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2011

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Barth Syndrome Mutations That Cause Tafazzin Complex Lability, Steven M. Claypool, Kevin Whited, Santi Srijumnong, Xianlin Han, Carla M. Koehler Jan 2011

Barth Syndrome Mutations That Cause Tafazzin Complex Lability, Steven M. Claypool, Kevin Whited, Santi Srijumnong, Xianlin Han, Carla M. Koehler

Open Access Publications

Deficits in mitochondrial function result in many human diseases. The X-linked disease Barth syndrome (BTHS) is caused by mutations in the tafazzin gene TAZ1. Its product, Taz1p, participates in the metabolism of cardiolipin, the signature phospholipid of mitochondria. In this paper, a yeast BTHS mutant tafazzin panel is established, and 18 of the 21 tested BTHS missense mutations cannot functionally replace endogenous tafazzin. Four BTHS mutant tafazzins expressed at low levels are degraded by the intermembrane space AAA (i-AAA) protease, suggesting misfolding of the mutant polypeptides. Paradoxically, each of these mutant tafazzins assembles in normal protein complexes. Furthermore, in the …


Genome-Wide Identification And Quantification Of Cis- And Trans-Regulated Genes Responding To Marek’S Disease Virus Infection Via Analysis Of Allele-Specific Expression, Sean Maceachern, William M. Muir, Seth D. Crosby, Hans H. Cheng Jan 2011

Genome-Wide Identification And Quantification Of Cis- And Trans-Regulated Genes Responding To Marek’S Disease Virus Infection Via Analysis Of Allele-Specific Expression, Sean Maceachern, William M. Muir, Seth D. Crosby, Hans H. Cheng

Open Access Publications

No abstract provided.


The Tumor Suppressor Gene Trp53 Protects The Mouse Lens Against Posterior Subcapsular Cataracts And The Bmp Receptor Acvr1 Acts As A Tumor Suppressor In The Lens, Luke A. Wiley, Ramya Rajagopal, Lisa K. Dattilo, David C. Beebe Jan 2011

The Tumor Suppressor Gene Trp53 Protects The Mouse Lens Against Posterior Subcapsular Cataracts And The Bmp Receptor Acvr1 Acts As A Tumor Suppressor In The Lens, Luke A. Wiley, Ramya Rajagopal, Lisa K. Dattilo, David C. Beebe

Open Access Publications

No abstract provided.


Year In Review 2010: Critical Care- Neurocritical Care, Michael T. Scalfani, Michael N. Diringer Jan 2011

Year In Review 2010: Critical Care- Neurocritical Care, Michael T. Scalfani, Michael N. Diringer

Open Access Publications

No abstract provided.


Effect Of Supplementation During Pregnancy With L-Arginine And Antioxidant Vitamins In Medicalfood On Pre-Eclampsia In High Risk Population: Randomised Controlled Trial, Felipe Vadillo-Ortega, Otilia Perichant-Perera, Salvador Espino, Marco Antonio Avila-Vergara, Isabel Ibarra, Roberto Ahued, Myrna Godines, Samuel Parry, George Macones, Jerome F. Strauss Jan 2011

Effect Of Supplementation During Pregnancy With L-Arginine And Antioxidant Vitamins In Medicalfood On Pre-Eclampsia In High Risk Population: Randomised Controlled Trial, Felipe Vadillo-Ortega, Otilia Perichant-Perera, Salvador Espino, Marco Antonio Avila-Vergara, Isabel Ibarra, Roberto Ahued, Myrna Godines, Samuel Parry, George Macones, Jerome F. Strauss

Open Access Publications

No abstract provided.


Bcl3 Prevents Acute Inflammatory Lung Injury In Mice By Restraining Emergency Granulopoiesis, Daniel Kreisel, Seiichiro Sugimoto, Jeremy Tietjens, Jihong Zhu, Sumiharu Yamamoto, Alexander S. Krupnick, Ruaidhri J. Carmody, Andrew E. Gelman Jan 2011

Bcl3 Prevents Acute Inflammatory Lung Injury In Mice By Restraining Emergency Granulopoiesis, Daniel Kreisel, Seiichiro Sugimoto, Jeremy Tietjens, Jihong Zhu, Sumiharu Yamamoto, Alexander S. Krupnick, Ruaidhri J. Carmody, Andrew E. Gelman

Open Access Publications

No abstract provided.


