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2011

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Essential Oils Of Cupressus Funebris, Juniperus Communis, And J. Chinensis (Cupressaceae) As Repellents Against Ticks (Acari: Ixodidae) And Mosquitoes (Diptera: Culicidae) And As Toxicants Against Mosquitoes, John F. Carroll, Nurhayat Tabanca, Matthew H. Kramer, Natasha M. Elejalde, David E. Wedge, Ulrich R. Bernier, Monique Coy, James Becnel, Betul Demirci, Kemal Husnu Can Başer, Jian Zhang, Sui Zhang Dec 2011

Essential Oils Of Cupressus Funebris, Juniperus Communis, And J. Chinensis (Cupressaceae) As Repellents Against Ticks (Acari: Ixodidae) And Mosquitoes (Diptera: Culicidae) And As Toxicants Against Mosquitoes, John F. Carroll, Nurhayat Tabanca, Matthew H. Kramer, Natasha M. Elejalde, David E. Wedge, Ulrich R. Bernier, Monique Coy, James Becnel, Betul Demirci, Kemal Husnu Can Başer, Jian Zhang, Sui Zhang

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

Juniperus communis leaf oil, J. chinensis wood oil, and Cupressus funebris wood oil (Cupressaceae) from China were analyzed by gas chromatography and gas chromatography-mass spectrometry. We identified 104 compounds, representing 66.8-95.5% of the oils. The major components were: α-pinene (27.0%), α-terpinene (14.0%), and linalool (10.9%) for J. communis; cuparene (11.3%) and δ-cadinene (7.8%) for J. chinensis; and α-cedrene (16.9%), cedrol (7.6%), and β-cedrene (5.7%) for C. funebris. The essential oils of C. funebris, J. chinensis, and J. communis were evaluated for repellency against adult yellow fever mosquitoes, Aedes aegypti (L.), host-seeking nymphs of the lone …


Whole Body Vibration In Anterior Cruciate Ligament Rehabilitation, Sara Ruby Vargas Dec 2011

Whole Body Vibration In Anterior Cruciate Ligament Rehabilitation, Sara Ruby Vargas

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

There has been an increasing prevalence of anterior cruciate ligament (ACL) injuries. In the literature describing ACL rehabilitation program flexibility, muscle strength, proprioception, and postural stability have been identified as reoccurring struggles that have arisen during rehabilitation. Whole Body Vibration (WBV) has been investigate as a rehabilitation tool that can be used when recovering from an ACL injury. Research has suggested that WBV can be used to increase flexibility, improve muscular strength, increase proprioception, and improve postural stability. The purpose of this review is to gather the WBV protocols used in previous research and apply them to ACL rehabilitation. An …


Genetic Status Of Isolated Populations Of Colorado River Cutthroat Trout (Oncorhynchus Clarkii Pleuriticus) In The North Fork Little Snake River Drainage, Wyoming, Rachel Van Horne Dec 2011

Genetic Status Of Isolated Populations Of Colorado River Cutthroat Trout (Oncorhynchus Clarkii Pleuriticus) In The North Fork Little Snake River Drainage, Wyoming, Rachel Van Horne

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Over the last century native cutthroat trout populations have declined in the western United States. Habitat fragmentation is one of the main causes for this decline. Human actions such as the construction of roads, weirs, dams, and water diversions intersect streams and prevent the natural movement of fish. In many cases native cutthroat trout are now confined to headwater streams above human-created barriers. These barriers not only fragment the populations but also increase the risk of individual population extinction.

This study established a baseline genetic structure for nine isolated populations of Colorado River cutthroat trout in the North Fork Little …


Analyzing The Construction Of The Medical Professional Identity: How Do Doctors Learn To "Do Doctoring?", Lauren Dougall Dec 2011

Analyzing The Construction Of The Medical Professional Identity: How Do Doctors Learn To "Do Doctoring?", Lauren Dougall

Honors Program Theses

This study is a qualitative analysis of how primary care physicians within the first five years of practice after residency construct their medical professional identity. An open-ended interview schedule was used to collect data which revealed the main themes of observational learning, dealing with uncertainty, and the importance of communication and education in patient interaction. Each doctor's professional identity was ultimately a refined version of the image they attributed to doctors as a lay-person.


