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2012

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Translating Vocative Sentences By Exclamation In The Glorious Qur`An: A Semantic Analysis And Message Change, Nida S. Omar, Salahuddin Mohd, Kais A. Kadhim Jan 2012

Translating Vocative Sentences By Exclamation In The Glorious Qur`An: A Semantic Analysis And Message Change, Nida S. Omar, Salahuddin Mohd, Kais A. Kadhim

Research Publications (2011 to 2015)

The present study takes place under the fifth item of this conference .It is concerned with investigation message change in vocative sentences in the glorious Qur'an when translated to English. The present study aims to find the answers to the following research question: “Do the syntactical and grammatical changes affect the quality of the rhetorical message when translating vocative sentences of Qur’anic texts [source language text (SLT)] to English [target language text (TLT)]? To achieve this aim, a componential analysis of both the SLT and the TLT is adopted to uncover the similarities and differences in the message content of …

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Treatment With Captopril Abrogates The Altered Expression Of Alpha1 Macroglobulin And Alpha1 Antiproteinase In Sera Of Spontaneously Hypertensive Rats, Norhaniza Aminudin, N. A. Abdullah, H. Misbah, S. A. Karsani, R. Husain, S. Z. Hoe, Onn Haji Hashim Jan 2012

Treatment With Captopril Abrogates The Altered Expression Of Alpha1 Macroglobulin And Alpha1 Antiproteinase In Sera Of Spontaneously Hypertensive Rats, Norhaniza Aminudin, N. A. Abdullah, H. Misbah, S. A. Karsani, R. Husain, S. Z. Hoe, Onn Haji Hashim

Research Publications (2011 to 2015)

BACKGROUND: Proteins that are associated with hypertension may be identified by comparing the 2-dimensional gel electrophoresis (2-DE) profiles of the sera of spontaneously hypertensive rats (SHR) with those generated from normotensive Spraque-Dawley rats (SDR). RESULTS: Five proteins of high abundance were found to be significantly altered when the 2-DE serum profiles of the SHR were compared to those that were similarly generated from the SDR. Analysis by mass spectrometry and database search identified the proteins as retinol binding protein 4, complement C3, albumin (19.9 kDa fragment), alpha1 macroglobulin and alpha1 antiproteinase, which are all known to be associated with hypertension. …

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The Effects Of Simulated Rainfall On Immature Population Dynamics Of Aedes Albopictus And Female Oviposition, H. Dieng, G.M.S. Rahman, A. Abu Hassan, M.R. Che Salmah, T. Satho, F. Miake, M. Boots, Sazaly Abubakar Jan 2012

The Effects Of Simulated Rainfall On Immature Population Dynamics Of Aedes Albopictus And Female Oviposition, H. Dieng, G.M.S. Rahman, A. Abu Hassan, M.R. Che Salmah, T. Satho, F. Miake, M. Boots, Sazaly Abubakar

Research Publications (2011 to 2015)

Larvae of Aedes albopictus Skuse typically inhabit natural and artificial containers. Since these larval habitats are replenished by rainfall, Ae. albopictus may experience increased loss of immature stages in areas with high levels of rainfall. In this study, we investigated the effects of rainfall and container water level on population density, and oviposition activity of Ae. albopictus. In field and laboratory experiments, we found that rainfall resulted in the flushing of breeding habitats. Excess rain negatively impacted larval and pupal retention, especially in small habitats. When filled with water to overflowing, container habitats were significantly repellent to ovipositing females. Taken …

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1 '- Acetoxychavicol Acetate Inhibits Growth Of Human Oral Carcinoma Xenograft In Mice And Potentiates Cisplatin Effect Via Proinflammatory Microenvironment Alterations, L.L.A. In, N.M. Arshad, H. Ibrahim, M.N. Azmi, Khalijah Awang, Noor Hasima Nagoor Jan 2012

1 '- Acetoxychavicol Acetate Inhibits Growth Of Human Oral Carcinoma Xenograft In Mice And Potentiates Cisplatin Effect Via Proinflammatory Microenvironment Alterations, L.L.A. In, N.M. Arshad, H. Ibrahim, M.N. Azmi, Khalijah Awang, Noor Hasima Nagoor

Research Publications (2011 to 2015)

Background: Oral cancers although preventable, possess a low five-year survival rate which has remained unchanged over the past three decades. In an attempt to find a more safe, affordable and effective treatment option, we describe here the use of 1'S-1'-acetoxychavicol acetate (ACA), a component of Malaysian ginger traditionally used for various medicinal purposes. Methods: Whether ACA can inhibit the growth of oral squamous cell carcinoma (SCC) cells alone or in combination with cisplatin (CDDP), was explored both in vitro using MTT assays and in vivo using Nu/Nu mice. Occurrence of apoptosis was assessed using PARP and DNA fragmentation assays, while …

