Digital Commons Network^™

Exploring The Functional Interaction Between Camk-Ii And P53, Raymond Lai

Theses and Dissertations

Calcium (Ca2+)/calmodulin-dependent kinase 2 (CaMK-II) is a multifunctional member of a family of Ca2+/calmodulin-dependent serine/threonine protein kinases that respond to transient intracellular calcium signaling. CaMK-II has been reported to be involved with transcription regulation, cell motility, neuronal development, cell cycle regulation, and more recently early development of vertebrates (Easley et al., 2008; Rothschild et al., 2009; Francescatto et al., 2010). Through previous work in the lab using tandem mass spectrometry and “substrate-trapping mutants”, tumor suppressor protein 53 (p53) was identified as a novel CaMK-II binding partner in tissue culture. In this study, I sought to provide characterization of the functional …

The Role Of The Propeptide And Its Residues In Activation And Secretion Of Elastase, An M4 Metalloprotease Secreted By Pseudomonas Aeruginosa, Emily Boice

Theses and Dissertations

Pseudomonas aeruginosa secretes several proteases associated with pathogenesis, but the most abundant and active is elastase (M4 metalloendopeptidase). Elastase (lasB), is first synthesized as a preproenzyme, with a signal peptide, an 18-kDa N-terminal propeptide, and a 33-kDa mature domain. The propeptide functions as an intramolecular chaperone that is required for the folding and secretion of elastase, but ultimately is proteolytically removed and degraded. Previous research has identified the conserved residues in the propeptide of elastase as compared to other M4 protease precursors and showed some among them to be important for the production of active elastase. In this project, the …

3d Functional Modeling Of Dbs Efficacy And Development Of Analytical Tools To Explore Functional Stn, Deepak Kumbhare

Theses and Dissertations

Introduction: Exploring the brain for optimal locations for deep brain stimulation (DBS) therapy is a challenging task, which can be facilitated by analysis of DBS efficacy in a large number of patients with Parkinson’s disease (PD). The Unified Parkinson's Disease Rating Scale (UPDRS) scores indicate the DBS efficacy of the corresponding stimulation location in a particular patient. The spatial distribution of these clinical scores can be used to construct a functional model which closely models the expected efficacy of stimulation in the region. Designs and Methods: In this study, different interpolation techniques were investigated that can appropriately model the DBS …

Parasitic Interiors, Michael Kanasink

Theses and Dissertations

This project is an experiment in the adaptive reuse of an Art Deco style manufacturing facility in Richmond, VA. The building has fallen into disrepair and has been inhabited by two different owners over the years, but the structure remains very much as it did when it was erected in 1946. I will propose adapting to the defunct space, a forward thinking school based on hands-on, creative learning. This school will challenge accepted pedagogies and serve as an exapmple of future learning. I have always looked as adaptive reuse interior design as a parasitic form of designing. The new program …

Spatial Parameters In Therapeutic Spaces: Design Of A Residential Treatment Facility For Eating Disorder Patients, Sarah Beth Basinger

Theses and Dissertations

Can the built environment positively influence the treatment of an eating disorder? Does the built environment play a role in the quality of care, the rehabilitation process and the lasting affects of treatment in eating disorders and if so, what role does it play? What are the important parameters to consider in designing such a space? Currently there are few facilities designed specifically for the treatment of this disorder. Of those facilities, there is a lack of research regarding the effects of the built environment. Therefore, the process of answering these questions must begin by assessing parameters in architectural precedents …

Electrophysiological Characterization Of Enteric Neurons Isolated From The Immortomouse, Edward G. Hawkins

Theses and Dissertations

The availability of murine genetic models is extremely advantageous to studying gastrointestinal function, but the benefits afforded by studying enteric neurons in mice has been hindered by their accessibility. Fetal (E13) and 2 day post-natal (P2) enteric neuron cell lines (IM-FEN and IM-PEN, respectively) were recently developed from the H-2Kb-tsA58 immortomouse. Our goal was to identify the electrophysiological properties of these cell lines and clarify their utility as a model of enteric neurons. IM-PEN cells stained positively for the neuron specific markers βIII-tubulin and PGP9.5 and were negative for the glial cell marker S100. Detection of mRNA for TRPA1, TRPV1, …

Montana Kaimin, April 27, 2011, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

April 27, 2011, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

The Daily Egyptian, April 26, 2011, Daily Egyptian Staff

April 2011

No abstract provided.

