Digital Commons Network^™

Human Endogenous Retrovirus Transcription Profiles Of The Kidney And Kidney-Derived Cell Lines, Sonja Haupt, Michele Tisdale, Michelle Vincendeau, Mary Anne Clements, David T. Gauthier, Raymond Lance, O. John Demmes, Adriana Tuqueti-Neves, Elfriede Noessner, Christine Leib-Mösch, Alex D. Greenwood

Biological Sciences Faculty Publications

The human genome comprises approximately 8-9% of human endogenous retroviruses (HERVs) that are transcribed with tissue specificity. However, relatively few organs have been examined in detail for individual differences in HERV transcription pattern, nor have tissue-to-cell culture comparisons been frequently performed. Using an HERV-specific DNA microarray, a core HERV transcription profile was established for the human kidney comparing 10 tissue samples. This core represents HERV groups expressed uniformly or nearly so in non-tumour kidney tissue. The profiles obtained from non-tumour tissues were compared to 10 renal tumour tissues (renal cell carcinoma, RCC) derived from the same individuals and additionally, to …

Conformation And Ion Transport Of Neuronal Uncoupling Proteins: Ucp2, Ucp4, And Ucp5, Tuan Hoang

Theses and Dissertations (Comprehensive)

Located in the inner mitochondrial membrane of brown adipose tissue, uncoupling protein -1 (UCP1) dissipates the proton electrochemical gradient, causing reduction in the rate of ATP synthesis, and generates heat by non-shivering thermogenesis. Three other UCP homologs (UCP2, UCP4 and UCP5), expressed in neurons, are suggested to have potential roles in the function and protection of the central nervous system (CNS). Up to date, structural information for UCPs still remains limited. Extensive biochemical studies on UCP2 have provided adequate evidence for its participation in proton and anion transport. So far, no functional studies in proteoliposome systems have been performed on …

An Approach To Engagement With Youth In Gangs Participatory Action Projects, Lisa Armstrong

Theses and Dissertations (Comprehensive)

The purpose of this study was to investigate the process of engaging youth who have been involved with gangs in the context of a local street gang prevention project. A case study of the local project was conducted with interviews with twelve (N= 12) participants, most of whom were project staff Interviews were conducted by the author and two youth co-researchers. Findings illustrate the meaning of youth engagement to the participants, ideal roles for staff members and youth, and the relevance of a youth advisory committee as an outlet for future engagement in this program. Based on these …

Examining Experiences Of English Literacy Development (Eld) Program From Multiple Stakeholders’ Perspectives, Hany Ibraham

Theses and Dissertations (Comprehensive)

The present study, conducted in collaboration with a public school board in southern Ontario, Canada, focused on stakeholders’ perspectives of an English Literacy Development (ELD) program offered in secondary schools within this particular board. The purpose of this research was to identify resources that would help address school absenteeism, credit accumulation and graduation needs of ELD learners, as well as to learn which factors in ELD better assist students who are refugees with school integration and in reaching their academic potentials. The research objectives were (1) to identify factors that influence integration of refugee students in school and (n) to …

The Role Of Taste And Calories In Access-Induced Excessive Sweets Consumption By The Rat, Adam Celejewski

Theses and Dissertations (Comprehensive)

For individuals diagnosed with Binge Eating Disorder (BED) or Bulimia Nervosa (BN) eating is often manifested in intermittent bouts of gorging, a behaviour that is similar to excessive consumption of rewarding drugs in addiction (American Psychiatric Association, 2000; Corwin & Grigson, 2009; Epstein & Shaham, 2010). Our laboratory has found that sucrose solution intake by rats escalates markedly when provided on Discontinuous Access (DisA; 24h once every 3 or 4 days) schedules but is maintained at lower, stable levels with Continuous Access (ConA; ad lib) schedules (Hewitt & Eikelboom, 2008). Once DisA/ConA consumption differences are established, they persist even …

Specters Of Law: Why The History Of The Legal Spectacle Has Not Been Written, Peter Goodrich

Articles

The article examines the intersection of law, theology, and visual/performance elements, arguing that legal discourse often overlooks the significance of typography, imagery, and theatricality. It highlights how legal texts use formatting techniques like bold and italics to convey meaning and draws parallels with theological concepts, such as the duality of power and the role of images in governance. The analysis critiques the legal tradition for neglecting these performative aspects and emphasizes the need to recognize law as a theater that denies its own theatricality.