Rna Sensor-Induced Type I Ifn Prevents Diabetes Caused By A Β Cell-Tropic Virus In Mice, Stephen A. Mccartney, William Vermi, Silvia Lonardi, Cristina Rossini, Karel Otero, Boris Calderon, Susan Gilfillan, Michael S. Diamond, Emil R. Unanue, Marco Colonna Jan 2011

Rna Sensor-Induced Type I Ifn Prevents Diabetes Caused By A Β Cell-Tropic Virus In Mice, Stephen A. Mccartney, William Vermi, Silvia Lonardi, Cristina Rossini, Karel Otero, Boris Calderon, Susan Gilfillan, Michael S. Diamond, Emil R. Unanue, Marco Colonna

Open Access Publications

No abstract provided.


Notch1 Loss Of Heterozygosity Causes Vascular Tumors And Lethal Hemorrhage In Mice, Zhenyi Liu, Ahu Turkoz, Erin N. Jackson, Joseph C. Corbo, John A. Engelbach, Joel R. Garbow, David R. Piwnica-Worms, Raphael Kopan Jan 2011

Notch1 Loss Of Heterozygosity Causes Vascular Tumors And Lethal Hemorrhage In Mice, Zhenyi Liu, Ahu Turkoz, Erin N. Jackson, Joseph C. Corbo, John A. Engelbach, Joel R. Garbow, David R. Piwnica-Worms, Raphael Kopan

Open Access Publications

No abstract provided.


Cd2ap In Mouse And Human Podocytes Controls A Proteolytic Program That Regulates Cytoskeletal Structure And Cellular Survival, Andrey S. Shaw, Suma Yaddanapudi, Mehmet M. Altintas, Andreas D. Kistler, Isabel Fernandez, Clemens C. Moller, Changli Wei, Vasil Peev, Jan B. Flesche, Anna-Lena Forst, Jing Li, Jaakko Patrakka, Zhijie Xiao, Florian Grahammer, Et Al. Jan 2011

Cd2ap In Mouse And Human Podocytes Controls A Proteolytic Program That Regulates Cytoskeletal Structure And Cellular Survival, Andrey S. Shaw, Suma Yaddanapudi, Mehmet M. Altintas, Andreas D. Kistler, Isabel Fernandez, Clemens C. Moller, Changli Wei, Vasil Peev, Jan B. Flesche, Anna-Lena Forst, Jing Li, Jaakko Patrakka, Zhijie Xiao, Florian Grahammer, Et Al.

Open Access Publications

No abstract provided.


Rhoa Protects The Mouse Heart Against Ischemia/Reperfusion Injury, Sunny Yang Xiang, Davy Vanhoutte, Dominic P. Del Re, Nicole H. Purcell, Haiyun Ling, Indroneal Banerjee, Julie Bossuyt, Richard A. Lang, Yi Zheng, Scot J. Matkovich, Shigeki Miyamoto, Jeffrey D. Molkentin, Gerald W. Dorn Ii, Joan Heller Brown Jan 2011

Rhoa Protects The Mouse Heart Against Ischemia/Reperfusion Injury, Sunny Yang Xiang, Davy Vanhoutte, Dominic P. Del Re, Nicole H. Purcell, Haiyun Ling, Indroneal Banerjee, Julie Bossuyt, Richard A. Lang, Yi Zheng, Scot J. Matkovich, Shigeki Miyamoto, Jeffrey D. Molkentin, Gerald W. Dorn Ii, Joan Heller Brown

Open Access Publications

No abstract provided.


Oscar Is A Collagen Receptor That Costimulates Osteoclastogenesis In Dap12-Deficient Humans And Mice, Alexander David Barrow, Marina Cella, Marco Colonna, Nicolas Raynal, Thomas Levin Anderson, David A. Slatter, Dominique Bihan, Nicholas Pugh, Taesoo Kim, Jaerang Rho, Takako Nedishi-Koga, Jean-Marie Delaisse, Hiroshi Takayanagi, Joseph Lorenzo, Et Al. Jan 2011

Oscar Is A Collagen Receptor That Costimulates Osteoclastogenesis In Dap12-Deficient Humans And Mice, Alexander David Barrow, Marina Cella, Marco Colonna, Nicolas Raynal, Thomas Levin Anderson, David A. Slatter, Dominique Bihan, Nicholas Pugh, Taesoo Kim, Jaerang Rho, Takako Nedishi-Koga, Jean-Marie Delaisse, Hiroshi Takayanagi, Joseph Lorenzo, Et Al.

Open Access Publications

No abstract provided.


