Digital Commons Network^™

Theory Of Mind, Social Functioning, And Awareness Of Ability In Older Adults., Sarah Vedrody Rowe

Electronic Theses and Dissertations

Declines in social resources and in the quality of interpersonal interactions have been observed in some older adults. Unawareness of ability is a clinical problem that has been found in some older adults with dementia, but has also been found in non-demented older adults, and the clinical correlates have not been reliably established. Theory of mind (ToM) is a social-cognitive construct that refers to the ability to infer the mental states of others and the self. ToM has been linked with social functioning and self-awareness, but few studies have examined these variables in older adults. The current study tested the …

Widespread Regulation Of Mirna Biogenesis At The Dicer Step By The Cold-Inducible Rna-Binding Protein, Rbm3, Julie Pilotte, Esther E. Dupont-Versteegden, Peter W. Vanderklish

Physical Therapy Faculty Publications

MicroRNAs (miRNAs) play critical roles in diverse cellular events through their effects on translation. Emerging data suggest that modulation of miRNA biogenesis at post-transcriptional steps by RNA-binding proteins is a key point of regulatory control over the expression of some miRNAs and the cellular processes they influence. However, the extent and conditions under which the miRNA pathway is amenable to regulation at posttranscriptional steps are poorly understood. Here we show that RBM3, a cold-inducible, developmentally regulated RNA-binding protein and putative protooncogene, is an essential regulator of miRNA biogenesis. Utilizing miRNA array, Northern blot, and PCR methods, we observed that over …

Mathematical Modeling Of Peristaltic Flow Of Chyme In Small Intestine, Daniel N. Riahi, Ranadhir Roy

Applications and Applied Mathematics: An International Journal (AAM)

Mathematical models based on axisymmetric Newtonian incompressible fluid flow are studied for the peristaltic flow of chyme in the small intestines, which is an axisymmetric cylindrical tube. The flow is modeled more realistically modeled by assuming that the peristaltic rush wave is a non-periodic mode composed of two sinusoidal waves of different wavelengths, which propagate at the same speed along the outer boundary of the tube. Both cases of flow in a tube and in an annulus that are modeled and investigated in the present paper correspond respectively to the cases of flow of chyme in the small intestine in …

The Dynamics Of Stage Structured Prey-Predator Model Involving Parasitic Infectious Disease, Raid K. Naji, Dina S. Al-Jaf

Applications and Applied Mathematics: An International Journal (AAM)

In this paper a prey-predator model involving parasitic infectious disease is proposed and analyzed. It is assumed that the life cycle of predator species is divided into two stages immature and mature. The analysis of local and global stability of all possible subsystems is carried out. The dynamical behaviors of the model system around biologically feasible equilibria are studied. The global dynamics of the model are investigated with the help of Suitable Lyapunov functions. Conditions for which the model persists are established. Finally, to nationalize our analytical results, numerical simulations are worked out for a hypothetical set of parameter values.

Mechanisms Of Brain Edema Formation In Mouse Models Of Intracerebral Hemorrhage, Qingyi Ma

Loma Linda University Electronic Theses, Dissertations & Projects

Perihematomal edema causes major neurologic deterioration following intracerebral hemorrhage (ICH), mainly resulting from the disruption of the blood-brain barrier (BBB) by multiple mediators, including inflammatory mediators and thrombin. The objective of our study was to investigate the mechanisms by which inflammation and thrombin respectively lead to the formation of brain edema following ICH. Our long-term goal is to develop new therapeutic strategies against ICH-induced brain edema by targeting: (1) VAP-1 mediated inflammatory response and (2) PDGFR-α orchestrated BBB impairment. Vascular adhesion protein-1 (VAP-1) was previously shown to promote leukocyte adhesion and transmigration. Additionally, PDGFR-α was also found to play a …

Age, Stratigraphy And Depositional Environment Of The Pliocene Copper Canyon Formation, Death Valley, California, Torrey Nyborg

Loma Linda University Electronic Theses, Dissertations & Projects

The Copper Canyon Formation, a fluvial-lacustrine deposit exposed within the Black Mountains of Death Valley National Park, has only previously been broadly included in regional tectonic and depositional analyses. The formation is significant because it preserves numerous shoreline-playa features including highly abundant and diverse mammal and bird tracks. The formation represents a basin fill sequence consisting of approximately 1800 m of conglomerates, basalt flows, and lacustrine deposits. A measured type section along with x-ray diffraction, isotopic analysis, and thin section petrography shows an evolution of the ancient Copper Canyon lake from an hypersaline evaporative lake to a perennial saline lake …

