Digital Commons Network^™

The Energy Landscape Analysis Of Cancer Mutations In Protein Kinases, Anshuman Dixit, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

The growing interest in quantifying the molecular basis of protein kinase activation and allosteric regulation by cancer mutations has fueled computational studies of allosteric signaling in protein kinases. In the present study, we combined computer simulations and the energy landscape analysis of protein kinases to characterize the interplay between oncogenic mutations and locally frustrated sites as important catalysts of allostetric kinase activation. While structurally rigid kinase core constitutes a minimally frustrated hub of the catalytic domain, locally frustrated residue clusters, whose interaction networks are not energetically optimized, are prone to dynamic modulation and could enable allosteric conformational transitions. The results …

The Positive Real Lemma And Construction Of All Realizations Of Generalized Positive Rational Functions, Daniel Alpay, Izchak Lewkowicz

Mathematics, Physics, and Computer Science Faculty Articles and Research

We here extend the well known Positive Real Lemma (also known as the Kalman-Yakubovich-Popov Lemma) to complex matrix-valued generalized positive rational function, when non-minimal realizations are considered. All state space realizations are partitioned into subsets, each is identified with a set of matrices satisfying the same Lyapunov inclusion. Thus, each subset forms a convex invertible cone, cic in short, and is in fact is replica of all realizations of positive functions of the same dimensions. We then exploit this result to provide an easy construction procedure of all (not necessarily minimal) state space realizations of generalized positive functions. As a …

Governance And Merger Activity In Banking, Thomas J. Piskula

Dissertations, Theses, and Capstone Projects

One method of evaluating the success of management decisions regarding acquisitions is to examine equity price movements as the news of the merger is made public. The price movement of the acquiring firm's equity around the announcement of the acquisition indicates if shareholders believe management has acted in their interest. In the banking industry, researchers have found that on average equity values of the acquiring bank do not display abnormal positive returns upon announcement, and often display statistically significant negative returns. Another line of research has documented that CEOs are better compensated for managing larger organizations, particularly when involved in …

[Alpha]₂A Adrenergic Receptor-Mediated Sedation & Inhibition Of Seizures, Jolynn Azure

Undergraduate Theses and Senior Projects

No abstract provided.

Pigeon : Precision Integrated Geographical Navigation, Evan Andrist

Undergraduate Theses and Senior Projects

No abstract provided.

The Impact Of A Wave Farm On Large Scale Sediment Transport, R Gonzalez Santamaria, Qp Zou, S Pan

School of Engineering, Computing and Mathematics

This study investigates the interactions of waves and tides at a wave farm in the southwest of England, in particular their effects on radiation stress, bottom stress, and consequently on the sediment transport and the coast adjacent to the wave-farm (the Wave Hub). In this study, an integrated complex numerical modelling system is setup at the Wave Hub site and is used to compute the wave and current fields by taking into account the wave-current interaction, as well as the sediment transport. Results show that tidal elevation and tidal currents have a significant effect on the wave height and direction …

Affordances, Adaptive Tool Use And Grounded Cognition., A Pellicano, S Thill, T Ziemke, F Binkofski

School of Engineering, Computing and Mathematics

No abstract provided.

Equity, Antitrust, And The Reemergence Of The Patent Unenforceability Remedy, Jorge Contreras

Scholarly Articles in Law Reviews & Journals

The conventional legal analysis of technical standard setting derives primarily from antitrust law. But antitrust remedies, taken alone, may not be broad enough to address recent abuses of the standardization process. The principal example of this shortcoming is the well-known case of Rambus, Inc., which, over the course of several years, was alleged to have concealed relevant patent applications from a standards organization in which it participated and then successfully sued the entire DRAM industry for royalties after the standard was “locked-in.” Remarkably, Rambus prevailed in its litigation campaign despite aggressive enforcement efforts by the Federal Trade Commission. Rambus’s success …

Securitization And Suburbia, Heather Hughes

Scholarly Articles in Law Reviews & Journals

This Article explores the relationship between one typical form of real estate development finance-the securitized mezzanine loanand one controversial phenomenon-suburban sprawl. It asks foundational questions about the connection between financial transactions and real-world applications of the capital they raise. In this work, sprawl serves as an example of an environmental consequence of applications of capital raised with a common form of transaction. This Article considers the extent to which commercial finance laws release forceful incentives driven by capital markets upon land use decisions, potentially undermining the collective, morally informed determination such decisions require. It rejects the aesthetic aversion to looking …

Secret Inventions, Jonas Anderson

Scholarly Articles in Law Reviews & Journals

Patent law - and innovation policy more generally - has traditionally been conceptualized as antithetical to secrecy. Not only does the patent system require inventors to publicly disclose their inventions in order to receive a patent, but various patent doctrines are designed to encourage inventors to forego trade secrecy. This Article offers a critique of the law’s preference for patents. In particular, this Article examines whether and under what circumstances the law should prefer patents over secrets, and vice versa.

As an initial step towards a theoretically-supported system of inventor incentives, this Article constructs a framework that attempts to balance …

Legal Education And Civility, Mark Niles

Scholarly Articles in Law Reviews & Journals

No abstract provided.

Punctuated Equilibrium: A Model For Administrative Evolution, Mark Niles

Scholarly Articles in Law Reviews & Journals

No abstract provided.

Merger Simulation In An Administrative Context, Jonathan Baker

Scholarly Articles in Law Reviews & Journals

This article addresses the application of the economic literature on merger simulation to the practical context of antitrust enforcement. It highlights the value of simple simulations as a basis for creating screens and presumptions – particularly the gross upward pricing pressure index for the preliminary review of unilateral effects among sellers of branded consumer products and a presumption based on identifying mavericks for the analysis of coordinated effects – in order to provide guidance to merging firms and judges, who may not have specialized competition policy expertise. The article explains why antitrust agencies should rely on these approaches to identify …

The Future Of Climate Change Litigation After Aep V. Connecticut, Amanda Leiter, Rick Faulk, Eric Lasker, Mike Myers

Scholarly Articles in Law Reviews & Journals

No abstract provided.