Digital Commons Network^™

International Day Of Persons With Disabilities, Unh Communications And Public Affairs

UNH Today Archive

No abstract provided.

The P2y(12) Antagonists, 2mesamp And Cangrelor, Inhibit Platelet Activation Through P2y(12)/G(I)-Dependent Mechanism, Binggang Xiang, Guoying Zhang, Hongmei Ren, Manjula Sunkara, Andrew J. Morris, T. Kent Gartner, Susan S. Smyth, Zhenyu Li

Saha Cardiovascular Research Center Faculty Publications

BACKGROUND: ADP is an important physiological agonist that induces integrin activation and platelet aggregation through its receptors P2Y(1) (Gα(q)-coupled) and P2Y(12) (Gα(i)-coupled). P2Y(12) plays a critical role in platelet activation and thrombosis. Adenosine-based P2Y(12) antagonists, 2-methylthioadenosine 5'-monophosphate triethylammonium salt hydrate (2MeSAMP) and Cangrelor (AR-C69931MX) have been widely used to demonstrate the role of P2Y(12) in platelet function. Cangrelor is being evaluated in clinical trials of thrombotic diseases. However, a recent study reported that both 2MeSAMP and Cangrelor raise intra-platelet cAMP levels and inhibit platelet aggregation through a P2Y(12)-independent mechanism.

METHODOLOGY/PRINCIPAL FINDINGS: The present work, using P2Y(12) deficient mice, sought to …

The Adverse Effects Periodontal Disease Has On Women, Jennifer Long

Honors Theses

The Adverse Effects Periodontal Diseases Has on Women Periodontal diseases are challenging to define given the number and variety of different oral diseases. This review sought to answer the question: How does a periodontal disease impact a woman throughout the life span? Specifically, this document discussed how, because of the cycling hormones and the effects those hormones have on the different bacteria, women's periodontal diseases differ from men's. Diseases of the mouth were first discovered during the Egyptian period and the information and knowledge about the different diseases advanced as time progressed. From here, non-surgical and surgical treatments were discussed …

Reactive Oxygen Species Production And Brugia Pahangi Survivorship In Aedes Polynesiensis With Artificial Wolbachia Infection Types, Elizabeth S. Andrews, Philip R. Crain, Yuqing Fu, Daniel K. Howe, Stephen L. Dobson

Entomology Faculty Publications

Heterologous transinfection with the endosymbiotic bacterium Wolbachia has been shown previously to induce pathogen interference phenotypes in mosquito hosts. Here we examine an artificially infected strain of Aedes polynesiensis, the primary vector of Wuchereria bancrofti, which is the causative agent of Lymphatic filariasis (LF) throughout much of the South Pacific. Embryonic microinjection was used to transfer the wAlbB infection from Aedes albopictus into an aposymbiotic strain of Ae. polynesiensis. The resulting strain (designated "MTB") experiences a stable artificial infection with high maternal inheritance. Reciprocal crosses of MTB with naturally infected wild-type Ae. polynesiensis demonstrate strong bidirectional incompatibility. Levels of reactive …

Negotiating In Business, Politics And Peace, George J. Mitchell

Joan B. Kroc Distinguished Lecture Series

Table of Contents

Joan B. Kroc School of Peace Studies, University of San Diego
Kroc Institute for Peace and Justice – p. 3
Joan B. Kroc Distinguished Lecture Series – p. 4
Biography of Senator George J. Mitchell – p. 7
Welcome to Lecture – Edward C. Luck, PhD – p. 8
Introduction of Speaker – Julie H. Sullivan, PhD – p. 9
Lecture – Negotiating in Business, Politics and Peace – p. 10
Questions and Answers – p. 20
Related Resources – p. 26

Rethinking Information Literacy In A Globalized World, Laurie Kutner, Alison Armstrong

Communications in Information Literacy

As a profession, librarians have an important and unique role to play in higher education in producing information literate students equipped to be successful in a complex, twenty-first century global society. It is our contention that our guiding professional information literacy definitions and standards need to be reconsidered in order to remain relevant within the global learning context. Our preliminary conclusion is that the predominantly skills-based approach facilitated by the current ACRL Information Literacy Competency Standards for Higher Education, is not sufficient to facilitate teaching of twenty-first century "deep information literacy," which we feel encompasses additional content-based engagement with the …

Minutes From The December 6, 2012 Meeting Of The University Of Montana Faculty, University Of Montana--Missoula. Faculty

University of Montana Faculty Senate Meeting Minutes

Meeting minutes from the December 6, 2012 meeting of the University of Montana faculty.

