Digital Commons Network^™

Understanding How The Platinum Anticancer Drug Carboplatin Works: From The Bottle To The Cell, Anthony J. Di Pasqua, Jerry Goodisman, James C. Dabrowiak

Chemistry - All Scholarship

Carboplatin, a platinum anticancer drug used to treat many types of human cancer, contains a bidentate dicarboxylate chelate leaving ligand, a structural feature that makes it much less chemically reactive than the first-generation platinum anticancer drug cisplatin, which contains two monodentate chloride leaving ligands. In water, carboplatin exists in a monomer-dimer equilibrium with an association constant of K (M ^-1) ≈ 391, a property that accounts for the long-term stability of its ready-to-use infusion solution. When administered in the clinic, carboplatin is believed to exert its biological effects by interacting with genomic DNA and proteins. The slower substitution kinetics …

Understanding How The Platinum Anticancer Drug Carboplatin Works: From The Bottle To The Cell, Jerry Goodisman, James C. Dabrowiak, Anthony J. Di Pasqua

Chemistry - All Scholarship

Carboplatin, a platinum anticancer drug used to treat many types of human cancer, contains a bidentate dicarboxylate chelate leaving ligand, a structural feature that makes it much less chemically reactive than the first-generation platinum anticancer drug cisplatin, which contains two monodentate chloride leaving ligands. In water, carboplatin exists in a monomer–dimer equilibrium with an association constant of K (M⁻¹) ≈ 391, a property that accounts for the long-term stability of its ready-to-use infusion solution. When administered in the clinic, carboplatin is believed to exert its biological effects by interacting with genomic DNA and proteins. The slower substitution kinetics …

Familiares Y Amigos [10th Grade], Leah A. Morton-Gittens

Understanding by Design: Complete Collection

This unit addresses two enduring understandings: cultures evolve over time and who we become is dependent on where we live. Students will demonstrate mastery of knowledge and skills through the creation of an illustrated brochure for a summer study abroad program that compares a Spanish-speaking city or region of their choice to New Orleans. The unit addresses all five categories of National Standards in Foreign Language Education (Communication, Culture, Connections, Comparisons, and Communities), and features a variety of cooperative and communicative learning strategies.

Negotiating Relationships And Intimacy: Bangladeshi Female Migrant Workers In Malaysia, K. Chakraborty

Research Publications (2011 to 2015)

This paper will review the context of female Bangladeshi migrant workers in Malaysia. The paper begins by reviewing position of women in Bangladeshi society. This exploration points to the possibilities of a negative reputation when women do venture overseas to work. Then the paper investigates the historical background of Bangladeshi migration to Malaysia. This investigation shows that migration is a highly gendered discourse in both countries. Moreover post-modern policies in Bangladesh and Malaysia have problematized ‘women workers’ in many ways. The paper will then detail the methods used in this research and how they are culturally and gender sensitive to …

A Comparative Analysis Of Promos During The Super Bowl For Fox And Nbc, Nathan R. Mitchell

Research Papers

This study is a content analysis of the promotional methods used by the Fox Broadcasting Company (Fox) and the National Broadcasting Company (NBC) during the Super Bowl. It takes a comparative look at the promotional spots, or promos, each network aired, during Super Bowl XLV (2011) and XLVI (2012), spanning an hour before kick-off, the game, and through the post game show. The promos have been categorized under various groups in order to analyze and compare the networks’ strategy. The study documents trends and unique occurrences that occur when both networks are compared. The data is synthesized into percentages that …

La Guerra Civil [8th Grade], Merida Elizondo

Understanding by Design: Complete Collection

In this unit, students will explore the events and repercussions of the Spanish Civil War. Students will focus on how art illustrates world events and how an artist can be influenced by the world they occupy. Students will also take a look at how propaganda is used during war time and its effect on the population. This unit builds upon students’ knowledge of basic Spanish grammar and Spanish history. With the performance task, students will create a propaganda poster in the target language. The subject of the poster can be any issue students feel strongly about: the environment, politics, school …

Encuentro Entre Culturas [9th-12th Grades], Jennifer Aranda, Juanita Castillo

Understanding by Design: Complete Collection

In the teaching of the Spanish language, we know that it is not only assuring that students know the grammatical concepts and vocabulary, but also ensuring that the students understand the cultural references and connections. It is this way that students are able to fully involve themselves in the language and become life-long learners.

