Digital Commons Network^™

Evolution Of Functionally Diverse Alleles Associated With Ptc Bitter Taste Sensitivity In Africa, Michael Campbell

Department of Biology Faculty Publications

Although human bitter taste perception is hypothesized to be a dietary adaptation, little is known about genetic signatures of selection and patterns of bitter taste perception variability in ethnically diverse populations with different diets, particularly from Africa. To better understand the genetic basis and evolutionary history of bitter taste sensitivity, we sequenced a 2,975 bp region encompassing TAS2R38, a bitter taste receptor gene, in 611 Africans from 57 populations in West Central and East Africa with diverse subsistence patterns, as well as in a comparative sample of 132 non-Africans. We also examined the association between genetic variability at this locus …

Managing Individual And Organizational Performance: The Critical Mediating Role Of Collaboration, Oliver L.G Bouclier

Student Scholarship

Although collaboration has often been suggested as a critical factor for improving performance, its relation to individual and organizational performance has been given little attention in management research. This paper proposes a model of collaboration including affective, cognitive and organizational antecedents, and measures its effects on individual and organizational success. Over 900 front line employees in two firms in the service industry were surveyed. Structural Equation Modeling and bootstrap analysis were used to examine its role as a mediator between three independent variables (i.e. commitment, self-efficacy, and rewards) and three dependent variables (i.e. individual success, organizational efficiency and quality) while …

Competencies: A Cure For Pre-Med Curriculum, Winston Anderson, Richard Amasino, Manuel Ares, Utpal Banerjee, Bonnie Bartel, Victor Corces, Catherine Drennan, Sarah C.R. Elgin, Irving Epstein, Ellen Fanning, Louis Guillette, Jo Handelsman, Graham Hatfull, Ronald Hoy, Darcy Kelley, Leslie Leinwand, Richard Losick, Yi Lu, David Lynn, Claudia Neuhauser, Diane O'Dowd, Toto Olivera, Pavel Pevzner, Rebecca Richards-Kortum, Jasper Rine, Robert Sah, Scott Strobel, Graham Walker, David Walt, Isiah Warner, Sue Wessler, Huntington Willard, Richard Zare

Biology Faculty Research

No abstract provided.

Community Property V. The Elective Share, Terry L. Turnipseed

Louisiana Law Review

No abstract provided.

The Current Volume 22 : Issue 11, Nova Southeastern University

Student Newspapers

No abstract provided.

Spinal Locomotor Inputs To Individually Identified Reticulospinal Neurons In The Lamprey, James T. Buchanan

Biological Sciences Faculty Research and Publications

Locomotor feedback signals from the spinal cord to descending brain stem neurons were examined in the lamprey using the uniquely identifiable reticulospinal neurons, the Müller and Mauthner cells. The same identified reticulospinal neurons were recorded in several preparations, under reduced conditions, to address whether an identified reticulospinal neuron shows similar locomotor-related oscillation timing from animal to animal and whether these timing signals can differ significantly from other identified reticulospinal neurons. Intracellular recordings of membrane potential in identified neurons were made in an isolated brain stem-spinal cord preparation with a high-divalent cation solution on the brain stem to suppress indirect neural …

Chaos As Strategy, P. H. Liotta

The US Army War College Quarterly: Parameters

No abstract provided.

Book Reviews, Parameters Editors

The US Army War College Quarterly: Parameters

No abstract provided.

Laboratory Diagnosis Of Clostridium Difficile Infection: Can Molecular Amplification Methods Move Us Out Of Uncertainty?, Fred C. Tenover, Ellen Jo Baron, Lance R. Peterson, David Persing

Biology Faculty Publications

The laboratory diagnosis of Clostridium difficile infection (CDI) continues to be challenging. Recent guidelines from professional societies in the United States note that enzyme immunoassays for toxins A and B do not have adequate sensitivity to be used alone for detecting CDI, yet the optimal method for diagnosing this infection remains unclear. Nucleic acid amplification tests (NAATs) that target chromosomal toxin genes (usually the toxin B gene, tcdB) show high sensitivity and specificity, provide rapid results, and are amenable to both batch and on-demand testing, but these tests were not universally recommended for routine use in the recent guidelines. …

Civil Practice And Procedure, John R. Walk, Andrew P. Sherrod

University of Richmond Law Review

This article surveys recent significant developments in Virginia civil practice and procedure. Specifically, the article discusses opinions of the Supreme Court of Virginia from June 2010through June 2011 addressing civil procedure topics; significant amendments to the Rules of the Supreme Court of Virginia concerning procedural issues during the same period; and legislation enacted by the Virginia General Assembly during its 2011 session that relates to civil practice.

