Digital Commons Network^™

Bevacizumab Effect On Topotecan Pharmacokinetics In A Murine Orthotopic Rhabdomyosarcoma Xenograft Model, Zaifang Huang

Theses and Dissertations (ETD)

Increasing evidence suggests that inhibition of vascular endothelial growth factor (VEGF) can transiently normalize tumor vasculature, thereby improving delivery of systemic chemotherapy. Bevacizumab (BEV), an anti-VEGF antibody, has been shown to transiently normalize tumor vasculature by increasing tumor vessel maturity, decreasing tumor vessel permeability, and increasing tumor oxygenation in an Rh30 orthotopic rhabdomyosarcoma xenograft model. However, the effects of BEV on the pharmacokinetics of TPT and the antitumor activity of TPT have not been evaluated. This study aimed to investigate the effect of BEV on TPT systemic and tumoral pharmacokinetics and to determine how these changes affect the efficacy of …

Polymorphic Variation Of The Dgat1 Gene In Cal Poly Holstein And Jersey Breeds And The Correlation Of Milk Fat Content, And Genetic Values, Andrea M. Laubscher

Master's Theses

The selection of dairy cattle is dictated by improvement of yield and composition of milk. Genotyping tests give breeders the opportunity to use previously unavailable information to increase the frequency of beneficial alleles in their herds. A QTL influencing milk yield and composition is located in the centromeric end of chromosome 14. The polymorphism being analyzed is a K232A substitution (lysine to alanine amino acid change) in exon VII of the diacylglycerol acyl transferase 1 (DGAT1) gene. DGAT1 is a key acyltranferase in triglyceride biosynthesis. DGAT1 encodes an enzyme which catalyzes the final step of mammalian triglyceride synthesis from carbohydrates. …

Student Newsletter, December 2011, University Of Arkansas, Fayetteville

Student Newsletter, University of Arkansas First Year Experience

No abstract provided.

What Are The Effects Of Raw Vs. Pasteurized Milk Consumption On Growth Rate And Fertility In A Colony Of Mice?, Kari Sholing, Lindsay Ganong, Amy Olson

Nutrition Student Work

Interest in consuming unprocessed foods has led to assumptions that raw milk has health benefits over pasteurized milk. This study was designed to evaluate the belief that raw milk is nutritionally superior. Eighteen mice were randomly assigned to one of two groups: raw milk or pasteurized milk. Mice were grouped into breeding trios and given a fresh supply of milk every four hours between 7 a.m. and 11 p.m. for 55 days. Milk consumption was tracked at each feeding by measuring the amount of milk that was provided and the amount of milk that was left from the previous feeding. …

Primetimes Newsletter, Winter 2011, Office Of Lifespan Studies

PrimeTimes Newsletter

PrimeTimes is the newsletter of the Office of Lifespan Studies in the College of Science at Coastal Carolina University.

Citrate Binding To The Membrane Protein Proteorhodopsin, Farhana F. Syed

Chemistry - Dissertations

Proteorhodopsin (pR) is an intrinsic membrane protein with an important role in solar-energy storage of the biosphere. Earlier work in our lab has shown that polyhistidine-tagged pR can be purified by means of selective precipitation with citrate under specific conditions, as can a number of mutants based on this His₆-tagged pR. Purification of a heterologously-expressed trans-membrane protein by a simple salt such as citrate is novel. However, such a phenomenon leads to several questions: How does citrate cause pR precipitation? Does the polyhistidine-tag assist in such a precipitation? Is this precipitation pH-specific? Does citrate affect the function of …

Leadership In Building Communities: Crossing The Creek, Fitz Center For Leadership In Community, University Of Dayton

Dayton Neighborhood Studies

No abstract provided.

Eastern Kentucky University Magazine, Winter 2011, Eastern Kentucky University, Alumni Relations

The Eastern Magazine

No abstract provided.

