Digital Commons Network^™

Gene Duplication And The Evolution Of Hemoglobin Isoform Differentiation In Birds, Michael T. Grispo

School of Biological Sciences: Dissertations, Theses, and Student Research

The majority of bird species co-express two functionally distinct hemoglobin (Hb) isoforms in definitive erythrocytes: HbA (the major adult Hb isoform, with α-chain subunits encoded by the α^A-globin gene) and HbD (the minor adult Hb isoform, with α-chain subunits encoded by the α^D-globin gene). The α^D-globin gene originated via tandem duplication of an embryonic α-like globin gene in the stem lineage of tetrapod vertebrates, which suggests the possibility that functional differentiation between the HbA and HbD isoforms may be attributable to a retained ancestral character state in HbD that harkens back to a primordial, …

Originalism And Loving V. Virginia, Steven G. Calabresi, Andrea Matthews

BYU Law Review

No abstract provided.

Repudiating The Narrow Rule In Capital Sentencing, Scott W. Howe

BYU Law Review

This Article proposes a modest reform of Eighth Amendment law governing capital sentencing to spur major reform in the understanding of the function of the doctrine. The Article urges the Supreme Court to renounce a largely empty mandate known as the “narrowing” rule and the rhetoric of equality that has accompanied it. By doing so, the Court could speak more truthfully about the important but more limited function that its capital-sentencing doctrine actually pursues, which is to ensure that no person receives the death penalty who does not deserve it. The Court could also speak more candidly than it has …

Why The National Popular Vote Compact Is Unconstitutional, Norman R. Williams

BYU Law Review

Unable to secure passage of a federal constitutional amendment abolishing the Electoral College, several opponents of the Electoral College have sought to establish the direct, popular election of the President via an interstate compact according to which individual signatory states agree to appoint their presidential electors in accordance with the nationwide popular vote. Ostensibly designed to prevent elections, such as the one in 2000, in which the Electoral College “misfired” and chose the candidate who received fewer popular votes, the National Popular Vote Compact has been adopted by several states, including California. In this Article, I argue that the National …

The Dual-Faceted Federalism Framework And The Derivative Constitutional Status Of Local Governments, Michael W. Cannon

BYU Law Review

No abstract provided.

Taxing And Tuition: A Legislative Solution To Growing Endowments And The Rising Costs Of A College Degree, Matt Willie

BYU Law Review

No abstract provided.

Web-Based Interactive Video Vignettes Create A Personalized Active Learning Classroom For Introducing Big Ideas In Introductory Biology, Leslie Kate Wright, Dina L. Newman, Jean A. Cardinale, Robert Teese

Articles

The typical “flipped classroom” delivers lecture material in video format to students outside of class in order to make space for active learning in class. But why give students passive material at all? We are developing a set of high-quality online educational materials that promote active, hands-on science learning to aid in teaching of core concepts for introductory biology at the college level. Interactive video vignettes (IVVs) incorporate evidence based teaching strategies to address known areas of confusion for entering students. Each IVV includes a live action scenario with undergraduates investigating a biological problem with a realistic experiment that users …

Training Tomorrow’S Lawyers: What Empirical Research Can Tell Us About The Effect Of Law School Pedagogy On Law Student Learning Styles, Eric A. Degroff

Southern Illinois University Law Journal

Generations X and Y, which together account for the vast majority of today’s law school classes, are quite unlike previous generations in their approach to learning.  Legal scholars have begun to note the disparity between the learning styles and thought processes of today’s students and many of their professors, and some have suggested that a more experiential pedagogy might enhance the learning process for many of today’s students.  Unfortunately, the academy has little empirical data to evaluate what kind of difference a more experiential approach would make. The research described in this article was designed to help bridge that gap …

Respondents In Discovery: A Beneficent Statute With Traps For The Unwary, John T. Hundley

Southern Illinois University Law Journal

A variety of factors have converged to thwart the beneficent purposes of the Illinois Respondents in Discovery Statute (now 735 Ill. Comp. Stat. 5/2-402 (2010)) and to create hidden dangers for the unwary who rely upon it.  This article explains the Statute and its history, and sheds light on the hidden dangers the Statute poses. 

Introduction: Noncitizen Participation In The American Polity, Angela M. Banks

William & Mary Bill of Rights Journal

No abstract provided.

