Digital Commons Network^™

Dermal Reduction Of Urushiols Using An Activated Charcoal Formulated Dermal Care Patch, Celena Cameron

Honors Theses

For centuries, activated Charcoal (AC) has been used externally in a poultice form to adsorb "poisons" trapped in the outer layers of skin and internally to relieve intestinal discomfort and to remove toxic materials. The largest use for activated charcoal, in our society, is as a filter bed in air and water remediation cartridges. Recently, scientists have formulated AC into a nonstick dermal bandage called the Charcoal Patch (CP), but the adsorption properties are not well understood for this new formulation. Experiments have been conducted to see if these dermal bandages can be used to adsorb oils such as poison …

The Synthesis And Characterization Of Novel Imino Stilbenes, Shieun Jang

Honors Theses

We are in the process of developing a two-step synthesis of imino stilbenes as potential molecular switches, which are important in biology, electronics and other applications especially at nanoscopic scale. While both imines and stilbenes are well known, we have not uncovered any prior research and documentation on our proposed imino stilbenes in the scientific literature. In pursuit of our goal we have developed a new procedure for synthesis of t-butyl imines derived from aromatic aldehydes and ketones. We are also currently evaluating four different stilbene synthesis methods. Future work will systematically investigate the effect of electron withdrawing and donating …

Eaarth: Making A Life On A Tough New Planet [Review] / Mckibben, Bill, Tom Goodwin

Andrews University Seminary Studies (AUSS)

No abstract provided.

Synthesis And Testing Of Second Generation Azatilbenes, Maurice Hardy

Honors Theses

Based on previous research, azastilbenes have been reported as effective chemical sensors for organophosphates and organothiophosphates; they are related classes and the active components of agricultural pesticides, environmental pollutants and chemical warfare agents. This project builds on previous work and involves the synthesis of a variety of these azastilbenes and the testing of their respective properties. Azastilbene sensors are prepared using high-yield organic synthetic methodology developed in Professor Murray's lab. The next step involves testing the sensors through a measure, by UV-Vis spectroscopy and fluorometry, of an optical change upon the addition of analyte to a solution containing azastilbene sensor.

The Effects Of Valproate Prodrugs On The Inositol Biosynthetic Pathway In Saccharomyces Cerevisiae Yeast, Lisa Thompson

Honors Theses

Bipolar disorder is a psychiatric disorder characterized by episodes of abnormally elevated mood followed by periods of extreme depression. Currently, valproate is one of the drugs used to treat the disorder but it is associated with many negative side effects. The goal of this project is to create a prodrug with structural similarities to valproate and determine if its effect on growth of the yeast Saccharomyces cerevisiae is similar to that of valproate. Yeast cells were grown in media with or without the prodrug in the presence or absence of inositol. The results showed that the prodrug inhibited growth.

Non-Labeled, Real-Time Detection Of H1n1 Dna Hybridization Using Combined Qcm-D System, Sandra P. Prieto

Honors Theses

Detection of H1N1 or other seasonal and highly contagious viruses are of vital importance, since early diagnosis from a patient's fluid, such as saliva, would accelerate treatment and containment of the flu. Current lab tests often require cumbersome labeling steps and several hours to detect the presence of viral DNAs. The QCM-D (quartz crystal microbalances with dissipation) technology was used to detect presence as well as distinguish H1N1 and H1N5 DNAs in real-time (a few minutes) with the use of relatively small sample volume (200-500 ul). Single stranded complementary H1N1 DNA was immobilized via Neutravidin-biotin linkage on a gold substrate …

The Role Of Ci(-) Channel-Inhibition In The Brain On The Phonotactic Selectivity Of Female Crickets, Brent H. Sherwin

Honors Theses

The goal of this project was to determine if picrotoxin influences phonotactic selectivity of female crickets when nanoinjected into the supraesophageal ganglion. Adult females of Acheta domesticus were pre-tested for phonotaxis on a treadmill to a range of calling songs with different syllable periods. Following dissection to expose the brain, 9.2 nL of either saline (control group) or 10-5 M picrotoxin (experimental group) was nanoinjected into the supraesophageal ganglion. Post-tests following saline injection (10 min later) were similar to the pre-tests. Picrotoxin-treated females became more phonotactically selective displaying a preference for calling songs with the shorter syllable periods.

The Creation Of The Soul, The Creation Of The Body: Dual Creations In Christian Tradition, Karen K. Abrahamson

Andrews University Seminary Studies (AUSS)

No abstract provided.