Effect Of Toothbrush Abrasion On Frictional Resistance Of Aesthetic Orthodontic Archwires, Stephen Alexander Yamodis Dec 2011

Effect Of Toothbrush Abrasion On Frictional Resistance Of Aesthetic Orthodontic Archwires, Stephen Alexander Yamodis

UNLV Theses, Dissertations, Professional Papers, and Capstones

Fixed orthodontic appliances (braces) are one of the most widely used appliances to correct malocclusion, however many patients prefer less metal display. To meet this demand more esthetically pleasing brackets and archwires have been developed. These esthetic components are often clear, white or tooth colored. Coatings of various types are commonly used to produce an esthetic archwire. However, these coating materials tend to wear and degrade, which may cause binding and increased resistance to friction, thereby potentially reducing the efficiency of tooth movement. Therefore, in vitro testing of tooth brush abrasion on frictional resistance of various aesthetic archwires was tested. …


Seasonal Influenza Vaccination Disparities Between U.S. Non-Hispanic Whites And Hispanics, 2000-2009, Andrew E. Burger Dec 2011

Seasonal Influenza Vaccination Disparities Between U.S. Non-Hispanic Whites And Hispanics, 2000-2009, Andrew E. Burger

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Seasonal influenza produces substantial disease within the United States every year. Despite the availability of safe and effective vaccines for influenza, millions of individuals go unvaccinated each flu season, with notable differences across racial/ethnic groups. Using the Behavioral Risk Factor Surveillance System (BRFSS), I examine vaccination rates among non-Hispanic whites and Hispanics during the 2000-2009 influenza seasons. After developing a new method that addresses shortcomings of BRFSS vaccination measures, I find that non-Hispanic whites exhibit higher vaccination rates than Hispanics. Through a series of logistic regression models I show that the disparities between non-Hispanic whites and Hispanics narrow after controlling …


Relative Importance Of Environmental Variables For Spawning Cues And Tributary Use By An Adfluvial Lake Sucker, Brian A. Hines Dec 2011

Relative Importance Of Environmental Variables For Spawning Cues And Tributary Use By An Adfluvial Lake Sucker, Brian A. Hines

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The endangered June sucker (Chasmistes liorus mictus), which is only found in Utah Lake, UT, historically spawned in all streams flowing into the lake, but due to human-caused changes their spawning is restricted to the Provo River. The purpose of this study was to gain a better understanding of the spawning and early life-history of the
June sucker for recovery purposes. My specific objectives were to determine:

  1. what environmental factors attract or deter June suckers to certain Utah Lake tributaries for spawning,
  2. what cues June suckers to migrate upstream to spawn,
  3. if June suckers use more than one …


Prediction Models For Estimation Of Soil Moisture Content, Swathi Gorthi Dec 2011

Prediction Models For Estimation Of Soil Moisture Content, Swathi Gorthi

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The Center for Self-Organizing Intelligent Systems (CSOIS) has been successful in developing personal remote sensing systems. These systems can be further enhanced to monitor important resources of earth such as soil moisture content. Soil moisture is the major component of the soil in relation to plant growth. Soil water dissolves salts and makes up the soil solution, which is important as medium for supply of nutrients to growing plants.

Usually, measuring such physical quantities would include using derived formulas that mathematically describe the relationships between the parameters involved. With the advancements in computer modeling, other methods such as empirical modeling …


Designing Predictive Mathematical Models For The Metabolic Pathways Associated With Polyhydroxybutyrate Synthesis In Escherichia Coli, Angela Dixon Dec 2011

Designing Predictive Mathematical Models For The Metabolic Pathways Associated With Polyhydroxybutyrate Synthesis In Escherichia Coli, Angela Dixon

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Plastics are a versatile and widely used material. However, traditional plastics are derived from petrochemicals and are not biodegradable. Polymers synthesized from microorganisms that have similar properties to plastic are potential biodegradable replacements. The objective of this project is to use mathematical modeling as a tool to engineer a strain of bacteria optimized for the production of bio-plastics.

