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Evaluating A Social Skills Training Protocol In A Private Setting: Outcomes And Issues, Judi Davis Dec 2011

Evaluating A Social Skills Training Protocol In A Private Setting: Outcomes And Issues, Judi Davis

UNLV Theses, Dissertations, Professional Papers, and Capstones

Society is dealing with a trend of aggressive and destructive behavior among children and adolescence. Children with social, emotional, and conduct problems are at high risk for academic failure, peer rejection, conduct disorder, school dropout, delinquency, and drug and alcohol problems (Webster-Stratton, Reid, & Stoollmiller, 2008). A high priority for the United States public health and crime prevention is the prevention of aggressive and delinquent behavior during childhood and adolescence (Taylor, Eddy, & Biglan 1999).

Social skills trainings aim to increase the performance of key social behaviors that are important for children to succeed in social situations. Solutions may be …


Boundary Element Method (Bem) And Method Of Fundamental Solutions (Mfs) For The Boundary Value Problems Of The 2-D Laplace's Equation, Ermes Anthony Salgado-Ibarra Dec 2011

Boundary Element Method (Bem) And Method Of Fundamental Solutions (Mfs) For The Boundary Value Problems Of The 2-D Laplace's Equation, Ermes Anthony Salgado-Ibarra

UNLV Theses, Dissertations, Professional Papers, and Capstones

In this thesis we study the solution of the two dimensional Laplace equation by the boundary Element method (BEM) and the method of fundamental solutions (MFS). Both the BEM and MFS used to solve boundary value problems involving the Laplace equation 2-D settings. Both methods rely on the use of fundamental solution of the Laplace's equation (the solution of Laplace's equation in the distributional sense). We will contrast and compare the results we get using the BEM with results we get using the MFS.


The Utilization And Effectiveness Of The Hesi E(Square) Exit Exam As A Graduation Requirement Toward Increasing Nclex-Rnrtm Pass Rates In Baccalaureate Nursing Programs, Debra Henline Sullivan Dec 2011

The Utilization And Effectiveness Of The Hesi E(Square) Exit Exam As A Graduation Requirement Toward Increasing Nclex-Rnrtm Pass Rates In Baccalaureate Nursing Programs, Debra Henline Sullivan

UNLV Theses, Dissertations, Professional Papers, and Capstones

Due to a desire to better prepare BSN students for the Nurse Council Licensure Examination for Registered Nurses (NCLEX-RN® ) and to increase first-time pass rates, nursing programs across the US are using predictive testing to implement policies that require students to pass a standardized exit exam to graduate (National League for Nursing, 2010). Evolve Learning Systems owned by Elsevier, Inc. offers such an exit exam named the HESI E 2 , which recommends a benchmark score to predict success on the NCLEX-RN® . To offset an expected decrease in NCLEX-RN® pass rates due to recent changes …


Bryoecology In The American Southwest: Patterns Of Biodiversity And Responses To Global Change, John Carroll Brinda Dec 2011

Bryoecology In The American Southwest: Patterns Of Biodiversity And Responses To Global Change, John Carroll Brinda

UNLV Theses, Dissertations, Professional Papers, and Capstones

This dissertation combines investigation of the large-scale responses of bryophyte species diversity and distribution with small-scale physiological adaptations to global change. These two areas of inquiry are linked because one way to predict plant species responses to global change is to examine their distribution across current ecological gradients produced by factors such as latitude and elevation. By examining these biogeographic patterns one can identify those species that have a narrow tolerance and therefore are most sensitive to change. Selected bryophytes might then be used as indicator species in long-term monitoring programs. Where historical data exist, these can be used to …


Spectroscopic Methods Of Process Monitoring For Safeguards Of Used Nuclear Fuel Separations, Jamie Lee Warburton Dec 2011

Spectroscopic Methods Of Process Monitoring For Safeguards Of Used Nuclear Fuel Separations, Jamie Lee Warburton

UNLV Theses, Dissertations, Professional Papers, and Capstones

To support the demonstration of a more proliferation-resistant nuclear fuel processing plant, techniques and instrumentation to allow the real-time, online determination of special nuclear material concentrations in-process must be developed. An ideal materials accountability technique for proliferation resistance should provide nondestructive, realtime, on-line information of metal and ligand concentrations in separations streams without perturbing the process. UV-Visible spectroscopy can be adapted for this precise purpose in solvent extraction-based separations.