Binding Of An Indenoisoquinoline To The Topoisomerase-Dna Complex Induces Reduction Of Linker Mobility And Strengthening Of Protein-Dna Interaction., Giordano Mancini, Ilda D'Annessa, Andrea Coletta, Giovanni Chillemi, Yves Pommier, Mark S. Cushman, Alessandro Desideri

Borch Department of Medicinal Chemistry and Molecular Pharmacology Faculty Publications

Long-duration comparative molecular dynamics simulations of the DNA-topoisomerase binary and DNA-topoisomerase-indenoisoquinoline ternary complexes have been carried out. The analyses demonstrated the role of the drug in conformationally stabilizing the protein-DNA interaction. In detail, the protein lips, clamping the DNA substrate, interact more tightly in the ternary complex than in the binary one. The drug also reduces the conformational space sampled by the protein linker domain through an increased interaction with the helix bundle proximal to the active site. A similar alteration of linker domain dynamics has been observed in a precedent work for topotecan but the molecular mechanisms were different …

Diverse Lifestyles And Strategies Of Plant Pathogenesis Encoded In The Genomes Of Eighteen Dothideomycetes Fungi., Robin A. Ohm, Nicolas Feau, Bernard Henrissat, Conrad L. Schoch, Benjamin A. Horwitz, Kerry W. Barry, Bradford J. Condon, Alex C. Copeland, Braham Dhillon, Fabian Glaser, Cedar N. Hesse, Idit Kosti, Kurt Labutti, Erika A. Lindquist, Susan Lucas, Asaf A. Salamov, Rosie E. Bradshaw, Lynda Ciuffetti, Richard C. Hamelin, Gert H.J. Kema, Christopher Lawrence, James A. Scott, Joseph W. Spatafora, B Gillian Turgeon, Pierre J.G.M. De Wit, Shaobin Zhong, Stephen B. Goodwin, Igor V. Grigoriev

Department of Botany and Plant Pathology Faculty Publications

The class Dothideomycetes is one of the largest groups of fungi with a high level of ecological diversity including many plant pathogens infecting a broad range of hosts. Here, we compare genome features of 18 members of this class, including 6 necrotrophs, 9 (hemi)biotrophs and 3 saprotrophs, to analyze genome structure, evolution, and the diverse strategies of pathogenesis. The Dothideomycetes most likely evolved from a common ancestor more than 280 million years ago. The 18 genome sequences differ dramatically in size due to variation in repetitive content, but show much less variation in number of (core) genes. Gene order appears …

The Cowl - V.77 - N.12 - Dec 6, 2012

The Cowl

The Cowl - student newspaper of Providence College. Vol 77 - No. 12 - December 6, 2012. 32 pages.

My Beautiful, Jacquetta Harvey

Theses and Dissertations

In creating my work I use bold, bright colors and fundamental shapes and patterns. My images reflect how I view the world and genuinely express my imagination, feelings, and thinking. Working this way allows me to apply a symbolic face to personal concerns, beliefs, fears, ideologies, and philosophies. I see a world where life and art blend to create images of triumph and tragedy, joy and pain, or growth and change. My ideas have grown from the desire to understand myself as a woman, as a Christian, and as a unique individual. Dealing with personal questions, I explore the varying …

Disability Work Gives Occupational Therapy International Exposure, Unh Communications And Public Affairs

UNH Today Archive

No abstract provided.

Waidelich V. Wengler Respondent's Brief 1 Dckt. 40019

Not Reported

No abstract provided.