Family Law, Ronald R. Tweel, Elizabeth P. Coughter, Jason P. Seiden

University of Richmond Law Review

No abstract provided.

Third Practice Electroacoustic Music Festival, Department Of Music, University Of Richmond

Music Department Concert Programs

No abstract provided.

Genotype And Cardiovascular Phenotype Correlations With Tbx1 In 1,022 Velo-Cardio-Facial/Digeorge/22q11.2 Deletion Syndrome Patients, Tingwei Guo, Donna Mcdonald-Mcginn, Anna Blonska, Alan L. Shanske, Anne S. Bassett, Eva Chow, Mark Bowser, Molly Sheridan, Frits Beemer, Koen Devriendt, Ann Swillen, Jeroen Breckpot, Maria C. Digilio, Bruno Marino, Bruno Dallapiccola, Courtney Carpenter, Xin Zheng, Jacob Johnson, Jonathan Chung, Anne Marie Higgins, Nicole Philip, Tony J. Simon, Karlene Coleman, Damian Heine-Suner, Jordi Rosell, Wendy R. Kates, Marcella Devoto, Elizabeth Goldmuntz, Elaine Zackai, Tao Wang, Robert J. Shprintzen, Beverly Emanuel, Bernice Morrow, The International Chromosome 22q11.2 Consortium

Communication Disorders Faculty Publications

Haploinsufficiency of TBX1, encoding a T-box transcription factor, is largely responsible for the physical malformations in velo-cardio-facial /DiGeorge/22q11.2 deletion syndrome (22q11DS) patients. Cardiovascular malformations in these patients are highly variable, raising the question as to whether DNA variations in the TBX1 locus on the remaining allele of 22q11.2 could be responsible. To test this, a large sample size is needed. The TBX1 gene was sequenced in 360 consecutive 22q11DS patients. Rare and common variations were identified. We did not detect enrichment in rare SNP (single nucleotide polymorphism) number in those with or without a congenital heart defect. One exception …

Assessing The Impact Of Non-Differential Genotyping Errors On Rare Variant Tests Of Association, Scott Powers, Shyam Gopalakrishnan, Nathan L. Tintle

Faculty Work Comprehensive List

Background/Aims: We aim to quantify the effect of non-differential genotyping errors on the power of rare variant tests and identify those situations when genotyping errors are most harmful. Methods: We simulated genotype and phenotype data for a range of sample sizes, minor allele frequencies, disease relative risks and numbers of rare variants. Genotype errors were then simulated using five different error models covering a wide range of error rates. Results: Even at very low error rates, misclassifying a common homozygote as a heterozygote translates into a substantial loss of power, a result that is exacerbated even further as the minor …

The Association Between Parity, Infant Gender, Higher Level Of Paternal Education And Preterm Birth In Pakistan: A Cohort Study, Kiran Shaikh, Shahirose Sadrudin Premji, Marianne S. Rose, Ambreen Kazi, Shaneela Khowaja, Suzanne Tough

School of Nursing & Midwifery

Background:

High rates of antenatal depression and preterm birth have been reported in Pakistan. Self reported maternal stress and depression have been associated with preterm birth, however findings are inconsistent. Cortisol is a biological marker of stress and depression, and its measurement may assist in understanding the influence of self reported maternal stress and depression on preterm birth.

Methods:

In a prospective cohort study pregnant women between 28 to 30 weeks of gestation from the Aga Khan Hospital for Women and Children completed the A-Z Stress Scale and the Centre for Epidemiology Studies Depression Scale to assess stress and depression …

Adaptive Evolution Of The Matrix Extracellular Phosphoglycoprotein In Mammals, Joao P. Machado, Warren E. Johnson, Stephen J. O'Brien, Vitor Vasconcelos, Agostinho Antunes

Biology Faculty Articles

Background

Matrix extracellular phosphoglycoprotein (MEPE) belongs to a family of small integrin-binding ligand N-linked glycoproteins (SIBLINGs) that play a key role in skeleton development, particularly in mineralization, phosphate regulation and osteogenesis. MEPE associated disorders cause various physiological effects, such as loss of bone mass, tumors and disruption of renal function (hypophosphatemia). The study of this developmental gene from an evolutionary perspective could provide valuable insights on the adaptive diversification of morphological phenotypes in vertebrates.