Ua12/2/1 College Heights Herald, Vol. 86, No. 51, Wku Student Affairs

WKU Administration Documents

WKU campus newspaper reporting campus, athletic and Bowling Green, Kentucky news.

New Treatment Strategies In The Treatment Of Juvenile Idiopathic Arthritis, Ibrahim Gökçe, Erkan Demirkaya

Paediatrics Publications

Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in childhood with an incidence of 10-19/100.000 children below the age of 16 years, and it is also one of the major causes of acquired disability and impairment of quality of life in childhood. Early and aggressive control of arthritis is essential to prevent long-term disability. Methotrexate (MTX) provides clinical benefits in JIA with an acceptable profile of toxic effects. Nevertheless, in many cases, inefficacy, especially in patients with polyarticular and systemic-onset form of JIA (SOJIA) or intolerance to MTX, has led investigators to try other therapeutic options. Biologic …

Ucc Minutes Apr 26, 2011, Undergraduate Curriculum Council

Undergraduate Currirculum Committee Minutes

No abstract provided.

The Effects Of Coping On The Psychological Well-Being Of Inidividuals Who Are Late-Deafened, Jill Marie Meyer

Dissertations

Abstract Recent research supports the application of the theory of adaptation to various groups of individuals with disabilities. The premise of the theory is that individuals with certain disabilities may have greater difficulty adapting to their newly acquired level of functioning (Diener, Lucas, & Scollon, 2006). The purpose of this study was to examine the relationships between disability factors and psychosocial outcomes, specifically psychological well-being, in a sample of individuals who lost their hearing after age 12. Coping was examined to determine if it was a mediator of the relationships between the disability factors (age of onset, severity of disability, …

2011 - The Sixteenth Annual Symposium Of Student Scholars

Symposium of Student Scholars Program Books

The full program book from the Sixteenth Annual Symposium of Student Scholars, held on April 26, 2011. Includes abstracts from the presentations and posters.

Monitoring And Prevalence Rates Of Metabolic Syndrome In Military Veterans With Serious Mental Illness, Sameed Ahmed M. Khatana, Kane, Tracey H. Taveira, Mark S. Bauer, Wen-Chih Wu

Pharmacy Practice and Clinical Research Faculty Publications

Background:

Cardiovascular disease is the leading cause of mortality among patients with serious mental illness (SMI) and the prevalence of metabolic syndrome—a constellation of cardiovascular risk factors—is significantly higher in these patients than in the general population. Metabolic monitoring among patients using second generation antipsychotics (SGAs)—a risk factor for metabolic syndrome—has been shown to be inadequate despite the release of several guidelines. However, patients with SMI have several factors independent of medication use that predispose them to a higher prevalence of metabolic syndrome. Our study therefore examines monitoring and prevalence of metabolic syndrome in patients with SMI, including those …

Fifth Year Teacher Perceptions Of Induction Programs Upon Teacher Retention, Arleen Reinhardt

Theses and Dissertations

Due to teacher shortages, school districts have offered incentives and alternative licensure programs. Recently, however, school districts have shifted the focus from recruitment to one of teacher retention which places an emphasis upon beginning teacher induction programs. These programs help teachers improve in their craft of teaching, help teachers remain satisfied with their jobs, help teachers enculturate into the districts in which they work, and help to improve student achievement. This quantitative study examined fifth year teachers’ perceptions of their induction programs in terms of teacher retention. The 280 eligible teachers from three different school districts were asked to participate …

Uab To Celebrate Commencement May 7, Ceremony Live Online, Shannon Thomason

Browse All News

No abstract provided.