Notes From The Field: 10 Short Lessons On One-Shot Instruction, Megan Oakleaf, Steven Hoover, Beth Woodard, Jennifer Corbin, Randy Hensley, Diana Wakimoto, Christopher V. Hollister, Debra Gilchrist, Michelle Millet, Patty Iannuzzi

Communications in Information Literacy

Librarians teach. It might not be what they planned to do when they entered the profession, or it may have been a secret hope all along. Either way, librarians teach, and one teaching scenario remains quintessential: the one-shot library instruction session. In recognition of the centrality of the "one-shot," this article shares several authors' "notes from the field." The notes provide a range of strategies for developing pedagogically sound one-shot library instruction sessions, grouped loosely into three categories: planning, delivery, and integration. The authors offer these insights in their own words in hopes that other teaching librarians may benefit from …

Information Literacy On The Web: How College Students Use Visual And Textual Cues To Assess Credibility On Health Websites, Katrina L. Pariera

Communications in Information Literacy

One of the most important literacy skills in today's information society is the ability to determine the credibility of online information. Users sort through a staggering number of websites while discerning which will provide satisfactory information. In this study, 70 college students assessed the credibility of health websites with a low and high design quality, in either low or high credibility groups. The study's purpose was to understand if students relied more on textual or visual cues in determining credibility, and to understand if this affected their recall of those cues later. The results indicate that when viewing a high …

Collaboration And Problem-Based Learning: Integrating Information Literacy Into A Political Science Course, Peg Cook, Mary Barbara Walsh

Communications in Information Literacy

This paper details the collaborative efforts of a reference librarian and a political science professor to seamlessly meld the study of politics with the acquisition of information literacy skills using a problem-based learning approach. Students in an introductory American Government class were engaged in a group project in which they acted as media consultants for the political candidate of their choice. Two information literacy sessions were embedded into the project. ACRL Information Literacy Standards were used to generate and assess performance outcomes. Student feedback, as well as pre-test and post-test results, indicate that a problem-based approach to enhancing information literacy …

Microflora Of Traditional Mexican Corn Masa And Its Effect On Folic Acid Degradation, Stephen J. Adolphson

Theses and Dissertations

Many Mexican women consume inadequate amounts of folic acid. Fortification of the corn tortilla could be an effective way to help increase the folic acid levels among the Mexican population. Previous studies have shown significant folic acid losses in fortified tortilla dough (masa) as it is held before baking. This loss in folic acid could be due to degradation by lactic acid bacteria naturally present in the masa. The microflora of traditionally made nixtamalized corn masa from six tortilla mills in Guadalajara, Mexico were isolated and characterized, and their effect on folic acid content was evaluated. Isolated bacteria were identified …

The Eastern Echo, December 6, 2012, Eastern Michigan University

EMU Student Newspaper: The Normal News & The Eastern Echo

No abstract provided.

The Eastern Echo, December 6, 2012, Eastern Michigan University

EMU Student Newspaper: The Normal News & The Eastern Echo

No abstract provided.

The Eastern Echo, December 6, 2012, Eastern Michigan University

EMU Student Newspaper: The Normal News & The Eastern Echo

No abstract provided.

Westerner, December 6, 2012, Western New England University

Student Newspapers

The official student newspaper of Western New England University

Modernization, Sexual Risk-Taking, And Gynecological Morbidity Among Bolivian Forager-Horticulturalists, Jonathan Stieglitz, Aaron D. Blackwell, Raúl Quispe Gutierrez, Edhitt Cortez Linares, Michael Gurven, Hillard Kaplan

ESI Publications

Sexual risk-taking and reproductive morbidity are common among rapidly modernizing populations with little material wealth, limited schooling, minimal access to modern contraception and healthcare, and gendered inequalities in resource access that limit female autonomy in cohabiting relationships. Few studies have examined how modernization influences sexual risk-taking and reproductive health early in demographic transition. Tsimane are a natural fertility population of Bolivian forager-farmers; they are not urbanized, reside in small-scale villages, and lack public health infrastructure. We test whether modernization is associated with greater sexual risk-taking, report prevalence of gynecological morbidity (GM), and test whether modernization, sexual risk-taking and parity are …

Can Public Education Be Saved? An Argument For Educational Reform, Kathrine Hyatt

Honors Theses

Education, a key to later success, needs to be the number one priority. However, the American of public education has many systemic problems that are inhibiting children from reaching their full potential. This literature review first examines the colonial roots of American education and briefly tracks the development. Then, four major systemic problems are addressed: the over reliance on standardized testing, teaching methods and curriculum, lack of creativity, and how the cycle of poverty impacts learning. Finally solutions are discussed, with the ultimate recommendation being to adapt the Montessori Method.