Results

Here we studied the adaptive evolution of the MEPE gene in 26 Eutherian mammals and three birds. The comparative genomic analyses revealed a high degree …

Municipal Stormwater Management In Northern New England: A Comparative Study Of Leading Programs, Doug Roncarati, Keisha Payson, Rod Melanson, Fred Dillon

Muskie School Capstones and Dissertations

To gain a better understanding of how regulated municipalities in northern New England are addressing current stormwater rules and anticipating future stormwater rules, detailed questionnaires were administered through interviews to eleven MS4 communities in Maine, New Hampshire and Vermont during the winter of 2010 – 2011.

Disputes Over Water Resources: A History Of Conflict And Cooperation In Drainage Basins, Shavkat Kasymov

Peace and Conflict Studies

This paper presents the analysis of conflict history over freshwater in several drainage basins across the planet. As will be demonstrated in this paper, unilateral water policies have proved to reduce the role and prospect of water treaties and international water sharing regimes, and led to political tensions and conflicts. The main argument of the essay is that unilateral diversions of water flows will instigate wars between riparian states because of the rising demand for freshwater in the future. Unilateral practices of water diversion create a situation of inequitable distribution of water among nation-states within a basin which is a …

The Evolution Of Function In Strictosidine Synthase-Like Proteins, Michael A. Hicks, Alan E. Barber, Lesley Ann Giddings, Jenna Caldwell, Sarah E. O'Connor, Patricia C. Babbitt

Chemistry: Faculty Publications

The exponential growth of sequence data provides abundant information for the discovery of new enzyme reactions. Correctly annotating the functions of highly diverse proteins can be difficult, however, hindering use of this information. Global analysis of large superfamilies of related proteins is a powerful strategy for understanding the evolution of reactions by identifying catalytic commonalities and differences in reaction and substrate specificity, even when only a few members have been biochemically or structurally characterized. A comparison of >2500 sequences sharing the six-bladed β-propeller fold establishes sequence, structural, and functional links among the three subgroups of the functionally diverse N6P superfamily: …

A Recognition-Based Motion Capture Baseline On The Humaneva Ii Test Data, Nicholas Howe

Computer Science: Faculty Publications

The advent of the HumanEva standardized motion capture data sets has enabled quantitative evaluation of motion capture algorithms on comparable terms. This paper measures the performance of an existing monocular recognition-based pose recovery algorithm on select HumanEva data, including all the HumanEva II clips. The method uses a physically-motivated Markov process to connect adajacent frames and achieve a 3D relative mean error of 8.9 cm per joint. It further investigates factors contributing to the error, and finds that research into better pose retrieval methods offers promise for improvement of this technique and those related to it. Finally, it investigates the …

Brca1 Status In Pakistani Breast Cancer Patients With Moderate Family History, Tariq Moatter, Muniba Aban, Shaista Khan, Iqbal Azam, Shahid Pervez

Department of Pathology and Laboratory Medicine

OBJECTIVE: To determine BRCA1 status in breast carcinoma patients of Pakistani origin.

STUDY DESIGN: Observational study.

PLACE AND DURATION OF STUDY: The Oncology Clinics of the Aga Khan University Hospital, Karachi, between May 2005 and December 2009.

METHODOLOGY: Fifty three breast cancer patients based on clinical and laboratory diagnosis were recruited for this study. Moderate family history was defined as having a close relative (mother, daughter, sister) diagnosed with breast cancer under 45 years. Peripheral blood samples were collected from each patient in a 5 ml tube containing EDTA as anticoagulant. Subsequent to DNA extraction, mutational analysis of BRCA1 exons …

Vesicular Stomatitis Virus In The Treatment Of Hepatocellular Carcinoma, Celene Joza

Animal Science

No abstract provided.

Linking Impulsivity And Inhibitory Control Using Manual And Oculomotor Response Inhibition Tasks, Walter Roberts, Mark T. Fillmore, Richard Milich

Psychology Faculty Publications

Separate cognitive processes govern the inhibitory control of manual and oculomotor movements. Despite this fundamental distinction, little is known about how these inhibitory control processes relate to more complex domains of behavioral functioning. This study sought to determine how these inhibitory control mechanisms relate to broadly defined domains of impulsive behavior. Thirty adults with attention-deficit/ hyperactivity disorder (ADHD) and 28 comparison adults performed behavioral measures of inhibitory control and completed impulsivity inventories. Results suggest that oculomotor inhibitory control, but not manual inhibitory control, is related to specific domains of self-reported impulsivity. This finding was limited to the ADHD group; no …

Future Warfare And The Decline Of Human Decisionmaking, Thomas K. Adams

The US Army War College Quarterly: Parameters

No abstract provided.

