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Equipment Qualification Of Ion Mobility Spectrometry And Method Development And Validation For Pharmaceutical Equipment Cleaning Validation, Amy Lee Heiser

Masters Theses

Ion mobility spectrometry (IMS) instrumentation has been identified as a suitable technology for the detection and reporting of drug product and detergent residues from pharmaceutical manufacturing equipment. Ion mobility is not a new technology, but is entering the field of cleaning validation because of tightened requirements from the US Food and Drug Administration (FDA).

The purpose of this thesis is to outline a practical implementation of the analytical technique, Ion Mobility Spectrometry in a cleaning validation program. Ion Mobility Spectrometry (IMS) is fast and specific for the analysis of small organic molecules and has been gaining popularity in the pharmaceutical …

The Effects Of Altering Response Effort During Data Collection On Observer Accuracy: Data Collection Procedures On Hand Hygeine Compliance, Krista Hinz

Masters Theses

When dealing with human observers and error, tight control in data collection and methodology is essential for accurate representation of compliance. Although observational studies are popular, little has been done to study the integrity of human observers and the data collection process. Incomplete analysis of data collection integrity threatens functional findings, leading to problematic interpretation and decreased replication. The purpose of the current study was to assess whether manipulating the response effort associated with data collection has an effect on the accuracy of data collection. Participants of the study were undergraduate psychology students at a Midwestern university who were enrolled …

The Rise And Fall Of Kin Structure In The Neotropical, Family-Living Buff-Breasted Wren (Cantorchilus Leucotis) In Gamboa, Panama, Sarah C. Alessi

Masters Theses

Family-living species provide an exciting model to examine how natal dispersal and kin structure influence genetic structuring within local populations. Juvenile buff-breasted wrens (Cantorchilus leucotis) of both sexes delay dispersal and exhibit short-distance natal dispersal, which should lead to kin-structured populations in which relatives of both sexes occupy neighboring territories. Blood samples collected from juvenile and adult wrens in Gamboa, Panama were analyzed using microsatellite markers to determine whether related individuals are spatially clustered on neighboring territories, spatial clusters of relatives change over time, and if kin structure is sex-specific. Global and local spatial autocorrelation analyses detected genetic …

High Capacity Lithium-Ion Battery Characterization For Vehicular Applications, Sazzad Hossain Ahmed

Masters Theses

A lithium-ion battery is one of the key research topics in energy storage technologies. Major characterization tests such as static capacity, open circuit voltage (OCV), hybrid pulse power characterization (HPPC) have been conducted on two different chemistries, LiMnNi and LiFePO₄, high capacity lithium-ion batteries over a wide range of temperatures from 50ºC to -30ºC. Detail analysis of temperature effects on battery capacity and simple models of direct current resistance (DCR) increment and power decrement over temperatures have been proposed using the test results. Electrochemical impedance spectroscopy (EIS) tests have been performed to find out the dominant internal resistances …

Direct Analysis Of Hops By Leaf Spray And Paper Spray Mass Spectrometry, Kari Blain

Masters Theses

The objective of this research is to develop a new and innovative method of hops analysis, which is much faster than standard testing methods, as well as reduce the amount of consumables and solvent used. A detailed discussion on the development of an ambient ionization mass spectrometry method called paper spray (PS-MS) and leaf spray (LS-MS) mass spectrometry will be presented. This research investigates the use of PS-MS and LS-MS techniques to determine the α- and β- acids present in hops. PS-MS and LS-MS provide a fast way to analyze hops samples by delivering data as rapidly as a UV-Vis …

Laboratory Measures Of Aggression In Methadone Patients, Catherine M. Gayman

Masters Theses

Research suggests that current heroin users and individuals with a prior history of heroin dependence tend to be more aggressive than nonusers. No study has yet investigated whether opioid withdrawal affects aggressive responses on a laboratory task. The present study investigates whether mild opioid withdrawal affects aggression in six males and six females (N=12) undergoing methadone maintenance therapy. Aggressive behavior is measured using the Point Subtraction Aggression Paradigm (Cherek, 1981) computer task. Participants press buttons to earn money towards gift certificates. Money subtractions occur periodically and these are attributed to the behavior of a partner who is actually fictitious. Participants …