The primary goal of this project is to understand fundamental URanium EXtraction (UREX) and Plutonium-URanium EXtraction (PUREX) reprocessing chemistry and corresponding UV-Visible spectroscopy for application in process monitoring for safeguards. By …


A Diffusion Tensor Imaging Software Comparison And Between Control Subjects And Subjects With Known Anatomical Diagnosis, Michael C. Moore Dec 2011

A Diffusion Tensor Imaging Software Comparison And Between Control Subjects And Subjects With Known Anatomical Diagnosis, Michael C. Moore

UNLV Theses, Dissertations, Professional Papers, and Capstones

Diffusion weighted imaging (DWI) is a magnetic resonance imaging (MRI) method that produces in vivo images of biological tissues weighted with the local micro-structural characteristics of water diffusion. Diffusion tensor imaging (DTI), a form of DWI, is useful when a tissue, such as the neural axons of white matter in the brain, has an internal fibrous structure that allows water to diffuse more rapidly in alignment with the fibers. Changes in the water diffusion pattern indicate changes in the fiber structure which can result from damage to the fibers. Measurements of the water diffusion patterns include overall diffusivity, Apparent Diffusion …


Effects Of High-Impedance-Contrast Boundary Upon Multi-Modal Seismic Surface Wave Data, Prajwol Tamrakar Dec 2011

Effects Of High-Impedance-Contrast Boundary Upon Multi-Modal Seismic Surface Wave Data, Prajwol Tamrakar

UNLV Theses, Dissertations, Professional Papers, and Capstones

Synthetic studies and analyses of an experimental dataset were conducted to address the use of Rayleigh-type surface waves for estimation of shear wave velocity (VS) profiles of shallow bedrock sites. The shallow bedrock presents a high impedance contrast boundary which causes surface wave energy to be partitioned to higher modes. Idealized studies of hypothetical datasets and root-mean-squared calculations of error surfaces showed that if reliable dispersion data are available over a broad frequency spectrum, the VS profile can be recovered using the fundamental mode alone. However, when dispersion data are limited to a relatively narrow frequency band representing what might …


Electrochemistry Of Pani/Metal Composites In Basic Solutions, Tamthinhan Quy Dec 2011

Electrochemistry Of Pani/Metal Composites In Basic Solutions, Tamthinhan Quy

UNLV Theses, Dissertations, Professional Papers, and Capstones

Polyaniline (PANI) has been extensively investigated due to its unique conductivity, which is primarily dependent on the oxidation state of the material and the solution pH. PANI is an insulator when it is oxidized, and the solution pH exceeds four. Numerous attempts to extend PANI's conductivity to neutral and alkaline environments have been unsuccessful. However, our previous study has demonstrated that PANI/Pd composite is conductive and catalytically active in a basic solution, pH ∼ 12. Therefore, the conductivity and the electrochemical properties of PANI composites including PANI/Au, PANI/Pd and PANI/Pt were evaluated in basic solutions. The fundamental studies of PANI/metal …


Paired Positive Carbonate Carbon Isotope, Organic Carbon Isotope, And Oxygen Isotope Composition Study Across The Lower Mississippian Positive Carbon Isotope Excursion, Southeastern Nevada, Usa, Robert Alan Henry Dec 2011

Paired Positive Carbonate Carbon Isotope, Organic Carbon Isotope, And Oxygen Isotope Composition Study Across The Lower Mississippian Positive Carbon Isotope Excursion, Southeastern Nevada, Usa, Robert Alan Henry

UNLV Theses, Dissertations, Professional Papers, and Capstones

A prominent positive carbonate carbon isotope (delta13Ccarb) excursion of Early Mississippian age (ca 351 Ma) has been documented by previous studies from numerous sites globally. This delta13Ccarb excursion has been interpreted as resulting from enhanced organic carbon burial that removed 13C-depleted carbon from the ocean and atmosphere. Anticipated outcomes from enhanced organic carbon burial would include a similar positive excursion in organic carbon isotopes (delta13Corg) and a global cooling event resulting from reduced CO2 in the atmosphere and ocean. These predictions, however, were not tested sufficiently in previous studies. This research has tested these predictions through an integrated study of …