Nest Predation And Circulating Corticosterone Levels Within And Among Species, Joseph J. Fontaine, Elena Arriero, Hubert Schwabl, Thomas E. Martin

Wildlife Biology Faculty Publications

Variation in the risk of predation to offspring can influence the expression of reproductive strategies both within and among species. Appropriate expression of reproductive strategies in environments that differ in predation risk can have clear advantages for fitness. Although adult-predation risk appears to influence glucocorticosteroid levels, leading to changes in behavioral and life-history strategies, the influence of offspring-predation risk on adult glucocorticosteroid levels remains unclear. We compared total baseline corticosteronc concentrations in Gray-headed Juncos (Junco hyemalis dorsalis) nesting on plots with and without experimentally reduced risk of nest predation. Despite differences in risk between treatments, we failed to find differences …

Chromosome Missegregation In Human Cells Arises Through Specific Types Of Kinetochore–Microtubule Attachment Errors, Sarah L. Thompson, Duane A. Compton

Dartmouth Scholarship

Most solid tumors are aneuploid, and many missegregate chromosomes at high rates in a phenomenon called chromosomal instability (CIN). CIN reflects the erosion of mitotic fidelity, and it correlates with poor patient prognosis and drug resistance. The most common mechanism causing CIN is the persistence of improper kinetochore–microtubule attachments called merotely. Chromosomes with merotelic kinetochores often manifest as lagging chromosomes in anaphase, suggesting that lagging chromosomes fail to segregate properly. However, it remains unknown whether the lagging chromosomes observed in anaphase segregate to the correct or incorrect daughter cell. To address this question, we tracked the segregation of a single …

Infant Places, Spaces And Objects: Exploring The Physical In Learning Environments For Infants Under Two, Helen Lynch

Doctoral

While the relationship between play and development is well documented, there is less known about the influence of the physical environment in that process. The purpose of this qualitative study is to describe play interactions of infants under two with the home physical environment. The aim is to explore and identify ways in which infants develop and learn through engaging with objects and spaces of everyday life in the home. A qualitative ethnographic approach was employed to gather data on five infants, two new-borns and three one-year olds, and their families over twelve months. Data was generated through video, interview …

Alarm-Calling And Response Behaviors Of The Black-Tailed Prairie Dog In Kansas, Lloyd W. Towers Iii

Master's Theses or Doctor of Nursing Practice

Prairie dogs (Cynomys spp.) use alarm calls to warn offspring and other kin of predatory threats. Dialects occur when vocalizations contain consistent differences among populations not isolated by geographic barriers. The Gunnison’s prairie dog (C. gunnisoni) has dialects in its alarm calls. The objectives of my study were to: (1) assess if the black-tailed prairie dog (C. ludovicianus) responded differently to alarm calls from other colonies than it did to alarm calls from its own colony, and (2) detect dialects, if they existed, in the alarm calls of the black-tailed prairie dog. The study included 8 black-tailed prairie dog colonies …

Sustainability Leader Competencies: A Grounded Theory Study, Pamela G. Schwalb

Department of Agricultural Leadership, Education, and Communication: Dissertations, Theses, and Student Research

The purpose of this critical qualitative study was to develop a theory of the competencies of a sustainability leader, grounded in research. A sustainability leader is generally described as an individual who creates profit for his/her stakeholders, while protecting the environment and improving the lives of those for whom he/she impacts as a result of his/her leadership. Nearly 60 individuals familiar with sustainability were asked to characterize an effective leader of a sustainability initiative or a sustainability organization.

The study revealed there is more than one way to be a sustainability leader—different paths can result in decisions and actions that …

Dung Beetle Ecology: Habitat And Food Preference, Hypoxia Tolerance, And Genetic Variation, Sean Doyle Whipple

Department of Entomology: Dissertations, Theses, and Student Research

Four studies were conducted on dung beetles (Coleoptera: Scarabaeidae), which are insects of great ecological and economic importance. Range management practices were found to impact dung beetle diversity and abundance. While sampling on organic and conventionally managed ranches in Nebraska, 93% (5,767) of total dung beetle capture was from the organically managed ranch. Only 480 dung beetles (7% of total) were collected from the conventionally managed ranch. Results indicated that organic ranching had increased numbers and diversity of dung beetles.

Comparison of the attractiveness of native and exotic herbivore, carnivore, and omnivore dung yielded 9,089 dung beetles from 15 species. …