Arhgap24 Inactivates Rac1 In Mouse Podocytes, And A Mutant Form Is Associated With Familial Focal Segmental Glomerulosclerosis, Shreeram Akilesh, Hani Suleiman, Christine Stander, Haiyang Yu, Peter Lavin, Rasheed Gbadegesin, Corinne Antignac, Martin Pollack, Jeffrey B. Kopp, Michelle P. Winn, Andrey S. Shaw Jan 2011

Arhgap24 Inactivates Rac1 In Mouse Podocytes, And A Mutant Form Is Associated With Familial Focal Segmental Glomerulosclerosis, Shreeram Akilesh, Hani Suleiman, Christine Stander, Haiyang Yu, Peter Lavin, Rasheed Gbadegesin, Corinne Antignac, Martin Pollack, Jeffrey B. Kopp, Michelle P. Winn, Andrey S. Shaw

Open Access Publications

No abstract provided.


Pml-Rara Can Increase Hematopoietic Self-Renewal Without Causing A Myeloproliferative Disease In Mice, John S. Welch, Wenlin Yuan, Timothy J. Ley Jan 2011

Pml-Rara Can Increase Hematopoietic Self-Renewal Without Causing A Myeloproliferative Disease In Mice, John S. Welch, Wenlin Yuan, Timothy J. Ley

Open Access Publications

No abstract provided.


Dna Repair And Synthetic Lethality, Gong-She Guo, Feng-Mei Zhang, Rui-Jie Gao, Robert Delsite, Zhi-Hui Feng, Simon N. Powell Jan 2011

Dna Repair And Synthetic Lethality, Gong-She Guo, Feng-Mei Zhang, Rui-Jie Gao, Robert Delsite, Zhi-Hui Feng, Simon N. Powell

Open Access Publications

No abstract provided.


Micrornas, An Active And Versatile Group In Cancers, Jeffrey Liu, Min Zheng, Ya-Ling Tang, Xin-Hua Liang, Qin Yang Jan 2011

Micrornas, An Active And Versatile Group In Cancers, Jeffrey Liu, Min Zheng, Ya-Ling Tang, Xin-Hua Liang, Qin Yang

Open Access Publications

No abstract provided.


Targeting Htlv-1 Activation Of Nfκb In Mouse Models And Atll Patients, Daniel A. Rauch, Lee Ratner Jan 2011

Targeting Htlv-1 Activation Of Nfκb In Mouse Models And Atll Patients, Daniel A. Rauch, Lee Ratner

Open Access Publications

No abstract provided.


Molecular Determinants Of Human T-Lymphotropic Virus Type 1 Transmission And Spread, Michael D. Lairmore, Rajaneesh Anupam, Nadine Bowden, Robyn Haines, Rashade A. H. Hayness Ii, Lee Ratner, Patrick L. Green Jan 2011

Molecular Determinants Of Human T-Lymphotropic Virus Type 1 Transmission And Spread, Michael D. Lairmore, Rajaneesh Anupam, Nadine Bowden, Robyn Haines, Rashade A. H. Hayness Ii, Lee Ratner, Patrick L. Green

Open Access Publications

No abstract provided.


Five Questions About Non-Mevalonate Isoprenoid Biosynthesis, Audrey R. Odom Jan 2011

Five Questions About Non-Mevalonate Isoprenoid Biosynthesis, Audrey R. Odom

Open Access Publications

No abstract provided.


Genetic Basis For In Vivo Daptomycin Resistance In Enterococci, Elizabeth Lobos, Erica Sodergren, George M. Weinstock, Et Al Jan 2011

Genetic Basis For In Vivo Daptomycin Resistance In Enterococci, Elizabeth Lobos, Erica Sodergren, George M. Weinstock, Et Al

Open Access Publications

No abstract provided.


Prevention Of Intraoperative Awareness In A High-Risk Surgical Population, Michael S. Avidan, Beth A. Burnside, Lini Zhang, Saima Kamal, Brian Torres, Alex S. Evers, Stephen Gradwohl, Ben J. Palanca, Nan Lin, David Glick, Leah Karl, Michael O'Connor, George A. Mashour Jan 2011

Prevention Of Intraoperative Awareness In A High-Risk Surgical Population, Michael S. Avidan, Beth A. Burnside, Lini Zhang, Saima Kamal, Brian Torres, Alex S. Evers, Stephen Gradwohl, Ben J. Palanca, Nan Lin, David Glick, Leah Karl, Michael O'Connor, George A. Mashour

Open Access Publications

No abstract provided.


Prevention Of Nosocomial Pneumonia In The Intensive Care Unit: Beyond The Use Of Bundles, Marin H. Kollef Jan 2011

Prevention Of Nosocomial Pneumonia In The Intensive Care Unit: Beyond The Use Of Bundles, Marin H. Kollef

Open Access Publications

No abstract provided.