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A Brief Review On Anti Diabetic Plants: Global Distribution, Active Ingredients, Extraction Techniques And Acting Mechanisms, C.H. Chan, G.C. Ngoh, R. Yusoff Jan 2012

A Brief Review On Anti Diabetic Plants: Global Distribution, Active Ingredients, Extraction Techniques And Acting Mechanisms, C.H. Chan, G.C. Ngoh, R. Yusoff

Research Publications (2011 to 2015)

A study has been conducted with the aim to provide researchers with general information on anti diabetic extracts based on relevant research articles collected from 34 reliable medical journals. The study showed that Asian and African continents have 56 and 17 share of the worldwide distribution of therapeutic herbal plants, respectively. In Asia, India and China are the leading countries in herbal plants research, and there has been an increase in medicinal research on plants extract for diabetes treatment since 1995 in these regions. The information collected shows that plant leaves are about 20 more favorable for storing active ingredients, …

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A Study On The Energy Source In The Developing Embryo Of The Mangrove Horseshoe Crab, Carcinoscorpius Rotundicauda (Latreille), T.C. Srijaya, P.J. Pradeep, F. Shaharom, A. Chatterji Jan 2012

A Study On The Energy Source In The Developing Embryo Of The Mangrove Horseshoe Crab, Carcinoscorpius Rotundicauda (Latreille), T.C. Srijaya, P.J. Pradeep, F. Shaharom, A. Chatterji

Research Publications (2011 to 2015)

The mangrove horseshoe crab, Carcinoscorpius rotundicauda, is an Asian species found in Malaysia. This ancient arthropod has a long incubational period during which it depends on various energy sources for both embryogenesis and organogenesis. This study describes the trend of energy utilization from the endogenous reserves by the developing embryos from 0 to 40 days of incubation (until the hatching of the larvae). The dry weight, insoluble protein, carbohydrate, glycogen and lipid showed a declining trend from 0 to 40 days of incubation, whereas the wet weight, water content, ash content and soluble protein showed an increasing trend. Selected micro-elements …

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Acute Oral Toxicity Evaluations Of Some Zinc(Ii) Complexes Derived From 1-(2-Salicylaldiminoethyl)Piperazine Schiff Bases In Rats, Muhammad Saleh Salga, Hapipah Mohd Ali, Mahmood Ameen Abdulla, Siddig Ibrahim Abdelwahab Jan 2012

Acute Oral Toxicity Evaluations Of Some Zinc(Ii) Complexes Derived From 1-(2-Salicylaldiminoethyl)Piperazine Schiff Bases In Rats, Muhammad Saleh Salga, Hapipah Mohd Ali, Mahmood Ameen Abdulla, Siddig Ibrahim Abdelwahab

Research Publications (2011 to 2015)

The current study described the synthesis and the in vivo acute oral toxicity evaluations in Sprague Dawley rats. The compounds were characterized by elemental analyses, LC-MS, FTIR, H-1 NMR, C-13 NMR and UV-visible spectroscopy. In the acute toxicity study, a single administration of the compounds was performed orally to the rats at the single doses of 2000 mg/kg and they were then monitored for possible side effects, mortality or behavioral changes up to 14 days. The serum level of aspartate (AST), alanine aminotransferases (ALT), alkaline phosphate (ALP), triglyceride, high density lipoprotein (HDL), immunoglobulins (GAM) and the C-reactive proteins did not …

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Acute Toxicity And Gastroprotective Effect Of The Schiff Base Ligand ¹H-Indole-3-Ethylene-5-Nitrosalicylaldimine And Its Nickel (Ii) Complex On Ethanol Induced Gastric Lesions In Rats, M.M. Ibrahim, Hapipah Mohd Ali, M.A. Abdullah, P. Hassandarvish Jan 2012

Acute Toxicity And Gastroprotective Effect Of The Schiff Base Ligand ¹H-Indole-3-Ethylene-5-Nitrosalicylaldimine And Its Nickel (Ii) Complex On Ethanol Induced Gastric Lesions In Rats, M.M. Ibrahim, Hapipah Mohd Ali, M.A. Abdullah, P. Hassandarvish

Research Publications (2011 to 2015)