The Unit, “Encuentro entre culturas”, fuses the Spanish culture with the united states, depicting some of the beautiful architectural influences that have been fused to our own.

In this Unit, students will be able to describe how different cultures interact, and be able to understand cultural …

Tissue Engineering A Blood Vessel Mimic While Monitoring Contamination Through Sterility Assurance Testing, Navid Djassemi

Master's Theses

Tissue Engineering A Blood Vessel Mimic While Monitoring Contamination Through Sterility Assurance Testing

Navid Djassemi

Tissue engineering blood vessel mimics has been proposed as a method to analyze the endothelial cell response to intravascular devices that are used in today’s clinical settings for the treatment of cardiovascular disease. Thus, the development of in vitro blood vessel mimics (BVMs) in Cal Poly’s Tissue Engineering Lab has introduced the possibility of assessing the characteristics of cellular response to past, present, and future intravascular devices that aim at treating coronary artery disease.

This thesis aimed at improving the methods and procedures utilized in …

A Hybrid Artificial Intelligence Modelling Framework For The Simulation Of The Complete, Socio-Technical, Urban Water System, Sotiria Baki, Ifigeneia Koutiva, Christos Makropoulos

International Congress on Environmental Modelling and Software

A (truly) integrated approach to the management of urban water should take into account, further to the characteristics of the technical system, a range of socio-economic processes and interactions – combined into what has been termed the “socio-technical system”. This is by no means an easy endeavour: conventional simulation tools often fail to capture socio-economic processes and their interactions with the technical urban water system. Variables depicting the socioeconomic environment are usually static and estimated from literature and/or expert opinion. To address this issue, new socio-technical modelling approaches are emerging aiming to explicitly account for the feedback loops between the …

Collaborating Across Cultures: Cultural Metacognition And Affect-Based Trust In Creative Collaboration, Roy Y. J. Chua, Michael W. Morris, Shira Mor

Research Collection Lee Kong Chian School Of Business

We propose that managers adept at thinking about their cultural assumptions (cultural metacognition) are more likely than others to develop affect-based trust in their relationships with people from different cultures, enabling creative collaboration. Study 1, a multi-rater assessment of managerial performance, found that managers higher in metacognitive cultural intelligence (CQ) were rated as more effective in intercultural creative collaboration by managers from other cultures. Study 2, a social network survey, found that managers lower in metacognitive CQ engaged in less sharing of new ideas in their intercultural ties but not intracultural ties. Study 3 required participants to work collaboratively with …

Reverberations Of The Victim's "Voice": Victim Impact Statements And The Cultural Project Of Punishment, Erin L. Sheley

Indiana Law Journal

No abstract provided.

In Medias Res, Larry Yackle

Faculty Scholarship

It’s common in academic circles to distinguish between positive arguments (which describe things as they are) and normative arguments (which prescribe the way things ought to be). The distinction dissolves as soon as accounts of how the world works spill over into justifications for the status quo. That happens a lot, especially in discussions of theory. It happens again in David Strauss’ wonderful monograph.1 Strauss offers a succinct exposition of the constitutional system we actually observe, coupled with a powerful explanation of how and why the scheme functions as it does and genuine reassurance that, on the whole, we can …

Singapore’S State-Enterprise Network In The Gulf Region: Boom, Bane Or An Ongoing Game, Caroline Yeoh, Wilfred Pow Ngee How, Febbry Lasgon

Research Collection Lee Kong Chian School Of Business

Singapore’s state-enterprise network has been, and continues to be, at the forefront of Singapore's internationalization efforts; most recently in the city-state's newest area of focus, the Gulf region. This paper, as part of our series on this topic, studies the city-state’s determined efforts to encapsulate economic space for Singapore-based firms to expand beyond the region through a lens on the Singapore government-linked companies (GLCs), in the context of the unique ‘Arabian allure’ of the GCC economies. Our results show that while the government ‘endorsement’ appears to provide a distinct advantage, the strategic advantages created in the Singapore-styled projects remains uncertain; …

Shamanism In Cross-Cultural Perspective, Michael Winkelman

International Journal of Transpersonal Studies

This article reviews the origins of the concept of the shaman and the principal sources of

controversy regarding the existence and nature of shamanism. Confusion regarding the

nature of shamanism is clarified with a review of research providing empirical support for a

cross-cultural concept of shamans that distinguishes them from related shamanistic healers.

