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Medical Alert: Alarming Challenges Facing Medical Technology Innovation, Lawrence M. Sung

Journal of Business & Technology Law

No abstract provided.

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The Geneticists' Approach To Bilski, Joann A. Boughman, Kyle M. Brown

Journal of Business & Technology Law

No abstract provided.

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Facilitating Patient Access To Patent-Protected Genetic Testing, Janice M. Mueller

Journal of Business & Technology Law

No abstract provided.

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Evolutionary History And Spread Of Multidrug Resistant Inchi1 Plasmids In Salmonella Typhi, Kathryn Holt, Minh Duy Phan, Stephen Baker, Pham Thanh Duy, Tran Vu Thieu Nga, Satheesh Nair, Arthur Keith Turner, Ciara Walsh, Seamus Fanning, Sinrad Farrell-Ward, Shanta Dutta, François-Xavier Weill, Julian Parkhill, Gordon Dougan, John Wain

Articles

Typhoid fever, infection with Salmonella enterica serovar Typhi (S. Typhi), remains a serious health concern in many parts of the world, particularly where sanitation is poor. While vaccines against S. Typhi are available, coverage in endemic regions is low, leaving antimicrobial therapy central to disease control. Unfortunately, drug resistant S. Typhi emerged in the mid-1970s and multi-drug resistance (MDR) is now a significant problem in many typhoid endemic areas. In the S. Typhi population, MDR is almost exclusively conferred by self-transmissible IncHI1 plasmids carrying a suite of antimicrobial resistance genes. We compared eight IncHI1 plasmid sequences and identified single nucleotide …

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The Use Of The National Marine Sanctuaries Act As A Tool For The Enhanced Preservation Of Marine Resources Under The New National Oceans Policy, Colin F. Lynch

Sea Grant Law Fellow Publications

No abstract provided.

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Legal Considerations Relating To The Development Of Hydroelectric Facilities Within Rhode Island, Scott R. Gunst Jr.

Sea Grant Law Fellow Publications

No abstract provided.

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Stratigraphy And Palaeoenvironment Of The Paleocene/Eocene Boundary Interval In The Indus Basin, Pakistan, Muhammad Hanif

School of Geography, Earth and Environmental Sciences Theses

Marine sedimentary sections across the Paleocene/Eocene (P/E) boundary interval are preserved in the Patala Formation (Upper Indus Basin) and Dungan Formation (Lower Indus Basin), Pakistan. The P/E interval of the Patala Formation is composed of limestone and shale inter-beds indicating deposition on a carbonate platform. The analysis of larger foraminifera across the P/E interval from the Patala Formation (Kala Chitta Ranges), allows the recognition of the Larger Foraminiferal Turnover (LFT). The Larger Foraminiferal Turnover (LFT) observed in the Patala Formation is associated with the PETM (Paleocene Eocene Thermal Maximum) global climatic event and allows the recognition of the P/E boundary …

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The Effect Of Psychosocial Information Resources On The Psychological Impact Of Genetic Testing For Patients, Celine Lewis

School of Nursing and Midwifery Theses

The effect of psychosocial information resources on the psychological impact of genetic testing for patients Background: The genetic testing process has been shown to have a profound psychosocial impact on patients and families, yet research suggests that there is a lack of practical and helpful psychosocial information written to support decision-making. Ideally, this should be available for use both before and after genetic testing and should be easily accessed through genetic clinics. The development of pre-written leaflets or on-line resources which draw on the experiences and advice of families who have been through similar experiences, and are readily available through …

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Informed Consent For Pharmacogenomic Testing In People With A Learning Disability, Lesley Goldsmith

School of Nursing and Midwifery Theses

Informed consent for pharmacogenomic testing in people with a learning disability Background Advances in genomic healthcare will enable medication to be tailored to each individual’s needs, based on subtle genetic variations. This will result in individuals being asked to consent to genetic testing for this purpose. The recent political agenda for social change has emphasised the right of people with learning disabilities to have more autonomy and make their own decisions. There have also been significant changes in the way healthcare practitioners relate to their patients, with a shift away from paternalism towards shared decision-making. Research Aim The aims of …