Effects Of Resistance Training On Functional Ability In Elderly Individuals, Mariane M. Fahlman, Nancy Mcnevin, Debra Boardley, Amy Morgan, Robert V. Topp

College of Nursing Faculty Research and Publications

Purpose. Determine the effects of 16 weeks of strength training on measures of functional ability in elderly who are functionally limited.

Design. Quasi-experimental trial in which elderly volunteers were assigned to either an exercise group or a control group.

Participants. Eighty-seven participants (65–93 years) living independently but with some functional limitations.

Intervention. Thirteen different strength training exercises using Thera-Band resistive bands (Hygenic Corporation, Akron, Ohio). The program was 16 weeks in duration, and the frequency was three times per week. Participants exercised in a group setting one time per week and were given a home exercise book to follow for …

The Effects Of Positive Cognitions On The Relationship Between Alienation And Resourcefulness In Nursing Students In Egypt, Abir K. Bekhet, Mervat Elguenidi, Jaclene A. Zauszniewski

College of Nursing Faculty Research and Publications

Alienation is a subjective state, a feeling of being a stranger, as if one were not one's normal self. It is also a sense of homelessness; a feeling of uneasiness or discomfort, which signifies the person's exclusion from social or cultural participation. Alienation can adversely affect healthy functioning of nursing students. Nursing students are the adolescents of today and the nurses of tomorrow who will deal with human behavior, and their psychological well-being will be important in managing their clients’ conditions. Healthy nursing students are likely to become healthy nurses who can then model and promote healthy lifestyles for their …

Multi-Wavelength Observations Of The Flaring Gamma-Ray Blazar 3c 66a In 2008 October, P. T. Reynolds, Fermi-Lat, Veritas, Gasp-Webt

Physical Sciences Publications

The BL Lacertae object 3C 66A was detected in a flaring state by the Fermi Large Area Telescope (LAT) and VERITAS in 2008 October. In addition to these gamma-ray observations, F-GAMMA, GASP-WEBT, PAIRITEL, MDM, ATOM, Swift, and Chandra provided radio to X-ray coverage. The available light curves show variability and, in particular, correlated flares are observed in the optical and Fermi-LAT gamma-ray band. The resulting spectral energy distribution can be well fitted using standard leptonic models with and without an external radiation field for inverse Compton scattering. It is found, however, that only the model with an external …

Advancing Nursing Education Science: An Analysis Of Nln's Grant Program 2008-2010, Joanne R. Duffy, Marilyn Frenn, Barbara Patterson

College of Nursing Faculty Research and Publications

The National League for Nursing has responded to the increasing need for nursing education research through its grant program. Significant growth in proposals has intensified competition for funds and challenged the Nursing Education Research Advisory Council’s review process. The purpose of this article is to explore the NLN’s nursing education research proposals from 2008 to 2010 in order to improve performance and provide guidance to future nursing education researchers. Beginning with the 2008 grant cycle, a database was developed to assist in performance improvement. A total of 113 proposals were submitted; of those, 24 were funded for a success rate …

Sequential Climate Change Policy, Edward A. Parson, Darshan Karwat

Articles

Successfully managing global climate change will require a process of sequential, or iterative, decision‐making, whereby policies and other decisions are revised repeatedly over multiple decades in response to changes in scientific knowledge, technological capabilities, or other conditions. Sequential decisions are required by the combined presence of long lags and uncertainty in climate and energy systems. Climate decision studies have most often examined simple cases of sequential decisions, with two decision points at fixed times and initial uncertainties that are resolved at the second decision point. Studies using this formulation initially suggested that increasing uncertainty favors stronger immediate action, while the …