The present study was performed to evaluate the gastroprotective activity of Schiff base ligand derived from the condensation reaction of tryptamine (an indole derivative) and 5-nitrosalicylaldehyde (TNS) and its nickel (II) complex against ethanol-induced gastric ulcer in rats. The compounds were orally administered with low (30 mg/kg) and high (60 mg/kg) doses to ulcer-induced Sprague-Dawley rats. Macroscopically, the ulcer control group exhibited severe mucosal injury, whereas pre-treatment with either cimetidine or TNS and its nickel (II) complex each resulted in significant protection against gastric mucosal injury. Flattening of gastric mucosal folds was also observed in rats pretreated with TNS and …

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Acute Toxicity And Gastroprotective Effect Of The Schiff Base Ligand 1h-Indole-3-Ethylene-5-Nitrosalicylaldimine And Its Nickel (Ii) Complex On Ethanol Induced Gastric Lesions In Rats, M.A. Abdullah, M.M. Ibrahim, Hapipah Mohd Ali, P. Hassandarvish Jan 2012

Acute Toxicity And Gastroprotective Effect Of The Schiff Base Ligand 1h-Indole-3-Ethylene-5-Nitrosalicylaldimine And Its Nickel (Ii) Complex On Ethanol Induced Gastric Lesions In Rats, M.A. Abdullah, M.M. Ibrahim, Hapipah Mohd Ali, P. Hassandarvish

Research Publications (2011 to 2015)

The present study was performed to evaluate the gastroprotective activity of Schiff base ligand derived from the condensation reaction of tryptamine (an indole derivative) and 5-nitrosalicylaldehyde (TNS) and its nickel (II) complex against ethanol-induced gastric ulcer in rats. The compounds were orally administered with low (30 mg/kg) and high (60 mg/kg) doses to ulcer-induced Sprague-Dawley rats.Macroscopically, the ulcer control group exhibited severe mucosal injury, whereas pre-treatment with either cimetidine or TNS and its nickel (II) complex each resulted in significant protection against gastric mucosal injury. Flattening of gastric mucosal folds was also observed in rats pretreated with TNS and its …

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An Appraisal Of Al-Ijarah Al-Mawsufah Fi Al-Dhimmah (Forward Ijarah) From Fiqh Perspective, A.T. Mohammad Monawer Jan 2012

An Appraisal Of Al-Ijarah Al-Mawsufah Fi Al-Dhimmah (Forward Ijarah) From Fiqh Perspective, A.T. Mohammad Monawer

Research Publications (2011 to 2015)

Al-IjÉrah Al-MawÎËfah FÊ Al-Dhimmah (forward ijÉrah) is a new form of transactions introduced to the Islamic banking industry which has original ground in the classical books of Islamic Jurisprudence. Most of the classical scholars discussed it with particularized ijÉrah in parallel without any separation of chapters or headings unlike al-BahËtÊ and al-MinhÉjÊ. The scholars of four schools of Islamic Law are unanimously agreed on the legality of forward ijÉrah albeit some contemporary scholars mention the early dispute in this regard and attribute prohibition of forward ijÉrah to ×anafÊ School. This attribution is not accurate as it is proved by their …

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Antioxidant Activity, Phenolic And Flavonoid Contents In The Leaves Of Different Varieties Of Sweet Potato (Ipomoea Batatas), S.M. Hue, A.N. Boyce, C. Somasundram Jan 2012

Antioxidant Activity, Phenolic And Flavonoid Contents In The Leaves Of Different Varieties Of Sweet Potato (Ipomoea Batatas), S.M. Hue, A.N. Boyce, C. Somasundram

Research Publications (2011 to 2015)

The study of antioxidants from natural sources has gained popularity in the recent years. Six Ipomoea batatas leafy varieties namely Batu Kelantan, Batu Biasa, Biru Putih, Oren, Vitato and Indon were compared to assess the total phenols, flavonoids, reducing power and antioxidant activity. In this study, the Indon variety showed the highest level of total phenolic contents at 5.35 ± 0 g GAE/100 g DW. The flavonoid contents in the leaves ranged from 96 ± 47.6 μg/ g in Indon variety to 263.5 ± 43.5 μg/g in Batu Biasa variety. 1,1-diphenyl-2-picryl hydrazyl (DPPH) was used to determine the radical scavenging …

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Antioxidant And Hypoglycemic Activities Of Leaf Extracts Of Three Popular Terminalia Species, A. Arya, S. Nyamathulla, M.I. Noordin, M.A. Mohd Jan 2012

Antioxidant And Hypoglycemic Activities Of Leaf Extracts Of Three Popular Terminalia Species, A. Arya, S. Nyamathulla, M.I. Noordin, M.A. Mohd

Research Publications (2011 to 2015)