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Production And Preservation Of The Arctic Sea Ice Diatom Biomarker Ip25, Thomas Brown

School of Geography, Earth and Environmental Sciences Theses

The presence of the sea ice biomarker IP25 in Arctic marine sediments has previously been used as a proxy measure of past sea ice conditions in the Arctic. Although the sea ice diatom origin of IP25 was established previously, the nature of its production within sea ice, along with its transport through the water column to underlying sediments and its short-term preservation therein, had not been investigated in any significant detail. Variations in the concentration of the sea ice diatom biomarker IP25, were measured in sea ice collected from the eastern Beaufort Sea and Amundsen Gulf from January to June …

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An Investigation Into Use Of The Freshwater Gastropod Viviparus As A Recorder Of Past Climatic Change, Melanie Jane Bugler

School of Geography, Earth and Environmental Sciences Theses

Through isotopic analysis of Viviparus lentus (V. lentus) a high resolution record of stepwise changes in 8 180 and 8 13C across the Eocene I Oligocene transition and Oi-l glacial maximum has been produced for the continental Solent Group strata, Isle of Wight (UK). Comparison of this V. lentus δ18 Ocarb. record with high resolution marine δ18 Ocarb. records shows that similar isotopic shifts exist in the near coastal continental and marine realms. In order to calculate palaeotemperatures from this new continental record an investigation into the biology of modern Viviparus and its effect on the isotopic composition of its …

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Diffuse Minewater Pollution: Quantification And Risk Assessment In The Tamar Catchment, Alison Turner

School of Geography, Earth and Environmental Sciences Theses

Abandoned metal mines in the Tamar catchment, south west England, represent a significant threat to surface water quality via generation of acid mine waters. Currently the River Tamar fails environmental quality standards (EQS) established under the Water Framework Directive (2000/60/EC) for dissolved Cu (x ̅ = 0.19 ± 0.05 μmol L-1) and Zn (x ̅ = 0.19 ± 0.06 μmol L-1, both 1997-2007) downstream of historic mining area of Gunnislake. The aim of this study was to quantify the risk to surface water quality by diffuse drainage generated by mine waste tips. For the first time, a GIS model was …

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Attaining A Sustainable Future For Public Higher Education: The Role Of Institutional Effectiveness And Resource Dependence, Mirela Blekic

Dissertations and Theses

The world of today's higher education organizations is characterized by complexities brought about as a result of rapid change, economic and political turbulence, and increasing global interdependence. The complexity of the environment in which colleges and universities operate is also due in part to a need to serve multiple internal and external constituencies. In order to be more responsive to the demands of its numerous constituencies and at the same time preserve their intrinsic values, colleges and universities need to know how effective they are in what they do. This research asked: To what degree does institutional effectiveness allow public …

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Factors Influencing The Marine Spatial Ecology Of Seabirds: Implications For Theory, Conservation And Management, William James Grecian

Other Faculty of Science and Engineering Theses

Seabirds are wide-ranging apex-predators and useful bio-indicators of marine systems. Nevertheless, changes are occurring in the marine environment, and seabirds require protection from the deleterious effects of climate change, fisheries, pollution, offshore development, introduced predators and invasive species. The UK supports internationally important populations of seabirds but also has vast wind and wave resources, therefore understanding how seabirds use the marine environment is vital in order to quantify the potential consequences of further exploiting these resources. In this thesis I first describe the range of wave energy converting devices operational or in development in the UK, and review the potential …

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Life Cycle Assessment Of Flax Fibres, Nilmini Pj Dissanayake