The common shamanistic universals involving altered states of consciousness are examined

from psychobiological perspectives to illustrate shamanism’s relationships to human nature.

Common biological aspects of altered states of consciousness help explain the origins of

shamanism while social influences on this aspect of human nature help to explain …

An Empirical Understanding Of The Dialectic Relationship Between A Central Governing Body And The Individual Sites In A Multisite Enterprise Resource Planning (Erp) System Implementation, Tedde J. Taege

College of Business: Dissertations, Theses, and Student Research

Multisite enterprise resource planning (ERP) system implementations are a challenge faced by organizations. One of the facets of this challenge is to balance the central control of the multisite implementation with the unique requirements desired by each of the sites. The competing interests of the individual sites against the other sites as well as the total organization are forces at work with respect to the collective interest of the organization’s ERP. The study seeks to gain insights into the dynamics of a multisite organizational ERP implementation by analyzing the motivations and challenges in the interactive relationship. The grounded theory approach …

George Orwell's Nineteen Eighty-Four: Is This Where It All Began?, Jacinta Maria Matos

Reconstruction: Studies in Contemporary Culture

[First paragraph]

Orwell’s Nineteen Eighty-Four is arguably the most influential political novel of the twentieth century, providing us with a set of concepts and a vocabulary to discuss the state’s totalitarian control of the individual. As such, Orwell can be seen as one of the founding fathers of literary representations of a threatening urban space which functions as the microcosm of a global, totalizing and dystopian reality. His seminal contribution to the discourse of (in)security and surveillance has been widely recognized. David Lyon is one among the many theorists who place Orwell at the top of the list of early …

Globalization And Counseling: Professional Issues For Counselors, Sonya Lorelle, Rebekah J. Byrd, Stephanie Crockett

ETSU Faculty Works

Scholars have examined globalization for many years in terms of its impact on individuals, but it remains a concept not often discussed in the counseling literature (Paredes et al., 2008). As counseling transforms from a Western-based practice to a global phenomenon, it is important to understand counseling within an international context. In this article, the ways in which the process of globalization are currently impacting the field of counseling, implications and future research directions are examined.

Contributors, Susana S. Martins, Susana Araújo

Reconstruction: Studies in Contemporary Culture

Information about contributors to articles in volume 12, issue 3 of Reconstruction.

Beautiful, Unethical, Dangerous': Screening Surveillance And Maintaining Insecurities, Adam Brown, Tony Chalkley

Reconstruction: Studies in Contemporary Culture

[First paragraph]

In Christopher Nolan’s blockbuster hit, The Dark Knight (2008), the roguish caped crusader builds a massive computer system to locate his arch-nemesis, the Joker, using sonar technology. After being called on by Batman to use the system and assist with the pursuit, the deeply moral CEO of Wayne Enterprises, Lucius Fox, reluctantly agrees to help just one time, but threatens to quit immediately afterwards. The film’s subsequent climactic scenes are thus played out in a cityscape under surveillance, both thematically and aesthetically, with Batman’s (anti)heroic exploits only possible through his (temporary) establishment of a virtual “surveillancescape.” Yet there …

Review Of The Psychology And Character Of Virtue, Ed. Craig Steven Titus, Rebecca Konyndyk Deyoung

University Faculty Publications and Creative Works

No abstract provided.

Craig Steven Titus, Ed., The Psychology Of Character And Virtue, Rebecca Konyndyk Deyoung

Faith and Philosophy: Journal of the Society of Christian Philosophers

No abstract provided.

David Brown, Tradition And Imagination: Revelation And Change; Discipleship And Imagination: Christian Tradition And Truth; God And Enchantment Of Place: Reclaiming Human Experience; God And Grace Of Body: Sacrament In Ordinary; And God And Mystery In Words: Experience Through Metaphor And Drama, Robert Macswain

Faith and Philosophy: Journal of the Society of Christian Philosophers

No abstract provided.

Characterization Of Tight Junction Formation In An In-Vitro Model Of The Blood-Brain Barrier, Michael Robert Machado

Master's Theses

Active and passive transport of substances between the microcirculation in the brain and the central nervous system is regulated by the Blood-Brain Barrier (BBB). This barrier allows for chronic and acute modulation of the CNS microenvironment, and protects the brain from potentially noxious compounds carried in the circulatory system. In-vitro modeling of the BBB has become the target of much research over the past decade, as there are many unanswered questions regarding modulations in the permeability of this barrier. Additionally, the development of a practical and inexpensive model of the BBB would facilitate a much more efficient drug development process. …

The Contributors, Marites Tiongco

DLSU Business & Economics Review

No abstract provided.

