Digital Commons Network^™

Clinical Review Of Treatment Options For Major Depressive Disorder In Patients With Coronary Heart Disease, Fahad D. Alosaimi, Brian Baker

Saudi Medical Journal

It is established that the prevalence of major depressive disorder (MDD) in coronary heart disease (CHD) populations is high and is associated with increased mortality. In this systematic review, we examined the evidence for the effective treatment of MDD in CHD patients by reviewing randomized control trials (RCTs) between 1980 and 2011 and then assessing whether these treatments were clinically meaningful. A total of 8 RCTs were retrieved. Sertraline, citalopram, and mirtazapine were safe from a cardiac perspective, but only sertraline and citalopram were clearly more effective than placebo in CHD patients with moderate-to-severe type, recurrent MDD, or MDD episode …

Molecular Mechanism For Depolarization-Induced Modulation Of Kv Channel Closure, Alain J. Labro, Jerome J. Lacroix, Carlos A. Villalba-Galea, Dirk J. Snyders, Francisco Bezanilla

School of Pharmacy Faculty Articles

Voltage-dependent potassium (Kv) channels provide the repolarizing power that shapes the action potential duration and helps control the firing frequency of neurons. The K(+) permeation through the channel pore is controlled by an intracellularly located bundle-crossing (BC) gate that communicates with the voltage-sensing domains (VSDs). During prolonged membrane depolarizations, most Kv channels display C-type inactivation that halts K(+) conduction through constriction of the K(+) selectivity filter. Besides triggering C-type inactivation, we show that in Shaker and Kv1.2 channels (expressed in Xenopus laevis oocytes), prolonged membrane depolarizations also slow down the kinetics of VSD deactivation and BC gate closure during the …

A Human Phospholipid Phosphatase Activated By A Transmembrane Control Module, Christian R. Halaszovich, Michael G. Leitner, Angeliki Mavrantoni, Audrey Le, Ludivine Frezza, Anja Feuer, Daniela N. Schreiber, Carlos A. Villalba-Galea, Dominik Oliver

School of Pharmacy Faculty Articles

In voltage-sensitive phosphatases (VSPs), a transmembrane voltage sensor domain (VSD) controls an intracellular phosphoinositide phosphatase domain, thereby enabling immediate initiation of intracellular signals by membrane depolarization. The existence of such a mechanism in mammals has remained elusive, despite the presence of VSP-homologous proteins in mammalian cells, in particular in sperm precursor cells. Here we demonstrate activation of a human VSP (hVSP1/TPIP) by an intramolecular switch. By engineering a chimeric hVSP1 with enhanced plasma membrane targeting containing the VSD of a prototypic invertebrate VSP, we show that hVSP1 is a phosphoinositide-5-phosphatase whose predominant substrate is PI(4,5)P(2). In the chimera, enzymatic activity …

International Activity And Domestic Law, Adam I. Muchmore

Faculty Scholarship

This invited essay explores the ways States use their domestic laws to regulate activities that cross national borders. Domestic-law enforcement decisions play an underappreciated role in the development of international regulatory policy, particularly in situations where the enforcing State's power to apply its law extraterritorially is not contested. Collective action problems suggest there will be an undersupply of enforcement decisions that promote global welfare and an oversupply of enforcement decisions that promote national welfare. These collective action problems may be mitigated in part by government networks and other forms of regulatory cooperation.

Hauerwas And Disability Law: Exposing The Cracks In The Foundations Of Disability Law , Elizabeth R. Schiltz

Law and Contemporary Problems

No abstract provided.

Hauerwas And The Law: Framing A Productive Conversation , Cathleen Kaveny

Law and Contemporary Problems

No abstract provided.

Hauerwas, Liberalism, And Public Reason: Terms Of Engagement? , Stephen Macedo

Law and Contemporary Problems

No abstract provided.

Must Liberalism Be Violent? A Reflection On The Work Of Stanley Hauerwas , Stephen L. Carter

Law and Contemporary Problems

No abstract provided.

