Digital Commons Network^™

Intact Statistical Word Learning In Autism Spectrum Disorders, Jessica Mayo

Master's Theses

Individuals with Autism Spectrum Disorders (ASD) have impairments in language acquisition, but the underlying mechanism of these deficits is poorly understood. Implicit learning appears potentially relevant to language development, particularly in speech segmentation, which relies on sensitivity to the transitional probabilities between speech sounds. This study aimed to investigate the relationship between implicit learning and current language abilities in school-aged children with autism (n = 17) and typical development (n = 24) using a well-studied artificial language learning task. Results suggest that the ASD and TD groups were equally able to implicitly learn transitional probabilities from a lengthy …

Aronia Mitschurinii: Solving A Horticultural Enigma, Peter J. Leonard

Master's Theses

Aronia (Medik.), commonly known as chokeberry, is a taxonomically misunderstood genus currently experiencing a renaissance in North America as both an ornamental and fruit crop. Three species of chokeberry are commonly accepted as native in North America: A. arbutifolia (L.) Pers. red chokeberry; A. melanocarpa (Michx.) Elliot, black chokeberry; and A. prunifolia (Marshall) Rehder, or purple chokeberry. In Europe a fourth species of human origin is recognized as Aronia mitschurinii (A.K.Skvortsov & Maitul.), or cultivated, black-fruited Aronia. It is widely speculated that this genotype originated in the early 20^th century with Russian pomologist Ivan Michurin, as the product …

Critical Role Of Pi3k/Akt/Gsk3Β In Motoneuron Specification From Human Neural Stem Cells In Response To Fgf2 And Egf, Luis Ojeda, Junling Gao, Kristopher G. Hooten, Enyin Wang, Jason R. Thonhoff, Tiffany J. Dunn, Tianyan Gao, Ping Wu

Markey Cancer Center Faculty Publications

Fibroblast growth factor (FGF) and epidermal growth factor (EGF) are critical for the development of the nervous system. We previously discovered that FGF2 and EGF had opposite effects on motor neuron differentiation from human fetal neural stem cells (hNSCs), but the underlying mechanisms remain unclear. Here, we show that FGF2 and EGF differentially affect the temporal patterns of Akt and glycogen synthase kinase 3 beta (GSK3β) activation. High levels of phosphatidylinositol 3-kinase (PI3K)/Akt activation accompanied with GSK3β inactivation result in reduction of the motor neuron transcription factor HB9. Inhibition of PI3K/Akt by chemical inhibitors or RNA interference or overexpression of …

Genomic And Karyotypic Variation In Drosophila Parasitoids (Hymenoptera, Cynipoidea, Figitidae), Vladimir E. Gokhman, J. Spencer Johnston, Chiyedza Small, Roma Rajwani, Shawn J. Hanrahan, Shubha Govind

Publications and Research

Abstract Drosophila melanogaster Meigen, 1830 has served as a model insect for over a century. Sequencing of the 11 additional Drosophila Fallen, 1823 species marks substantial progress in comparative genomics of this genus. By comparison, practically nothing is known about the genome size or genome sequences of parasitic wasps of Drosophila. Here, we present the first comparative analysis of genome size and karyotype structures of Drosophila parasitoids of the Leptopilina Förster, 1869 and Ganaspis Förster, 1869 species. The gametic genome size of Ganaspis xanthopoda (Ashmead, 1896) is larger than those of the three Leptopilina species studied. The genome sizes of …

Do-Or-Die Time For Huntington’S Clinical Trials, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Judicial Review As Soft Power: How The Courts Can Help Us Win The Post-9/11 Conflict, Dawinder S. Sidhu

American University National Security Law Brief

No abstract provided.

Rethinking Computer Network "Attack": Implications For Law And U.S. Doctrine, Paul A. Walker

American University National Security Law Brief

No abstract provided.