The Effects Of Climate Change And Overexploitation On Birds And Mammals: Phenological Shifts, Range Shifts, And Population Changes, Rachel Denny

Honors Theses

Our world is changing more than many individuals could imagine. Climate change is not a hoax. Comprehensive empirical records of changes since 1900 in local, regional, and global temperature clearly indicate that Earth is warming more rapidly than ever in recorded history. In response, some bird species are already shifting, both phenologically (timing) and geographically. However, the majority of birds are not shifting or not shifting fast enough, and this is resulting in population declines. A much smaller number of studies suggest that mammals are also shifting phenologically and geographically.

If we do not alter our current behaviors soon, Earth …

Selection Of Trna Charging Quality Control Mechanisms That Increase Mistranslation Of The Genetic Code, Srujana S. Yadavalli, Michael Ibba

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Mistranslation can follow two events during protein synthesis: production of non-cognate amino acid:transfer RNA (tRNA) pairs by aminoacyl-tRNA synthetases (aaRSs) and inaccurate selection of aminoacyl-tRNAs by the ribosome. Many aaRSs actively edit non-cognate amino acids, but editing mechanisms are not evolutionarily conserved, and their physiological significance remains unclear. To address the connection between aaRSs and mistranslation, the evolutionary divergence of tyrosine editing by phenylalanyl-tRNA synthetase (PheRS) was used as a model. Certain PheRSs are naturally error prone, most notably a Mycoplasma example that displayed a low level of specificity consistent with elevated mistranslation of the proteome. Mycoplasma PheRS was found …

A Lack Of Willpower May Influence A Leader’S Ability To Act Morally, Tom Karp

The Journal of Values-Based Leadership

Acts of moral leadership do not come without risks of loss of employment, a lessening of personal stature, and compromised mental and physical wellbeing. Thus, the quest to act as a values-based leader necessarily commands the exercise of unfettered willpower and a tenacious willingness to assume such risks.

Appalachian Farmers: Building Value From Values, Natalie Shubert, Amy Taylor-Blanco, Ana L. Rosado Feger

The Journal of Values-Based Leadership

This trio of authors has presented a microcosm of values-based shared business practices, involving local food production and distribution in a small, rural Appalachian region in the United States. They focus upon the collective activities of a group committed to advancing local business practices while eliminating unnecessary transportation costs, boosting the region’s economic infrastructure, and most importantly, bringing people together to share experiences and pass along knowledge designed to benefit their communities and generate a sustainable agricultural-based economy.

Ethical Governance In The Indian Construction Industry: A Case Study Of Larsen & Toubro Ltd., Shashank Shah

The Journal of Values-Based Leadership

Governance has moved beyond mere fulfilment of legal requirements. The corporate debacles of the last decade and more have indicated how very respectable corporate organisations across the globe succumbed to greed and compromised on ethics and organisational value systems. Corporate Governance is mainly concerned with the intrinsic nature, purpose, integrity, and identity of an organisation. It encompasses the entire gamut of organisational stakeholders. While a lot of literature is available in the field of Corporate Governance, an analysis of corporate organisations in terms of their stakeholder-related initiatives has hitherto not been attempted. In this paper, the author has used the …

Corporate Political Spending: Why Shareholders Must Weigh In, Julie N.W. Goodridge, Christine Jantz

The Journal of Values-Based Leadership

This article focuses upon the growing problem confronting companies and their shareholders: the use of general treasury (i.e., shareholder money) to propagate political agendas which are not only contrary to companies’ policies of employment, but are committed without the input or knowledge of the shareholder, leading to an aura of distrust, alienation, and diminution of both shareholder value and principled leadership.

Value Shifts: Redefining “Leadership” A Narrative, Joseph Hester

The Journal of Values-Based Leadership

This article provides a historical narrative documenting the major rifts and shifts in the concept of “value” in the 20th and 21st centuries. It is the author’s contention that these shifts have confused the conceptualization of value, making it a rather broad and meaningless term. Thus, to define “leadership” as “values- or ethically-based,” one must first provide a substantial defense of a particular moral view upon which leadership is want to be situated. This task is made arduous because “value” and “morals” have become confused in the morass of postmodernism and its political correlate, political correctness.