The Mechanics Of Embodiment: A Dialogue On Embodiment And Computational Modeling, G Pezzulo, Lw Barsalou, A Cangelosi, Et Al

School of Engineering, Computing and Mathematics

Embodied theories are increasingly challenging traditional views of cognition by arguing that conceptual representations that constitute our knowledge are grounded in sensory and motor experiences, and processed at this sensorimotor level, rather than being represented and processed abstractly in an amodal conceptual system. Given the established empirical foundation, and the relatively underspecified theories to date, many researchers are extremely interested in embodied cognition but are clamouring for more mechanistic implementations. What is needed at this stage is a push toward explicit computational models that implement sensory-motor grounding as intrinsic to cognitive processes. In this article, six authors from varying backgrounds …

Specialization In Plant-Hummingbird Networks Is Associated With Species Richness, Contemporary Precipitation And Quaternary Climate-Change Velocity, B Dalsgaard, E Magard, J Fjeldsa, Amm Gonzalez, C Rahbek, Jm Olesen, J Ollerton, R Alarcon, Ac Araujo, Pa Cotton, C Lara, Cg Machado, I Sazima, M Sazima, A Timmermann, S Watts, B Sandel, Wj Sutherland, J-C Svenning

School of Biological and Marine Sciences

No abstract provided.

Short-Term Exposure To Warm Microhabitats Could Explain Amphibian Persistence With Batrachochytrium Dendrobatidis., Joshua H. Daskin, Ross A. Alford, Robert Puschendorf

School of Biological and Marine Sciences

Environmental conditions can alter the outcomes of symbiotic interactions. Many amphibian species have declined due to chytridiomycosis, caused by the pathogenic fungus Batrachochytrium dendrobatidis (Bd), but many others persist despite high Bd infection prevalence. This indicates that Bd's virulence is lower, or it may even be a commensal, in some hosts. In the Australian Wet Tropics, chytridiomycosis extirpated Litoria nannotis from high-elevation rain forests in the early 1990 s. Although the species is recolonizing many sites, no population has fully recovered. Litoria lorica disappeared from all known sites in the early 1990 s and was thought globally extinct, but a …

Fresh Waters And Fish Diversity: Distribution, Protection And Disturbance In Tropical Australia., Stephanie R. Januchowski-Hartley, Richard G. Pearson, Robert Puschendorf, Thomas Rayner

School of Biological and Marine Sciences

BACKGROUND: Given the globally poor protection of fresh waters for their intrinsic ecological values, assessments are needed to determine how well fresh waters and supported fish species are incidentally protected within existing terrestrial protected-area networks, and to identify their vulnerability to human-induced disturbances. To date, gaps in data have severely constrained any attempt to explore the representation of fresh waters in tropical regions. METHODOLOGY AND RESULTS: We determined the distribution of fresh waters and fish diversity in the Wet Tropics of Queensland, Australia. We then used distribution data of fresh waters, fish species, human-induced disturbances, and the terrestrial protected-area network …

Numerical Investigation Of Deep Water Circulation In The Faroese Channels, Nataliya Stashchuk, Vasiliy Vlasenko, Toby J. Sherwin

School of Biological and Marine Sciences

The overflow of dense water from the Nordic Seas through the Faroese Channels is investigated numerically using the Massachusetts Institute of Technology General Circulation Model. The model is forced by the removal of a barrier that separates different water masses in the bottom layer of the Faroe-Shetland Channel at the north-eastern boundary. An analysis of the output reveals that during its adjustment in the rotating channel the propagating flow is unstable and forms cyclonic and anti-cyclonic eddies in the Faroese Channels. The life-time of the cyclonic eddy is about 10 days, but an anti-cyclonic eddy that is formed upstream of …

Complete Genome Sequence Of Treponema Paraluiscuniculi, Strain Cuniculi A: The Loss Of Infectivity To Humans Is Associated With Genome Decay, David Smajs, Marie Zobaníková, Michal Strouhal, Darina Cejková, Shannon Dugan-Rocha, Petra Pospíšilová, Steven J Norris, Tom Albert, Xiang Qin, Kym Hallsworth-Pepin, Christian Buhay, Donna M Muzny, Lei Chen, Richard A Gibbs, George M Weinstock

Faculty, Staff and Student Publications

Treponema paraluiscuniculi is the causative agent of rabbit venereal spirochetosis. It is not infectious to humans, although its genome structure is very closely related to other pathogenic Treponema species including Treponema pallidum subspecies pallidum, the etiological agent of syphilis. In this study, the genome sequence of Treponema paraluiscuniculi, strain Cuniculi A, was determined by a combination of several high-throughput sequencing strategies. Whereas the overall size (1,133,390 bp), arrangement, and gene content of the Cuniculi A genome closely resembled those of the T. pallidum genome, the T. paraluiscuniculi genome contained a markedly higher number of pseudogenes and gene fragments (51). In …

