Digital Commons Network^™

Acid Sphingomyelinase Gene Knockout Ameliorates Hyperhomocysteinemic Glomerular Injury In Mice Lacking Cystathionine-Β-Synthase, Krishna M. Boini, Min Xia, Justine M. Abais, Ming Xu, Cai-Xia Li, Pin-Lan Li

Pharmacology and Toxicology Publications

Acid sphingomyelinase (ASM) has been implicated in the development of hyperhomocysteinemia (hHcys)-induced glomerular oxidative stress and injury. However, it remains unknown whether genetically engineering of ASM gene produces beneficial or detrimental action on hHcys-induced glomerular injury. The present study generated and characterized the mice lacking cystathionine β-synthase (Cbs) and Asm mouse gene by cross breeding Cbs+/− and Asm+/− mice. Given that the homozygotes of Cbs−/−/Asm−/− mice could not survive for 3 weeks. Cbs+/−/Asm+/+, Cbs+/−/Asm+/− and Cbs+/−/Asm−/− as well as their Cbs wild type littermates were used to study the role of Asm−/− under a background of Cbs+/− with hHcys. HPLC …

The Natural Law Bridge Between Private Law And Public International Law, Richard A. Epstein

Articles

One keg similarity between natural law and international law is that they seek to obtain a stable social order without the intervention of any state authority capable of issuing and enforcing its commands to those subject to its rule. Among ordinary individuals in a state of nature that weakness tends to lead to a stripped-down libertarian regime that features simple rules of acquisition, contract, and protection. The system gains its relative stability from the brute fact that between rough equals the part in the defensive posture will win out, so that great disparities in power are needed to disrupt the …

Phylogeny Of Shiga Toxin-Producing Escherichia Coli O157 Isolated From Cattle And Clinically Ill Humans, James L. Bono, Timothy P. L. Smith, James E. Keen, Gregory P. Harhay, Tara G. Mcdaneld, Robert E. Mandrell, Woo Kyung Jung, Thomas E. Besser, Peter Gerner-Smidt, Martina Bielaszewska, Helge Karch, Michael L. Clawson

Roman L. Hruska U.S. Meat Animal Research Center: Reports

Cattle are a major reservoir for Shiga toxin-producing Escherichia coli O157 (STEC O157) and harbor multiple genetic subtypes that do not all associate with human disease. STEC O157 evolved from an E. coli O55:H7 progenitor; however, a lack of genome sequence has hindered investigations on the divergence of human- and/or cattle-associated subtypes. Our goals were to 1) identify nucleotide polymorphisms for STEC O157 genetic subtype detection, 2) determine the phylogeny of STEC O157 genetic subtypes using polymorphism-derived genotypes and a phage insertion typing system, and 3) compare polymorphism-derived genotypes identified in this study with pulsed field gel electrophoresis (PFGE), the …

Associations Of Genetic Markers In Cattle Receiving Differing Implant Protocols, D. A. King, S. D. Shackelford, T. G. Mcdaneld, L. A. Kuehn, C. M. Kemp, T. P.L. Smith, T. L. Wheeler, M. Koohmaraie

Roman L. Hruska U.S. Meat Animal Research Center: Reports

The potential interaction of growth promoting implants and genetic markers previously reported to be associated with growth, carcass traits, and tenderness was evaluated. Two implant protocols were applied to subsets of steers (n = 383) and heifers (n = 65) that were also genotyped for 47 SNP reported to be associated with variation in growth, fat thickness, LM area, marbling, or tenderness. The “mild” protocol consisted of a single terminal implant [16 mg estradiol benzoate (EB), 80 mg trenbalone acetate (TBA) or 8 mg EB, 80 mg TBA given to steers and heifers, respectively]. The “aggressive” protocol consisted of both …

Zen Communication - A Cross Cultural Approach To Mindfulness, Appropriate Response, And Flow In Dyadic Interactions, Gregory Husak

