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Lmw-E Mediates Mammary Tumorigenesis By Deregulating Acinar Morphogenesis & Generating Cancer Stem Cells, Mylinh T. Duong

Dissertations and Theses (Open Access)

Cyclin E is the regulatory subunit of the cyclin E/CDK2 complex that

mediates the G1-S phase transition. N-terminal cleavage of cyclin E by elastase in

breast cancer generates two low molecular weight (LMW) isoforms that exhibit both

enhanced kinase activity and resistance to p21 and p27 inhibition compared to fulllength cyclin E. Clinically, approximately 27% of breast cancer patients overexpress

LMW-E and associate with poor survival. Therefore, we hypothesize that LMW-E

disrupts normal mammary acinar morphogenesis and serves as the initial route into

breast tumor development. We first demonstrate that LMW-E overexpression in

non-tumorigenic hMECs is sufficient to induce tumor …

Assessments Of An Exogenous Proteolytic Enzyme In Beef Steer Diets To Improve Growth Performance And Ruminal Fermentation, Juan Manuel Vera

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

A series of experiments were conducted to investigate the effects of adding an exogenous proteolytic enzyme (EPE) on growth performance and ruminal fermentation characteristics of beef steers fed growing and finishing diets containing 30% dried distillers grains with solubles (DDGS).

In the first experiment, 48 beef steers were divided into two treatments: DDGS diets with and without EPE. Dry matter intake (DMI) was increased (P = 0.02) by the addition of EPE, but neutral detergent fiber (NDF) digestibility was decreased on the growing phase. For the finishing phase, average daily gain ( …

Prairie Bound: How Laura's Past Forged My Future, Lori J. Houston

Theses and Dissertations - UTB/UTPA

This work of creative non-fiction seeks to explore my past at the same time as I explore the past of a favorite childhood author, Laura Ingalls Wilder. This exploration took the form of a road trip with my father to visit the sites written about in Laura’s books. I found that Laura’s life appealed to me because it represented an insular security that I felt I needed, and that was why I chose, as a child, to immerse myself in the 1880’s. While finding out what she meant to me then, I also discovered that Laura is an even better …

The Critical Rumble: Marinetti, Benjamin, And The Politics Of Gastroaesthetics In Modernity, Kelly Rae Aldridge

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This paper initiates an investigation into the aesthetic spaces surrounding comestibility and potability. Throughout the Western philosophic tradition, eating and drinking have been subject to dismissal on the grounds of the corporeality, subjectivity, and temporality implicit in the consumptive act. After briefly tracing the systematic marginalization of both the properties and pleasures of food and drink throughout the development of art discourse, this paper will turn two unlikely contemporaries, F.T. Marinetti and Walter Benjamin, who shared an interest in the potential revolutionary ramifications of food to expand the category of aesthetic experience and to radically thrust corporeality and temporality into …

Epigenetic Regulations And Promoter Characterization Of Cerig (Cancer Endoplasmic Reticulum Gene-Kiaa1199), Cem Kuscu

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Although human genome project is complete, the biological function of most genes remains obscure. In this thesis project, the regulatory mechanisms of a novel endoplasmic reticulum (ER) resident protein identified by a PCR-subtraction hybridization technique, designated as Cancer ER Invasion Gene (CERIG), is investigated. CERIG is found to be highly expressed in human invasive breast cancer specimens examined by immunohistochemistry and real-time RT-PCR. This up-regulation of CERIG is associated with poor prognosis of patients with breast cancer assessed by a DNA microarray data-mining approach from three publicly available cohorts containing a total of 696 breast cancer patients. In study of …

Philosophy And Satire Back To Back: On Edouard Manet's Philosopher With Oysters And Other Beggar-Philosohers, Olga Sergeevna Lomshakova

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This thesis explores two genres of visual representation, philosophy and satire, as interconnected emanations of visuality/discourse conundrum and as related to art historical interpretations of the modern painter Edouard Manet. Particular attention is given to his painting called "Philosopher With Oysters" among a small series of works called "beggar-philosophers" and the numerous single-figure portraits that Manet painted. The iconography of sources, technical specifications and aesthetic intentions of Manet's works are discussed with reference to an old and rich tradition of depicting the ancient philosophers Democritus and Heraclitus, known as "the laughing and crying couple." Ultimately, this thesis aims to disclose …

The Impact Of Celebrity Endorser Type And Source Credibility On The Advertising Attitudes And Purchase Intentions Of Indian Rural Consumers, Sidharth Muralidharan