Other Faculty of Science and Engineering Theses

This thesis aims to investigate the sustainability of bast fibres specifically flax fibres as the reinforcement for polymer matrix composites (referenced to glass fibres) by undertaking a quantitative Life Cycle Assessment using the eight environmental impact classification factors of global warming, acidification, eutrophication, human toxicity, aquatic toxicity, ozone depletion, photochemical oxidants creation and non-renewable/abiotic resource depletion. A data set was compiled from numerous literature sources to complete the Life Cycle Inventory for the production of flax fibres. Three scenarios were studied for the production of either flax sliver (pre-spun fibre) or yarn (post-spun fibre): low (no-till combined with warm water …

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Cobalt Biogeochemistry In The Atlantic Ocean Using Flow Injection-Chemiluminescence, Rachel Shelley

Other Faculty of Science and Engineering Theses

As ~ 50% of global photosynthesis occurs in marine environments, the factors regulating this process e.g. trace metal availability, have an impact on the global carbon cycle. The key cyanobacteria genera Prochlorococcus and Synechococcus have an absolute requirement for Co. Dissolved cobalt (dCo) concentrations in the open ocean are extremely low (5–120 pM). A sensitive flow injection technique using chemiluminescence detection (FI-CL) was developed (detection limit 4.5 pM dCo, RSD ≤ 4%). Seawater samples must be UV-irradiated prior to analysis, in order to liberate organically-bound Co. A field study in the Sargasso Sea, demonstrated that aerosol Co was significantly more …

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The Ecotoxicology Of Engineered Nanoparticles To Freshwater Fish, Benjamin John Shaw

Other Faculty of Science and Engineering Theses

The use of nanoscale materials is growing exponentially, but there are also concerns about the environmental hazard to aquatic biota. Metal-containing engineered nanoparticles (NPs) are an important group of these new materials, and whilst there are undoubtedly a plethora of beneficial uses for these NPs, it is essential that an appropriate risk assessment is carried out in order to protect the environment and human health, with the consumption of contaminated fish a distinct possibility. The current study aimed to assess the bioavailability, uptake and toxicological effects of two metal-NPs (TiO2 NPs and Cu-NPs) to fish from both dietary and waterborne …

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Encoding Strategies And Mechanisms Underpinning Adaptation To Stimulus Statistics In The Rat Barrel Cortex, Lucy Anne Davies

Other Faculty of Science and Engineering Theses

It is well established that, following adaptation, cells adjust their sensitivity to reflect the global stimulus conditions. Two recent studies in guinea pig inferior colliculus (IC, Dean, Harper & McAlpine 2005) and rat barrel cortex (Garcia-Lazaro, Ho, Nair & Schnupp 2007) found that neural stimulus-response functions were displaced laterally in a manner that was dependent on the mean adapting stimulus. However, the direction of gain change, following adaptation to variance, was in contradiction to Information Theory, which predicts a decrease in gain with increased stimulus variance. On further analysis of the experimental data, presented within this thesis, it was revealed …

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Detecting Phytoplankton Size Class Using Satellite Earth Observation, Robert J. W. Brewin

Other Faculty of Science and Engineering Theses

A new range of multi-plankton biogeochemical models have recently been developed, designed to advance our understanding of the ocean carbon cycle to improve predictions of its future influence on climate. Synoptic measurements of the different phytoplankton communities are required to validate and ultimately improve such models. Measuring ocean colour from satellite is the only method currently available for synoptically monitoring wide-area properties of ocean ecosystems, such as phytoplankton chlorophyll biomass. Recently, a variety of bio-optical methods have been established that use satellite data to identify and differentiate between either phytoplankton functional types (PFTs) or phytoplankton size classes (PSCs). In this …

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Elucidating The Relative Importance Of The Bacterial And Fungal Feeding Channels Within The Soil Food Web Under Differing Land Managements, Felicity Victoria Crotty

Other Faculty of Science and Engineering Theses

The overall aim of this thesis was to elucidate the relative importance of the bacterial and fungal energy channels within the soil food web and to differentiate and appreciate the differences in niche of the soil fauna when affected by differing land management. Feeding niche of the soil fauna is ambiguous and has been previously determined by observation, inference or biochemical studies. One method that can determine feeding preferences in situ is the use of stable isotopes. Stable isotopes trace the passage of C and N through different trophic levels, both at natural abundance and by the addition of a …