Muscle-Fiber Type And Blood Oxidative Stress After Eccentric Exercise, John Quindry, Lindsey Miller, Graham Mcginnis, Megan Irwin, Charles Dumke, Meir Magal, N, Travis Triplett, Jeffrey Mcbride, Zea Urbiztondo

Integrative Physiology and Athletic Training Faculty Publications

Acute strength exercise elicits a transient oxidative stress, but the factors underlying the magnitude of this response remain unknown. The purpose of this investigation was to determine whether muscle-fiber type relates to the magnitude of blood oxidative stress after eccentric muscle activity. Eleven college-age men performed 3 sets of 50 eccentric knee-extensions. Blood samples taken pre-, post-, and 24, 48, 72, and 96 hr postexercise were assayed for comparison of muscle damage and oxidative-stress biomarkers including protein carbonyls (PCs). Vastus lateralis muscle biopsies were assayed for relative percentage of slow-and fast-twitch muscle fibers. There was a mixed fiber composition (Type …

Back Where You Belong: Individuals, Corporations, And The Third Circuit’S Redefinition Of Personal Privacy Under Foia, Emily A. Schneider

Texas Wesleyan Law Review

The Freedom of Information Act ("FOIA" or "the Act") serves an important purpose in informing the citizenry of its government's actions. Congress created it as a disclosure statute, the Supreme Court has decided FOJA in favor of disclosure, and the D. C. Circuit has kept that goal of disclosure by refusing to broaden its exemptions. Despite this history of consistent treatment, the Third Circuit attempted to change the game with its holding in AT&T v. FCC. The Third Circuit held that corporations may have personal privacy under FOIA Exemption 7(C). This paper will argue that this holding contradicted three FOIA …

How Does The Rural Food Environment Affect Rural Childhood Obesity?, David Hartley Phd, Mha, Nathaniel J. Anderson Ms, Mph, Kimberley Fox Mph, Jennifer D. Lenardson Mhs

Population Health

Objective: Assess the impact of the rural food environment on the eating behaviors and BMI of rural low-income children. Method: Statewide (Maine, 2009) household survey of parents of children on Medicaid (n=1722), oversampled in six rural communities, resulting in n=272 for six target communities. Food environment measured using modified Nutrition Environment Measures Survey in Stores (NEMS-S) for 46 retail food outlets. Multi-variate analysis assessed factors affecting home food environment, child's eating behavior and BMI. Results: Home food behaviors (how often: family eats together, child eats breakfast, vegetables served) and parent food consumption were significantly associated with children's healthy eating behaviors. …

Factors Influencing Travel Order As Proxy For Leadership And Trade-Offs In Activity Budgets In Lactating And Nonlactating African Savanna Elephants, Malgorzata Wisniewska

Masters Theses & Specialist Projects

Nutritional and energetic needs of female mammals depend upon size or reproductive investment and shape individual activity budgets and behavioral patterns. To maximize nutritional and energetic intake females may increase time allocated to foraging or access resources through risk-prone behaviors, represented as aggression or leadership. Conversely, to minimize nutritional and energetic spending females may engage in risk-averse activities such as resting or nonaggressive social interactions. Females with the highest needs should exhibit activities and behaviors that facilitate the greatest nutritional and energetic returns or highest metabolic savings. The propensity for risk-prone behaviors may be greater among older as well as …

Universal Women's Rights Since 1970: The Centrality Of Autonomy And Agency, Rhoda E. Howard-Hassmann

Political Science Faculty Publications

This article reviews the development of universal women’s human rights since 1970. It begins by discussing how the international feminist movement influenced the development of women’s legal human rights, and continues by reviewing three debates in the literature on women’s rights. The first debate is whether human rights as originally formulated were actually men’s rights; the second debate is about the relationship between culture and women’s rights; and the third considers the effects of globalization on women’s rights. The author defends a liberal approach to human rights via the principles of equality and autonomy for women, but also argues that …

An Analysis Of Burmese And Iraqi Resettlement Location And Assimilation In A Midsized City: Implications For Educational And Other Community Leaders, Donna Schiess Renaud

Dissertations

Refugees face different circumstances than other immigrants regarding housing in initial resettlement in the U.S. Refugees have no choice of their initial residence as this is determined in advance by the resettlement agency. Refugees who belong to minority ethnic groups and who have little education or skills may experience discrimination and hostility from local citizens. Resettlement areas that are high in population density, rental units, minorities, crime, unemployment, inadequate transportation, and low income may present additional barriers to cultural and economic assimilation.