All Graduate Theses, Dissertations, and Other Capstone Projects

This study examined the question of how the qualities that arise from the practice of traditionally East Asian disciplines such as Zen and related martial arts might be effectively applied to dyadic interactions. Long-form interviews of about 40 minutes each were conducted with academics who have studied these topics and with expert practitioners who have extensive direct experience. Most subjects had significant cross-cultural experience, having studied and/or practiced in both the U.S. and in Japan. Detailed analysis of transcripts of these recorded interviews indicated that, in particular, the seated Zen meditation practice known as zazen generates personally transformational qualities that …

Physiology And Endocrinology Symposium: Factors Controlling Puberty In Beef Heifers, P. M. Fricke, R. A. Cushman

Roman L. Hruska U.S. Meat Animal Research Center: Reports

The Physiology and Endocrinology Symposium on “Factors controlling puberty in beef heifers” was held at the Joint Annual Meeting of the American Society of Animal Science and the American Dairy Science Association in New Orleans, Louisiana, July 10 to 14, 2011. The objective of the symposium was to provide attendees with new insights and perspectives from recent research findings on puberty in beef heifers. To that end, the 2011 physiology and endocrinology symposium program was organized to review recent research findings in beef cattle puberty with a broad overview of areas affecting puberty including management, genetics, nutrition, and hormonal manipulation …

Next-Generation Sequencing Of The Porcine Skeletal Muscle Transcriptome For Computational Prediction Of Microrna Gene Targets, Tara G. Mcdaneld, Tim P. L. Smith, Gregory P. Harhay, Ralph T. Wiedmann

Roman L. Hruska U.S. Meat Animal Research Center: Reports

Background: MicroRNA are a class of small RNAs that regulate gene expression by inhibiting translation of protein encoding transcripts through targeting of a microRNA-protein complex by base-pairing of the microRNA sequence to cognate recognition sequences in the 39 untranslated region (UTR) of the mRNA. Target identification for a given microRNA sequence is generally accomplished by informatics analysis of predicted mRNA sequences present in the genome or in databases of transcript sequence for the tissue of interest. However, gene models for porcine skeletal muscle transcripts in current databases, specifically complete sequence of the 39 UTR, are inadequate for this exercise.

Methodology/Principal …

Juan De Arguijo Y Las Pasiones, Olympia Gonzalez

Modern Languages and Literatures: Faculty Publications and Other Works

No abstract provided.

The Spirit Of Contradiction In The Buddhist Doctrine Of Not-Self, Hugh Nicholson

Theology: Faculty Publications and Other Works

An essay is presented discussing the various interpretations of the Theravāda Buddhist doctrine of "Not-self," or anattā. The author points out two contrasting manifestations of the teaching, including the "political-oppositional" form and the "spiritual-transformative" form. The relations between these paradigms are examined in depth through reference to works by Steven Collins, Richard Combrich, and Johannes Bronkhorst.

Marcello Pera: Why We Should Call Ourselves Christians Study Guide, 2012, Steven A. Samson

Faculty Publications and Presentations

Marcello Pera’s Why We Should Call Ourselves Christians provides a framework for understanding the moral crisis of our age represented by liberalism’s diversion from its foundations in a Christian culture and its conversion into a corrupter of that culture through what he calls “the secular equation.”

Asset Price Bubbles And Central Bank Policies: The Crash Of The "Jackson Hole Consensus", A. G. Malliaris

School of Business: Faculty Publications and Other Works

This chapter examines whether or not monetary policy should respond to asset price bubbles. More specifically, it asks how central banks respond while an asset bubble is growing and how they respond after the bubble bursts. It begins with a general overview of asset bubbles that supports the existence of the real and financial sectors of an economy before discussing how the bursting of asset price bubbles may cause financial instability that often adversely affects the real sector of an economy. It then describes the normative vs. positive responses of a central bank to asset price bubbles, along with the …

Rotating Magnets Produce A Prompt Analgesia Effect In Rats, Zhong Chen, Hui Ye, Haiyun Xu, Shukang An, Anmin Jin, Chusong Zhou, Shaoan Yang