Ziram Activates Mitogen-Activated Protein Kinases And Decreases Cytolytic Protein Levels In Human Natural Killer Cells, Thyneice R. Taylor, Margaret M. Whalen

Chemistry Faculty Research

Human natural killer (NK) cells are central in immune defense with their ability to lyse tumor cells and virally infected cells. Tumor formation and viral infection may increase if NK cytotoxic function is disrupted. Ziram (zinc dithiocarbamate) is used as an accelerating agent in the production of latex and to protect various fruits and vegetables from fungal infection. Previously, we have shown that exposure to ziram inhibits NK lytic function. Butyltin environmental contaminants, which also inhibit NK lytic function, cause rapid activations of mitogen-activated protein kinases (MAPKs) and decreases in expression of the cytolytic proteins granzyme B and perforin (after …

State Of The University Address, 2011, John R. Broderick

State of the University Addresses

President John R. Broderick's 2011 State of the University Address and Faculty Welcome.

Cerebral Lateralization Determines Hand Preferences In Australian Parrots, Culum Brown, Maria Magat

Sentience Collection

Individual preference for the use of one limb over the other to explore the environment or manipulate objects is common trait among vertebrates. Here, we explore the hypothesis that limb preference is determined by the engagement of a particular cerebral hemisphere to analyse certain stimuli. We recorded the eye and foot preferences of 322 individuals from 16 species of Australian parrots while investigating potential food items. Across all species, eye preferences explained 99 per cent of the variation in foot use in Australian parrots. The vast majority of species showed significant relationships between eye and foot preferences at the population …

2011 Ursinus College Academic Convocation Program, Ursinus College

Academic Convocation Programs

This Ursinus College Academic Convocation program lists speakers and events for the opening of the 2011 academic year.

August 23, 2011, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Passive Nutrient Removal Material Mixes Div, Martin Wanielista, Ni-Bin Chang

UCF Patents

Materials, compositions, substances and methods and systems for stormwater treatment in wet ponds, dry ponds and a green roof system. A first embodiment provides in-situ treatment unit to sorb nitrogen from the stored stormwater. A second embodiment provides uses a riprap apron, a perforated riser located at the bottom of the riprap apron and a goetextile media encased in a sorption medida jacket around the perforated riser. A third embodiment provides a green roof stormwater treatment system that includes protection for waterproofing and insulating the roof, a pollution control media layer for filtration and sorption of solids and dissolved materials …

Green Sorption Material Mixes For Water Treatment Cip, Martin Wanielista, Ni-Bin Chang, Ammarin Makkeasorn

UCF Patents

Media compositions for use in wastewater treatment, stormwater treatment, CSO treatment and greenroof stormwater management systems as filtration media, plant growth media or pollutant retention media. Media compositions includes at least one of the recycled material selected from a group consisting of tire crumb, wood sawdust, and paper and naturally occuring material selected from a group consisting of sand, limestone, sandy clay, expanded clay, organics used for processing geothermal water, organics used for agricultural drainage basins and filtration, and organics for aquaculture drainage and organics used for silviculture and forest drainage, and organics used as growing media.

Metastasis Of Tumor Cells Is Enhanced Bydownregulation Of Bit1, Priya Prakash Karmali, Chris Brunquell, Shubha Kale Ireland, Erkki Ruostlahti, Hau Tram, Hector Biliran

Faculty and Staff Publications

Abstract Background: Resistance to anoikis, which is defined as apoptosis induced by loss of integrin-mediated cell attachment to the extracellular matrix, is a determinant of tumor progression and metastasis. We have previously identified the mitochondrial Bit1 (Bcl-2 inhibitor of transcription) protein as a novel anoikis effector whose apoptotic function is independent from caspases and is uniquely controlled by integrins. In this report, we examined the possibility that Bit1 is suppressed during tumor progression and that Bit1 downregulation may play a role in tumor metastasis. Methodology/Principal Findings: Using a human breast tumor tissue array, we found that Bit1 expression is suppressed …

Monoclonal Antibodies Recognizing The Non-Tandem Repeat Regions Of The Human Mucin Muc4 In Pancreatic Cancer., Maneesh Jain, Ganesh Venkatraman, Nicolas Moniaux, Sukhwinder Kaur, Sushil Kumar, Subhankar Chakraborty, Grish C. Varshney, Surinder K. Batra