Trauma Of The Sudden Death Of A Child: The Impact On Couple Relationship, Blessing Okoro Rellias

Loma Linda University Electronic Theses, Dissertations & Projects

A traumatic life event such as the death of a child can be very devastating and confusing for many couples and people tend to respond in different ways to such trauma due to different factors such as gender differences. Research studies have traditionally focused on the personal effects of trauma on individual family members, whereas less attention centered on the systemic outcomes and consequences that trauma has on family functioning especially from the couples' perspective. Previous research has indicated that parents who lost their children to sudden death are likely to have serious mental distress and some disruption in functioning. …

Chronic Hypoxia Induces Epigenetic Modifications In The Fetal Rat Heart, Andrew James Grant Patterson

Loma Linda University Electronic Theses, Dissertations & Projects

Heart disease remains the leading cause of death worldwide. As a result of studies done by Barker and associates, our awareness of the significance of stress during gestation as a risk factor for heart diseases has expanded. We now know that events in utero can significantly alter gene expression patterns in heart tissue leading to increase susceptibility to ischemia reperfusion injury in adulthood. The focus of this project was to elucidate the role of chronic hypoxia in the programming of the cardio-protective gene, Protein Kinase C epsilon (PKCε) in fetal rat heart. We used an animal, organ base, and cell …

Mechanisms Of Erythropoietin-Induced Neuroprotection In: In-Vivo And In-Vitro Models Of Hypoxia Ischema, Rhonda Andrea Souvenir

Loma Linda University Electronic Theses, Dissertations & Projects

Hypoxic ischemic brain injury (HIBI) is a common cause of neonatal mortality and morbidity. Approximately 60 % of preterm babies and 2% of full term infants suffer from asphyxia. Asphyxia related death accounts for approximately 23% of neonatal mortality annually. Many therapeutic interventions show promise in the laboratory but fail in clinics. A thorough understanding of mechanisms by which promising therapeutic intervention confers its neuroprotection is necessary to promote smoother transitions from bench to the bedside. Erythropoietin (EPO), a hematopoietic growth factor that increases oxygen availability during hypoxia/ischemia is associated with cell survival and neuroprotection in: in vivo and in …

Allosteric Modulation Of Vla-4 With The Atypical Antipsychotic Thioridazine, Bart Williams

Biomedical Sciences ETDs

A recent primary drug screen by the University of New Mexico Center for Molecular Discovery uncovered a novel group of allosteric-modulators of VLA-4 integrins known as phenothiazines. Phenothiazine family compounds were initially discovered as organic dyes in the 1800's, the most well-known of which is methylene blue. Relatively soon thereafter phenothiazines were found to be useful clinically, a trend that has continued in the century since peaking as antipsychotics in the 1950's. Today, phenothiazines are still being pursued clinically as seen in a number of recent patents for phenothiazine use in autoimmune disorders. This study sought to further characterize the …

Spatiotemporal Dynamics Of Transport In The Squid Giant Axon: Competition Between Cargo Motor Receptors, Jip-1, App-C, And Negative Charge, Pamela E. Seamster

Biomedical Sciences ETDs

Transport of membrane-bound organelles is critical to neuronal cell function yet mechanisms hitching vesicles to transport machinery remain elusive. Here we test whether jun-kinase interacting protein (JIP-1), a peripheral membrane scaffolding protein that binds kinesin light chain, is sufficient to mediate cargo transport in axons and study its competition with amyloid precursor protein cytoplasmic domain (APP-) and negative charge, also known motor receptors. Fluorescent beads (100 nm diameter) exhibit sequence-specific fast anterograde transport (0.46μm/s instantaneous velocity) in the squid giant axon when conjugated to a 14- amino acid synthetic peptide derived from the carboxyl terminus of JIP-1. JIP-1- beads have …

Association Of Race And Ethnicity With Cognitive And Language Testing At 18-22 Months In Extremely Preterm Infants, Andrea Freeman Duncan