Biology: Faculty Publications and Other Works

The beneficial effects of chronic/repeated magnetic stimulation on humans have been examined in previous studies. Although pain relief effects have been reported several weeks after magnetic treatment, no report is available regarding the prompt effect of magnetic stimulations. In this study, a novel apparatus was developed to generate time-varying magnetic fields with rotating magnets. Adult, conscious rats were exposed to the rotating magnets in a posture in which their spines were parallel to the induced electric current. The magnetic field suppressed the paw withdrawal reflex in the anesthetized rats, and the suppression effect disappeared 5 minutes after magnets stopped rotating. …

Assessing The Use Of Non-Lethal Tail Clips For Measuring Stable Isotopes Of Plethodontid Salamanders, Joseph Milanovich, John C. Maerz

Biology: Faculty Publications and Other Works

Stable isotopes are increasingly used in ecology to study the diets, trophic position, and migratory patterns of wildlife including herpetofauna. When using stable isotopes, it is important to consider which tissues can or should be sampled, and how selecting tissues may affect the inferences drawn from stable isotope data. Amphibians offer fewer tissues than other larger organisms that can be harvested in sufficient quantity without killing the animal; however, many salamanders have tails that readily autotomize and regenerate. We used three species of plethodontid salamander (Plethodon cinereus, P. metcalfi, and Desmognathus quadramaculatus) to determine whether distal tail tissue had carbon …

A Labor Contract For A Pronoetes (P.Lond. Inv. )*, James G. Keenan

Classical Studies: Faculty Publications and Other Works

The document, the fourth of its kind to be published, is what the editors of the first and still most complete specimen (P.Oxy. I 136 = W.Chr. 383) called a “contract of a farm steward.”

Reference--I'Ve Got An App For That!, Sue Polanka

University Libraries' Staff Publications

These days, it seems there's an app for everything. So it should come as no surprise that several reference publishers are producing apps for Apple-and Android-based tablets and phones. Why should reference publishers develop apps? "Our focus is on helping libraries reach new users where they reside. We believe that one of the most effective ways to do this is through apps," says Nader Qaimari, senior vice president of marketing for Cengage Learning. Mike Robinson, e-book sales and marketing manager at Oxford University Press, agrees, stating, "Apps represent a means by which people all over the world are using devices …

Forearm Orientation In Hadrosauridae (Dinosauria: Ornithopoda) And Implications For Museum Mounts, Phil Senter

College of Health, Science, and Technology

Skeletons of hadrosaurids (“duck-billed dinosaurs”) are usually mounted with palms facing caudally (posteriorly). To achieve this, the radius is articulated with the medial (ulnar) condyle of the humerus instead of the lateral (radial) condyle, which would be unique among vertebrates if it were correct. However, articulated specimens reveal that in hadrosaurids the radius articulates with the lateral condyle of the humerus, as in other vertebrates, and the palms face caudomedially, though more medially than caudally. Active pronation is prevented by the shapes of the radial and ulnar shafts and by the lack of rolling articulations between radius and ulna. This …

More "Dinosaur" And "Pterosaur" Rock Art That Isn't, Phil Senter

College of Health, Science, and Technology

To support claims of the coexistence of humans with dinosaurs and pterosaurs, young-earth creationist authors have identified several pieces of ancient rock art as depictions of dinosaurs or pterosaurs. Here, nine such claims are investigated. An alleged pterosaur painting in Black Dragon Canyon, Utah, is actually not a single painting. Its "head" and "neck" are a painting of a person with outstretched arms. Its torso and limbs are those of a painting of a second person with outstretched arms, whose body continues into the "pterosaur's" "wing." The other "wing" is a painting of a horned serpent. The three paintings only …

Response Of Ectomycorrhizal Fungi To Inorganic And Organic Forms Of Nitrogen And Phosphorus, Christa M. Luokkala