Production costs can be reduced by using a bacterial strain specifically optimized for bio-plastic production. By reducing production costs, bio-plastics will be able to commercially compete with traditional plastics. Society will benefit as bio-plastics replace traditional plastics. Fossil fuels will not be …


Using Species Distribution Models To Assess Invasion Theory And Provide Management Recommendations For Riparian Areas In The Eastern Columbia And Western Missouri River Basins, Diane R. Menuz Dec 2011

Using Species Distribution Models To Assess Invasion Theory And Provide Management Recommendations For Riparian Areas In The Eastern Columbia And Western Missouri River Basins, Diane R. Menuz

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Globalization has created opportunities for plant and animal species to be transported to novel ecosystems. A subset of these species become invasive species, which are able to persist and spread rapidly to become influential components in their new ecosystems. Invasive species are often able to out-compete co-occurring native species and can alter fundamental ecosystem properties, such as soil nutrient availability or time between wildfires in a region. The United States is estimated to lose $34 billion per year to invasive plant species through costs to control unwanted species and lowered crop and forage production.

We used statistical models to better …


Rotating Algal Biofilm Reactors: Mathematical Modeling And Lipid Production, Paul A. Woolsey Dec 2011

Rotating Algal Biofilm Reactors: Mathematical Modeling And Lipid Production, Paul A. Woolsey

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Harvesting of algal biomass presents a large barrier to the success of biofuels made from algae feedstock. Small cell sizes coupled with dilute concentrations of biomass in lagoon systems make separation an expensive and energy intense-process. The rotating algal biofilm reactor (RABR) has been developed at USU to provide a sustainable technology solution to this issue. Algae cells grown as a biofilm are concentrated in one location for ease of harvesting of high density biomass. A mathematical model of this biofilm system was developed based on data generated from three pilot scale reactors at the City of Logan, Utah wastewater …


Is Computer Science A Relevant Academic Discipline For The 21st Century, Doug Baldwin Dec 2011

Is Computer Science A Relevant Academic Discipline For The 21st Century, Doug Baldwin

Mathematics

The current view of computing as technology overlooks the discipline’s theoretical and scientific foundations in computer science, weakening the entire computing enterprise.


Switches, Excitable Responses And Oscillations In The Ring1b/Bmi1 Ubiquitination System., Lan K Nguyen, Javier Muñoz-García, Helene Maccario, Aaron Ciechanover, Walter Kolch, Boris N Kholodenko Dec 2011

Switches, Excitable Responses And Oscillations In The Ring1b/Bmi1 Ubiquitination System., Lan K Nguyen, Javier Muñoz-García, Helene Maccario, Aaron Ciechanover, Walter Kolch, Boris N Kholodenko

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

In an active, self-ubiquitinated state, the Ring1B ligase monoubiquitinates histone H2A playing a critical role in Polycomb-mediated gene silencing. Following ubiquitination by external ligases, Ring1B is targeted for proteosomal degradation. Using biochemical data and computational modeling, we show that the Ring1B ligase can exhibit abrupt switches, overshoot transitions and self-perpetuating oscillations between its distinct ubiquitination and activity states. These different Ring1B states display canonical or multiply branched, atypical polyubiquitin chains and involve association with the Polycomb-group protein Bmi1. Bistable switches and oscillations may lead to all-or-none histone H2A monoubiquitination rates and result in discrete periods of gene (in)activity. Switches, overshoots …


The Effects Of Physical Activity On Self-Injurious Behavior, Lynnette D. Aguilar Dec 2011

