, a large number of synthetic glycoconjugates have been investigated in the last decade. In order to explore the effects of structural features of glycopolymers on the binding events, a series of polymers were synthesized. Multivalent ligands with pendant saccharide moieties were prepared from two different types …

The Confessions Of Augustine's Flesh: Counter-Conducts Overwhelming To Pastoral Power In Christian Conversion, Darla Senami Migan

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

In his 1978 lectures at the College de France, Security Territory Population, Michel Foucault shifts his analysis of power by arguing for pastoral power as both the prelude to governmentality and as the decisive moment in the constitution of the Western subject. If the history of the Christian pastorate involves " the entire history of procedures of human individualization in the West (184)," then, Foucault argues, there has never been a revolt against pastoral power because such a revolt would be a revolt against the constitution of the self, that is to say against self-consciousness. If the revolt against pastoral …

A Gay Neoclassical Movement, Robert E. Diamond

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

In anticipation of a larger project, I propose a broad view of the Neoclassical period. The question of gay culture, and, particularly, where it exists before the emergence of the modern internal gay subculture in the 20th century, is a pertinent art historical topic, since the very evidence for gay communities comes in large part from visual culture. The Neoclassical period offers a rich repository of homoerotic art that is, in fact, based on self-conscious artistic expression emerging from an underground but bourgeoning homosexual community. This expression includes not only the movement's important theorist, Winckelmann, but also many of the …

Artifacts And Noise In Dna Profiling, Dan E. Krane

Biological Sciences Faculty Publications

No abstract provided.

Hostile Mood And Social Strain During Daily Life: A Test Of The Transactional Model., Elizabeth J. Vella, Thomas W. Karmarck, Janine D. Flory, Stephen B. Manuck

Faculty Publications

Hostility is a multidimensional construct related to cardiovascular (CV) disease risk. Daily hostile mood and social interactions may precipitate stress-related CV responses in hostile individuals. Purpose: Determine whether trait cognitive hostility best predicts daily hostile mood and social interactions relative to other trait hostility factors and explore the temporal links between these daily measures

The Nursing Standard Of Care In Illinois: Rethinking The Wingo Exception In The Wake Of Sullivan V. Edward Hospital, Emily Chase-Sosnoff

Chicago-Kent Law Review

This note analyzes the current circuit split among Illinois courts over whether the same-license requirement for medical expert testimony applies to testimony about the standard of care for nurse-doctor communications. Part I traces the history of the problem by explaining the original same-license requirement, the Wingo exception for nurse-doctor communications, and the Illinois Supreme Court's decision in Sullivan, which cast doubt on Wingo's continued survival. Part II illustrates the nature of the circuit split by describing the lower courts' three distinct interpretations of Sullivan. Finally, Part III argues that courts should apply Sullivan strictly and abandon the Wingo exception because …

Benchmarks 2012, December 14, The Rockefeller University

BenchMarks 2012

BenchMarks. Friday, December 14, 2012

The community newsletter of The Rockefeller University

BenchMarks is published monthly and is distributed on the campus of The Rockefeller University. It produced by the Office of Communications and Public Affairs

Number 16, 2012, Palara Editors

PALARA: Publication of the Afro-Latin/American Research Association

Complete Issue

Message From The Senior Vice Provost And Dean Of Undergraduate Studies, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Notes From The Director, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Acknowledgements, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

The Association Between Acrochorda (Skin Tags), Metabolic Syndrome, And Adenomatous Polyps, Brendan O'Hare, Md, Anastasia Shnitser, Md, Jason Korenblit, Md, Mba, Ali Siddiqui, Md

Division of Gastroenterology and Hepatology Faculty Papers

BACKGROUND

Acrochorda (skin tags) are benign skin tumors that form primarily at skin creases, generally on the neck, armpit, and groin areas. There have been a small number of published studies in 1980s in patients who were found to have increased number of skin tags and colonic polyps, with a direct correlation described between the two. In addition, metabolic syndrome has been linked to adenomatous polyps, but a link between skin tags and metabolic syndrome has not been established.

Contents, Journal Editors

Journal of Food Law & Policy

No abstract provided.

Pepsin And Salivary Amylase Biomarkers Of Microaspiration In Oral And Tracheal Secretions Of Intubated Patients, Aurea Middleton

HIM 1990-2015

Introduction: The presence of an endotracheal tube (ETT) increases the risk for microaspiration of secretions around the ETT. Biomarkers of pepsin and salivary amylase may be used to identify microaspiration in intubated patients because of their naturally occurring presence in the stomach or oral cavity and non-occurrence in the respiratory tract. Microaspiration may be difficult to detect until pulmonary complications, such as lung injury or infection, occur. This study assessed the presence of pepsin and salivary amylase in oral and tracheal secretions of ventilated adults. Method(s): This is a secondary analysis of data collected from 11 critically ill, adult patients …