Dissertations, Master's Theses and Master's Reports - Open

The nutrient uptake response of ectomycorrhizal fungi (ECM) to different nutrient substrates is a driving force in ecosystem nutrient cycling. We hypothesized that taxa from low nitrogen (N) soils would be more likely to use organic N compared to taxa from high N soils, and that taxa from high N would be more likely to use organic phosphorus (P) sources when compared to the ECM dominant in low N soils. This study focuses on the growth response of ECM species collected over a N gradient to different forms of N and P nutrient substrates and whether ECM growth in a …

Through The Eyes Of Sailors And Citizens: How Sailors On The Uss Constitution Viewed The Greek Revolution, Elizabeth George

Undergraduate Review

Around noon on October 21, 1797, a crowd of men and women gathered at Hartt’s shipyard in Boston, Massachusetts to attend the launching of the USS Constitution. The Americans who witnessed the launching of the Constitution on that cold, overcast, autumn day must have marveled at the sight of the newly completed 44-gun frigate. Joshua Humphreys, a Philadelphian shipbuilder, designed the Constitution longer and thinner than the typical frigate of the time in order to facilitate the ship’s ability to sail with greater alacrity and precision through the ocean. Humphrey also ordered the ship’s hull to consist predominantly of live …

The German Model For American Medical Reform, Charles E. Mcclelland

History Faculty Publications

The Flexner Report of 1910, which radically transformed American medical education and medical schools, may be seen not so much as a completely novel initiative as the culmination of a longer transfer of models from Germany, with which Flexner was intimately acquainted.

Children's Mercy Hospital Annual Report 2011, Children's Mercy Hospital

Children's Mercy Annual Reports

Annual report for The Children's Mercy Hospital in Kansas City MO, a pediatric medical center.

Working Trees For Livestock

Working Trees (USDA-NAC)

Conventional wisdom in the past has been that livestock and trees can’t co-exist. Yet moderm agricultural practice is showing their livestock and trees not only can co-exist, but, if properly managed, can provide additional income from land formerly used for a single crop.

Trees can provide livestock with protection from cold wind and blowing snow in winter, as well as from the hot sun and drying winds of summer. And, if commercially desirable timber or nut trees are planted, landowners can enjoy significant additional income from this diverse use of their land.

This publication will acquaint you with some of …

Scwds Briefs: Volume 27, Number 4 (January 2012), Jeanenne Brewton, Michael J. Yabsley

Southeastern Cooperative Wildlife Disease Study: Publications

TB or Not TB: Michigan and Minnesota

Continued Public Support for Hunting

CWD Update: February 2012

Lymphoproliferative Disease in Turkeys

H5N1 HPAI Virus Studies at SCWDS

We Have Lost a Good Friend

Wetland And Riparian Plant Communities At Risk Of Invasion By Transgenic Herbicide-Resistant Agrostis Spp. In Central Oregon, Michael A. Bollman, Marjorie J. Storm, George A. King, Lidia S. Watrud

United States Environmental Protection Agency: Publications

Creeping bentgrass (Agrostis stolonifera) and redtop (A. gigantea) are introduced turfgrasses that are naturalized throughout the northern U.S. Interest in creeping bentgrass has risen following the 2003 escape of a genetically modified (GM), herbicide- resistant cultivar near Madras, Oregon. The objectives of this study were to characterize the floristic attributes of the plant communities associated with naturalized Agrostis populations in the Madras area, and to identify plant communities at risk of invasion by transgenic Agrostis. Vegetation data collected from 62 stratified random vegetation plots with and without A. stolonifera and A. gigantea identified 11 distinct …

Screening-Level Risk Assessment For Styrene-Acrylonitrile (San) Trimer Detected In Soil And Groundwater, C. R. Kirman, M. L. Gargas, J. J. Collins, J. C. Rowlands