Biomedical Sciences ETDs

Objective: The objective of this study was to evaluate the relationship of race/ethnicity to cognitive and language scores on the Bayley Scales of Infant and Toddler Development 3rd edition (BSID-III) in extremely preterm toddlers (< 28+0 weeks estimated gestational age). Study Design: Extremely preterm toddlers at NICHD Neonatal Research Network Centers evaluated at 18-22 months adjusted age from 3 race/ethnic groups (White, Black, and Hispanic-White) were included in this cohort study. Multivariable regression modeling was used to identify race/ethnic differences adjusting for medical and psychosocial factors. Results: Children included 369 Whites, 352 Blacks and 144 Hispanic-Whites. Cognitive scores differed between groups in unadjusted analysis (p=< 0.001), but not after adjusting for medical and psychosocial factors (p=0.13). Language scores differed in adjusted and unadjusted analyses. Whites scored higher than Blacks or Hispanic-Whites, and Blacks scored higher than Hispanic- Whites. Conclusions:A combination of medical variables and primary caretaker education accounted for differences in BSID-III cognitive scores between groups. Black and Hispanic-White toddlers had lower language scores than Whites, even after adjustment. Early intervention should be targeted to these identified risk factors. Assessment of early language development among minority groups may be warranted.

Quantitative Comparison Of Late Effects Following Photon Versus Proton External-Beam Radiation Therapies: To Ward An Evidence-Based Approach To Selecting A Treatment Modality, Rui Zhang

Dissertations and Theses (Open Access)

Radiation therapy has been used as an effective treatment for malignancies in pediatric patients. However, in many cases, the side effects of radiation diminish these patients’ quality of life. In order to develop strategies to minimize radiogenic complications, one must first quantitatively estimate pediatric patients’ relative risk for radiogenic late effects, which has not become feasible till recently because of the calculational complexity. The goals of this work were to calculate the dose delivered to tissues and organs in pediatric patients during contemporary photon and proton radiotherapies; to estimate the corresponding risk of radiogenic second cancer and cardiac toxicity based …

Regulation Of Hgf Expression By Δegfr-Mediated C-Met Activation In Glioblastoma Cells, Jeannine Garnett

Dissertations and Theses (Open Access)

Overexpression of the hepatocyte growth factor receptor (c-Met) and its ligand, the hepatocyte growth factor (HGF), and a constitutively active mutant of the epidermal growth factor receptor (∆EGFR/EGFRvIII), occur frequently in glioblastoma. c-Met is activated in a ligand-dependent manner by HGF or in a ligand-independent manner by ∆EGFR. Dysregulated c-Met signaling contributes to the aggressive phenotype of glioblastoma, yet the mechanisms underlying the production of HGF in glioblastoma are poorly understood. We found a positive correlation between HGF and c-Met expression in glioblastoma, suggesting that they are coregulated. This is supported by the finding that in a c-Met/HGF axis-dependent glioblastoma …

The Role Of Receptor Tyrosine Kinase Axl In Pancreatic Ductal Adenocarcinoma And Its Regulation By Hematopoietic Progenitor Kinase 1, Xianzhou Song

Dissertations and Theses (Open Access)

Pancreatic ductal adenocarcinoma (PDA) is one of the most aggressive malignancies with less than 5% of five year survival rate. New molecular markers and new therapeutic targets are urgently needed for patients with PDA. Oncogenic receptor tyrosine kinase Axl has been reported to be overexpressed in many types of human malignancies, including diffuse glioma, melanoma, osteosarcoma, and carcinomas of lung, colon, prostate, breast, ovary, esophagus, stomach, and kidney. However, the expression and functions of Axl in PDA are unclear. We hypothesized that Axl contributes to the development and progression of PDA. We examined Axl expression in 54 human PDA samples …

Prognostic Significance Of Xct Polymorphisms And Expression In Patients With Advanced Pancreatic Cancer Treated With Chemotherapy, Tzu-Chuan Jane Huang Md

Dissertations and Theses (Open Access)

The plasma membrane x_c^- cystine/glutamate transporter mediates cellular uptake of cystine in exchange for intracellular glutamate and is highly expressed by pancreatic cancer cells. The xCT gene, encoding the cystine-specific xCT protein subunit of x_c^-, is important in regulating intracellular glutathione (GSH) levels, critical for cancer cell protection against oxidative stress, tumor growth and resistance to chemotherapeutic agents including platinum. We examined 4 single nucleotide polymorphisms (SNPs) of the xCT gene in 269 advanced pancreatic cancer patients who received first line gemcitabine with or without cisplatin or oxaliplatin. Genotyping was performed using Taqman real-time PCR …