This mixed-method study had a twofold purpose. The first was to describe quantitatively how the initial resettlement address …

Uses Of Genomic Predictions In Commercial Beef Cattle Operations, Matt Miller

Dairy Science

This paper aimed to achieve two different objectives. The first objective of this study was to identify and explain the genetic gain achieved in commercial beef cattle operations with the use of genomic predictions versus the use of visual appraisal and EPDs. The second goal of this paper was to develop a method to easily explain genomic predictions and their practical applications on commercial beef operations to a lay audience, specifically to ranchers. In order to accomplish these objectives, I evaluated three of the most common selection methods used by producers today. These included visual appraisal, expected progeny differences (EPDs), …

Obstetricians And Violence Against Women, Sonya Charles

Philosophy and Religious Studies Department Faculty Publications

I argue that the American Congress of Obstetricians and Gynecologists (ACOG), as an organization and through its individual members, can and should be a far greater ally in the prevention of violence against women. Specifically, I argue that we need to pay attention to obstetrical practices that inadvertently contribute to the problem of violence against women. While intimate partner violence is a complex phenomenon, I focus on the coercive control of women and adherence to oppressive gender norms. Using physician response to alcohol use during pregnancy and court-ordered medical treatment as examples, I show how some obstetrical practices mirror the …

Suppression Of Phospholipase Dγs Confers Increased Aluminum Resistance In Arabidopsis Thaliana, Xuemin Wang, Jian Zhao, Cunxi Wang, Mohamed Bedair, Ruth Welti, Lloyd Sumner, Ivan Baxter

Biology Department Faculty Works

Aluminum (Al) toxicity is the major stress in acidic soil that comprises about 50% of the world's arable land. The complex molecular mechanisms of Al toxicity have yet to be fully determined. As a barrier to Al entrance, plant cell membranes play essential roles in plant interaction with Al, and lipid composition and membrane integrity change significantly under Al stress. Here, we show that phospholipase Dγs (PLDγs) are induced by Al stress and contribute to Al-induced membrane lipid alterations. RNAi suppression of PLDγ resulted in a decrease in both PLDγ1 and PLDγ2 expression and an increase in Al resistance. Genetic …

Irish Culinary Manuscripts And Printed Books: A Discussion, Máirtín Mac Con Iomaire, Dorothy Cashman

Articles

This paper provides a discussion of Irish Culinary Manuscripts and Printed Cookbooks. It covers Gaelic hospitality and aristocratic hospitality, setting the background for the Anglo-Irish households from which many manuscripts emerge. It charts the growing sources of information on Irish culinary history. It outlines Barbara Wheaton's framework for reading historic cookbooks and discusses the growing manuscript cookbook collection in the National Library of Ireland.

Trans-Translation Dependent Degradation Of Mrnas And Proteins, Zhiyun Ge

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The translation of mRNAs without in-frame stop codons results in the following problems: the ribosomes are stalled and sequestered on the defective mRNA, the incomplete polypeptides produced are potentially toxic to the cells, and the defective mRNA can result in more futile translational cycles. Bacteria have developed a unique system, called trans-translation to resolve all of the above-mentioned problems. The key players of the trans-translation system are tmRNA and its protein cofactor SmpB. One part of my work showed that the system mediates the degradation of non-stop mRNAs by recruiting RNase R to stalled ribosomes through the interaction between the …

Dayton Lawyer, Winter 2011-12, University Of Dayton

Dayton Lawyer

No abstract provided.

Dietary Supplement Education In A Senior Population, Kimberly G. Elder, Sarah A. Nisly

Scholarship and Professional Work – COPHS

Background. Dietary supplements are widely used among United States senior citizens for various indications. Potential dangers with supplement use include the lack of regulation by the Food and Drug Administration (FDA) and the possibility for drug-supplement interactions. Senior focused education may in- crease the safe use of dietary supplements by older adults.

Objective. The primary objective of this study was to determine the effectiveness of a pharmacist driven educational seminar in a local senior population.

Methods. Participants aged 55 years and older in one of three senior programs were eligible for inclusion. Initially, a needs-assessment interview was con- ducted …

Voices Raised, Issue 34, University Of Dayton. Women's Center

Women’s Center Newsletter

Included in this issue: Sweats to Suits 2012; 100 years of Engineering Excellence: Women’s strides in a challenging field; WGS goes to London; The women of 39 Evanston; Memories and Musings from Mrs. Claus; Dining hall health foods?; Navigating the holidays after the death of a loved one; Sweats to Suits 2011; All ages, learning from each other.