Weight Loss, Exercise, Or Both And Physical Function In Obese Older Adults, Dennis T. Villareal, Suresh Chode, Nehu Parimi, David R. Sinacore, Krupa Shah, Tiffany Hilton, Reina Armamento-Villareal, Nicola Napoli, Clifford Qualls Jan 2011

Weight Loss, Exercise, Or Both And Physical Function In Obese Older Adults, Dennis T. Villareal, Suresh Chode, Nehu Parimi, David R. Sinacore, Krupa Shah, Tiffany Hilton, Reina Armamento-Villareal, Nicola Napoli, Clifford Qualls

Open Access Publications

No abstract provided.


Role Of Nadph Oxidase Versus Neutrophil Proteases In Antimicrobial Host Defense, R. Robert Vethanayagam, Nikolaos G. Almyroudis, Melissa J. Grimm, David C. Lewandowski, Christine T. N Pham, Timothy S. Blackwell, Ruta Petraitiene, Vidmantas Petraitis, Thomas J. Walsh, Constantin F. Urban, Brahm H. Segal Jan 2011

Role Of Nadph Oxidase Versus Neutrophil Proteases In Antimicrobial Host Defense, R. Robert Vethanayagam, Nikolaos G. Almyroudis, Melissa J. Grimm, David C. Lewandowski, Christine T. N Pham, Timothy S. Blackwell, Ruta Petraitiene, Vidmantas Petraitis, Thomas J. Walsh, Constantin F. Urban, Brahm H. Segal

Open Access Publications

No abstract provided.


In-Depth Analysis Of The Antibody Response Of Individuals Exposed To Primary Dengue Virus Infection, Ruklanthi De Alwis, Martina Beltramello, William B. Messer, Soila Sukupolvi-Petty, Wahala M. P. B. Wahala, Annette Kraus, Nicholas P. Olivarez, Quang Pham, James Brian, Wen-Yang Tsai, Wei-Kung Wang, Scott Halstead, Srisakul Kliks, Michael S. Diamond, Ralph Baric, Antonio Lanzavecchia, Federica Sallusto, Aravinda M. De Silva Jan 2011

In-Depth Analysis Of The Antibody Response Of Individuals Exposed To Primary Dengue Virus Infection, Ruklanthi De Alwis, Martina Beltramello, William B. Messer, Soila Sukupolvi-Petty, Wahala M. P. B. Wahala, Annette Kraus, Nicholas P. Olivarez, Quang Pham, James Brian, Wen-Yang Tsai, Wei-Kung Wang, Scott Halstead, Srisakul Kliks, Michael S. Diamond, Ralph Baric, Antonio Lanzavecchia, Federica Sallusto, Aravinda M. De Silva

Open Access Publications

No abstract provided.


Astrovirus Mlb1 Is Not Associated With Diarrhea In A Cohort Of Indian Children, Lori R. Holtz, Irma K. Bauer, Priya Rajendran, Gagandeep Kang, David Wang Jan 2011

Astrovirus Mlb1 Is Not Associated With Diarrhea In A Cohort Of Indian Children, Lori R. Holtz, Irma K. Bauer, Priya Rajendran, Gagandeep Kang, David Wang

Open Access Publications

No abstract provided.


Glucose And Fatty Acids Synergize To Promote B-Cell Apoptosis Through Activation Of Glycogen Synthase Kinase 3beta Independent Of Jnk Activation, Katsuya Tanabe, Yang Liu, Syed D. Hasan, Sara C. Martinez, Corentin Cras-Meneur, Cris M. Welling, Ernesto Bernal-Mizrachi, Yukio Tanizawa, Christopher J. Rhodes, Erik Zmuda, Tsonwin Hai, Nada A. Abumrad, M. Alan Permutt Jan 2011

Glucose And Fatty Acids Synergize To Promote B-Cell Apoptosis Through Activation Of Glycogen Synthase Kinase 3beta Independent Of Jnk Activation, Katsuya Tanabe, Yang Liu, Syed D. Hasan, Sara C. Martinez, Corentin Cras-Meneur, Cris M. Welling, Ernesto Bernal-Mizrachi, Yukio Tanizawa, Christopher J. Rhodes, Erik Zmuda, Tsonwin Hai, Nada A. Abumrad, M. Alan Permutt

Open Access Publications

No abstract provided.