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Communicating Air: Alternative Pathways To Environmental Knowing Through Computational Ecomedia, Andrea Polli

Other Faculty of Arts, Humanities and Business Theses

This dissertation, Communicating Air: Alternative Pathways to Environmental Knowing through Computational Ecomedia, is the culmination of an art practice-led investigation into ways in which the production of ecomedia may open alternative pathways to environmental knowing in a time of urgent climate crisis. This thesis traces the author’s artistic, personal and political development across the period of study and presents an extended argument for greater public engagement with weather and climate science, greater public and private support for long-term collaborations between media art and climate science, and increased public open access to global weather and climate monitoring and computationally modelled data.

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Gestalt Biometrics And Their Applications; Instrumentation, Objectivity And Poetics, Hannah Drayson

Other Faculty of Arts, Humanities and Business Theses

This thesis is about the relationship between human bodies and instrumental technologies that can be use to measure them. It adopts the position that instruments are technological structures that evoke and manifest particular phenomena of embodied life. However, through their history of association and use in the sciences and scientific medicine, instruments tend to be attached to a particular ontology, that of mechanical objectivity. Embarking from research into the artistic uses of physiological sensor technology in creative practices such as performance and installation art, this thesis asks whether it is possible to use instruments in a way that departs from …

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Ageing Futures: Towards Cognitively Inclusive Digital Media Products, John Charles Vines

Other Faculty of Arts, Humanities and Business Theses

This thesis is situated in a moment when the theory and practice of inclusive design appears to be significantly implicated in the social and economic response to demographic changes in Western Europe by addressing the need to reconnect older people with technology. In light of claims that cognitive ageing results in an increasing disconnection from novel digital media in old age, inclusive design is apparently trapped in a discourse in which digital media products and interfaces are designed as a response to a deterministic decline in abilities. The thesis proceeds from this context to ask what intellectual moves are required …

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Application Of Intermediate Multi-Agent Systems To Integrated Algorithmic Composition And Expressive Performance Of Music, Alexis Kirke

Other Faculty of Arts, Humanities and Business Theses

We investigate the properties of a new Multi-Agent Systems (MAS) for computer-aided composition called IPCS (pronounced “ipp-siss”) the Intermediate Performance Composition System which generates expressive performance as part of its compositional process, and produces emergent melodic structures by a novel multi-agent process. IPCS consists of a small-medium size (2 to 16) collection of agents in which each agent can perform monophonic tunes and learn monophonic tunes from other agents. Each agent has an affective state (an “artificial emotional state”) which affects how it performs the music to other agents; e.g. a “happy” agent will perform “happier” music. The agent performance …

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A Cortical Model Of Object Perception Based On Bayesian Networks And Belief Propagation., Salvador Durá-Bernal

Other Faculty of Science and Engineering Theses

Evidence suggests that high-level feedback plays an important role in visual perception by shaping the response in lower cortical levels (Sillito et al. 2006, Angelucci and Bullier 2003, Bullier 2001, Harrison et al. 2007). A notable example of this is reflected by the retinotopic activation of V1 and V2 neurons in response to illusory contours, such as Kanizsa figures, which has been reported in numerous studies (Maertens et al. 2008, Seghier and Vuilleumier 2006, Halgren et al. 2003, Lee 2003, Lee and Nguyen 2001). The illusory contour activity emerges first in lateral occipital cortex (LOC), then in V2 and finally …

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A Review Of Self-Organizing Map Applications In Meteorology And Oceanography, Yonggang Liu, Robert H. Weisberg

Marine Science Faculty Publications

No abstract provided.