This study aimed to ascertain the antioxidant and hypoglycemic activity of methanolic extracts of the leaves of Terminalia arjuna, T. bellerica, and T. chebula. Extracts were evaluated for total phenolic, flavonoid, and tannin content, and in vitro antioxidant potential with DPPH, ORAC, and FRAP assays. The extracts' hypoglycemic activities were evaluated by hypoglycemic screening and an oral glucose tolerance test (OGTT) in normal rats. The methanolic extracts of T. chebula leaves exhibited the highest quantity of total phenolic and flavonoid content, followed by those of T. bellerica and T. arjuna. T. arjuna contained more tannin than T. bellerica did, but …

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Antipsychotic-Like Activity Of Noni (Morinda Citrifolia Linn.) In Mice, V. Pandy, M. Narasingam, Z. Mohamed Jan 2012

Antipsychotic-Like Activity Of Noni (Morinda Citrifolia Linn.) In Mice, V. Pandy, M. Narasingam, Z. Mohamed

Research Publications (2011 to 2015)

Background: Noni fruit is widely consumed in tropical regions of Indonesia to the Hawaiian Islands. The noni plant has a long history of use as a medicinal plant to treat a wide variety of ailments including CNS disorders. The present investigation was designed to evaluate the antipsychotic effect of noni fruits (Morinda citrifolia Linn.) using mouse models of apomorphine-induced climbing behaviour and methamphetamine-induced stereotypy (licking, biting, gnawing and sniffing).Methods: In acute study, the methanolic extract of Morinda citrifolia (MMC) at different doses 1, 3, 5, 10 g/kg was administered orally one hour prior to apomorphine (5 mg/kg, i.p) and methamphetamine …

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Antipsychotic-Like Activity Of Noni (Morinda Citrifolia Linn.) In Mice, P. Vijayapandi, M. Narasingam, Z. Mohamed Jan 2012

Antipsychotic-Like Activity Of Noni (Morinda Citrifolia Linn.) In Mice, P. Vijayapandi, M. Narasingam, Z. Mohamed

Research Publications (2011 to 2015)

Background: Noni fruit is widely consumed in tropical regions of Indonesia to the Hawaiian Islands. The noni plant has a long history of use as a medicinal plant to treat a wide variety of ailments including CNS disorders. The present investigation was designed to evaluate the antipsychotic effect of noni fruits (Morinda citrifolia Linn.) using mouse models of apomorphine-induced climbing behaviour and methamphetamine-induced stereotypy (licking, biting, gnawing and sniffing). Methods: In acute study, the methanolic extract of Morinda citrifolia (MMC) at different doses 1, 3, 5, 10 g/kg was administered orally one hour prior to apomorphine (5 mg/kg, i.p) and …

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Apoptosis Induction, Cell Cycle Arrest And In Vitro Anticancer Activity Of Gonothalamin In A Cancer Cell Lines, A.M. Alabsi, R. Ali, A.M. Ali, S.A.R. Al-Dubai, H. Harun, N.H. Abu Kasim, A. Alsalahi Jan 2012

Apoptosis Induction, Cell Cycle Arrest And In Vitro Anticancer Activity Of Gonothalamin In A Cancer Cell Lines, A.M. Alabsi, R. Ali, A.M. Ali, S.A.R. Al-Dubai, H. Harun, N.H. Abu Kasim, A. Alsalahi

Research Publications (2011 to 2015)

Cancer is one of the major health problems worldwide and its current treatments have a number of undesired adverse side effects. Natural compounds may reduce these. Currently, a few plant products are being used to treat cancer. In this study, goniothalamin, a natural occurring styryl-lactone extracted from Goniothalamus macrophyllus, was investigated for cytotoxic properties against cervical cancer (HeLa), breast carcinoma (MCF-7) and colon cancer (HT29) cells as well as normal mouse fibroblast (3T3) using MTT assay. Fluorescence microscopy showed that GTN is able to induce apoptosis in HeLa cells in a time dependent manner. Flow cytometry further revealed HeLa cells …

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Assessing The Value Of Dna Barcodes For Molecular Phylogenetics: Effect Of Increased Taxon Sampling In Lepidoptera, J.J. Wilson Jan 2012

Assessing The Value Of Dna Barcodes For Molecular Phylogenetics: Effect Of Increased Taxon Sampling In Lepidoptera, J.J. Wilson

Research Publications (2011 to 2015)

Background: A common perception is that DNA barcode datamatrices have limited phylogenetic signal due to the small number of characters available per taxon. However, another school of thought suggests that the massively increased taxon sampling afforded through the use of DNA barcodes may considerably increase the phylogenetic signal present in a datamatrix. Here I test this hypothesis using a large dataset of macrolepidopteran DNA barcodes. Methodology/Principal Findings: Taxon sampling was systematically increased in datamatrices containing macrolepidopteran DNA barcodes. Sixteen family groups were designated as concordance groups and two quantitative measures; the taxon consistency index and the taxon retention index, were …