From The "War On Poverty" To Reagan's "New Right," What's In A Name? : The Symbolic Significance Of The "Welfare Queen" In Politics And Public Discourse., Kem Roper

Electronic Theses and Dissertations

This dissertation is a rhetorical analysis of the political discourse surrounding the role of poor African American women within the American social and political economy beginning in 1965 with Lyndon Johnson's War on Poverty initiatives and extending to the early 1980s with Ronald Reagan and the "religious right." I argue that an ideology of whiteness permeates both the Johnson and Reagan administrations even though each worked towards different ends. In Chapter 1, I begin by discussing how America's establishment as a capitalist society made it a nation ill-fitted for government-funded social programs. In particular, I discuss the impact of distinctions …

Tobacco Dependence Treatment Education For Dental Students Using Standardized Patients., Jacqueline A. Singleton 1955-

Electronic Theses and Dissertations

Dentists can play a key role in helping patients quit tobacco use by providing tobacco cessation treatment (TCT) in their practice. Although the majority of dentists receive training in TCT, most do not provide adequate intervention. Many feel they are not adequately trained. Using standardized patients (SPs) shows promise in TCT training by providing a simulated clinical environment for students to practice counseling skills with individuals trained to portray patients. Standardized patients evaluate students' skills and provide immediate feedback. The purpose of this study is to determine if there is a difference in dental students' attitudes, perceived barriers, subjective norms, …

Hyperhomocysteinemia Alters Sinoatrial And Atrioventricular Nodal Function : Role Of The Cardiac Nmda Receptor., Chirag V. Soni

Electronic Theses and Dissertations

Introduction: Hyperhomocysteinemia (HHcy) is a pathological condition characterized by excessive levels of plasma homocysteine (Hcy). Patients with HHcy are reported to be at risk for arrhythmias like atrial fibrillation and sudden cardiac death (SCD); however, the causative mechanisms remain unknown. The effects of HHcy on sinus node function, atrioventricular conduction and ventricular vulnerability were investigated by in vivo electrophysiological (EP) analysis, and the role of the cardiac N-methyl-D-aspartate receptor (NMDA-R) in promoting Hcy-induced conduction abnormalities was explored. Materials and Methods: Anesthetized wild-type control mice (WT), mice receiving Hcy in the drinking water for 12 weeks (DW), and heterozygous cystathionine-ß-synthase knockout …

Effect Of Viewing Conditions On The Detection Of Proximal Dental Caries In Intraoral Digital Images With And Without Computer-Assisted Diagnosis., Lauren Christine Szechy 1989-

Electronic Theses and Dissertations

Background: Dental caries is the most common childhood ailment and one of the most prevalent chronic diseases of people worldwide. Approximately 91% of dentate adults 20 years or older have experienced dental caries. Carious lesions on proximal surfaces are particularly difficult to detect clinically, which is why intraoral radiography has become a supplemental method used to aid diagnosis. It was hypothesized that the accuracy of detection of proximal caries with the unaided eye would be reduced in sub-optimal viewing conditions; furthermore, the use of computer-assisted diagnostic software (Logicon Caries Detector) would improve the overall accuracy of observers. Methods: Eighteen radiographs …

Finding The Brutal Aesthetic., Marcy R. Werner

Electronic Theses and Dissertations

This thesis project documents the curatorial and archival work completed using the collection of photographs, negatives, and ephemeral materials of John Ranard. This collection belongs to his estate and is currently housed at the University of Louisville. Mounting an exhibit, processing the collection, and constructing a finding aid were parts of this project. Approaching the materials with a curatorial mindset informed the arrangement of the collection, one that compliments potential future curatorial endeavors with the collection.

The Effect Of Implant Placement And Simultaneous Soft Tissue Augmentation In The Esthetic Zone Using Either Connective Tissue Autograft Or Acellular Dermal Matrix Allograft On Peri-Implant Hard And Soft Tissue Healing., Gretchen A. Wigand

Electronic Theses and Dissertations

Aims. The primary aims of this randomized, controlled, blinded clinical trial were to compare the hard and soft tissue response following either a connective tissue (CT) or acellular dermal matrix (ADM) graft placed simultaneously with a laser-grooved implant. Methods. Twenty-five patients received a single tooth implant in the maxillary anterior that was bordered by two teeth. Patients were randomly selected, using to coin toss, to receive either an ADM (test) or a CT (control) graft. At the 2-month appointment, the implant was uncovered and a lab-fabricated provisional was placed. At the 4-month appointment, following 2 months of tissue shaping, a …

Combating The Sophomore Slump Through Peer-Mentoring Among African American Students At Predominantly White Institutions., Tiffany Christina Evans

Electronic Theses and Dissertations

There is a plethora of research regarding the first year undergraduate student experience; however, 2nd year students are facing adversity and consequently high rates of attrition. This phenomenon is known as the sophomore slump. There is limited research of how the sophomore slump impacts African Americans and research supports involvement, particularly as a peer mentor, increases student persistence beyond the 2nd year. This study uses Tinto's theory of student departure and Collin's theory of other-mothering to explore how the academic and social skills of CONECT peer mentors contribute to their experiences as peer mentors and their overall persistence.