After The Spill Is Gone: The Gulf Of Mexico, Environmental Crime, And Criminal Law, David M. Uhlmann

Articles

The Gulf oil spill was the worst environmental disaster in U.S. history, and will be the most significant criminal case ever prosecuted under U.S. environmental laws. The Justice Department is likely to prosecute BP, Transocean, and Halliburton for criminal violations of the Clean Water Act and the Migratory Bird Treaty Act, which will result in the largest fines ever imposed in the United States for any form of corporate crime. The Justice Department also may decide to pursue charges for manslaughter, false statements, and obstruction of justice. The prosecution will shape public perceptions about environmental crime, for reasons that are …

Trait Anxiety And Trait Disgust In Spider Phobia, Laura Vernon, Michiyo Hirai

Psychological Science Faculty Publications

There is evidence for the role of trait anxiety in the specific phobias, and spider phobia in particular. Recently, trait disgust has received attention in relation to specific phobia and researchers and theorists have begun to address its contributions to phobia etiology, maintenance, and treatment processes. There is now strong evidence that a trait or dispositional proneness to experience disgust is related to spider phobia. What is perhaps more important is emerging evidence that both trait anxiety and trait disgust may contribute to spider phobia severity independently of one another. However, the overall picture is far from clear and distinguishing …

Circulation, Sediment Concentration And Oxygen Depletion In The Tidal Ems River, Stefan A. Talke, Huib E. De Swart

Civil and Environmental Engineering Faculty Publications and Presentations

We present measurements which show that the tidal Ems River in Germ any is extremely muddy over a 30 km + turbid zone, with fluid mud o f 1-2 m thickness covering the bed with suspended sediment concentrations (SSC) o f greater than 50 kg.m^-3. Moreover, we show that these elevated SSC contain large quantities of organic material which deplete dissolved oxygen (DO) and produce summertime hypoxic zones. Using mathematical modeling, we develop simplified representations o f the estuary physics that reproduce the tidally-averaged circulation, SSC distribution, and oxygen depletion. These models show that SSC and oxygen concentrations …

Freight Distribution Problems In Congested Urban Areas: Fast And Effective Solution Procedures To Time-Dependent Vehicle Routing Problems, Miguel A. Figliozzi

Civil and Environmental Engineering Faculty Publications and Presentations

Congestion is a common phenomenon in all medium to large cities of the world. Reliability of freight movement in urban areas is an important issue to manufacturing or service companies whose operation is based in just-in-time approaches. These companies tend to provide high value or time sensitive products/services. As congestion increases, carriers face increasing challenges to satisfy their time sensitive customers in an economical way. Route designs or schedules which require long computation times or ignore travel time variations will result in inefficient and suboptimal solutions. Poorly designed routes that lead freight vehicles into congested arteries and streets not only …

Uncertainty Analysis Of A Low Flow Model For The Rhine River, Mehmet C. Demirel, Martijn Booij

Civil and Environmental Engineering Faculty Publications and Presentations

It is widely recognized that hydrological models are subject to parameter uncertainty. However, little attention has been paid so far to the uncertainty in parameters of the data-driven models like weights in neural networks. This study aims at applying a structured uncertainty analysis to a data-driven model for low flow forecasting with a lead time of 14 days in the Rhine River. In the modeling phase, the Rhine basin is divided into seven major sub-basins. Each sub-basin is modeled separately with a data-driven model and the output discharges were routed to Lobith with another data-driven model. Basin averaged precipitation, basin …

Do Sex Offender Registration And Notification Laws Affect Criminal Behavior?, J. J. Prescott, Jonah E. Rockoff