United States Environmental Protection Agency: Publications

A screening-level risk assessment was conducted for styrene-acrylonitrile (SAN) Trimer detected at the Reich Farm Superfund site in Toms River, NJ. Consistent with a screening-level approach, on-site and off-site exposure scenarios were evaluated using assumptions that are expected to overestimate actual exposures and hazards at the site. Environmental sampling data collected for soil and groundwater were used to estimate exposure point concentrations. Several exposure scenarios were evaluated to assess potential on-site and off-site exposures, using parameter values for exposures to soil (oral, inhalation of particulates, and dermal contact) and groundwater (oral, dermal contact) to reflect central tendency exposure (CTE) and …

Dose-Response Analysis Of Bromate-Induced Dna Damage And Mutagenicity Is Consistent With Low-Dose Linear, Nonthreshold Processes, Maria A. Spassova, David J. Miller, David A. Eastmond, Nadejda S. Nikolova, Suryanarayana V. Vulimiri, Jane Caldwell, Chao Chen, Paul D. White

United States Environmental Protection Agency: Publications

Mutagenic agents have long been inferred to act through low-dose linear, nonthreshold processes. However, there is debate about this assumption, with various studies interpreting datasets as showing thresholds for DNA damage and mutation. We have applied rigorous statistical analyses to investigate the shape of dose-response relationships for a series of in vitro and in vivo genotoxicity studies using potassium bromate (KBrO3), a water ozonation byproduct that is bioactivated to a reactive species causing oxidative damage to DNA. We analyzed studies of KBrO3 genotoxicity where no-effect/threshold levels were reported as well as other representative datasets. In all cases, the data were …

Adaptive Management To Protect Biodiversity: Best Available Science And The Endangered Species Act, Olivia Odom Green, Ahjond S. Garmestani

United States Environmental Protection Agency: Publications

Although flawed, the most powerful tool for protecting biodiversity in the United States is the Endangered Species Act, which requires the use of the best available science to ensure that endangered and threatened species are not put in jeopardy of extinction. Unfortunately, the best available science mandate is virtually meaningless and imposes no additional scientific rigor in agency decision making beyond what is normally required of administrative procedures. In this paper, we propose to define best available science in a way that shifts from a way of using science to a way of doing science, and a sound method of …

An Energy Systems View Of Sustainability: Emergy Evaluation Of The San Luis Basin, Colorado, Daniel E. Campbell, Ahjond S. Garmestani

United States Environmental Protection Agency: Publications

Energy Systems Theory (EST) provides a framework for understanding and interpreting sustainability. EST implies that “what is sustainable” for a system at any given level of organization is determined by the cycles of change originating in the next larger system and within the system of concern. The pulsing paradigm explains the ubiquitous cycles of change that apparently govern ecosystems, rather than succession to a steady state that is then sustainable. Therefore, to make robust decisions among environmental policies and alternatives, decision-makers need to know where their system resides in the cycles of change that govern it. This theory was examined …

Chapter 1 An Introduction To Agricultural Biotechnology Regulation In The U.S., Chris A. Wozniak, Annabel Fellman Waggoner, Sheryl Reilly

United States Environmental Protection Agency: Publications

The regulation of agricultural plant and microbial biotechnology products in the United States of America has a rich history that re fl ects the challenges the federal government has faced in the development of appropriate rules and standards needed to determine their safety to humans and the environment. Several factors – the insuf fi cient global food supply, loss or curtailment of the use of older chemistries to control pests due to risks and environmental persistence, the rising demand for safer food commodities, and the uncertainty surrounding the sustainability of agriculture in this and other countries – have added to …

The Mouse: An‘‘Average’’Homeotherm, Christopher J. Gordon

United States Environmental Protection Agency: Publications

Mice, rats, and nearly all mammals and birds are classified as homeothermic, meaning that their core temperature is regulated at a constant level over a relatively wide range of ambient temperatures. In one sense, this homeothermic designation has been confirmed by the advent of radiotelemetry and other techniques that allow for the remote monitoring of awake, unrestrained animals in laboratory or natural settings. This technology confirmed that, when averaged over many hours, core temperature of mammals is regulated at a nearly constant level. On the other hand, telemetric sampling in relatively small mammals such as mice and rats also revealed …