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Biofilm Formation And Control In A Novel Warm Water Distribution System, Paul Waines

Other Faculty of Science and Engineering Theses

Biofilm Formation and Control in a Novel Warm Water Distribution System By Paul Lewis Waines Abstract Investigations were carried out to assess biofilm formation within a model warm water distribution system (test rig) under a variety of conditions. Analysis methods included ATP-/ culture-based analysis, SEM and confocal microscopy. Molecular-based community analysis was carried out using PCR/DGGE. High pH (9.53-10.08), induced by the presence of a sacrificial anode within the water heater, had a profound inhibitive effect on the culturability of biofilm bacteria on copper (Cu) pipe within the test rig. Concurrent investigations into the effect of stagnation (varied periods of …

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The Molecular And Behavioural Ecology Of Click Beetles (Coleoptera: Elateridae) In Agricultural Land, Carly Marie Benefer

Other Faculty of Science and Engineering Theses

The larvae (wireworms) of some click beetle genera inhabit the soil in agricultural land and are crop pests. In the UK, a pest complex of Agriotes species, A. obscurus, A. sputator and A. lineatus, has been identified as the cause of the majority of damage. However, studies on their ecology are lacking, despite knowledge of this being important for the development of sustainable risk assessment and pest management strategies, in part due to the morphologically cryptic nature of wireworms. The ecology of economically important click beetle species was investigated, focusing on UK Agriotes species. The relationship between sex pheromone trapped …

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Population Structuring And Dispersal In The Highly Pelagic Leach's Storm-Petrel: Implications For The Eu Population, Anthony William James Bicknell

Other Faculty of Science and Engineering Theses

Dispersal is a fundamental process that shapes many aspects of population ecology and evolution. Dramatic local population declines brought about by anthropogenic-driven changes to ecological processes are unfortunately becoming ubiquitous and increasing the urgency to understand dispersal behaviour in many species. For species where direct methods of tracking movement and dispersal are unsuitable, other indirect methods need to be employed to understand and characterise these behaviours. The steep population decline, due to predation, at the largest EU population of Leach’s storm-petrels Oceanodroma leucorhoa (St Kilda, Scotland), and the potential part immigrant birds have in buffering this threat, highlighted the need …

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An Integrated Ecotoxicological Assessment Of The Engineered Nanoparticles, C60 Fullerenes In Different Life Stages Of Marine Mussels, Mytilus Edulis, Sherain Al-Subiai

Other Faculty of Science and Engineering Theses

Studies were undertaken to determine ecotoxicological effects of model manufactured or engineered nanoparticles (ENPs), either alone or in combination with a representative polycyclic aromatic hydrocarbon (i.e. PAHs: fluoranthene) at different levels of biological organisation (viz. biochemical, histological and behavioural levels) in a sentinel, widely distributed marine invertebrate species, Mytilus edulis. With the current and predicted levels of pollution in the marine and coastal environment, there is an urgent need to establish the potential effects of persistent and emerging contaminants which includes ENPs and PAHs, to protect human and environmental health. In this study, initially, it was aimed to optimise the …

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Full-Text Articles in Entire DC Network

Medical Alert: Alarming Challenges Facing Medical Technology Innovation, Lawrence M. Sung

Journal of Business & Technology Law

The Geneticists' Approach To Bilski, Joann A. Boughman, Kyle M. Brown

Journal of Business & Technology Law

Facilitating Patient Access To Patent-Protected Genetic Testing, Janice M. Mueller

Journal of Business & Technology Law

Articles

The Use Of The National Marine Sanctuaries Act As A Tool For The Enhanced Preservation Of Marine Resources Under The New National Oceans Policy, Colin F. Lynch

Sea Grant Law Fellow Publications

Legal Considerations Relating To The Development Of Hydroelectric Facilities Within Rhode Island, Scott R. Gunst Jr.