Dissertations

India is among the fastest growing economies in the world and has the second largest population out of which 70% are considered rural. The rural consumer has witnessed a lifestyle shift wherein they have become brand conscious, consumption of media content has increased and a rising income has opened up possibilities never experienced before. Understanding the love for cinema, celebrity endorsement has become a popular marketing strategy being employed by advertisers in India. The purpose of this study was to find out which celebrity endorser type (national, regional or non-celebrity) was the most effective on rural consumer’s attitude toward the …

What’S In A Test? Constructions Of Literacy And Its Implications For English Proficiency Test Design, Josye Marie Brookter

Dissertations

Although college-level composition pedagogy is becoming more open to language diversity, some crucial current-traditional vestiges remain, particularly in proficiency exams. Too often these exams only identify students who are slipping through the cracks of literacy instruction, while the definition of English represented by this test limits alternate notions of writing and literacy. The test represents local, institutional values about written English, although those values must also be consistent with national standards. Typically, administrators, teachers, and students feel compelled to choose traditional forms of writing over postmodern ones, a choice that is seldom discussed in the literature. Conflicting perspectives of English …

Ideological “Smackdown”: A Textual Analysis Of Class, Race And Gender In Wwe Televised Professional Wrestling, Casey Brandon Hart

Dissertations

The focus of this study is an in-depth intertextual examination of how the WWE in 2010 and by extension contemporary professional wrestling in general represents a microcosm of modern cultural ideology. The study examines three major areas in which this occurs. The first of these areas is that of class values. This section focuses on the establishment and extension middle-American values, defined as those values generally shared by the middle-class of the United States. The second section of this study focuses on how the WWE uses racial commodification in the treatment of people of color. Using concepts of Marxist power …

Exploring Hope And Quality Of Life: A Proposal For A Group Art Therapy Hope Intervention For Individuals Diagnosed With Lupus, Paige Scheinberg

EVMS School of Health Professions Theses & Dissertations

As a result of the importance of hope and quality of life in disease management for individuals who have been diagnosed with lupus, there is support in the literature for the need for an effective intervention that targets these constructs with this population. The efficacy of art therapy in meeting the physical, mental, and emotional needs of diverse populations is also supported in existing research, making this an ideal form of treatment for lupus patients. In an effort to fill a gap in the literature on the relationship(s) between lupus, hope, and art therapy, this study was created. The original …

Cultural Competence In The Baccalaureate Degree Nursing Curriculum, Angela Elizabeth Silvestri

UNLV Theses, Dissertations, Professional Papers, and Capstones

Health care providers are members of a helping profession and need to provide quality care to all members of society. As a result of current and projected demographic changes within the United States (U.S.), health care professionals are faced with the challenges of providing culturally competent care and fulfilling the role as the "helping profession." In the past 10 years, minority populations have increased in the U.S. For example, the African American population experienced an approximate 12.3% increase, and the Hispanic population increased by 43%. Just as it is necessary for health care professionals to respond to the increase in …

Leveling The Playing Field: Curriculum Studies And Fast Pitch Softball, Melinda M. Roberts

College of Graduate Studies: Theses & Dissertations

Women in sport challenge our cultural assumptions about gender and sexuality. Athletics has been viewed as a male domain, with its emphasis on strength, agility, competition, intellect, and aggression. To play sports, women are pressured to maintain and emphasize their femininity without appearing overly aggressive or possessing masculine traits associated with sport, particularly in the team sport of softball. This research examines the expectations a patriarchal society places on young women who play sports competitively and how such expectations with regards to femininity in both behavior and appearance influence a young female athlete's identity formation. Through the lenses of gender …

The Value Of Literary Journalism: Searching For Truths Through An Objective/Subjective Dialectic, Omar Rodriguez

Theses and Dissertations - UTB/UTPA

Literary Journalism is a hybrid genre that combines literary devices with advanced journalistic techniques to create nonfiction narratives. The distinctive qualities of literary journalism, working in addition to so-called objective approaches of conventional journalism, provide the reader with an alternative observation of specific social phenomena. In the introduction, issues revolving around the genre will be discussed followed by the introduction of the objective/subjective dialectic thus formulating my thesis that insists combining the two approaches allows the reader to see truth beyond ideology. The three chapters that follow offer readings of three key and representative works of literary journalism. The Armies …

Organizational Citizenship Behavior, Collectivism, And Job Satisfaction: Evidence From Mexico, Miguel Angel Baeza

Theses and Dissertations - UTB/UTPA

The purpose of this dissertation was to conduct a field study in a Mexican company in several Mexican regions. This study considered administrative professionals as a continuation to assess the validity of a recently developed Mexican Border OCB (MBOCB) scale by Ortiz (2000). This validation/refinement of an MBOCB scale was accomplished by comparing and contrasting results of this investigation, given the name of Mexican OCB (MOCB), with other OCB dimensions studies in other regions in order to evaluate criterion validity (e.g., convergent and discriminat) through factor loadings. Furthermore, this dissertation categorized these MOCB dimensions into more conceptualized terms utilized by …