Physics Faculty Use Of Example Solutions In Teaching Introductory Physics, William O. Mamudi

Masters Theses

This study investigates how physics faculty perceive and use features of example problem solutions. Thirty physics instructors from diverse institutions participated in semi-structured interviews. In addition to open-ended questions, three example problem solution artifacts were used to focus on specific solution features. Data were analyzed to identify instructors’ goals for the use of example solutions and whether their goals were consistent with the solution features that they valued and used. The study concludes that many faculty have three major goals: keeping students cognitively involved, helping students become better problem solvers, and supporting students in learning physics. The study also found …

"His Head Rolled Forth Onto The Floor:" Women, The Abject, And The Male Gaze In Old English Poetry, Jaime Michelle Myers

Masters Theses

Old English poetry features several female characters who challenge androcentric authority by violently killing men. I argue in this thesis that three of these women—Modthryth, Grendel’s mother, and Judith—are linked together by their rejection or reversal of the male gaze. In their forceful refusal to be visually objectified, each character is portrayed as abject—outside of normal and outcast from community. They cause disorder, illustrate the fragility of androcentric control, and force a confrontation with death. In so doing, they create ambiguity and, at times, reverse the subject/object and masculine/feminine gender binaries.

Early Arrest Mutant Ogre: A Defect In Cytokineis Caused By A Mutation In The Gene Racgap1, April Wicklund

Masters Theses

The early arrest mutant ogre, isolated in the Tübingen screen, has a block in cytokinesis (Kane et al., 1996). Here I use genetic and molecular techniques to demonstrate that the ogre phenotype is caused by a lesion in the gene encoding Racgap1. I performed fine mapping studies using microsatellite markers to a 0.15 cM region containing the ogre locus. DNA sequence data revealed a nonsense mutation in the Racgap1 gene of ogre mutants, and in situ hybridization experiments showed a loss of racgap1 mRNA at later stages of development, likely by nonsense mediated decay. This evidence supports the abolishment …

Factors Influencing The Spatial And Temporal Distrubtion Of Primary Productivity And Community Respiration In The Mississippi Coastal Estuarine Region, Ryan Anthony Vandermeulen

Master's Theses

This study describes the spatial and temporal distribution of net primary productivity (NetPP) and respiration (RESP) in relation to the biogeochemical, optical, and hydrographic variability in the Mississippi Sound and Mississippi Bight over the course of one year. Surface in-situ measurements of NetPP and RESP were regularly determined at two stations by a time-course detection of dissolved oxygen (DO) using novel optode technology. In addition, various biogeochemical, optical, and hydrographic parameters were examined over 14 stations throughout the estuary over a year, using ground and satellite (MODIS Aqua) measurements. In this study, consistently low dissolved inorganic N:P ratios (average N:P …

Search For A Correlation Between Very-High-Energy Gamma Rays And Giant Radio Pulses In The Crab Pulsar, E. Aliu, S. Archambault, T. Arlen, T. Aune, M. Beilicke, W. Benbow, A. Bouvier, J. H. Buckley, V. Bugaev, P. T. Reynolds, Et Al

Physical Sciences Publications

We present the results of a joint observational campaign between the Green Bank radio telescope and the VERITAS gamma-ray telescope, which searched for a correlation between the emission of very-high-energy (VHE) gamma rays (E γ > 150 GeV) and giant radio pulses (GRPs) from the Crab pulsar at 8.9 GHz. A total of 15,366 GRPs were recorded during 11.6 hr of simultaneous observations, which were made across four nights in 2008 December and in 2009 November and December. We searched for an enhancement of the pulsed gamma-ray emission within time windows placed around the arrival time of the GRP events. …

Moral Responsibility For Computing Artifacts: "The Rules" And Issues Of Trust, Frances S. Grodzinsky, Keith W. Miller, Marty J. Wolf