Volatile Memory Message Carving: A "Per Process Basis" Approach, Aisha Ibrahim Ali-Gombe

LSU New Orleans Theses and Dissertations

The pace at which data and information transfer and storage has shifted from PCs to mobile devices is of great concern to the digital forensics community. Android is fast becoming the operating system of choice for these hand-held devices, hence the need to develop better forensic techniques for data recovery cannot be over-emphasized. This thesis analyzes the volatile memory for Motorola Android devices with a shift from traditional physical memory extraction to carving residues of data on a “per process basis”. Each Android application runs in a separate process within its own Dalvik Virtual Machine (JVM) instance, thus, the proposed …

The Effects Of Energy Beverages In Counteracting The Symptoms Of Mild Hypoxia At Legal General Aviation Altitudes, Daniel Mark Bull

Doctoral Dissertations and Master's Theses

The purpose of this thesis was to conduct preliminary research, in the form of a pilot study, concerning the natural effects of hypoxia compared to the effects of hypoxia experienced after the consumption of an energy beverage. The study evaluated the effects of hypoxia on FAA certificated pilots at a simulated legal general aviation altitude, utilizing the normobaric High Altitude Lab (HAL) located at Embry Riddle Aeronautical University, Daytona Beach, Florida. The researcher tested 11 subjects, who completed three simulated flight tasks within the HAL using the Frasca International Mentor Advanced Aviation Training Device (AATD). The flight tasks were …

Implementation Of Microwave Transmissions For Rocket Exhaust Plume Diagnostics, Nicholas George Coutu

Doctoral Dissertations and Master's Theses

Rocket-launched vehicles produce a trail of exhaust that contains ions, free electrons, and soot. The exhaust plume increases the effective conductor length of the rocket. A conductor in the presence of an electric field (e.g. near the electric charge stored within a cloud) can channel an electric discharge. The electrical conductivity of the exhaust plume is related to its concentration of free electrons. The risk of a lightning strike in-flight is a function of both the conductivity of the body and its effective length. This paper presents an approach that relates the electron number density of the exhaust plume to …

Identification And Classification Of Stratospheric Sudden Warming Events, Thomas S. Ehrmann

Doctoral Dissertations and Master's Theses

Analysis of northern hemisphere stratospheric data from 1978-2011 is used to identify and classify Stratospheric Sudden Warming events. A total of 41 events are identified during this 33 year period, resulting in an average occurrence rate of 1.24 events/year. No significant variation in the rate is observed during the period analyzed. The average temperature increase during an SSW event is 12 K and the average duration is 32 days. Each identified event is classified as either a vortex displacement or split event and the ratio of displacement to split events is found to be 0.86.

Private Pension Protections Since Erisa: The Expanded Role Of The Individual, Karen A. Zurlo

The Journal of Sociology & Social Welfare

Designed to provide security and equity to defined benefit (DB) pension plans, the Employee Retirement Income Security Act (ERISA) became law in 1974. Since that time, the economy has shifted to a more globalized, non-unionized, service-based environment, where defined contribution (DC) plans replaced DB plans as the dominant type of private pension plan. Today workers and retirees bear the burden of managing their pension plans and the associated risks. To protect Americans against the financial risks they face in retirement and ensure greater economic security in old age, targeted financial education, research, and fundamental pension policy reform are required.

4th Asian Preventive Cardiology And Cardiac Rehabilitation Conference

Journal of the Hong Kong College of Cardiology

No abstract provided.

Treatment Of Steroid-Induced Elevated Intraocular Pressure With Anecortave Acetate: A Randomized Clinical Trial., Ingeborg Stalmans, David G. Callanan, Monte S. Dirks, Marlene R. Moster, Alan L. Robin, Joachim Van Calster, Sally A. Scheib, Jaime E. Dickerson, Theresa A. Landry, Michael V. W. Bergamini

Wills Eye Hospital Papers

PURPOSE: The present study is the first randomized clinical trial designed to evaluate the intraocular pressure (IOP)-lowering effect of anecortave acetate (AA) administered at 3 doses (3, 15, or 30 mg) as an anterior juxtascleral depot (AJD) in patients experiencing elevated IOP due to corticosteroid therapy.

METHODS: This was a double-masked, randomized, placebo-controlled, multicenter, parallel group trial. Eligible patients had an IOP of at least 24 mmHg and an IOP increase of at least 10 mmHg relative to their IOP before treatment with steroids. A target IOP was established for each patient at baseline. Patients were randomized to 1 of …

Skin Cell Proliferation Stimulated By Microneedles, Horst Liebl, Luther C. Kloth

Physical Therapy Faculty Research and Publications

A classical wound may be defined as a disruption of tissue integrity. Wounds, caused by trauma from accidents or surgery, that close via secondary intention rely on the biological phases of healing, i.e., hemostasis, inflammation, proliferation, and remodeling (HIPR). Depending on the wound type and severity, the inflammation phase begins immediately after injury and may last for an average of 7–14 days. Concurrent with the inflammation phase or slightly delayed, cell proliferation is stimulated followed by the activation of the remodeling (maturation) phase. The latter phase can last as long as 1 year or more, and the final healed state …