The Effects Of Physical Activity On Self-Injurious Behavior, Lynnette D. Aguilar

Theses and Dissertations - UTB/UTPA

Auto-mutilation is a maladaptive coping mechanism and a major problem confronting behavioral medicine with no known treatment to date to place the behavior on complete extinction. The purpose of this experiment is to examine the possible beneficial effects of running relative to caffeine-induced SIB. Female Sprague Dawley rats (n = 4) served as subjects with each having a different extended baseline and treatment condition. Visual analysis of a multiple baseline graph did not support the hypothesis that as treatment (physical activity) was implemented SIB would decrease. It was found that subjects who drank more caffeinated water had higher amounts of …


Enriched Vs Impoverished Housing: Food Choice And Consumption, Berenice Martinez Dec 2011

Enriched Vs Impoverished Housing: Food Choice And Consumption, Berenice Martinez

Theses and Dissertations - UTB/UTPA

This study focused on the relationship between environmental setting, eating choices and food intake. Ten Swiss Webster female subjects were socially housed under impoverished environmental conditions and ten under enriched housing conditions. Subjects were exposed to a nutritious food and sweet fat-laden food diet together with ad lib access to regular tap water on a 12 h light and dark cycle for four weeks. Results showed that an impoverished environment does not lead to an increase in body weight (t(6)= 0.293, p > .05) and environmental manipulations do not delineate a preference for diet type (t(6)= .877, p >.05). Further research …


The Effect Of Acceptance Training On Psychological And Physical Health Outcomes In Elders With Chronic Conditions, Patricia Mcdonald, Jaclene Zauszniewski, Abir K. Bekhet, Laura Dehelian, Diana L. Morris Dec 2011

The Effect Of Acceptance Training On Psychological And Physical Health Outcomes In Elders With Chronic Conditions, Patricia Mcdonald, Jaclene Zauszniewski, Abir K. Bekhet, Laura Dehelian, Diana L. Morris

College of Nursing Faculty Research and Publications

This pilot trial investigated the short and long-term effects of Acceptance Training (ACT) intervention on acceptance, perceived health, functional status, anxiety, and depression in elders with chronic conditions living in retirement communities (RCs). The ACT intervention combined Rational Emotive Behavior Therapy with music, relaxation, and guided imagery during six weekly 2-hour sessions. Face-to-face interviews were conducted with 16 African-American and 46 White elders across four data collection points in six randomly selected RCs using well-established measures of perceived health, functional status, anxiety, and depression, and a measure of acceptance of chronic conditions adapted from a previous measure of acceptance of …


Density, Shell Use And Species Composition Of Juvenile Fiddler Crabs (Uca Spp.) At Low And High Impact Salt Marshes On Georgia Barrier Islands, Michelle D. Carlson Dec 2011

Density, Shell Use And Species Composition Of Juvenile Fiddler Crabs (Uca Spp.) At Low And High Impact Salt Marshes On Georgia Barrier Islands, Michelle D. Carlson

College of Graduate Studies: Theses & Dissertations

Coastal wetlands offer refuge for juveniles of many species, with protection often coming in the form of dense vegetation. Human impacts have led to a 67% loss of coastal wetlands worldwide in the past 300 years, thus decreasing available refuges. There are no studies that show what affect this has on fiddler crabs (Uca spp.), a key species in salt marsh habitats. The present study looks at how human impacts are affecting juvenile fiddler crab densities, shell use, and species compositions. This study was conducted at 3 low and 3 high impact sites on Tybee and Skidaway Island, Georgia. Six …


The Induction Of Positive Affect In A Community Setting Using Electronic Communications., Philip Andrew Smeltzer Dec 2011

The Induction Of Positive Affect In A Community Setting Using Electronic Communications., Philip Andrew Smeltzer

Electronic Theses and Dissertations

Objective: To evaluate the influence of positive affect inductions on daily and weekly Positive and Negative Affect Scales (PANAS) in a community setting. Methods: Humor messages were distributed to participants four times per day during a treatment week with general health messages distributed in the crossover week. Subjects completed a series of self-report psychosocial and behavioral survey instruments on a weekly basis and daily PANAS responses. Messages were delivered through either email or SMS/text messages. Results: The daily and weekly PANAS scores were higher during treatment periods compared to the neutral periods. The observed trends were suggestive of successful positive …