School of Computer Science & Engineering Faculty Publications

“The Rules” are found in a collaborative document (started in March 2010) that states principles for responsibility when a computer artifact is designed, developed and deployed into a sociotechnical system. At this writing, over 50 people from nine countries have signed onto The Rules (Ad Hoc Committee, 2010). Unlike codes of ethics, The Rules are not tied to any organization, and computer users as well as computing professionals are invited to sign onto The Rules. The emphasis in The Rules is that both users and professionals have responsibilities in the production and use of computing artifacts. In this paper, we …

Effective Computer Programming Instruction For Pre-University Albanian Students, Robert Mccloud, Ardiana Sula

School of Computer Science & Engineering Faculty Publications

The relationship between pre-university students and technology is frequently overrated. While we receive glowing reports about how young people are knowledgeable about computers, the truth is that their knowledge is typically about computer content and the manipulation of applications. Young students too often treat the actual programming and understanding of computers as a sort of magical mystery.

In this paper we look at a new Albanian initiative to identify and nurture the most talented of our pre-university students. In particular we look at contributions to the goal of making Albanians the most talented programmers in this area of Europe.

The …

Lean And Mean: Workplace Culture And The Prevention Of Workplace Bullying, Andra Gumbus, Patricia Meglich

WCBT Faculty Publications

Workplace bullying has become a hot topic in the popular press as well as scholarly literature. Compared to targets of sexual harassment, bullied workers quit their jobs more often, are more unhappy, stressed at work, and less committed to the workplace. Little is done about it because there currently is no US law against bullying and often the only recourse for targets is to quit their jobs. We present a case study and then review various legal remedies and sample company policies to explore the actions organizations might take to eliminate this destructive workplace behavior.

Residential Grid-Tied With Battery Backup Photovoltaic System, Thomas Stobuagh

Electrical Engineering

When power outages occur, many homes are left without power for some time as they are dependent on the power grid. This project aims to design a residential grid tied battery backup photovoltaic system that will provide up to 7.2kW in an area that gets 5.36-5.49 kWh/m2/day [1] to support a home with an average daily usage of 28.4 kWh/day. To effectively use this system the house remains connected to the electric utility at all times, so any power needed above what the solar system can produce is simply drawn from the utility. It includes battery backup or uninterruptible power …

Reassessing The Impact Of Inflation Targeting In Emerging Market Economies, Babatunde Aiyemo

Research Papers

In this paper, we subject a seeming consensus on the impact of inflation targeting in emerging market economies to some robustness assessments. First we report performance along carefully redefined country brackets, we find little evidence to support the notion that economies with inflation targeting policies performed better than non-targeting economies in terms of GDP growth, inflation and economic volatility. In fact, there is a suggestion in the results that amongst certain clusters of economies, certain restrictive aspects of the policy actually inhibit growth

In a subsequent assessment, we control for extent of development using specific country proxies but equally observe, …

Evaluation Of Multiple Schedules With Naturally Occurring And Contrived Discriminative Stimuli Following Functional Communication Training, Kenneth D. Shamlian Psyd

All Student Scholarship

The purpose of this dissertation is to describe a doctoral research study designed to compare use of contrived and naturally occurring discriminative stimuli when using multiple schedules to thin reinforcement following functional communication training and their subsequent efficacy when introduced to novel contexts. Results indicated for one participant training with contrived stimuli was most effective, both contrived and naturally occurring stimuli were similarly effective for a second, and further modifications of a) pairing specific therapists to training conditions and, (b) adding toys during EXT components were necessary for either training condition to be effective for a third. For one participant, …

Deporting The Pardoned, Jason A. Cade

Scholarly Works

Federal immigration laws make noncitizens deportable on the basis of state criminal convictions. Historically, Congress implemented this scheme in ways that respected the states’ sovereignty over their criminal laws. As more recent federal laws have been interpreted, however, a state’s decision to pardon, expunge, or otherwise set-aside a conviction under state law will often have no effect on the federal government’s determination to use that conviction as a basis for deportation. While scholars have shown significant interest in state and local laws regulating immigrants, few have considered the federalism implications of federal rules that ignore a state’s authority to determine …

Determining Diversity Jurisdiction Of National Banks After Wachovia Bank V. Schmidt, Michael Podolsky