Dna As Patentable Subject Matter And A Narrow Framework For Addressing The Perceived Problems Caused By Gene Patents, Stephen H. Schilling

Duke Law Journal

Concerns about the alleged harmful effects of gene patents— including hindered research and innovation and impeded patient access to high-quality genetic diagnostic tests—have resulted in overreactions from the public and throughout the legal profession. These overreactions are exemplified by Association for Molecular Pathology v. U.S. Patent and Trademark Office, a 2010 case in the Southern District of New York that held that isolated DNA is unpatentable subject matter under 35 U.S.C. § 101. The problem with these responses is that they fail to adequately consider the role that gene patents and patents on similar biomolecules play in facilitating investment in …

Issue 0

The Synapse: Intercollegiate science magazine

No abstract provided.

To The Brink Of Understanding, Isaac H. Mcceery

The Synapse: Intercollegiate science magazine

No abstract provided.

Cruzin' With Yolanda: The Life And Research Of The Biology 100 Icon

The Synapse: Intercollegiate science magazine

No abstract provided.

The Short-Term Effects Of Cortisol

The Synapse: Intercollegiate science magazine

No abstract provided.

Deterrence And Escalation In Cross-Domain Operations: Where Do Space And Cyberspace Fit?, Vincent Manzo

Strategic Forums

Warfare has become even more complicated since Richard Smoke wrote this description of escalation in 1977. The National Security Space Strategy describes space as “congested, contested, and competitive,” yet satellites underpin U.S. military and economic power. Activity in cyberspace has permeated every facet of human activity, including U.S. military operations, yet the prospects for effective cyber defenses are bleak. Many other actors depend on continued access to these domains, but not nearly as much as the United States.

Characterization And Molecular Analysis Of University Of Arkansas Peach, Prunus Persica (L.) Batsch, Flesh Types And Development Of A Post-Harvest Evaluation Protocol For Arkansas Peach And Nectarine Genotypes, Paul James Sandefur

Graduate Theses and Dissertations

This study determined the effect of pre-cold storage treatment on P. persica genotypes, developed a protocol for the evaluation of breeding selection and cultivar storage performance, and provided information on post-harvest performance of these individuals. Additionally, characterization of the peach and nectarine flesh types, validation of endopolygalacturonase (endoPG) DNA markers, and investigation of endoPG marker allele combinations associated with the slow-melting-flesh (SMF) trait were done.

Fruit from 30 individuals were harvested at minimum- and well-mature states. After conditioning for 24 h at 20 ◦C, all 2010 fruit were exposed to 2 min of 1 ◦C 100 ppm chlorinated hydro-cooling, a …

Flexibility In The Patterning And Control Of Axial Locomotor Networks In Lamprey, James T. Buchanan

Biological Sciences Faculty Research and Publications

In lower vertebrates, locomotor burst generators for axial muscles generally produce unitary bursts that alternate between the two sides of the body. In lamprey, a lower vertebrate, locomotor activity in the axial ventral roots of the isolated spinal cord can exhibit flexibility in the timings of bursts to dorsally-located myotomal muscle fibers versus ventrally-located myotomal muscle fibers. These episodes of decreased synchrony can occur spontaneously, especially in the rostral spinal cord where the propagating body waves of swimming originate. Application of serotonin, an endogenous spinal neurotransmitter known to presynaptically inhibit excitatory synapses in lamprey, can promote decreased synchrony of dorsal–ventral …

Identifying Polyglutamine Protein Species In Situ That Best Predict Neurodegeneration, Jason Miller, Montserrat Arrasate, Elizabeth Brooks, Clare Peter Libeu, Justin Legleiter, Danny Hatters, Jessica Curtis, Kenneth Cheung, Preethi Krishnan, Siddhartha Mitra, Kartika Widjaja, Benjamin A. Shaby, Gregor P. Lotz, Yvonne Newhouse, Emily M. Sontag, Alex Osmand, Michelle Gray, Vanitha Thulasiramin, Frederic Saudou, Mark Segal, X William Yang, Eliezer Masliah, Leslie M. Thompson, Paul J. Muchowski, Karl H. Weisgraber, Steven Finkbeiner