April 26, 2011 General Faculty Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

April 26, 2011 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

Chelating Compounds And Immobilized Tethered Chelators, Robert A. Yokel, Wesley R. Harris, Christopher D. Spilling, Chang-Guo Zhan

Pharmaceutical Sciences Faculty Patents

Novel di- and tripodal compounds useful as chelators, intermediates for their production and a method for treating an aqueous solution to remove trivalent metal ions are presented.

The Road To Success: Online Engagement & Identity Management, Kiyomi D. Deards

University of Nebraska-Lincoln Libraries: Faculty Publications

In the increasingly competitive job market, being good at your job isn't good enough. Potential employees must be able to do the job and have excellent interpersonal skills, enthusiasm, compassion, and ambition. Communicating these traits in a CV or resume is difficult at best. Prospective employers and colleagues will search for you online in an attempt to discover these traits; what will they find? Come join us as we talk about defining and managing your online identity in order to create and maintain a solid and professional reputation!

Evaluation Of Flexible Regression For Non-Unimodal Hazard Functions, Marco Fornili, Patrizia Boracchi, Federico Ambrogi, Elia Biganzoli

COBRA Preprint Series

Longer follow-up for various kinds of cancer, particularly breast cancer, has made it possible the observation of complex forms of the hazard function of occurrence of metastasis and death. In several studies a bimodal hazard function was obtained, with a possible interpretation in the context of tumor dormancy. The shape of the hazard function is usually estimated by spline regression functions. In the case of breast cancer, no general agreement is obtained on the presence of a complex behavior. This may depend on the properties of the smoothing function adopted. We evaluate through simulations of a bimodal hazard function the …

C-C Chemokine Receptor 5 And Hiv: Therapeutic Potentials Of The Δ32 Base Pair Deletion, Amanda R. Antczak

Honors Projects

The human immunodeficiency virus, a retrovirus discovered in 1981, has reached pandemic status worldwide. Without an existing cure or vaccine, a majority of the world’s population remains at risk for infection and more than 35 million people to date have died from AIDS. Resistance to the virus, however, has been discovered in about 10% of the world’s population in the form of an allelic base pair deletion, located on C-C chemokine receptor 5. Those homozygous for the base pair deletion are resistant to HIV, while heterozygotes have displayed delayed onset of HIV infection. The CCR5 mutation and observed resistance to …

Muc4 Stabilizes Her2 Expression And Maintains The Cancer Stem Cell Population In Ovarian Cancer Cells., Moorthy P. Ponnusamy, Parthasarathy Seshacharyulu, Arokia P. Vaz, Parama Dey, Surinder K. Batra

Journal Articles: Biochemistry & Molecular Biology

BACKGROUND: Recent evidence has suggested that the capability of cancer to grow, propagate and relapse after therapy is dependent on a small subset of the cell population within the tumor, called cancer stem cells. Therefore, this subpopulation of cells needs to be targeted with different approaches by identification of unique stem-cell specific target antigens. One of the well known tumor antigens is the epithelial cell mucin MUC4, which is aberrantly expressed in ovarian cancer as compared to the normal ovary and plays a pivotal role in the aggressiveness and metastasis of ovarian cancer cells. In the present study, we aimed …

Periodic Fever, Aphthous Stomatitis, Pharyngitis, And Adenitis (Pfapa) Is A Disorder Of Innate Immunity And Th1 Activation Responsive To Il-1 Blockade., Silvia Stojanov, Sivia Lapidus, Puja Chitkara, Henry Feder, Juan C Salazar, Thomas A Fleisher, Margaret R Brown, Kathryn M Edwards, Michael M Ward, Robert A Colbert, Hong-Wei Sun, Geryl M Wood, Beverly K Barham, Anne Jones, Ivona Aksentijevich, Raphaela Goldbach-Mansky, Balu Athreya, Karyl S Barron, Daniel L Kastner