A Quantitative Content Analysis Of The Common Core State Standards Compared To Missouri’S Grade-Level Expectations Using The Revised Bloom’S Taxonomy Framework, Toni Gallia

Dissertations

With the pressure in education to develop a 21st century learner with higher-level thinking skills, many educators connected previous state curriculum to the Common Core State Standards (CCSS). Missouri’s Department of Education experts paired the previous state’s curriculum known as the Missouri Grade Level Expectations (MO GLEs) with a corresponding CCSS based on Webb’s depth-of-knowledge model in a document commonly referred to as the Missouri Crosswalk. This quantitative content analysis study compared the MO GLEs and CCSS by quantifying the language using an adapted and revised Bloom’s taxonomy framework. This study tested for a cognitive difference in means and for …

Cross Regulation Of Sirtuin 1, Ampk, And Ppary In Conjugated Linoleic Acid Treated Adipocytes, Shan Jiang, Wei Wang, Jess Miner, Michael E. Fromm

Department of Biochemistry: Faculty Publications

Trans-10, cis-12 conjugated linoleic acid (t10c12 CLA) reduces triglyceride (TG) levels in adipocytes through multiple pathways, with AMP-activated protein kinase (AMPK) generally facilitating, and peroxisome proliferator-activated receptor γ (PPARγ) generally opposing these reductions. Sirtuin 1 (SIRT1), a histone/protein deacetylase that affects energy homeostasis, often functions coordinately with AMPK, and is capable of binding to PPARγ, thereby inhibiting its activity. This study investigated the role of SIRT1 in the response of 3T3-L1 adipocytes to t10c12 CLA by testing the following hypotheses: 1) SIRT1 is functionally required for robust TG reduction; and 2) SIRT1, …

Gene Duplication And The Evolution Of Hemoglobin Isoform Differentiation In Birds, Michael T. Grispo, Chandrasekhar Natarajan, Joana Projecto-Garcia, Hideaki Moriyama, Roy E. Weber, Jay F. Storz

Jay F. Storz Publications

The majority of bird species co-express two functionally distinct hemoglobin (Hb) isoforms in definitive erythrocytes as follows: HbA (the major adult Hb isoform, with α-chain subunits encoded by the α^A-globin gene) and HbD (the minor adult Hb isoform, with α-chain subunits encoded by the α^D-globin gene). The α^D-globin gene originated via tandem duplication of an embryonic α-like globin gene in the stem lineage of tetrapod vertebrates, which suggests the possibility that functional differentiation between the HbA and HbD isoforms may be attributable to a retained ancestral character state in HbD that harkens back to …

Chronic Exposure Of Rats To Native High Altitude Increases In Blood Pressure Via Activation Of The Renin-Angiotensin-Aldosterone System, Fahaid H. Al-Hashem, Mahmoud A. Alkhateeb, Abdullah S. Shatoor, Mohammad A. Khalil, Hussein F. Sakr

Saudi Medical Journal

OBJECTIVE: To study the effect of chronic exposure to native high altitude (HA) on blood pressure, and to investigate the underlying mechanism of action. METHODS: This study was carried out between February and April 2011. A total of 20 male rats were divided into 2 groups (n=10 rats). The low altitude (LA) group were rats born and lived in an LA environment at King Saud University, College of Pharmacy, Riyadh, Kingdom of Saudi Arabia (KSA), and the HA group were rats born in the same LA area, then acclimatized to HA area in Physiology Department, King Khalid University, College of …

Caroli Disease With Bilateral Severe Bullous Emphysema. An Unknown Component, Zeynep Keskin, Suat Keskin, Mihrican Y. Yesildag, Ahmet Yesildag

Saudi Medical Journal

We suspected that the multi-bullous parenchymal disease of our patient could be related to Caroli disease (CD) because he had no pulmonary pathology before the diagnosis of CD. The CD associated with bilateral multiple bullous emphysema may be an unknown component.

The Mediating Effects Of Job Engagement Between Spirituality At Work And Performance, Eileen Pei Shan Lai

Dissertations and Theses Collection (Open Access)

This research study explores the mediating role that work engagement plays between spirituality at work and performance. Spirituality at work is measured by four dimensions of meaningful work, having a sense of community, alignment with corporate values and having an inner life. Work engagement is recognized to comprise of physical, emotional and cognitive engagement (Kahn, 1990). Performance, on the other hand, refers to in-role behaviours, organizational citizenship behaviours – individuals ("OCB – I"), organizational citizenship behaviours – organizations ("OCB – O") and employee creativity.

My main contribution to the management, spirituality and religion (MSR) scholarship is the extension of the …

The Soulless Machine, Nathan Lomas

Theses

Since their creation, we have grown increasingly reliant on machines to aid us in our understanding and perceptions of the world - the camera is no exception. As an extension of the human eye, it allows us the opportunity to examine our environments from new perspectives, offering up views that we may not be able to witness on our own. Though in truth, the structure of the machine is ingrained in everything we know: from the natural world to our social patterns, actions are prescribed, parts move with united purpose, yet there is a certain comfort in the surrender of …

Vincentian Pragmatism: Toward A Method For Systemic Change, Scott Kelley Ph.D.