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Assessing Toxicities Of Industrial Effluents And 1,4-Dioxane Using Sulphur-Oxidising Bacteria In A Batch Test, A. Gurung, S.H. Kim, J.H. Joo, M. Jang, S.E. Oh Jan 2012

Assessing Toxicities Of Industrial Effluents And 1,4-Dioxane Using Sulphur-Oxidising Bacteria In A Batch Test, A. Gurung, S.H. Kim, J.H. Joo, M. Jang, S.E. Oh

Research Publications (2011 to 2015)

In this study, the qualities of the final effluents from nine different industries (A, B, C, D, E, F, G, H and I) discharging 1,4-dioxane mainly as effluents were assessed using sulphur-oxidising bacteria (SOB) as a test micro-organism in batch mode. Results showed that effluent from industry 'B' was the most toxic of all the effluents tested, followed by E, C and A effluents. An EC50 value of 13 was obtained for effluent from B, whereas with E, C and A effluents, the EC50 values of 23, 25 and 29 were found, respectively. Similarly, batch tests were performed in order …

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Association Between Anaemia, Iron Deficiency Anaemia, Neglected Parasitic Infections And Socioeconomic Factors In Rural Children Of West Malaysia, R. Ngui, Y. A. L. Lim, L. C. Kin, C. S. Chuen, S. Jaffar Jan 2012

Association Between Anaemia, Iron Deficiency Anaemia, Neglected Parasitic Infections And Socioeconomic Factors In Rural Children Of West Malaysia, R. Ngui, Y. A. L. Lim, L. C. Kin, C. S. Chuen, S. Jaffar

Research Publications (2011 to 2015)

Background: Given that micronutrient deficiency, neglected intestinal parasitic infections (IPIs) and poor socioeconomic status are closely linked, we conducted a cross-sectional study to assess the relationship between IPIs and nutritional status of children living in remote and rural areas in West Malaysia. Methods/Findings: A total of 550 children participated, comprising 520 (94.5) school children aged 7 to 12 years old, 30 (5.5) young children aged 1 to 6 years old, 254 (46.2) boys and 296 (53.8) girls. Of the 550 children, 26.2 were anaemic, 54.9 iron deficient and 16.9 had iron deficiency anaemia (IDA). The overall prevalence of helminths was …

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Blastocystis Sp. : Waterborne Zoonotic Organism, A Possibility?, L.I. Lee, T.T. Chye, B.M. Karmacharya, S.K. Govind Jan 2012

Blastocystis Sp. : Waterborne Zoonotic Organism, A Possibility?, L.I. Lee, T.T. Chye, B.M. Karmacharya, S.K. Govind

Research Publications (2011 to 2015)

Background: Blastocystis sp. is a common intestinal parasite found in faecal sample surveys. Several studies have implicated human-to-human, zoonotic and waterborne transmissions by Blastocystis sp. However, there has been no study providing evidence interlinking these three transmissions in a community. We have previously shown a high prevalence of Blastocystis sp. subtype 4 amongst village dwellers in Bahunipati, Nepal, and the present study extends the observation to assess if the same subtype of Blastocystis sp. occurs in animals they rear and rivers they frequent. Methods: Faecal samples were collected from 65 animals. Four river water samples were collected from two rivers. …

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Boesenbergia Rotunda: From Ethnomedicine To Drug Discovery, T. Eng-Chong, L. Yean-Kee, C. Chin-Fei, H. Choon-Han, W. Sher-Ming, C.T. Li-Ping, F. Gen-Teck, Norzulaani Khalid, N. Abd Rahman, S.A. Karsani, S. Othman, R. Othman, R. Yusof Jan 2012

Boesenbergia Rotunda: From Ethnomedicine To Drug Discovery, T. Eng-Chong, L. Yean-Kee, C. Chin-Fei, H. Choon-Han, W. Sher-Ming, C.T. Li-Ping, F. Gen-Teck, Norzulaani Khalid, N. Abd Rahman, S.A. Karsani, S. Othman, R. Othman, R. Yusof

Research Publications (2011 to 2015)

Boesenbergia rotunda is a herb from the Boesenbergia genera under the Zingiberaceae family. B. rotunda is widely found in Asian countries where it is commonly used as a food ingredient and in ethnomedicinal preparations. The popularity of its ethnomedicinal usage has drawn the attention of scientists worldwide to further investigate its medicinal properties. Advancement in drug design and discovery research has led to the development of synthetic drugs from B. rotunda metabolites via bioinformatics and medicinal chemistry studies. Furthermore, with the advent of genomics, transcriptomics, proteomics, and metabolomics, new insights on the biosynthetic pathways of B. rotunda metabolites can be …