Articles

Sex offenders have become the targets of some of the most far-reaching and novel crime legislation in the U.S. Two key innovations in recent decades have been registration and notification laws which, respectively, require that convicted sex offenders provide valid contact information to law enforcement authorities, and that information about sex offenders be made public. Using the evolution of state law during the 1990s and 2000s, we study how registration and notification affect the frequency of reported sex offenses and the incidence of such offenses across victims. We find evidence that registration reduces the frequency of sex offenses by providing …

Tribute: Dores Mccrary Mccree, David L. Chambers

Articles

Dores McCree made your day a little better whenever she walked into a room. When you talked with her, you knew her goal was simply to enjoy your company, not to get something out of you, and not to show herself off. She was good at talking and good at listening. She'd cock her head slightly and ask questions to which she really cared about the answers. On more than one occasion, I had to jockey with others to be able to sit with her at a dinner.

Corrective Justice For Civil Recourse Theorists, Scott Hershovitz

Articles

Though I think the civil recourse critique of the leading conceptions of corrective justice is in some respects misguided, I do not want to join up to the thrust and parry here. My aim in this Article is to show that there is a better conception of corrective justice than the ones that Goldberg and Zipursky target, that this conception of corrective justice is untouched by the civil recourse critique, and that civil recourse is best understood as a corrective justice account of tort. In other words, I aim to explain corrective justice for civil recourse theorists.

No Harm, No Foul? Why Harmless Error Analysis Should Not Be Used To Review Wrongful Denials Of Counsel To Parents In Child Welfare Cases, Vivek Sankaran

Articles

The application of a harmless error standard by appellate courts reviewing erroneous denials of counsel in child protective cases undermines a critical procedural right that safeguards the interests of parents and children. Case law reveals that trial courts, on numerous occasions, improperly reject valid requests for counsel, forcing parents to navigate the child welfare system without an advocate. Appellate courts excuse these violations by speculating that the denials caused no significant harm to the parents, which is a conclusion that a court can never reach with any certainty. The only appropriate remedy for this significant problem is a bright-line rule …

Dores Mccree, Theodore J. St. Antoine

Articles

Dores McCree had an unusual combination of great qualities. She was totally dedicated to her role as a career advisor to students at the Law School and relentlessly persistent in pursuing opportunities for them among her large, nationwide group of lawyer friends. Yet she could be very hard-headed and realistic in appraising the qualifications of an individual candidate for a particular position. "John or Mary," she would say in that warm, disarming, and totally persuasive voice of hers, "I just don't think that job is the right fit for you. Let's find something better."

Securities Law In The Roberts Court: Agenda Or Indifference?, Adam C. Pritchard

Articles

To outsiders, securities law is not all that interesting. The body of the law consists of an interconnecting web of statutes and regulations that fit together in ways that are decidedly counter-intuitive. Securities law rivals tax law in its reputation for complexity and dreariness. Worse yet, the subject regulated-capital markets-can be mystifying to those uninitiated in modem finance. Moreover, those markets rapidly evolve, continually increasing their complexity. If you do not understand how the financial markets work, it is hard to understand how securities law affects those markets.

Free Rider: A Justification For Mandatory Medical Insurance Under Health Care Reform?, Douglas A. Kahn, Jeffrey H. Kahn

Articles

Section 1501 of the Patient Protection and Affordable Care Act added section 5000A to the Internal Revenue Code to require most individuals in the United States, beginning in the year 2014, to purchase an established minimum level of medical insurance. This requirement, which is enforced by a penalty imposed on those who fail to comply, is sometimes referred to as the “individual mandate.” The individual mandate is one element of a vast change to the provision of medical care that Congress implemented in 2010. The individual mandate has proved to be controversial and has been the subject of a number …

Slavery And The Law In Atlantic Perspective: Jurisdiction, Jurisprudence, And Justice, Rebecca J. Scott

Articles

The four articles in this special issue experiment with an innovative set of questions and a variety of methods in order to push the analysis of slavery and the law into new territory. Their scope is broadly Atlantic, encompassing Suriname and Saint-Domingue/Haiti, New York and New Orleans, port cities and coffee plantations. Each essay deals with named individuals in complex circumstances, conveying their predicaments as fine-grained microhistories rather than as shocking anecdotes. Each author, moreover, demonstrates that the moments when law engaged slavery not only reflected but also influenced larger dynamics of sovereignty and jurisprudence.