Quantified H I Morphology : Vi. The Morphology Of Extended Discs In Uv And H I., Benne W. Holwerda, N. Pirzkal, J. S. Heiner

Faculty and Staff Scholarship

Extended ultraviolet (XUV) discs have been found in a substantial fraction of late-type – S0, spiral and irregular – galaxies. Similarly, most late-type spirals have an extended gas disc, observable in the 21-cm radio line (H i). The morphology of galaxies can be quantified well using a series of scale-invariant parameters; concentration-asymmetry-smoothness (CAS), Gini, M20, and GM parameters. In this series of papers, we apply these to H i column density maps to identify mergers and interactions, lopsidedness and now XUV discs. In this paper, we compare the quantified morphology and effective radius (R50) of the Westerbork observations of neutral …

Judicial Innovation And Sexual Harassment Doctrine In The U.S. Court Of Appeals., Laura P. Moyer, Holley Takersley

Faculty and Staff Scholarship

The determination that sexual harassment constituted “discrimination based on sex” under Title VII was first made by the lower federal courts, not Congress. Drawing from the literature on policy diffusion, this article examines the adoption of hostile work environment standards across the U.S. Courts of Appeals in the absence of controlling Supreme Court precedent. The results bolster recent findings about the influence of female judges on their male colleagues and suggest that in addition to siding with female plaintiffs, female judges also helped to shape legal rules that promoted gender equality in the workplace.

Predictors Of Drug Court Client Graduation, Marie E. Gill

Theses and Dissertations (ETD)

Background: Substance use disorder in the United States adversely effects society by burdening the justice system with offender incarceration for drug-related crimes, it also strains in the healthcare system with costs in excess of $216 billion dollars for treatment of drug-related mental and physical illnesses. Many offenders of nonviolent crimes with substance use disorder have been diverted to Drug Court (DC) for year-long supervised community-based drug addiction treatment as an alternative to incarceration for non-violent drug-related crimes. Drug Court program outcomes, however, have been studied as a criminal justice intervention, rather than a primary care mental health intervention. The majority …

N200 And P300 Evoked By Stimuli Straddling Category Boundary In Lexical Context, Ji Young Lee

Theses and Dissertations (ETD)

Background and Objectives: Event-related potentials (ERPs) like N200 and P300 have been reported to reflect the categorical perception of speech. The purpose of the present study is to explore whether these ERP components reflect the influence of lexical context on categorical perception. Findings may provide evidence for bottom-up or top-down processing of speech. Methods: On a seven step series of the /bi/-/pi/ continuum, a two-forced choice labeling test was administered in two conditions: /bi/ context (e.g. bee sting) and /pi/ context (e.g. pea soup). From the labeling results, Stimulus 1which is a prototypical /bi/ was selected for standard stimuli, and …

Mrp4 Is A Crucial Regulator Of Testosterone Biosynthesis, Jessica Ann Morgan

Theses and Dissertations (ETD)

The physiological role of multidrug resistance protein 4 (Mrp4) in the testes is unknown. It was discovered that Mrp4 is expressed primarily in mouse and human Leydig cells; however, there is no current evidence that Mrp4 regulates testosterone biosynthesis. The role of Mrp4 was investigated in Leydig cells where testosterone production is regulated by cAMP, an intracellular second messenger formed when the luteinizing hormone (LH) receptor (Lhr) is activated. As Mrp4 regulates cAMP, we compared testosterone levels in our Mrp4 WT and KO mice. Prepubertal KO mice had significantly reduced testicular testosterone, impaired gametogenesis, and disrupted cAMP homeostasis, resulting in …

An Innovative Testing Protocol To Study Foot And Ankle Kinetics During Early Stance Phase Of Gait, Thomas E. Stewart

Theses and Dissertations (ETD)

The objective of this study was to improve upon existing testing platform limitations with respect to foot and ankle mechanics in the sagittal plane during dorsiflexion and plantar flexion. The intent was to develop a multi-loading protocol that simulated aspects of early stance phase of walking gait. This data were used to evaluate the influence an Achilles load has on the kinematic profile of the ankle complex. Also, resulting kinematic profile data can be used to evaluate ligament/tendon effects, ankle arthroplasty, and various surgical techniques.