Human Olfactory Epithelial-Derived Progenitors : A Potential Source For Cell Therapy For Parkinson's Disease., Meng Wang Dec 2011

Human Olfactory Epithelial-Derived Progenitors : A Potential Source For Cell Therapy For Parkinson's Disease., Meng Wang

Electronic Theses and Dissertations

Human adult olfactory epithelium contains neural progenitors (hONPs) which replace damaged cellular components throughout life. Methods to isolate and expand the hONPs have been developed in our laboratory. In response to morphogens, the hONPs differentiate along several neural lineages. This study optimized conditions for the differentiation of hONPs towards dopaminergic neurons. The hONPs were treated with Sonic Hedgehog, in the presence or absence of Retinoic acid and/or forskolin. Transcription factors (Nurrl, Pitx3 and Lmxla) that promote embryonic mouse or chicken dopaminergic development were employed to determine if they would modulate lineage restriction of these adult human progenitors. Transcription factor expression …


Theoretical And Experimental Studies On Manipulation Of Fluorescence By Gold Nanoparticle : Application For Molecular Imaging., Jianting Wang 1983- Dec 2011

Theoretical And Experimental Studies On Manipulation Of Fluorescence By Gold Nanoparticle : Application For Molecular Imaging., Jianting Wang 1983-

Electronic Theses and Dissertations

Gold nanoparticles (GNPs) have shown beneficial properties for biomedical use, e.g., their non-toxic nature and surface properties for easy modification. Upon receiving light, they generate a strong surface plasmon field, which can alter the fluorescence of fluorophores. The level and type of the fluorescence alteration depend on the GNP size and shape, excitation (Ex)/emission (Em) wavelengths and quantum yield of the fluorophore, as well as the distance between the fluorophore and GNP. In this dissertation, the effect of the properties listed above on the fluorescence output was theoretically analyzed for the fluorophores frequently used in biomedical studies. For fluorescence quenching, …


Gold Catalysis And Its Applications In Synthesis Of Fluorinated Organic Compounds., Weibo Wang Dec 2011

Gold Catalysis And Its Applications In Synthesis Of Fluorinated Organic Compounds., Weibo Wang

Electronic Theses and Dissertations

Our research activities are based on the catalytic systems that provide resource-saving synthetic methodologies through gold-catalyzed reactions of alkynes and alkenes. We have worked on three applications: i) an effective and straightforward hydration of 3-alkynoates catalyzed by gold (III); this mild and atom-economical method can be used effectively with a wide range of substrates with high regioselectivity; ii) an efficient monofluorination of allyl silanes using Selectfluor has been achieved without gold catalysts; iii) a fluorine-enabled cationic metal species, generated by fluorination of a low valence gold(l) complex, catalyzed the hydration of alkynes to give a-substituted-a-fluoroketones in one pot under mild …


Incidence Of Soft Tissue Calcifications Of The Head And Neck Region On Maxillofacial Cone Beam Computed Tomography., Adam B. Wells 1977- Dec 2011

Incidence Of Soft Tissue Calcifications Of The Head And Neck Region On Maxillofacial Cone Beam Computed Tomography., Adam B. Wells 1977-

Electronic Theses and Dissertations

The aim of the study was to determine the incidence and imaging characteristics of soft tissue calcifications on cone beam computed tomography (CBCT). 556 CBCT image datasets were reviewed and 308 included. The following conditions were recorded: 1) Carotid artery calcifications (CAC), 2) Triticeous cartilage (TC), 3) Superior cornu of the thyroid cartilage (SCT), 4) Tonsilloliths (T) and, 5) Other including lymph nodes (0). The age and sex of patients who were excluded served as controls. 107 (34.75%) demonstrated at least one calcification. Those with calcifications were approximately 12 years older than controls (t value = 6.32, p < 0.001). The incidence of calcifications in decreasing order are TC (11.4%), CAC (10.4%), T (10.4%) and, SCT (5.2%). Differential location and appearance of calcifications were described. Soft tissue calcifications were a common finding with TC, CAC and T presenting in almost equal frequency. Calcifications exhibit unique characteristics on CBCT images.