Journal Articles: Biochemistry & Molecular Biology

The MUC4 mucin is a high molecular weight, membrane-bound, and highly glycosylated protein. It is a multi-domain protein that is putatively cleaved into a large mucin-like subunit (MUC4α) and a C-terminal growth-factor like subunit (MUC4β). MUC4 plays critical roles in physiological and pathological conditions and is aberrantly overexpressed in several cancers, including those of the pancreas, cervix, breast and lung. It is also a potential biomarker for the diagnosis, prognosis and progression of several malignancies. Further, MUC4 plays diverse functional roles in cancer initiation and progression as evident from its involvement in oncogenic transformation, proliferation, inhibition of apoptosis, motility and …

The Prospector, August 23, 2011, Utep Student Publications

The Prospector

Headline: Welcome Home

Alpha-Defensins 1-3 Release By Dendritic Cells Is Reduced By Estrogen, Maria M. Escribese, Marta Rodríguez-García, Rhoda Sperling, Stephanie M. Engel

Dartmouth Scholarship

During pregnancy the immune system of the mother must protect any activation that may negatively affect the fetus. Changes in susceptibility to infection as well as resolution of some autoimmune disorders represent empirical evidence for pregnancy related alterations in immunity. Sex hormones reach extremely high levels during pregnancy and have been shown to have direct effects on many immune functions including the antiviral response of dendritic cells. Among the immunologically active proteins secreted by monocyte derived DCs (MDDC) are the alpha-defensins 1-3. This family of cationic antimicrobial peptides has a broad spectrum of microbicidal activity and has also been shown …

The George-Anne, Georgia Southern University

The George-Anne

• Eagles Voted Early Favorite By Coaches
• Camp Lawton Dig Progresses
• Police Beat
• Control The Masses
• Legalize Marijuana, Reduce National Debt
• Welcome Back, GSU
• If We Get Paid, Why Can’t Jaybo?
• Sunday Alcohol Sales for Liberty
• Human Resources Responds To HOPE Changes
• GSU Convocation ‘Investing in Future’
• BUILD Makes Student Connections
• Eagles Complete Operation Move-In
• Hurricane Irene Predicted To Hit East Coast Thursday
• Eagle Entertainment Gets Geared Up for Fall
• ‘Boro Supporters Buy Local At Farmer’s Market
• Murder Mystery Follows GSU Retiree’s Book Signing
• Classifieds
• First Aid for Your Future
• Puzzles/Comics
• Eagles Finish Exhibitions Untouched
• Dominating Defenseman
• Eagles Football Search for …

Do Lesbian Co-Parents Have Rights? A Recent Ohio Ruling Offers An Unusual Answer, Joanna L. Grossman

Hofstra Law Faculty Scholarship

In a recent ruling, In re Mullen, the Ohio Supreme Court took a somewhat unique approach to defining the rights of lesbian co-parents. The court’s approach leaves the door open for the recognition of such rights, but also makes them relatively difficult to establish in each individual case.

In this column, I will discuss the Mullen ruling, as well as the complicated and ever-changing general legal landscape for lesbian co-parents’ rights.

Potential Applications Of Curcumin And Its Novel Synthetic Analogs And Nanotechnology-Based Formulations In Cancer Prevention And Therapy., Murielle Mimeault, Surinder K. Batra

Journal Articles: Biochemistry & Molecular Biology

Curcumin has attracted great attention in the therapeutic arsenal in clinical oncology due to its chemopreventive, antitumoral, radiosensibilizing and chemosensibilizing activities against various types of aggressive and recurrent cancers. These malignancies include leukemias, lymphomas, multiple myeloma, brain cancer, melanoma and skin, lung, prostate, breast, ovarian, liver, gastrointestinal, pancreatic and colorectal epithelial cancers. Curcumin mediates its anti-proliferative, anti-invasive and apoptotic effects on cancer cells, including cancer stem/progenitor cells and their progenies, through multiple molecular mechanisms. The oncogenic pathways inhibited by curcumin encompass the members of epidermal growth factor receptors (EGFR and erbB2), sonic hedgehog (SHH)/GLIs and Wnt/β-catenin and downstream signaling elements …

Gsu View, 2011-08-22, Office Of Public Affairs

GSU View

Newsletter published by Governors State University 2007-current.