Vincentian Studies

Scott Kelley creates the term Vincentian Pragmatism and defines it as “Vincent [de Paul]’s way of proceeding . . . [it is] an integrated and holistic way of knowing that is capable of systemic change.” He writes, “Vincentian Pragmatism must also inform the way we engage, identify, explore, interpret, and decide in response to the complex systems that exacerbate poverty. It must unite action and contemplation.” Kelley identifies questions we must ask to pursue Vincentian epistemology and explains how Vincent developed it from his own experience. The process of overcoming our biases and forming a Vincentian worldview is also examined. …

Jean-Baptiste Étienne, C.M. And The Restoration Of The Daughters Of Charity, Edward R. Udovic C.M., Ph.D.

Vincentian Studies

The nineteenth-century superior general Jean-Baptiste Étienne has often been given the title of “Second Founder” of the Congregation and the Daughters of Charity. Edward Udovic argues that this title is deserved, not because of any similarity to Vincent de Paul, but because of Étienne’s faithfulness to the communities’ primitive spirit. Étienne made that the guiding principle of the communities’ re-establishment. His background, experience, agenda for restoration and reform, and worldview are all examined. According to Udovic, Étienne and his leadership are best described as “Vincentian-centric, Romantic, Gallican, and authoritarian.” A French nationalist and imperialist, he was particularly concerned with remaining …

Common Practices In Destination Website Design, Cuauhtémoc Luna-Nevarez, Michael R. Hyman

WCBT Faculty Publications

The Internet has become a key marketing channel for tourist destinations. To identify typical features of destination websites, a content analysis of websites for top global destinations—by number of international arrivals—was conducted. Six factors were evaluated: primary focus, navigation and interactivity, visual and presentation style, textual information, use of advertising, and use of social media and travel aids. In addition, a cluster analysis was conducted to identify homogeneous groups of websites in the sample. The findings revealed three naturally occurring groups. Inter-cluster differences suggest that DMOs use different approaches to target potential visitors, as evidenced by websites ranging from purely …

Distribution And Quantification Of Antibiotic Resistant Genes And Bacteria Across Agricultural And Non- Agricultural Metagenomes, Lisa M. Durso, Daniel N. Miller, Brian J. Wienhold

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

There is concern that antibiotic resistance can potentially be transferred from animals to humans through the food chain. The relationship between specific antibiotic resistant bacteria and the genes they carry remains to be described. Few details are known about the ecology of antibiotic resistant genes and bacteria in food production systems, or how antibiotic resistance genes in food animals compare to antibiotic resistance genes in other ecosystems. Here we report the distribution of antibiotic resistant genes in publicly available agricultural and non-agricultural metagenomic samples and identify which bacteria are likely to be carrying those genes. Antibiotic resistance, as coded for …

Using Dual Tasks To Test Immediate Transfer Of Training Between Naturalistic Movements: A Proof-Of-Principle Study, Sydney Y. Schaefer, Catherine E. Lang

Kinesiology and Health Science Faculty Publications

Theories of motor learning predict that training a movement reduces the amount of attention needed for its performance (i.e. more automatic). If training one movement transfers, then the amount of attention needed for performing a second movement should also be reduced, as measured under dual task conditions. The purpose of this study was to test whether dual task paradigms are feasible for detecting transfer of training between two naturalistic movements. Immediately following motor training, subjects improved performance of a second untrained movement under both single and dual task conditions. Subjects with no training did not. Improved performance in the untrained …

Truths We Must Tell Ourselves To Manage Climate Change, Robert H. Socolow

Vanderbilt Law Review

In 1958, Charles David Keeling began measuring the concentration of carbon dioxide (C02) in the atmosphere, at a site 11,000 feet above sea level near the top of Mauna Loa on the "big island" of Hawaii. The time series of monthly averages, the "Keeling Curve," is the iconic figure of climate change (see Figure 1). The curve oscillates and rises. The annual oscillations (whose details are seen in the Figure's inset) are the consequences of the seasonal breathing of the northern-hemisphere forests, which remove C02 from the atmosphere during their growing season and return C02 to the atmosphere as their …

Hydro Law And The Future Of Hydroelectric Power Generation In The United States, Dan Tarlock

Vanderbilt Law Review

Hydroelectric energy ("hydro") is the oldest major source of noncarbon, renewable energy in the United States. For three reasons, increased hydro generation should be a major element of any national climate change and energy-security policy designed to promote the greater use of renewables to help the country transition to the production of sustainable, i.e., noncarbon-based, energy. First, hydro is relatively clean because it does not cause air pollution or substantial greenhouse gas emissions.' Second, hydro is relatively reliable. Third, hydro can help wean the United States from its dependence on imported and often politically unstable hydrocarbon sources of energy, because …

“Two Parts Of The Landscape Of Family In America”: Maintaining Both Spousal And Domestic Partner Employee Benefits For Both Same-Sex And Different-Sex Couples, Nancy D. Polikoff

Fordham Law Review

No abstract provided.