The Filipino And Latino Managers: A Comparative Study Of Their Value Orientations, Arnel Onesimo O. Uy, Regina A. Greenwood, Edward F. Murphy, Jaime Alberto Ruiz Gutierrez, Miguel R. Olivas-Lujan, Sergio Madero, Neusa Maria Bastos F. Santos, Silvia Ines Monserrat, William Teeple, Julia Teahen

DLSU Business & Economics Review

Few studies have explored value similarities and differences between private sector managers in Latin countries like Argentina, Colombia, Mexico, and Brazil and the Philippines. These countries were former colonies of either Spain or Portugal or both. In our study, we found that managers from the Philippines, Argentina, and Brazil were more alike as they were classified as possessing High Personal and High Moral value orientations, while managers from Colombia and Mexico were most alike as they possessed a High Personal and High Competence value orientations. We discuss the implications of these findings, limitations of the study, and make recommendations for …

Cena Optima (The Best Dinner) [9th Grade], Amy Barnett

Understanding by Design: Complete Collection

This unit is designed to follow several chapters in the “Ecce Romani II” that discuss dinner preparation, dinner, and the dinner party that follows. In those chapters, students will have translated stories and learned vocabulary related to the dinner experience of upper-class ancient Romans. Through examining pros and cons of the dining experiences of ancient Romans and their own dining experiences, students will understand that although dining experiences across cultures are different, none is superior to another. To do this, they will create personal standards for the “best” dining experience. They will use what they know about the ancient Roman …

How Can Feminism Contribute To Design? A Framework For A Feminist Design Research And Practice, Sandra Buchmüller

DRS Biennial Conference Series

In this paper, I present a framework for a feminist design research and practice. It aims to guide design decisions from information, ideation to evaluation from a feminist point of view. It tries to facilitate the selection of appropriate approaches and methods in each phase with regard to feminist demands and requirements to support a feminist design on a methodological, practical and evaluative level. The framework integrates different gender theories whose perspectives correspond to main phases and focuses that can be regarded as mandatory for human centered design. The framework integrates the feminist standpoint theory, the theory of gender performativity …

Designers Coping With Culture In An Educational Setting, Annemiek Van Boeijen, Pieter Jan Stappers

DRS Biennial Conference Series

This paper presents the results of a qualitative study about how design students cope with culture in the i-do (international design opportunity) series of international design workshops in Hong Kong. We wanted to learn three things. (1) To what extent do the design students from different nations share common cultural values? (2) what difficulties do design students encounter in this type of workshops, and what techniques and strategies do they use to cope with (cultural) barriers? and (3) what opportunities (personal benefits) do they identify to attend this type of workshop? The results and conclusions are based on experiences of …

Design Process In Retrieving The Local Wisdom And Communal Identity: A Case Study Of Bangchaocha’S Bamboo Basketry Crafts, Woranooch Chuenrudeemol, Nanthana Boonlaor, Apirom Kongkanan

DRS Biennial Conference Series

This study aims to develop a method of retrieving indigenous knowledge, cultural identity, and artistic quality in local craft through design activities. Taking bamboo basketry product as the case study, this research selected Bangchaocha, a sub-district in Ang Thong province, as a representative of Thailand’s rich culture and established crafts village. The community has recently encountered a problem seen in many craft communities throughout Asia – one that sees the loss of their traditional craft identity due to foreign traders placing large orders for generic products that showcase neither indigenous craft knowledge nor traditional craftsmanship. This study aims to show …

The Aesthetics In Design And Cultural Studies, Theresa Lobo

DRS Biennial Conference Series

While industrial designers have traditionally advocated aesthetics in their work, with evocative forms and materials, recent advances in design philosophy about “user experience” suggest a deeper analysis. Thus, the purpose of this paper is to explore beauty as an experiential aesthetic value, dependent upon user-product interactions. The goal is to offer designers a valuable tool: a systematic, extensible model for describing beauty for design, with powerful insights drawn from other disciplines, including psychology, philosophy, computer science, and architecture. This paper strives to understand the concept of beauty as a value of human-product grounded in daily experience. Beauty is typically associated …