Fine Mapping Of Genetic Variants In Bin1, Clu, Cr1 And Picalm For Association With Cerebrospinal Fluid Biomarkers For Alzheimer’S Disease, John S. K. Kauwe, Carlos Cruchaga, Celeste M. Karch, Brooke Sadler, Mo Lee, Kevin Mayo, Wayne Latu, Manti Su'a, Anne M. Fagan, David M. Holtzman, John C. Morris, Alzheimer's Disease Neuroimaging Initative, Alison M. Goate Jan 2011

Fine Mapping Of Genetic Variants In Bin1, Clu, Cr1 And Picalm For Association With Cerebrospinal Fluid Biomarkers For Alzheimer’S Disease, John S. K. Kauwe, Carlos Cruchaga, Celeste M. Karch, Brooke Sadler, Mo Lee, Kevin Mayo, Wayne Latu, Manti Su'a, Anne M. Fagan, David M. Holtzman, John C. Morris, Alzheimer's Disease Neuroimaging Initative, Alison M. Goate

Open Access Publications

No abstract provided.


Complete Genome Sequence Of Treponema Paraluiscuniculi, Strain Cuniculi A: The Loss Of Infectivity To Humans Is Associated With Genome Decay, David Smajs, Marie Zobanikova, Michal Strouhal, Darina Cejkova, Shannon Dugan-Rocha, Petra Pospisilova, Steven J. Norris, Tom Albert, Xiang Qin, Kym Hallsworth-Pepin, Christian Buhay, Donna M. Muzny, Lei Chen, Richard A. Gibbs, George M. Weinstock Jan 2011

Complete Genome Sequence Of Treponema Paraluiscuniculi, Strain Cuniculi A: The Loss Of Infectivity To Humans Is Associated With Genome Decay, David Smajs, Marie Zobanikova, Michal Strouhal, Darina Cejkova, Shannon Dugan-Rocha, Petra Pospisilova, Steven J. Norris, Tom Albert, Xiang Qin, Kym Hallsworth-Pepin, Christian Buhay, Donna M. Muzny, Lei Chen, Richard A. Gibbs, George M. Weinstock

Open Access Publications

No abstract provided.


Characterizing Associations And Snp-Environment Interactions For Gwas-Identified Prostate Cancer Risk Markers—Results From Bpc3, Sara Lindstrom, Fredrick Schumacher, Afshan Siddiq, Ruth C. Travis, Daniele Campa, Sonja I. Berndt, W. Ryan Diver, Gianluca Severi, Naomi Allen, Gerald Andriole, Bas Bueno-De-Mesquita, Stephen J. Chanock, David Crawford, J. Michael Gaziano, Graham G. Giles, Edward Giovannucci, Carolyn Guo, Christopher A. Haiman, Richard B. Hayes, Jytte Halkjaer, David J. Hunter, Mattias Johansson, Rudolf Kaaks, Laurence N. Kolonel, Carmen Navarro, Elio Riboli, Carlotta Sacerdote, Meir Stampfer, Daniel O. Stram, Michael J. Thun, Dimitrios Trichopoulos, Jarmo Virtamo, Stephanie J. Weinstein, Meredith Yeager, Brian Henderson, Jing Ma, Loic Le Marchand, Demetrius Albanes, Peter Kraft Jan 2011

Characterizing Associations And Snp-Environment Interactions For Gwas-Identified Prostate Cancer Risk Markers—Results From Bpc3, Sara Lindstrom, Fredrick Schumacher, Afshan Siddiq, Ruth C. Travis, Daniele Campa, Sonja I. Berndt, W. Ryan Diver, Gianluca Severi, Naomi Allen, Gerald Andriole, Bas Bueno-De-Mesquita, Stephen J. Chanock, David Crawford, J. Michael Gaziano, Graham G. Giles, Edward Giovannucci, Carolyn Guo, Christopher A. Haiman, Richard B. Hayes, Jytte Halkjaer, David J. Hunter, Mattias Johansson, Rudolf Kaaks, Laurence N. Kolonel, Carmen Navarro, Elio Riboli, Carlotta Sacerdote, Meir Stampfer, Daniel O. Stram, Michael J. Thun, Dimitrios Trichopoulos, Jarmo Virtamo, Stephanie J. Weinstein, Meredith Yeager, Brian Henderson, Jing Ma, Loic Le Marchand, Demetrius Albanes, Peter Kraft

Open Access Publications

No abstract provided.


Binocular Disparity Tuning And Visual–Vestibular Congruency Of Multisensory Neurons In Macaque Parietal Cortex, Yun Yang, Sheng Liu, Syed A. Chowdhury, Gregory C. Deangelis, Dora E. Angelaki Jan 2011

Binocular Disparity Tuning And Visual–Vestibular Congruency Of Multisensory Neurons In Macaque Parietal Cortex, Yun Yang, Sheng Liu, Syed A. Chowdhury, Gregory C. Deangelis, Dora E. Angelaki

Open Access Publications

No abstract provided.