Health Disparities And Depression In Rural And Urban Older Adults., Jennifer Ann Zimmerman Dec 2011

Health Disparities And Depression In Rural And Urban Older Adults., Jennifer Ann Zimmerman

Electronic Theses and Dissertations

Depression is one of the most prevalent psychiatric conditions experienced by older adults and represents a major public health concern. Rural/urban residence may affect the prevalence of depression as rural older adults differ from their urban counterparts in many respects. One important difference found in the literature is that rural OAs are often faced with more health disparities (HDs) compared to their urban counterparts. The current study investigated the association between HDs and depression in a sample of rural and urban OAs, and examined whether HDs contribute to our understanding of how rurality impacts the prevalence and severity of depression. …


Thermolysis Stability, Solution Reactivity And Structural Studies Of A Thioperoxide-Bridged Dimolybdenum(V) Dimer., Ackim Maduvu Dec 2011

Thermolysis Stability, Solution Reactivity And Structural Studies Of A Thioperoxide-Bridged Dimolybdenum(V) Dimer., Ackim Maduvu

Electronic Theses and Dissertations

Molybdenum-sulfur complexes have developed a lot of interest in the chemistry of metal-coordinated sulfur due to their importance in biological systems and in industrial processes like catalysis. For example, in biological processes molybdenum has been recognized as a very important metal in enzymes used for nitrogen fixation for over 60 years. In this dissertation, the system of the imidodithiophosphate /l-carboxylatomolybdenum(V) dimer was studied for crystal thermolytic stability and solution reactivity. Mo2(NTo)2(S2P(OEt)2)2(µ-O2CR)(µ-SBn)(µ-SO) will be abbreviated as BnS{Mo2}SO, where R is CH3, CH2CH2CH3, C(CH3)3 or CH(OCH3)C6H5. In the crystal phase, the packing of BnS{Mo2}SO acetate allows the molecule to pair off on …


Cytotoxicity And Cellular Response To Alpha, Beta-Unsaturated Aldehydes : Role Of Aldehyde Dehydrogenases., Ngome Llewellyn Makia Dec 2011

Cytotoxicity And Cellular Response To Alpha, Beta-Unsaturated Aldehydes : Role Of Aldehyde Dehydrogenases., Ngome Llewellyn Makia

Electronic Theses and Dissertations

The lipid aldehydes, 4-hydroxy-2-nonenal (4-HNE) and propene-2-al (acrolein) are reactive a,ß-unsaturated aldehydes generated during the peroxidation of lipids and are implicated in the pathogenesis of several oxidative-stress mediated diseases, including steatohepatitis and cancer. We established that mouse liver aldehyde dehydrogenase 1 al (Aldhlal) efficiently metabolizes lipid aldehydes and protects a liver-derived cell line from the toxic effects of these aldehydes. Thus, mechanisms to induce the expression of Aldhlal might be a useful rationale for preventing oxidative stress-induced pathologies. We investigate whether well-known electrophiles, such as BHA or acrolein modulate the expression of Aldhlal and elucidate the signaling pathway involved. Microarray …


Role Of Hdacs And Sam In Interferon-Alpha Signaling And Epigenetic Regulation Of Anti-Hcv Gene Expression., Stephanie A. Mathews Dec 2011

Role Of Hdacs And Sam In Interferon-Alpha Signaling And Epigenetic Regulation Of Anti-Hcv Gene Expression., Stephanie A. Mathews

Electronic Theses and Dissertations

Hepatitis C virus (HCV) infection is a major cause of chronic liver disease in the United States and is a huge burden on the US healthcare system. The FDA-approved traditional standard of care for HCV is pegylated interferon-alpha (lFNa) combined with ribavirin, which is effective in about 50% of patients. The molecular mechanisms involved in resistance to IFNa therapy remain unclear. Recent data strongly suggest that histone deacetylases (HDACs) and methylation play critical roles in the regulation of IFNa anti-HCV signaling and gene expression. The present work was carried out to elucidate the roles of HDACs and S-adenosylmethionine (SAM) metabolism …