Reclaiming The Sacred Within The Legal Pluralism Phenomenon: Ndigenous People's Rights Over Cultural Property, Angela Mae C. Buenafe

Department of Anthropology: Theses and Student Research

Indigenous Peoples’ (IPs’) collective rights over their sacred and cultural properties are inherent human rights recognized in international declarations like the United Nations’ Declaration on the Rights of Indigenous Peoples (UN-DRIP) and the International Covenant on Economic, Social and Cultural Rights (ICESCR). The incorporation of these international declarations’ standards within the United States (US) and Philippine federal laws conflicts with the attainment of Indigenous Peoples’ collective rights to protect and preserve Indigenous Peoples’ sacred cultural properties. Through a critical and Indigenous methodological framework of legal pluralism, this study describes how the Omaha sacred (medicine) bundle and the Ifugao sacred bulul …

Evidence Of Anxiety: Women's Agency And Engagement Law In American Literature And Film, 1880-1935, Carl Nicholas Bloom

Dissertations

During the end of the nineteenth century, breach of promise laws, which had protected unmarried but engaged women for centuries during their vulnerable engagement period, began to come under public scrutiny. The demonization of this legal protection coincided with increased legal agency in other areas of married life for women, but in most historical and critical discussions of this era, breach of promise, also nicknamed Heartbalm, has been overlooked, and the purpose of this dissertation is to examine canonical and non-canonical literature from this period and recontextualize these works in light of breach of promise's historical impact on courting and …

Biology, Histopathology, And Improvements In Axenic Culture Of Labyrinthula Terrestris, Causal Agent Of Rapid Blight Of Cool-Season Turfgrasses, Kirthi Kiran Yadagiri

All Dissertations

Rapid blight is a disease of cool-season turfgrasses caused by Labyrinthula terrestris. Disease symptoms include water-soaked lesions, yellowing and browning of foliage, and coalescing patches of dead turf. L. terrestris belongs to a group of marine microorganisms in the kingdom Chromista (also known as Stramenopila). Morphological characteristics of Labyrinthula spp. include spindle-shaped vegetative cells that move in an ectoplasmic network. The biology and pathology of L. terrestris is not clearly understood; therefore, the ultrastructure, life cycle, and histopathology of L. terrestris were investigated. In addition, improvements in axenic culture and long-term storage methods were made to better culture L. terrestris. …

Nanopillar Based Electrochemical Biosensor For Monitoring Microfluidic Based Cell Culture, Rajan Gangadharan

All Dissertations

In-vitro assays using cultured cells have been widely performed for studying many aspects of cell biology and cell physiology. These assays also form the basis of cell based sensing. Presently, analysis procedures on cell cultures are done using techniques that are not integrated with the cell culture system. This approach makes continuous and real-time in-vitro measurements difficult. It is well known that the availability of continuous online measurements for extended periods of time will help provide a better understanding and will give better insight into cell physiological events.
With this motivation we developed a highly sensitive, selective and stable microfluidic …

Internationalization Into The Gcc: Singapore In Retrospect, Caroline Yeoh, Wilfred Pow Ngee How, Hong Hao Chong

Research Collection Lee Kong Chian School Of Business

As internationalization becomes, increasingly, the chosen method of (ironically) competing for competitiveness among firms, new and rich frontiers for business come into ever-expanding demand. Among the foremost of these frontiers, the countries of the GCC represent both fertile ground and uncharted waters for internationalizing firms, with cultures as rich as their markets and sometimes byzantine yet fascinating socio-political forces presenting a plethora of challenges to erstwhile investing firms. As a culmination of our research into this region over past years, then, we examine in this paper, as a case study of sorts, the experiences of Singapore firms in the various …

Negotiating Islam With Cinema; A Theoretical Discussion On Indonesian Islamic Films, Ahmad Nuril Huda

Wacana, Journal of the Humanities of Indonesia

This paper aims at exploring certain negotiations that justify Muslim's cinematic texts and practices. It focuses on the questions about what is Islamic and un-Islamic about film, who and what decides certain films as Islamic, and what are the meanings of cinematic practices of Islam for Muslim society. Furthermore, this paper tries to investigate these questions from a theoretical basis using concepts of Islamic modernity, Islamic Ummah and Public, in order to shed some light on the idea of how a production of an Islamic film may trigger the creation of a political and religious identity.