Fordham Law Review

   Prior to the U.S. Supreme Court’s decision in Wachovia Bank v. Schmidt, some courts held, for diversity jurisdiction purposes, that national banks were citizens of each and every state in which they had a branch. In Schmidt, the Supreme Court made it clear that this approach was incorrect, but failed to provide an alternative one. Not surprisingly, in the wake of that decision another court split developed. While some courts have found that national banks are citizens only of the state listed on their charters as their main office, others have found that national banks are also citizens …

Unearthing The Public Interest: Recognizing Intrastate Economic Protectionism As A Legitimate State Interest, Katharine M. Rudish

Fordham Law Review

   In Oklahoma, a person must complete sixty-credit hours of undergraduate training and embalm twenty-five bodies before being legally licensed to sell caskets in the state. In Louisiana, in order to sell caskets, one must operate a fully licensed funeral establishment, defined as a place dedicated to preparing bodies for burial. In recent years, these states and others have faced legal challenges to casket sale restrictions by individuals who wish to sell caskets directly to the public, yet who are unable to do so as they are not licensed funeral directors. Courts have grappled with whether these state regulations, which in …

A Pillar Of Democracy: Reflections On The Role And Work Of The Constitutional Court Of South Africa, Kate O’Regan

Fordham Law Review

No abstract provided.

Ibinhunt: Binary Hunting With Inter-Procedural Control Flow, Jiang Ming, Meng Pan, Debin Gao

Research Collection School Of Computing and Information Systems

Techniques have been proposed to find the semantic differences between two binary programs when the source code is not available. Analyzing control flow, and in particular, intra-procedural control flow, has become an attractive technique in the latest binary diffing tools since it is more resistant to syntactic, but non-semantic, differences. However, this makes such techniques vulnerable to simple function obfuscation techniques (e.g., function inlining) attackers any malware writers could use. In this paper, we first show function obfuscation as an attack to such binary diffing techniques, and then propose iBinHunt which uses deep taint and automatic input generation to find …

Lagrangian Relaxation For Large-Scale Multi-Agent Planning, Geoffrey J. Gordon, Pradeep Varakantham, William Yeoh, Hoong Chuin Lau, Ajay S. Aravamudhan, Shih-Fen Cheng

Research Collection School Of Computing and Information Systems

Multi-agent planning is a well-studied problem with various applications including disaster rescue, urban transportation and logistics, both for autonomous agents and for decision support to humans. Due to computational constraints, existing research typically focuses on one of two scenarios: unstructured domains with many agents where we are content with heuristic solutions, or domains with small numbers of agents or special structure where we can provide provably near-optimal solutions. By contrast, in this paper, we focus on providing provably near-optimal solutions for domains with large numbers of agents, by exploiting a common domain-general property: if individual agents each have limited influence …

South Africa’S First Five Years On The United Nations Human Rights Council, Eduard Christiaan Jordaan

Research Collection School of Social Sciences

In June 2011, the United Nations Human Rights Council (HRC) adopted its first resolution on sexual orientation and human rights. Resolution 17/19 expressed grave concern at violence and discrimination committed against people because of their sexual orientation and tasked the UN High Commissioner for Human Rights to report on such abuses. In a body marred by regional bloc voting, Resolution 17/19 passed with support from states in all five of the official regions of the UN. South Africa was widely praised for leading such a progressive resolution through the Council, especially in the face of considerable pressure from African and …

Peripheral Arterial Disease Affects The Frequency Response Of Ground Reaction Forces During Walking, Denise Mcgrath, Timothy N. Judkins, Iraklis Pipinos, Jason Johanning

Journal Articles

Background—Walking is problematic for patients with Peripheral Arterial Disease. The purpose of this study was to investigate the frequency domain of the ground reaction forces during walking to further elucidate the ambulatory impairment of these patients.