The Effects Of Stereotype Disconfirming Information And Self-Disclosure On Stereotype Endorsement, Prejudice, And Social Tolerance Of Schizophrenia And Major Depressive Disorder., Nicole Leigh Meyer 1983- Dec 2011

The Effects Of Stereotype Disconfirming Information And Self-Disclosure On Stereotype Endorsement, Prejudice, And Social Tolerance Of Schizophrenia And Major Depressive Disorder., Nicole Leigh Meyer 1983-

Electronic Theses and Dissertations

The current study examined how Disclosure, Stereotype Disconfirming Information, and Stereotype Disconfirming Information and Disclosure Combined) influences an individual's stigma (stereotype endorsement, emotional reactions, and discrimination) against individuals with Schizophrenia and Depression. The results of this experiment suggest that both Stereotype Disconfirming Information and Disclosure are successful in reducing stereotypes, emotional reactions, and social distance in the context of an interpersonal encounter. Self-disclosure, however, is stronger in increasing Pity and decreasing the desire for Social Distance than Stereotype Disconfirming Information. The combination of Stereotype Disconfirming Information and Disclosure provided the strongest stigma reduction, suggesting that Disclosure can benefit from the …


Structure-Based Design Of Inhibitors Of Cxcr4., Jason Bradley Meier 1980- Dec 2011

Structure-Based Design Of Inhibitors Of Cxcr4., Jason Bradley Meier 1980-

Electronic Theses and Dissertations

Metastasis is a complex process requiring directed migration of metastatic cells to favorable microenvironments. Increased CXCR4 expression has been implicated in more invasive, aggressive and metastatic tumor phenotypes and poor patient survival in twenty-three forms of cancer. CXCR4 has been linked to cancer metastasis and CXCR4 expression on the cell surface of tumor cells has been linked to increased migration and homing of neoplastic cells to sites where stromal cells express the chemokine CXCL 12 such as the lung and bone marrow. In this dissertation, we will utilize structure based drug design to identify inhibitors of CXCR4 targeting the extracellular …


A Survey Study Comparing Adult Orthodontic Patient Quality Of Life Between Invisalign And Fixed Appliances., Keith Christopher Nicholson Dec 2011

A Survey Study Comparing Adult Orthodontic Patient Quality Of Life Between Invisalign And Fixed Appliances., Keith Christopher Nicholson

Electronic Theses and Dissertations

We aimed to examine differences in treatment impacts and quality of life between adult orthodontic patients with Invisalign and fixed appliances. Adults represent a burgeoning branch of orthodontics yet many prospective patients have been reluctant to pursue orthodontics due to concerns with treatment. It was hypothesized that removable aligners would be better tolerated by adult patients. Sixty-three adult patients (forty Invisalign, twenty-three fixed appliances) were recruited from private practice. The treatment groups were largely comparable although the braces group reported more frequent unplanned appointments and use of auxiliaries. The Invisalign group experienced less negative impacts and these differences were generally …


Effects Of Environmental Pollution On Endothelial Progenitor Cells And Vascular Regeneration., Laura A. Wheat Nissley 1983- Dec 2011

Effects Of Environmental Pollution On Endothelial Progenitor Cells And Vascular Regeneration., Laura A. Wheat Nissley 1983-

Electronic Theses and Dissertations

Acrolein is a common pollutant present in ambient air, automobile exhaust, and tobacco smoke. Previous studies show that exposure to acrolein increases cardiovascular disease risk. To determine whether acrolein affect cardiovascular regeneration, we investigated the cardiovascular effects of inhaled acrolein. Adult male C57BL/6 mice were exposed to room air or acrolein (O.5, 1 or 5 ppm) for and the endothelial progenitor cells (EPC) level in peripheral blood (PB) was measured by flow cytometry. To examine the proliferative capacity of EPCs, bone marrow cells (BMCs) were cultured on fibronectin-coated slides. Brief exposure to acrolein (5 ppm, 6h) or 4 day (1 …