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Cardiovascular Activity Of Labdane Diterpenes From Andrographis Paniculata In Isolated Rat Hearts, Khalijah Awang, N.H. Abdullah, A.H. Hadi, Y. Su Fong Jan 2012

Cardiovascular Activity Of Labdane Diterpenes From Andrographis Paniculata In Isolated Rat Hearts, Khalijah Awang, N.H. Abdullah, A.H. Hadi, Y. Su Fong

Research Publications (2011 to 2015)

The dichloromethane (DCM) extract of Andrographis paniculata Nees was tested for cardiovascular activity. The extract significantly reduced coronary perfusion pressure by up to 24.5 ± 3.0 mm Hg at a 3 mg dose and also reduced heart rate by up to 49.5 ± 11.4 beats/minute at this dose. Five labdane diterpenes, 14-deoxy-12-hydroxyandrographolide (1), 14-deoxy-11,12-didehydroandrographolide (2), 14-deoxyandrographolide (3), andrographolide (4), and neoandrographolide (5), were isolated from the aerial parts of this medicinal plant. Bioassay-guided studies using animal model showed that compounds, (2) and (3) were responsible for the coronary vasodilatation. This study also showed that andrographolide (4), the major labdane diterpene …

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Computational Intelligence Based Technique In Multiple Facts Devices Installation For Power System Security, S.A. Jumaat, I. Musirin, M.M. Othman, Hazlie Mokhlis Jan 2012

Computational Intelligence Based Technique In Multiple Facts Devices Installation For Power System Security, S.A. Jumaat, I. Musirin, M.M. Othman, Hazlie Mokhlis

Research Publications (2011 to 2015)

This paper presents a study on optimal location and sizing of multiple FACTS devices based on Particle Swarm Optimization (PSO) for minimization of transmission losses, and voltage profile improvement, which takes into account the cost of installation. In this study, Static Var Compensator (SVC) and Thyristor Controlled Series Compensator (TCSC) are chosen as the compensating device for the purposes of maintaining security in power system. Simulations for various loading conditions at several load buses have been conducted in order to evaluate its robustness and feasibility for broad implementation. In addition, installation of several FACTS devices into the system has been …

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Cucurbitacin L 2-O-Β-Glucoside Demonstrates Apoptogenesis In Colon Adenocarcinoma Cells (Ht-29): Involvement Of Reactive Oxygen And Nitrogen Species Regulation, S.I. Abdelwahab, L.E. Hassan, A.M. Abdul Majid, S.M. Yagi, S. Mohan, M.M. Elhassan Taha, S. Ahmad, C.S. Chuen, P. Narrima, M.M. Rais, S. Syam, B.A. Moharam, A.H. Hadi Jan 2012

Cucurbitacin L 2-O-Β-Glucoside Demonstrates Apoptogenesis In Colon Adenocarcinoma Cells (Ht-29): Involvement Of Reactive Oxygen And Nitrogen Species Regulation, S.I. Abdelwahab, L.E. Hassan, A.M. Abdul Majid, S.M. Yagi, S. Mohan, M.M. Elhassan Taha, S. Ahmad, C.S. Chuen, P. Narrima, M.M. Rais, S. Syam, B.A. Moharam, A.H. Hadi

Research Publications (2011 to 2015)

Emerging evidence suggests that reactive oxygen (ROS) and nitrogen (RNS) species can contribute to diverse signalling pathways of inflammatory and tumour cells. Cucurbitacins are a group of highly oxygenated triterpenes. Many plants used in folk medicine to treat cancer have been found to contain cucurbitacins displaying potentially important anti-inflammatory actions. The current study was designed to investigate the anti-ROS and -RNS effects of cucurbitacin L 2-O-β-glucoside (CLG) and the role of these signaling factors in the apoptogenic effects of CLG on human colon cancer cells (HT-29). This natural cucurbitacin was isolated purely from Citrullus lanatus var. citroides (Cucurbitaceae). The results …

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Cytokine Expression Profile Of Dengue Patients At Different Phases Of Illness, A. Rathakrishnan, S.M. Wang, Y.L. Hu, A.M. Khan, S. Ponnampalavanar, L.C.S. Lum, R. Manikam, S.D. Sekaran Jan 2012

Cytokine Expression Profile Of Dengue Patients At Different Phases Of Illness, A. Rathakrishnan, S.M. Wang, Y.L. Hu, A.M. Khan, S. Ponnampalavanar, L.C.S. Lum, R. Manikam, S.D. Sekaran

Research Publications (2011 to 2015)