Alterations In Content And Localization Of Defensins In Rat Ileum And Jejunum Following Ischemia-Reperfusion Specific Peptides, In Specific Places, For Specific Jobs?, Rosemary A Kozar, Rachel J Santora, Brian J Poindexter, Stephen M Milner, Roger J Bick

Faculty, Staff and Student Publications

Objective: To determine alterations in quantities and distributions of natural antimicrobials following ischemia-reperfusion injury. We hypothesized that these compounds would be upregulated in areas of small intestine where changes in permeability and cellular disruption were likely and where protective mechanisms would be initiated. Methods: Rats with ischemia-reperfusion underwent superior mesenteric artery clamping and reperfusion. Shams were subjected to laparotomy but no clamping. Ileum and jejunum were harvested and sectioned, and subjected to fluorescence deconvolution microscopy for determinations of content and localization of rat beta defensins, 1, 2, 3; rat neutrophil protein-1; and cathelicidin LL-37. Modeling was performed to determine cellular …

Developmental Biology (Embryology), Steelman Library, Todd D. Schraw Dr.

Syllabus Repository

No abstract provided.

Developmental Biology (Embryology), Steelman Library, Todd Schraw

Syllabus Repository

No abstract provided.

The Money Blind: How To Stop Industry Bias In Biomedical Science, Without Violating The First Amendment, Christopher Robertson

Faculty Scholarship

The pharmaceutical and medical device industries use billions of dollars to support the biomedical science that physicians, regulators, and patients use to make healthcare decisions—the decisions that drive an increasingly large portion of the American economy. Compelling evidence suggests that this industry money buys favorable results, biasing the outcomes of scientific research. Current efforts to manage the problem, including disclosure mandates and peer reviews, are ineffective. A blinding mechanism, operating through an intermediary such as the National Institutes of Health, could instead be developed to allow industry support of science without allowing undue influence. If the editors of biomedical journals …

The Human Right To Health And Hiv/Aids: South Africa And South-South Cooperation To Reframe Global Intellectual Property Principles And Promote Access To Essential Medicines, Erika George

Faculty Scholarship

The HIV/AIDS pandemic has had a devastating and disproportionate impact in countries of the Global South. The experience of an individual infected with HIV in Africa is very different than that of an individual infected with HIV in America. Life expectancy varies sharply. The ability or inability to access medicines essential for treatment accounts for much of the variance. This article examines how the rhetoric of human rights used in the context of South Africa's AIDS crisis resonated across the Global South, resulted in a powerful social movement for access to medicines, and contributed to important changes in international intellectual …

Association Of Retinoic Acid Receptor Genes With Meningomyelocele, Phong X Tran, Kit Sing Au, Alanna C Morrison, Jack M Fletcher, Kathryn K Ostermaier, Gayle H Tyerman, Hope Northrup

Faculty, Staff and Student Publications

BACKGROUND: Neural tube defects (NTDs) occur in as many as 0.5-2 per 1000 live births in the United States. One of the most common and severe neural tube defects is meningomyelocele (MM) resulting from failed closure of the caudal end of the neural tube. MM has been induced by retinoic acid teratogenicity in rodent models. We hypothesized that genetic variants influencing retinoic acid (RA) induction via retinoic acid receptors (RARs) may be associated with risk for MM.

METHODS: We analyzed 47 single nucleotide polymorphisms (SNPs) that span across the three retinoic acid receptor genes using the SNPlex genotyping platform. Our …

Immunopathology Of Postprimary Tuberculosis: Increased T-Regulatory Cells And Dec-205-Positive Foamy Macrophages In Cavitary Lesions, Kerry J Welsh, Semyon A Risin, Jeffrey K Actor, Robert L Hunter

Faculty, Staff and Student Publications

Postprimary tuberculosis occurs in immunocompetent people infected with Mycobacterium tuberculosis. It is restricted to the lung and accounts for 80% of cases and nearly 100% of transmission. Little is known about the immunopathology of postprimary tuberculosis due to limited availability of specimens. Tissues from 30 autopsy cases of pulmonary tuberculosis were located. Sections of characteristic lesions of caseating granulomas, lipid pneumonia, and cavitary stages of postprimary disease were selected for immunohistochemical studies of macrophages, lymphocytes, endothelial cells, and mycobacterial antigens. A higher percentage of cells in lipid pneumonia (36.1%) and cavitary lesions (27.8%) were positive for the dendritic cell marker …