Biological Sciences Faculty Research and Publications

Polyglutamine (polyQ) stretches exceeding a threshold length confer a toxic function to proteins that contain them and cause at least nine neurological disorders. The basis for this toxicity threshold is unclear. Although polyQ expansions render proteins prone to aggregate into inclusion bodies, this may be a neuronal coping response to more toxic forms of polyQ. The exact structure of these more toxic forms is unknown. Here we show that the monoclonal antibody 3B5H10 recognizes a species of polyQ protein in situ that strongly predicts neuronal death. The epitope selectively appears among some of the many low-molecular-weight conformational states assumed by …

A New Genus Of Miniaturized And Pug-Nosed Gecko From South America (Sphaerodactylidae: Gekkota), Tony Gamble, Juan D. Daza, Guarino R. Colli, Laurie J. Vitt, Aaron M. Bauer

Biological Sciences Faculty Research and Publications

Sphaerodactyl geckos comprise five genera distributed across Central and South America and the Caribbean. We estimated phylogenetic relationships among sphaerodactyl genera using both separate and combined analyses of seven nuclear genes. Relationships among genera were incongruent at different loci and phylogenies were characterized by short, in some cases zero-length, internal branches and poor phylogenetic support at most nodes. We recovered a polyphyletic Coleodactylus, with Coleodactylus amazonicus being deeply divergent from the remaining Coleodactylus species sampled. The C. amazonicus lineage possessed unique codon deletions in the genes PTPN₁₂ and RBMX while the remaining Coleodactylus species had unique codon …

Current And Future Directions In Frailty Research., Anita Mohandas, Joanne Reifsnyder, Mimi Jacobs, Tim Fox

College of Population Health Faculty Papers

The concept of frailty has been evolving dramatically for the past 30 years. Through its evolution, a variety of single and multidimensional models have been used to describe frailty. This article reviews the current literature related to the defining dimensions of frailty and identifies the gaps in the literature requiring additional research. A detailed literature review was performed to identify key dimensions and models currently being used to define frailty, classify interventions that have been developed to reverse frailty, and identify potential areas for future research within this field. Despite the large body of research defining the dimensions of frailty, …

Effect Of Nutrient Supplements On Cucumber Fermentation By Lactic Acid Bacteria, Shruti Tripuraneni

Graduate Theses and Dissertations

Lactic acid bacteria (LAB) are important industrial microorganisms involved in fermentation of food and beverage products. The strict fermentative growth of LAB has complex requirements of various nutrients including amino acids, vitamins and minerals. Information about the effect of these nutrients on the growth of LAB in cucumber fermentation is not readily available. It is evident, from previous research that certain nutrients like; leucine, isoleucine, tryptophan, valine, biotin, nicotinic acid, pantothenic acid, riboflavin, manganese and magnesium are beneficial for LAB growth, but are not provided in sufficient quantities by the cucumber in the brine. The objective of this study was …

Subcritical Water Hydrolysis Of Whey Proteins, Ashley Dawn Espinoza

Graduate Theses and Dissertations

Hydrolyzing food by-products is a unique approach to potentially increase by-product value and reduce waste. An abundant by-product of cheese production, whey, contains all essential amino acids and some distinctive peptides with functional and nutraceutical properties. Typically, proteins from whey are tailored for specific uses by chemical or enzymatic hydrolysis; however, subcritical water hydrolysis is a novel alternative used successfully to hydrolyze various substrates. Nevertheless, minimal research exists on: (1) the hydrolysis of whey protein; (2) the incorporation of additives; (3) the hydrolysis of whole whey; and (4) the production of volatiles when using subcritical water hydrolysis.

Therefore, whey protein …

Patternicity And Persuasion: Evolutionary Biology As A Bridge Between Economic And Narrative Analysis In The Law, James D. Ridgway

Southern Illinois University Law Journal

Although economic and narrative analyses are clearly useful in exploring legal issues, their foundations and persuasive power have not been thoroughly investigated.  Evolutionary biology can now explain how human beings instinctively approach legal problems, and what features from economic and narrative analysis are rooted in the information processing functions of the brain.  As a result, the most effective aspects of each can be synthesized into a new tool, the archetypal narratives of human interaction.  This article proposes that evolutionary biology indicates that human beings process legal arguments using three archetypal narratives: (1) the story of cooperation, which describes maximizing the …