Background: Dengue is an important medical problem, with symptoms ranging from mild dengue fever to severe forms of the disease, where vascular leakage leads to hypovolemic shock. Cytokines have been implicated to play a role in the progression of severe dengue disease; however, their profile in dengue patients and the synergy that leads to continued plasma leakage is not clearly understood. Herein, we investigated the cytokine kinetics and profiles of dengue patients at different phases of illness to further understand the role of cytokines in dengue disease. Methods and Findings: Circulating levels of 29 different types of cytokines were assessed …

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Denguetools: Innovative Tools And Strategies For The Surveillance And Control Of Dengue, Annelies Wilder-Smith, Karl Erik Renhorn, Hasitha Tissera, Sazaly Abubakar, Luke Alphey, Pattamaporn Kittayapong, Steve Lindsay, James Logan, Christoph Hatz, Paul Reiter, Joacim Rocklöv, Peter Byass, Valerie R. Louis, Yesim Tozan, Eduardo Massad, Antonio Tenorio, Christophe Lagneau, Gregory L'Ambert, David Brooks, Johannah Wegerdt, Duane Gubler Jan 2012

Denguetools: Innovative Tools And Strategies For The Surveillance And Control Of Dengue, Annelies Wilder-Smith, Karl Erik Renhorn, Hasitha Tissera, Sazaly Abubakar, Luke Alphey, Pattamaporn Kittayapong, Steve Lindsay, James Logan, Christoph Hatz, Paul Reiter, Joacim Rocklöv, Peter Byass, Valerie R. Louis, Yesim Tozan, Eduardo Massad, Antonio Tenorio, Christophe Lagneau, Gregory L'Ambert, David Brooks, Johannah Wegerdt, Duane Gubler

Research Publications (2011 to 2015)

Dengue fever is a mosquito-borne viral disease estimated to cause about 230 million infections worldwide every year, of which 25,000 are fatal. Global incidence has risen rapidly in recent decades with some 3.6 billion people, over half of the world's population, now at risk, mainly in urban centres of the tropics and subtropics. Demographic and societal changes, in particular urbanization, globalization, and increased international travel, are major contributors to the rise in incidence and geographic expansion of dengue infections. Major research gaps continue to hamper the control of dengue. The European Commission launched a call under the 7th Framework Programme …

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Determining The Optimal Concentration Of Mannose As An Effective Selection Agent For Transformed Oil Palm Cells Using The Phosphomannose Isomerase (Pmi) Gene As A Positive Selectable Marker, B. Bahariah, G.K.A. Parveez, N. Khalid Jan 2012

Determining The Optimal Concentration Of Mannose As An Effective Selection Agent For Transformed Oil Palm Cells Using The Phosphomannose Isomerase (Pmi) Gene As A Positive Selectable Marker, B. Bahariah, G.K.A. Parveez, N. Khalid

Research Publications (2011 to 2015)

The elimination of antibiotic or herbicide resistance gene usage in genetically modified plants is being encouraged due to public concern. In response to this, alternative selection systems for the recovery of transgenic oil palm were developed using positive selectable markers. To establish a selection system that utilises the phosphomannose isomerase (pmi) gene for oil palm transformation, we first determined the optimal mannose concentration for selecting the transformed cells. Non-transformed embryogenic calli were cultured on media containing various combinations and concentrations of mannose and a usable source of carbon, i.e. sucrose, ranging in content from 0 to 30 g litre . …

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Differentiating Entamoeba Histolytica, Entamoeba Dispar And Entamoeba Moshkovskii Using Nested Polymerase Chain Reaction (Pcr) In Rural Communities In Malaysia, Romano Ngui, Lorainne Angal, Siti Aminah Fakhrurrazi, Yvonne Ai Lian Lim, Yee Ling Lau, Jamaiah Ibrahim, Rohela Mahmud Jan 2012

Differentiating Entamoeba Histolytica, Entamoeba Dispar And Entamoeba Moshkovskii Using Nested Polymerase Chain Reaction (Pcr) In Rural Communities In Malaysia, Romano Ngui, Lorainne Angal, Siti Aminah Fakhrurrazi, Yvonne Ai Lian Lim, Yee Ling Lau, Jamaiah Ibrahim, Rohela Mahmud

Research Publications (2011 to 2015)

Background: In this study, a total of 426 human faecal samples were examined for the presence of Entamoeba histolytica, Entamoeba dispar, Entamoeba moshkovskii infection via a combination of microscopic examination and nested polymerase chain reaction (PCR) targeting 16S ribosomal RNA of Entamoeba species. Methods: Faecal sample were collected from 426 participants in five rural villages in Peninsular Malaysia. The faecal samples were processed by direct wet smear and formalin ethyl acetate concentration technique followed by iodine staining and examined via microscopy for the presence of Entamoeba species and other intestinal parasites. Microscopically positive samples for Entamoeba species cysts were further …