2011 Fall Faculty Conference: Defining Academic Achievement At Otterbein: The Degree Profile Opportunity, Academic Affairs

Fall Faculty Conference

The 2011 Fall Faculty Conference features a talk by Dr. Paul Gaston, and table discussions of "As scholars and educators at Otterbein, what do you think of the degree profile?" and "In light of Otterbein's current and emerging identities, how might we us, adapt, and provide feedback on the profile?"

Ua3/9 Wku Convocation 2011, President Gary Ransdell, Gary Ransdell

Presidential Speeches

No abstract provided.

The Daily Gamecock, Monday, August 22, 2011, University Of South Carolina, Office Of Student Media

August

No abstract provided.

Connecting Brain Research With Teaching Practice Among Middle School Teachers, Irene Sanders

Theses and Dissertations

The discipline of mind, brain, and education science is the merger of psychology, neuroscience, and education. Its focus is to address complex problems in education and provide evidence-based solutions. One facet of this mixed methods action research study expanded middle school teachers' knowledge of brain function and brain-based strategies through a five-part workshop series and created a ten session professional learning community. Participants selected strategies such as relaxation, working memory tasks, or taught students about their brains to increase academic achievement, and tracked two groups' progress. Strategy implementation was judged to be too time consuming except for relaxation exercises. Alternate …

On The Lack Of Consensus Over The Meaning Of Openness: An Empirical Study, Alicia M. Grubb, Steve M. Easterbrook

Computer Science: Faculty Publications

This study set out to explore the views and motivations of those involved in a number of recent and current advocacy efforts (such as open science, computational provenance, and reproducible research) aimed at making science and scientific artifacts accessible to a wider audience. Using a exploratory approach, the study tested whether a consensus exists among advocates of these initiatives about the key concepts, exploring the meanings that scientists attach to the various mechanisms for sharing their work, and the social context in which this takes place. The study used a purposive sampling strategy to target scientists who have been active …

The Professional Staff And Librarian Learning Community At Rowan University, Katherine Boland

Theses and Dissertations

As powerful forces of change continue to exert pressure on institutions of higher education, scholars are calling for strategies to sustain our most valuable asset, the academic community. One promising response is Milton Cox's work. He created the Miami University model for faculty and professional learning communities, a nationally-recognized strategy for supporting faculty development, addressing institutional needs, and promoting meaningful change. This mixed methods action research project introduced a new version of Cox's technology, a project-based learning community. This project-based version was the basis of my work with the Professional Staff and Librarian Learning Community (PSLLC). The PSLLC engaged in …

Histone Deacetylase Inhibitors And Mithramycin A Impact A Similar Neuroprotective Pathway At A Crossroad Between Cancer And Neurodegeneration, Sama F. Sleiman, Jill Berlin, Manuela Basso, Saravanan S. Karuppagounder, Jürgen Rohr, Rajiv R. Ratan

Pharmaceutical Sciences Faculty Publications

Mithramycin A (MTM) and histone deacetylase inhibitors (HDACi) are effective therapeutic agents for cancer and neurodegenerative diseases. MTM is a FDA approved aureolic acid-type antibiotic that binds to GC-rich DNA sequences and interferes with Sp1 transcription factor binding to its target sites (GC box). HDACi, on the other hand, modulate the activity of class I and II histone deacetylases. They mediate their protective function, in part, by regulating the acetylation status of histones or transcription factors, including Sp1, and in turn chromatin accessibility to the transcriptional machinery. Because these two classes of structurally and functionally diverse compounds mediate similar therapeutic …

August 22, 2011 Reporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.