Chronic Maternal Protein Deprivation In Mice Is Associated With Overexpression Of The Cohesin-Mediator Complex In Liver Of Their Offspring, Alfred Balasa, Amarilis Sanchez-Valle, Bekim Sadikovic, Haleh Sangi-Haghpeykar, Jaclyn Bravo, Liang Chen, Wei Liu, Shu Wen, Marta L. Fiorotto, Ignatia B. Van Den Veyver

Paediatrics Publications

Epigenetic mechanisms may play an important role in the developmental programming of adult-onset chronic metabolic diseases resulting from suboptimal fetal nutrition, but the exact molecular mechanisms are incompletely understood. Given the central role of the liver in metabolic regulation, we investigated whether chronic maternal dietary protein restriction has long-term effects on liver gene expression in the offspring. We fed adult C57BL/6J dams ad libitum an 8% maternal lowprotein (MLP) or 20% protein control diet (C) from 4 wk prior to mating until the end of lactation. Male pups were weaned to standard nonpurified diet and singly housed at 21 d …

Maine's Community Living Program: Implementation And Outcomes, Julie T. Fralich Mba, Mark Richards Bs, Louise Olsen

Disability & Aging

In 2009, the Office of Elder Services, Maine Department of Health and Human Services (DHHS), was awarded a grant from the Administration on Aging (AoA) under its Community Living Program (CLP). The overall goal of the CLP announcement was to strengthen the capacity of the Aging Network to target and serve individuals at highest risk of residential facility placement by offering flexible services including consumer directed options. Over the last five years, options counseling has evolved from a general set of activities and functions within AAAs/ADRCs to a more standardized and generally accepted role within the Aging Network. With the …

Synthesis And Characterization Of Acceptor: Donor Block Copolymers For Organic Photovoltaics, Brandon Cory Achord

Dissertations

Mankind needs sources of clean power. Photovoltaic (PV) cells, in use since 1839, have proven reliable and practical for certain applications. PV cell efficiency has changed over the years from 1-2% to ultra-high efficiency cells operating at efficiencies greater than 40%. Organic photovoltaics are a potential transformative technology platform. The potential for cell use, efficiency and cost are all parts of the research and development focus at the time this document was written. This research was initiated with a focus on the synthesis and understanding of the variables effecting acceptor-donor block copolymer. The self-assembled morphology resulting from varying volume ratios …

Gene Expression And Physiological Analyses To Study Metabolic Shifts In Medicago Truncatula Subjected To Biotic Stresses, Michelle Ryan Martin

Graduate Theses and Dissertations

Plants are frequently under attack from pests and deploy various defense mechanisms to fight off predators. Many plant defenses are induced following herbivory or pathogen infection. An investment in defense could potentially lead to a diversion of metabolic resources away from primary metabolism, including reduction in plant commitment to photosynthesis. In this thesis, changes in expression levels of representative genes for primary and secondary metabolism were studied using real-time polymerase chain reaction (PCR) in Medicago truncatula Gaertner subjected to beet armyworm (Spodoptera exigua H¨¹bner) damage or Phoma medicaginis Malbr. & Roum. infection. Photosynthetic yield was also measured using chlorophyll fluorescence …

Creating A "Mock Essay" To Teach Mla Format, Erin Micklo

Writing Bootcamp Unit

This lesson requires students to write a “mock essay” using fictional sources and a creative, entertaining topic to demonstrate MLA proficiency.

The Relationship Of Strength And Body Composition To Vertical Jump Ability In Division 1 Female Volleyball Players., Alyssa Shedlarski

Undergraduate Honors Theses

Jump ability is important in volleyball; therefore analysis of factors that influence jump performance is necessary to ensure maximal jump ability. Purpose: To analyze how strength characteristics associated with jumping are affected by percent body fat, lean body mass and free fat mass. Methods: Data from eleven female NCAA DI volleyball players as part of an ongoing athlete monitoring program collected from 2007-2010 was analyzed. Data was separated into weakest and strongest based on isometric peak force allometrically scaled. In all cases the weakest data corresponded to testing during the athletes first year at ETSU. Body composition was measured using …

Expanding The Temporal Dimensions Of Developmental Biology: The Role Of Environmental Agents In Establishing Adult-Onset Phenotypes, Scott F. Gilbert

Biology Faculty Works

Developmental biology is expanding into several new areas. One new area of study concerns the production of adult-onset phenotypes by exposure of the fetus or neonate to environmental agents. These agents include maternal nutrients, developmental modulators (endocrine disruptors), and maternal care. In all three cases, a major mechanism for the generation of the altered phenotype is chromatin modification. Nutrient conditions, developmental modulators, and even maternal care appear to alter DNA methylation and other associated changes in chromatin that regulate gene expression. This brings a new, under-appreciated, dimension of gene regulation into developmental biology, and it also demonstrates the poverty of …

December 2011 Commencement Program, Bowling Green State University

Commencement Programs

No abstract provided.