The Role Of Endogenous Bcl-Xl In Regulation Of Apoptotic Signaling Pathways., Colins Ogwandi Eno 1982-

Electronic Theses and Dissertations

Bcl-2 proteins are major regulators of cellular responses to various apoptotic stimuli. Among them, overexpression of the anti-apoptotic BcI-2 protein BcI-xL modulates organelle-specific apoptotic pathways. To understand the mechanisms by which endogenous BcI-xL regulates apoptosis, mouse embryonic fibroblasts (MEFs) deficient in BcI-xL expression (Bcl-x-KO) was generated. Studies of BcI-xL exclusively targeted to an organelle in Bcl-x-KO MEFs indicate that the mitochondria- and ER-Iocalized BcI-xL play distinct roles in apoptosis resistance and Ca2+ homeostasis. Specifically, mitochondrial BcI-xL can regulate apoptosis independently of ER BcI-xL, and when localized exclusively at the ER, BcI-xL impinges on Ca2+ homeostasis but does not affect apoptosis …

The Art Of Natality : Virginia Woolf's And Kathe Kollwitz's Aesthetics Of Becoming., Jennifer Brooke Goldberg 1973-

Electronic Theses and Dissertations

Though Virginia Woolf’s and Kathe Kollwitz's personal histories and specific cultural circumstances were quite different, their aesthetics share fundamental qualities. This dissertation demonstrates that both artists affirm memory, the maternal, and creativity as coalescent, and through doing so assert a principle of connectivity that counters the turmoil of their times. Through this constellation, Woolf’s and Kollwitz's aesthetics exude faith in the continued viability of beauty and of possibility, faith that a commitment to becoming will undermine the sources of hopelessness that enshroud the modem world. Channeling their losses into their creative endeavors, Woolf and Kollwitz appropriated crises from their pasts …

Ridge Preservation Comparing The Clinical And Histologic Healing Of An Intrasocket Allograft Vs. A Facial Overlay Xenograft Using A Bioresorbable Barrier Membrane., Evmenios Poulias

Electronic Theses and Dissertations

Aim. The efficacy of ridge preservation procedures using grafting materials and barrier membranes has been well established in the literature. However, the loss of horizontal width even with the utilization of intrasocket only guided bone regeneration procedures can lead to loss of soft and hard tissue contour or even compromise implant placement. The primary aim of this study was to compare ridge preservation using an intrasocket mineralized particulate cancellous allograft to an intrasocket mineralized particulate cancellous allograft plus a facial overlay with a particulate bovine xenograft, both covered with a bioresorbable barrier membrane. Clinical and histologic data was used to …

Iron Acquisition By The Dental Pathogen Aggregatibacter Actinomycetemcomitans., Porscha Larai Jefferson 1986-

Electronic Theses and Dissertations

The dental pathogen A. actinomycetemcomitans, a Gram- negative organism, has been associated with aggressive forms of periodontitis. A. actinomycetemcomitans requires iron to grow. In the host, iron-binding proteins such as transferrin, lactoferrin, hemoglobin, and ferritin, maintain a low free-iron concentration. Microorganisms, however, have evolved complex systems to efficiently harvest iron. The iron acquisition systems encoded in the genome of A. actinomycetemcomitans are likely tailored towards the specific survival strategies needed to survive in the oral biofilm. The objectives of this project were to determine the growth of A. actinomycetemcomitans in different iron sources and to examine the expression of the …

Review Of Casino Women: Courage In Unexpected Places. Susan Chandler And Jill B. Jones. Reviewed By Jennifer Zelnick, Jennifer Zelnick

The Journal of Sociology & Social Welfare

Book review of Susan Chandler & Jill B. Jones, Casino Women: Courage in Unexpected Places (2011). New York: Cornell University Press. $29.95 (hardcover).

Morphological Comparison Of Visual Pathway Projections To The Temporal Lobe From Cortical Area Vi And The Tectorecipient Zone Of The Pulvinar Nucleus In The Tree Shrew (Tupaia Belangeri)., Donna Dillihay

Electronic Theses and Dissertations

The secondary visual pathway, from the retina through the superior colliculus and pulvinar nucleus has been linked to spatial attention (Snow et aI., 2009; Arend et aI., 2008) movement planning and motor response to visual stimuli (Wilke et aI. 2010; Grieve et aI. 2000). The tree shrew temporal cortex receives input from the tecto-recipient pulvinar nucleus, composed of the dorsal (PD) and central (PC) subdivisions (Lyon et al. 2003a). We looked at the projections from this pathway to the temporal cortex and compared them to the VI projections to the temporal cortex in the tree shrew. Our focus was to …

Valuing Privacy, Youngjae Lee

Fordham Law Review

No abstract provided.