College Of Education News, College Of Education, Georgia Southern University

College of Education: News & Publications (2003-2023)

• American Educational Research Association

Examining Leader-Member Exchange As A Moderator Of The Relationship Between Emotional Intelligence And Creativity Of Software Developers, Kyootai Lee, Terry Scandura, Youngkyun Kim, Kailash Joshi, Jooyeoun Lee

Ed G. Smith College of Business Faculty Works

This paper investigates how leader-member exchange (LMX) and emotional intelligence (EI) are associated with employees’ creativity in high-tech firms. We develop a model that considers LMX and EI as predictors of creativity with LMX as a boundary condition for the relationship between EI and creativity. Results reveal that LMX is a strong predictor of creativity. However, EI does not directly affect creativity. More interestingly, the interaction between EI and LMX negatively influences creativity such that EI is detrimental for creativity only when LMX is high. Thus, the role of LMX for employees’ creativity may be paradoxical. Further, the positive role …

V. 79, Issue 18, April 27, 2012

Archway (1946-2020)

No abstract provided.

Incorporating Hispanic Culture Into A Secondary Instrumental Classroom, Alexander Armstead

Honors Theses

For much of history, there has been a long-standing belief of the superiority of Western art music; that it is more natural, complex, expressive, and meaningful than other musics. This standpoint is being challenged more than ever as advances in musicology, ethnomusicolgy, global communication and media bring musics of other nations and cultures to the doorstep of the American people. There are many benefits to teaching cultural music in the instrumental classroom, including social and musical components. These components have the ability to open the minds of students to a higher sense of community as they enter the "world village" …

Parental Advisory Explicit Lyrics: A Case Study Of Music Censorship And Suppression In America, Nathaniel T. Belcik

Young Historians Conference

The paper talks about music censorship in the 1980s, specifically the PMRC hearings in 1985. The paper looks at the anti-Rock movement of the 1980s and the Parents Music Resource Center, an organization that wanted warning labels placed on albums. The paper examines the motives of the PMRC and opposition to their proposals from famous musicians. The thesis of the paper is that the PMRC's proposals were adopted by the RIAA because the RIAA wanted to get a tax on cassettes passed and the negative publicity over explicit music was hurting their efforts to get the tax passed.

Minutes, Arts & Sciences Faculty Meeting, Thursday, April 26, 2012, Arts & Sciences Faculty

The College of Liberal Arts Faculty Minutes

No abstract provided.

Ecowomanist Endeavors: Race, Gender, And Environmental Ethics In Contemporary Caribbean Women's Literature, Debbie-Ann C. Morrison

Open Access Dissertations

This dissertation examines the intersections of gender, sexuality, community, landscape, ecology, and social justice as they appear in selected literary texts by contemporary Caribbean women writers. Beginning with an awareness of the various ecological crises enveloping the Caribbean as well as a firm belief that an analysis of literature might reveal inherent values regarding ecological sustainability and the need for propagating environmentally ethical practices throughout the region, the project uses Alice Walker’s notion of womanism to craft what it calls an “ecologically womanist” reading of texts by Lorna Goodison, Olive Senior, Jamaica Kincaid, Mayra Montero, Dionne Brand, and Pauline Melville. …

Searching For A Father, Lewis Stafford

Research Papers

SEARCHING FOR A FATHER explores the lives of two African American men who grew up in broken homes. This documentary will emphasize that time is critically important from childhood to adulthood by profiling two African Americans around the very pressing themes of why African American fathers leave home. This film will allow the two African American men to discuss their lives in whatever way they see fit to explain and share their stories about their fathers and the role models that they found to replace their father figures

A Perspective On Scale Development In Entrepreneurship Research, Alenka Slavec, Mateja Drnovšek

Economic and Business Review

To develop a measurement scale that would lead to valid and reliable results is a tasking goal in any research field. We build from theoretical findings that are advanced in the measurement and scale development theory to review the type of measures used and scale development procedures of measures reported in top-tier entrepreneurship journals during the years 2009 and 2010. The in-depth review showed that not all steps in scale development in entrepreneurship research are always accomplished although every step is crucial when aiming for a sound measure. Additionally, the study showed that all too often measures, that have not …

Korean And American Leadership Styles In Business, Diana Estes

Senior Honors Theses

Korea and the USA have recently proceeded in efforts to become closer trading partners through the passing of the United States-Korea Free Trade Agreement (KORUS) and FTAs. More economic integration calls for a stronger understanding of the influences of each other’s cultures. Whether culture influences leadership style or not will be explored. Major influences include history, philosophy, and religion. The meaning of leadership and the characteristics of both of the cultures will succeed after the discussion of the major facets of culture. The application of the cultures and leadership in a business setting will be evaluated and explored. Sources will …