Smoking And The First Amendment, Kevin Outterson

Faculty Scholarship

On June 22, 2009, President Barack Obama signed the Family Smoking Prevention and Tobacco Control Act into law. For the first time, Congress had given the Food and Drug Administration (FDA) authority to directly regulate tobacco products, with the aim of improving public health. And indeed, effective tobacco control would be a remarkable public health achievement — and might be possible if the law is allowed to stand. But on November 7, 2011, a federal judge in Washington, D.C., issued a preliminary injunction blocking some of its key provisions as unconstitutional restrictions on commercial speech, and the battle seems likely …

Effectiveness Of The Coping Power Program In Middle-School Children With Disruptive Behaviours And Hyperactivity Difficulties, Diomaris E. Jurecska, Elizabeth Hamilton, Mary A. Peterson

Faculty Publications - Doctor of Psychology (PsyD) Program

The purpose of this article is to discuss the effectiveness of the Coping Power Program (CPP); an evidencebased treatment delivered in a group format to at-risk middle-school children. Initially, two groups were randomised and formed: an intervention group of 24 CPP sessions and a control group. All students were enrolled in public schools from two rural counties in the United States. Out of the 119 total participants 63 (37 male) were in the intervention and 56 (35 male) were in the control group. From the larger intervention group, a subset of students was identified as ‘significantly improved’. Using the Behavior …

The Emerging Church Part 1: Historical Background, Fernando Canale

Journal of the Adventist Theological Society

No abstract provided.

Biology Ii Lab, Steelman Library, Todd Schraw Dr

Syllabus Repository

No abstract provided.

Risk Ratio Of Benzene, Toluene, Ethylbenzene, And Xylene (Btex) Exposures And Their Relations To Biological Parameters Of Gasoline Workers In Bangkok, Thailand, Tanasorn Tunsaringkasrn, Panthira Ketkaew, Kalaya Zapaung, Anusorn Rugsiyothin, Surasak Taneepanichkul

Applied Environmental Research

Gasoline station is a common source of volatile organic compounds (VOCs) emissions around its perimeter. In order to conduct a monitoring of the VOC's emission, measurements of biological markers of blood benzene, toluene, ethylbenzene and xylene (BTEX) in gasolinestation workers are recommended. The purposes of this study were to evaluate exposure risk ratio (110 gasoline station workers from 11 gasoline stations in Bangkok Metropolitan area compared to 10 office workers in the same station as control group) and to determine the relations between blood BTEX and biological parameters of the gasoline workers. Results showed that blood BTEX levels of gasoline …

Animal Assisted Therapy And Autism Intervention: A Synthesis Of The Literature, Jocelyn Turner

Research Papers

AN ABSTRACT OF THE RESEARCH PAPER OF JOCELYN TURNER, for the Masters of Science degree, presented on November, 12, 2010, at Southern Illinois University Carbondale. TITLE: ANIMAL ASSISTED THERAPY AND AUTISM INTERVENTIONS: A SYNTHESIS OF THE LITERATURE MAJOR PROFESSOR: Dr. Brett Zyromski The overall intention of this research project was to determine if, based on the available literature, Animal Assisted Therapy (AAT) has potential as an efficacious adjunctive therapy method for helping to generate greater levels of social functioning, for individuals with Autism. This project draws from interdisciplinary research and professional accounts, to present an organized review of the literature …

Archive Fever : Performance Art, Anastasia Proshutinskaya

Research Papers

No abstract provided.

Training Parents Of An Adolescent With Autism Effective Behavior Management Strategies Across Multiple Settings, Kari Porter

Research Papers

Research suggests that rearing a child with a developmental disability can be highly stressful and may lead to a heightened risk for child maltreatment. This study demonstrates the utility of a behavioral skills teaching model to train parents to engage their child with autism in adaptive behavior and to manage her disruptions at home, in the car, and in public settings. In some conditions, the experimenter trained the child directly in order to establish control in these settings before attempting to train the parents. Parents were trained through a combination of discussion, video presentation, and guided (shadowed) practice. The results …

Defining The “Good” Mother: Examining The Myths Of Motherhood And The Hierarchical Construction Of Femininity In Weeds And Weekly Magazines, Johnanna Joy Ganz

Dissertations and Theses @ UNI

Throughout this thesis  investigate how images of motherhood in popular culture rely on specific ideological "myths" to convey implicit messages about appropriate femininity. To examine the depictions of motherhood I performed a textual analysis of the contents of the first two seasons of the television program Weeds as well as randomly sampled issues of the following celebrity gossip magazines: People Weekly, US Weekly, In Touch Weekly, and Life & Style Weekly. In order to make sense of the data, I rely on the theoretical concept of hegemonic femininity, as developed by Mimi Schippers. Additionally, I offer a more nuanced argument …