Department of Pediatrics Faculty Papers

The syndrome of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) is the most common periodic fever disease in children. However, the pathogenesis is unknown. Using a systems biology approach we analyzed blood samples from PFAPA patients whose genetic testing excluded hereditary periodic fevers (HPFs), and from healthy children and pediatric HPF patients. Gene expression profiling could clearly distinguish PFAPA flares from asymptomatic intervals, HPF flares, and healthy controls. During PFAPA attacks, complement (C1QB, C2, SERPING1), IL-1-related (IL-1B, IL-1RN, CASP1, IL18RAP), and IFN-induced (AIM2, IP-10/CXCL10) genes were significantly overexpressed, but T cell-associated transcripts (CD3, CD8B) were down-regulated. On the …

On Things And Margins, Will Machin

Theses and Dissertations

This thesis is an exploration into an alternate ground for discourse. It is an exploration of the edges of the possibilities of words, the centers of margins, and the question of the lives of objects in this time of abundant cast-offs. The truths and limits of an emerging globalized multi-polarity of culture, are put in play. The secret lives of things are brought into the same room as words. The potential for radical landscape is considered.

Involvement Of P53 In The S-Phase Checkpoint During Nucleotide Deficiencies, Cortney Heyer

Theses and Dissertations

Several classes of antimetabolites have been developed for the treatment of cancer, including numerous inhibitors of nucleotide biosynthesis. N-(phosphonacetyl)-L-aspartate (PALA) and hydroxyurea (HU) are two antimetabolites that inhibit nucleotide biosynthesis; PALA inhibits de novo pyrimidine synthesis and HU inhibits the conversion of ribonucleotide diphosphates to deoxyribonucleotide diphosphates. Due to the similar mechanisms, it was thought that cancer cells would respond similarly to HU and PALA treatment. However, studies in this dissertation revealed strikingly different responses to either HU or PALA treatment in HCT116 cells. A cytoprotective S-phase arrest was activated upon HU treatment while PALA treatment failed to activate the …

Transverse Permeability Of Fibrous Porous Media, Ali Tamayol, Majid Bahrami

Department of Mechanical and Materials Engineering: Faculty Publications

In this study, the transverse permeability of fibrous porous media is studied both experimentally and theoretically. A scale analysis technique is employed for determining the transverse permeability of various fibrous matrices including square, staggered, and hexagonal arrangements of unidirectionally aligned fibers, as well as simple two-directional mats and simple cubic structures. In the present approach, the permeability is related to the porosity, fiber diameter, and tortuosity of the medium. In addition, the pressure drop in several samples of tube banks of different arrangements and metal foams are measured in the creeping flow regime. The pressure-drop results are then used to …

Incidence And Prevention Of Injury Of The Anterior Cruciate Ligament In Females, Arielle E. Gillie

Senior Honors Theses

According to the American College of Sports Medicine, women are two to eight times more likely to sustain an anterior cruciate ligament injury than men at the same level of performance. This high incidence of women with an ACL injury is thought to be due to a number of gender differences. This study examines the research that has been conducted to determine the reason for the disproportionate incidence of anterior cruciate ligament in female population. The study encompasses anatomical structure of the knee joint, structural differences in the male and female knee, hormonal influences, biomechanical influences, neuromuscular influences, and strategies …

Hallowed Be Thy Name: The Effect Of Prayer On God-Schemata, Jennifer J. Healey

Senior Honors Theses

Religious ideologies and spiritual frameworks are first formed and later held together by the linking of encounters with the sacred, a spiritual Entity, ritualistic practices, and/or the recognition of spirituality in others or within one’s self. The concept of schemata, which are the mind’s processing frameworks wherein the individual connects information in a purposeful and meaningful way is fundamentally tied to this process of deliberating faith. According to the Christian faith, prayer molds this conceptualization of God. This study endeavors to establish the relationship between the subjective nature of schemata and its supernatural implications: how prayer influences one’s view of …