Cognitive Architectures And Autonomy: Commentary And Response, Włodzisław Duch, Ah-Hwee Tan, Stan Franklin

Research Collection School Of Computing and Information Systems

This paper provides a very useful and promising analysis and comparison of current architectures of autonomous intelligent systems acting in real time and specific contexts, with all their constraints. The chosen issue of Cognitive Architectures and Autonomy is really a challenge for AI current projects and future research. I appreciate and endorse not only that challenge but many specific choices and claims; in particular: (i) that “autonomy” is a key concept for general intelligent systems; (ii) that “a core issue in cognitive architecture is the integration of cognitive processes ....”; (iii) the analysis of features and capabilities missing in current …

Village Literacy: Adult Education In Northeastern Kenya, Jodi Heidorn

Senior Honors Theses

The underdevelopment of effective adult literacy programs in Northern Kenya is a problem that must be addressed to meet the needs of a changing generation of nomadic pastoralists. Existing programs must be reevaluated in order to increase their efficiency and incorporate the unique aspects of local cultures into their design. This paper explores the broadening definition of literacy and discusses how there are in fact multiple literacies in any given culture. Next, it examines the history of education in Kenya and the barriers that may be unique to adult literacy programs in Northern Kenya. Also, it examines how changes in …

Low Density Urbanism, Sustainability, And Ihope- Maya: Can The Past Provide More Than History?, Vernon L. Scarborough, Arlen F. Chase, Diane Z. Chase

Anthropology Faculty Research

No abstract provided.

Friends Of Hearst Castle: Creating A Social Media Plan Using Public Relations Strategies For A Nonprofit, Amy Jean Checho

Journalism

Nonprofits, like Friends of Hearst Castle, understand the importance of social media use such as Facebook. However, many times Facebook messages are inconsistent and the multiple channels of social media are overwhelming. A Social Media Strategy or Plan can help nonprofits communicate their goals effectively and efficiently, with more success than before. This project discusses the best ways nonprofits can maximize their Facebook usage. Facebook is an easy way for nonprofits to communicate with their target audiences and have consistent communication. Friends of Hearst Castle was the nonprofit I worked with to help create and implement a Social Media Plan. …

Harmonizing Commercial Wind Power And The Endangered Species Act Through Administrative Reform, J.B. Ruhl

Vanderbilt Law School Faculty Publications

This Article explores the intersection of utility-scale wind power development and the Endangered Species Act, which thus far has not been as happy a union as one might expect. Part I provides background on how the ESA and wind power have met in policy, permitting, and litigation. Part II then examines whether wind power (and other renewable energy sources) can and should receive a green pass under the ESA given its unquestioned climate change mitigation benefits, concluding that doing so would face a host of legal and policy concerns. Part III then outlines a model for administrative innovation of ESA …

The Endangered Species Act's Fall From Grace In The Supreme Court, J.B. Ruhl

Vanderbilt Law School Faculty Publications

Thirty-five years ago, the Endangered Species Act ("ESA") had as auspicious a debut in the U.S. Supreme Court as any statute could hope for. In Tennessee Valley Authority v. Hill, a majority of the Court proclaimed that the ESA was intended "to halt and reverse the trend toward species extinction, whatever the cost" and backed up those and other bold words by preventing a nearly completed federal dam from impounding its reservoir because doing so would eliminate the only known (at the time) habitat of a small fish, the now infamous snail darter. To this day, Hill remains actively discussed …

Comparative Study Of Influenza Virus Replication In Mdck Cells And In Primary Cells Derived From Adenoids And Airway Epithelium, Natalia A. Ilyushina, Mine R. Ikizler, Yoshihiro Kawaoka, Larisa G. Rudenko

Dartmouth Scholarship

Although clinical trials with human subjects are essential for determination of safety, infectivity, and immunogenicity, it is de- sirable to know in advance the infectiousness of potential candidate live attenuated influenza vaccine strains for human use. We compared the replication kinetics of wild-type and live attenuated influenza viruses, including H1N1, H3N2, H9N2, and B strains, in Madin-Darby canine kidney (MDCK) cells, primary epithelial cells derived from human adenoids, and human bron- chial epithelium (NHBE cells). Our data showed that despite the fact that all tissue culture models lack a functional adaptive im- mune system, differentiated cultures of human epithelium exhibited …