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Domiciliary Cockroaches Found In Restaurants In Five Zones Of Kuala Lumpur Federal Territory, Peninsular Malaysia, J. Jeffery, S. Sulaiman, P. Oothuman, S. Vellayan, P. Zainol-Ariffin, S. Paramaswaran, A. Razak, M. Muslimin, O.B. Kamil-Ali, M. Rohela, N.M. Abdul-Aziz Jan 2012

Domiciliary Cockroaches Found In Restaurants In Five Zones Of Kuala Lumpur Federal Territory, Peninsular Malaysia, J. Jeffery, S. Sulaiman, P. Oothuman, S. Vellayan, P. Zainol-Ariffin, S. Paramaswaran, A. Razak, M. Muslimin, O.B. Kamil-Ali, M. Rohela, N.M. Abdul-Aziz

Research Publications (2011 to 2015)

The following domiciliary cockroaches were collected from restaurants in five zones of Kuala Lumpur Federal Territory, Malaysia using IL glass beaker traps baited with ground mouse-pellets: Periplaneta americana (Linnaeus) (n = 820), Periplaneta brunnea Burmeister (n = 46), Blattella germanica (Linnaeus) (n = 12504), Supella longipalpa (Fabricius) (n = 321), Symploce pallens Stephens (n = 29) and Neostylopyga rhombifolia (Stoll) (n = 5). The following bacteria were isolated from 10 cockroach specimens: Enterobacter cloacae, Klebsiella pneumoniae ssp. pneumoniae, Klebsiella pneumoniae ssp. rhinoscleromatis and Serratia liquefaciens from 5 B. germanica; Acinetobacter calcoaceticus var. anitratus, Citrobacter diversus/amalonaticus, Escherichia vulneris and K.p. pneumoniae …

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Effect Of Mucuna Pruriens Seed Extract Pretreatment On The Responses Of Spontaneously Beating Rat Atria And Aortic Ring To Naja Sputatrix (Javan Spitting Cobra) Venom, Shin Yee Fung, Nget Hong Tan, Si Mui Sim, John C. Aguiyi Jan 2012

Effect Of Mucuna Pruriens Seed Extract Pretreatment On The Responses Of Spontaneously Beating Rat Atria And Aortic Ring To Naja Sputatrix (Javan Spitting Cobra) Venom, Shin Yee Fung, Nget Hong Tan, Si Mui Sim, John C. Aguiyi

Research Publications (2011 to 2015)

Mucuna pruriens Linn. (velvet bean) has been used by native Nigerians as a prophylactic for snakebite. Rats pretreated with M. pruriens seed extract (MPE) have been shown to protect against the lethal and cardiovascular depressant effects of Naja sputatrix (Javan spitting cobra) venoms, and the protective effect involved immunological neutralization of the venom toxins. To investigate further the mechanism of the protective effect of MPE pretreatment against cobra venom toxicity, the actions of Naja sputatrix venom on spontaneously beating rat atria and aortic rings isolated from both MPE pretreated and untreated rats were studied. Our results showed that the MPE …

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Effects Of Pithecellobium Jiringa Ethanol Extract Against Ethanol-Induced Gastric Mucosal Injuries In Sprague-Dawley Rats, M.A. Abdulla, I.A.A. Ibrahim, S.W. Qader, A.R. Nimir, S.I. Abdelwahab, F.H. Al-Bayaty Jan 2012

Effects Of Pithecellobium Jiringa Ethanol Extract Against Ethanol-Induced Gastric Mucosal Injuries In Sprague-Dawley Rats, M.A. Abdulla, I.A.A. Ibrahim, S.W. Qader, A.R. Nimir, S.I. Abdelwahab, F.H. Al-Bayaty

Research Publications (2011 to 2015)

Current anti-gastric ulcer agents have side effects, despite the progression and expansion of advances in treatment. This study aimed to investigate the gastroprotective mechanisms of Pithecellobium jiringa ethanol extract against ethanol-induced gastric mucosal ulcers in rats. For this purpose, Sprague Dawley rats were randomly divided into five groups: Group 1 (normal control) rats were orally administered with vehicle (carboxymethyl cellulose), Group 2 (ulcer control) rats were also orally administered with vehicle. Group 3 (positive control) rats were orally administered with 20 mg/kg omeprazole, Groups 4 and 5 (experimental groups) received ethanol extract of Pithecellobium jiringa ethanol extract at a concentration …

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