A pair of cadaveric human feet, from the same donor, 50 years of age were …

The Role Of Bip Nucleotide Exchange Factor Sil1 In Immunoglobulin Biosynthesis, Tyler Sanford

Theses and Dissertations (ETD)

BiP is an essential endoplasmic reticulum resident molecular chaperone of the HSP70 family that binds exposed hydrophobic regions of unfolded proteins. Substrates bound by BiP are protected from dangerous non-specific interaction with other unfolded proteins via their aggregation prone exposed hydrophobic regions, which are normally buried in the native state, and act as BiP binding targets. For these substrates to mature into the native state, BiP must be released. Like all HSP70 family members, cycles of BiP binding and release are nucleotide dependent and facilitated by two genres of cochaperones, HSP40s, and nucleotide exchange factors (NEFs). HSP40s function in stimulating …

Metabotropic Glutamate Receptor 5 In The Medial Prefrontal Cortex: Role In Cocaine Sensitization And Addiction, Kristin Marie Timmer

Theses and Dissertations (ETD)

Cocaine sensitization is associated with cocaine-induced hyperexcitability of pyramidal projection neurons within the medial prefrontal cortex (mPFC). Such hyperexcitability presumably results in increased glutamatergic input to reward-affiliated brain regions such as the ventral tegemental area (VTA) and nucleus accumbens (NAc), consequently facilitating drugseeking behavior. Metabotropic glutamate receptor 5 (mGluR5) has been implicated in cocaine addiction and demonstrated to increase neuronal excitability, therefore, the aim of the present study was to investigate the effect of intra-mPFC mGluR5 manipulation on behavioral and neurochemical sensitization and drug-seeking. Bilateral cannulae were implanted into the mPFC of male Sprague-Dawley rats and mGluR5 antagonist MTEP (15 …

Preparation And Characterization Of Conducting Polymer Materials For Electrochromic Devices, Lavina Astratine

Doctoral

An attempt has been made to improve the physical-chemical properties of conducting polymers by switching from aqueous solutions towards ionic liquids as novel electrolytic media in order to fabricate novel electrochromic materials. Formation and electrochemical characterization of Poly (2,3,5,6- Tetrafluoroaniline) (PTFA) was performed in aqueous solutions. The optical response was observed in order to establish the electrochromic properties of this material. Electrochromic activity of PTFA conducting polymer in aqueous conditions was investigated. Results indicated a slow colour change of 40 seconds, from delicate orange to a much intense orange colour. Electrochemical copolymerization of two monomers pyrrole (Py) and 3,4- ethylenedioxythiophene …

Learning Visual Features For The Avatar Captcha Recognition Challenge, Mohammed Korayem, Abdallah A. Mohamed, David Crandall, Roman Yampolskiy

Faculty and Staff Scholarship

Captchas are frequently used on the modern world wide web to differentiate human users from automated bots by giving tests that are easy for humans to answer but difficult or impossible for algorithms. As artificial intelligence algorithms have improved, new types of Captchas have had to be developed. Recent work has proposed a new system called Avatar Captcha, in which a user is asked to distinguish between facial images of real humans and those of avatars generated by computer graphics. This novel system has been proposed on the assumption that this Captcha is very difficult for computers to break. In …

Ralph Raico: Champion Of Authentic Liberalism, Daniel P. Stanford

History Theses

ABSTRACT OF THESIS

Ralph Raico: Champion of Authentic Liberalism

This paper explores the intellectual life and writings of Professor Emeritus in History at Buffalo State College, Ralph Raico. The central thesis seeks to portray Professor Raico as the great modern libertarian revisionist historian, and the great modern champion of historical, classical liberalism. More broadly, the work attempts to solidify Professor Raico’s reputation as a major figure in the modern American libertarian movement.

Raico’s intellectual foundations are fully developed, beginning from grade school at Bronx High School of Science, to his attendance of Ludwig von Mises’s New York University seminar, to …

Brooding Deficits In Memory: Focusing Attention Improves Subsequent Recall, Paula T. Hertel, Amanda A. Benbow, E. Geraerts

Psychology Faculty Research

Ruminative habits of thought about one’s problems and the resulting consequences are correlated with symptoms of depression and cognitive biases (Nolen-Hoeksema, Wisco, & Lyubomirsky, 2008). In our orienting task, brooders and nonbrooders concentrated on self-focusing phrases while they were also exposed to neutral target words. On each trial in the unfocused condition, participants saw and then reported the target before concentrating on the phrase; in the focused condition, the target was reported after phrase concentration. A brooding-related deficit on a subsequent unexpected test of free and forced recall was obtained in the unfocused condition only. Brooders recalled more successfully in …