Methods—Nineteen bilateral peripheral arterial disease patients and nineteen controls were included in this study. Subjects were matched for age and gait speed. Participants walked over a force plate sampling at 600Hz. PAD patients were tested before (pain-free condition) after the onset of claudication symptoms (pain). We calculated median frequency, frequency bandwidth, and frequency containing 99.5% of the signal for the vertical and …

Fibulin-2 Stabilizes Tumor Extracellular Matrix And Drives Malignant Progression Of Lung Adenocarcinoma, Brandi N. Baird

Dissertations and Theses (Open Access)

The ECM of epithelial carcinomas undergoes structural remodeling during periods of uncontrolled growth, creating regional heterogeneity and torsional stress. How tumors maintain ECM integrity in the face of dynamic biophysical forces is still largely unclear. This study addresses these deficiencies using mouse models of human lung adenocarcinoma. Spontaneous lung tumors were marked by disorganized basement membranes, dense collagen networks, and increased tissue stiffness. Metastasis-prone lung adenocarcinoma cells secreted fibulin-2 (Fbln2), a matrix glycoprotein involved in ECM supra-molecular assembly. Fibulin-2 depletion in tumor cells decreased the intra-tumoral abundance of matrix metalloproteinases and reduced collagen cross-linking and tumor compressive properties resulting in …

Simultaneous Induction Of Nkg2d And Nkg2d Ligand For Promoting Immune Surveillance By Il-12 Plus Doxorubicin Treatment, Jiemiao Hu

Dissertations and Theses (Open Access)

NKG2D (natural killer group 2, member D) and its ligands interaction in tumor microenvironment directs tumor infiltrating immune cells to recognize tumor cells, stimulate cytotoxic effector immune cells, and therefore eradicate tumor cells. IL-12, a cytokine produced by antigen presenting cells, has remarkable antitumor effect by activating innate and adaptive immunity. Doxorubicin, a commonly used chemotherapeutic agent also boosts the host antitumor immune response to cause tumor cell death. Our previous publication suggests that IL-12 plus doxorubicin enhances NKG2D function-dependent inhibition of tumor progression and promotes CD8⁺T cells infiltrating into tumors. The purpose of this study is to …

Fancm And Faap24 Maintain Genomic Stability Through Cooperative And Unique Functions, Yucai Wang

Dissertations and Theses (Open Access)

Fanconi anemia (FA) is a rare recessive genetic disease with an array of clinical manifestations including multiple congenital abnormalities, progressive bone marrow failure and profound cancer susceptibility. A hallmark of cells derived from FA patients is hypersensitivity to DNA interstrand crosslinking agents such as mitomycin C (MMC) and cisplatin, suggesting that FA- and FA-associated proteins play important roles in protecting cells from DNA interstrand crosslink (ICL) damage. Two genes involved in the FA pathway, FANCM and FAAP24, are of particular interest because they contain DNA interacting domains. However, there are no definitive patient mutations for these two genes, and the …

Genetic Interactions Of Factors That Regulate Alternative Rna Splicing In The Male Germ Line Of Drosophila, Shanzhi Wang

Dissertations and Theses (Open Access)

Alternative RNA splicing is a critical process that contributes variety to protein functions, and further controls cell differentiation and normal development. Although it is known that most eukaryotic genes produce multiple transcripts in which splice site selection is regulated, how RNA binding proteins cooperate to activate and repress specific splice sites is still poorly understood. In addition how the regulation of alternative splicing affects germ cell development is also not well known. In this study, Drosophila Transformer 2 (Tra2) was used as a model to explore both the mechanism of its repressive function on its own pre-mRNA splicing, and the …

Differential Activity Of The Kras Oncogene By Method Of Activation: Implications For Signaling And Therapeutic Intervention, Nathan Ihle

Dissertations and Theses (Open Access)

Despite having been identified over thirty years ago and definitively established as having a critical role in driving tumor growth and predicting for resistance to therapy, the KRAS oncogene remains a target in cancer for which there is no effective treatment. KRas is activated b y mutations at a few sites, primarily amino acid substitutions at codon 12 which promote a constitutively active state. I have found that different amino acid substitutions at codon 12 can activate different KRas downstream signaling pathways, determine clonogenic growth potential and determine patient response to molecularly targeted therapies. Computer modeling of the KRas structure …