Sea Grant Law Fellow Publications

Stratigraphy And Palaeoenvironment Of The Paleocene/Eocene Boundary Interval In The Indus Basin, Pakistan, Muhammad Hanif

School of Geography, Earth and Environmental Sciences Theses

The Effect Of Psychosocial Information Resources On The Psychological Impact Of Genetic Testing For Patients, Celine Lewis

School of Nursing and Midwifery Theses

Informed Consent For Pharmacogenomic Testing In People With A Learning Disability, Lesley Goldsmith

School of Nursing and Midwifery Theses

Production And Preservation Of The Arctic Sea Ice Diatom Biomarker Ip25, Thomas Brown

School of Geography, Earth and Environmental Sciences Theses

An Investigation Into Use Of The Freshwater Gastropod Viviparus As A Recorder Of Past Climatic Change, Melanie Jane Bugler

School of Geography, Earth and Environmental Sciences Theses

Diffuse Minewater Pollution: Quantification And Risk Assessment In The Tamar Catchment, Alison Turner

School of Geography, Earth and Environmental Sciences Theses

Attaining A Sustainable Future For Public Higher Education: The Role Of Institutional Effectiveness And Resource Dependence, Mirela Blekic

Dissertations and Theses

Factors Influencing The Marine Spatial Ecology Of Seabirds: Implications For Theory, Conservation And Management, William James Grecian

Other Faculty of Science and Engineering Theses

Life Cycle Assessment Of Flax Fibres, Nilmini Pj Dissanayake

Other Faculty of Science and Engineering Theses

Cobalt Biogeochemistry In The Atlantic Ocean Using Flow Injection-Chemiluminescence, Rachel Shelley

Other Faculty of Science and Engineering Theses

The Ecotoxicology Of Engineered Nanoparticles To Freshwater Fish, Benjamin John Shaw

Other Faculty of Science and Engineering Theses

Encoding Strategies And Mechanisms Underpinning Adaptation To Stimulus Statistics In The Rat Barrel Cortex, Lucy Anne Davies

Other Faculty of Science and Engineering Theses

Detecting Phytoplankton Size Class Using Satellite Earth Observation, Robert J. W. Brewin

Other Faculty of Science and Engineering Theses

Elucidating The Relative Importance Of The Bacterial And Fungal Feeding Channels Within The Soil Food Web Under Differing Land Managements, Felicity Victoria Crotty

Other Faculty of Science and Engineering Theses

Communicating Air: Alternative Pathways To Environmental Knowing Through Computational Ecomedia, Andrea Polli

Other Faculty of Arts, Humanities and Business Theses

Gestalt Biometrics And Their Applications; Instrumentation, Objectivity And Poetics, Hannah Drayson

Other Faculty of Arts, Humanities and Business Theses

Ageing Futures: Towards Cognitively Inclusive Digital Media Products, John Charles Vines

Other Faculty of Arts, Humanities and Business Theses

Application Of Intermediate Multi-Agent Systems To Integrated Algorithmic Composition And Expressive Performance Of Music, Alexis Kirke

Other Faculty of Arts, Humanities and Business Theses

A Cortical Model Of Object Perception Based On Bayesian Networks And Belief Propagation., Salvador Durá-Bernal

Other Faculty of Science and Engineering Theses

A Review Of Self-Organizing Map Applications In Meteorology And Oceanography, Yonggang Liu, Robert H. Weisberg

Marine Science Faculty Publications

Biofilm Formation And Control In A Novel Warm Water Distribution System, Paul Waines

Other Faculty of Science and Engineering Theses

The Molecular And Behavioural Ecology Of Click Beetles (Coleoptera: Elateridae) In Agricultural Land, Carly Marie Benefer

Other Faculty of Science and Engineering Theses

Population Structuring And Dispersal In The Highly Pelagic Leach's Storm-Petrel: Implications For The Eu Population, Anthony William James Bicknell

Other Faculty of Science and Engineering Theses

An Integrated Ecotoxicological Assessment Of The Engineered Nanoparticles, C60 Fullerenes In Different Life Stages Of Marine Mussels, Mytilus Edulis, Sherain Al-Subiai

Other Faculty of Science and Engineering Theses