Citizens United And The Corporate Form, Reuven S. Avi-Yonah

Articles

In Citizens United vs. FEC, the Supreme Court struck down a Federal statute banning direct corporate expenditures on political campaigns. The decision has been widely criticized and praised as a matter of First Amendment law. But it is also interesting as another step in the evolution of our legal views of the corporation. This article argues that by viewing Citizens United through the prism of theories about the corporate form, it is possible to see that the majority and the dissent departed from previous Supreme Court jurisprudence on the First Amendment rights of corporations. It is also possible to then …

Exclusion From Income Of Compensation For Services And Pooling Of Labor Occurring In A Noncommercial Setting, Douglas A. Kahn

Articles

When cash is received for services, it typically will constitute gross income to the recipient.' But what if the payments are made in a noncommercial setting such as the payment by a parent to a child for mowing the lawn or performing household chores? As discussed later in this Essay, there are reasons to conclude that such payments do not constitute income. The problem of how to treat receipts from a noncommercial activity frequently arises in the context of an exchange of services. A similar problem arises when services are provided by several persons pursuant to a pooling of labor …

Foreword: Rulemaking, Democracy, And Torrents Of E-Mail, Nina A. Mendelson

Articles

This Foreword is meant as an initial foray into the question of what agencies should do with mass public comments, particularly on broad questions of policy. Part I discusses the extent to which congressional control, presidential control, and agency procedures themselves can ensure that agency decisions are democratically responsive. In view of shortcomings in both congressional and presidential control, I underscore the need to focus closely on rulemaking procedures as a source of democratic responsiveness. The possibility that agencies may be systematically discounting certain public submissions raises difficulties, and I present some examples. Part II makes a preliminary case that …

The Illusory Right To Counsel, Eve Brensike Primus

Articles

Imagine a woman wrongly accused of murdering her fiance. She is arrested and charged with first-degree murder. If convicted, she faces a mandatory sentence of life without the possibility of parole. Her family scrapes together enough money to hire two attorneys to represent her at trial. There is no physical evidence connecting her to the murder, but the prosecution builds its case on circumstantial inferences. Her trial attorneys admit that they were so cocky and confident that she would be acquitted that they did not bother to investigate her case or file a single pre-trial motion. Rather, they waived the …

Hanging On By A Thread: The Exclusionary Rule (Or What's Left Of It) Lives For Another Day, David A. Moran

Articles

Back when there was a Soviet Union, foreign intelligence officers would anxiously await the May Day parade in Moscow to see who would be standing next to the chairman of the Communist Party and who would be missing from the reviewing platform altogether. Since the Soviet government and the statecontrolled press published very little about what was really going on in the halls of state power, this was considered the most reliable way to determine who was in or out of favor and, by extension, how the domestic and foreign policies of the world's second most powerful country were likely …

Behavior Constrains The Dispersal Of Long-Lived Spiny Lobster Larvae, Mark J. Butler Iv, Claire B. Paris, Jason S. Goldstein, Hirokazu Matsuda, Robert K. Cowen

Biological Sciences Faculty Publications

Behavior such as ontogenetic vertical migration (OVM) limits the transport of marine larvae with short pelagic larval durations (PLDs), but its effect on the supposed long-distance dispersal of larvae with long PLDs is unknown. We conducted laboratory tests of ontogenetic change in larval phototaxis and examined size-specific patterns of larval distribution in the plankton to characterize OVM in the Caribbean spiny lobster Panulirus argus during its long (6 mo) PLD. We then used a coupled biophysical model to explore the consequences of OVM and hydrodynamics on larval P. argus dispersal in the Caribbean Sea. Larvae reared in the laboratory were …