Microstructural Characterization Of Kinked Germanate Olivine Grains, Alex Gregory Drue Dec 2011

Microstructural Characterization Of Kinked Germanate Olivine Grains, Alex Gregory Drue

UNLV Theses, Dissertations, Professional Papers, and Capstones

Olivine is the most common and the weakest mineral in the upper mantle. Thus the strength of olivine controls the rheology of the earth's upper mantle. The rheology of olivine in the upper mantle has important implications for mantle flow, mountain building, and rates of isostatic adjustment. Recent experimental measurements of the flow strength of deformed olivine polycrystals have assumed a homogeneous state of stress. X-ray synchrotron diffraction experiments have implied that this assumption is not always valid. Elastic Plastic Self Consistent (EPSC) modeling offers an approach to estimating the flow strength of olivine that does not assume a homogeneous …


Consolidated Study On Query Expansion, Abhishek Biruduraju Dec 2011

Consolidated Study On Query Expansion, Abhishek Biruduraju

UNLV Theses, Dissertations, Professional Papers, and Capstones

A typical day of million web users all over the world starts with a simple query. The quest for information on a particular topic drives them to search for it, and in the pursuit of their info the terms they supply for queries varies from person to person depending on the knowledge they have. With a vast collection of documents available on the web universe it is the onus of the retrieval system to return only those documents that are relevant and satisfy the user’s search requirements. The document mismatch problem is resolved by appending extra query terms to the …


Sensing And Transmission Strategies In Wireless Cognitive Radio Systems, Babak Abbasi Bastami Dec 2011

Sensing And Transmission Strategies In Wireless Cognitive Radio Systems, Babak Abbasi Bastami

UNLV Theses, Dissertations, Professional Papers, and Capstones

The main challenge in any cognitive radio system is to maximize secondary users throughput while limiting interference imposed on licensed users. In this regard, finding the optimal sensing and transmission timing strategies and accurate sensing techniques are of great importance in a cognitive radio network.

In this thesis, we study a sensing-transmission scheme for secondary user in a cognitive radio system where the secondary user senses every primary channel independently and transmits a signal for a fixed duration if it finds the channel empty and stays idle for another fixed duration if it senses the channel busy. We obtain optimal …


Place, Purpose, And Practice: A Case Study Examining Rural Teachers’ Sense Of Community And Its Impact In The Classroom, Faith Beyer Hansen Dec 2011

Place, Purpose, And Practice: A Case Study Examining Rural Teachers’ Sense Of Community And Its Impact In The Classroom, Faith Beyer Hansen

Boise State University Theses and Dissertations

In an era in which education policy directs schools towards economic outcomes and away from local and/or community goals, this research is rooted in the notion that place matters (Howley & Howley, 1995). More specifically, this study examines what impact a rural teacher’s sense of community has on her experiencing both the broader community, the community of her individual classroom, and on her practice.

This collective case study followed six teachers in one rural middle school in the mountain west. Participants were nominated using a Sense of Community Index (SCI-2) and fell into the following categories: teachers with a low, …


Effects Of Grain Boundary Character On Dynamic Recrystallization Using A Modified Monte Carlo Method, Michael B. Morse Dec 2011

Effects Of Grain Boundary Character On Dynamic Recrystallization Using A Modified Monte Carlo Method, Michael B. Morse

Boise State University Theses and Dissertations

Dynamic recrystallization (DRX) is the recrystallization that occurs during high temperature deformation of metals and alloys. While DRX has been observed experimentally, the parameters that affect the microstructure are still being explored. For example, the effects of temperature, strain rate, and initial grain size have already been studied, yet the effect of initial special boundary fraction is still unknown. Special boundaries are high-angle, low-energy grain boundaries. It is believed that higher initial fractions of special boundaries will lead to a delay in the onset of recrystallization and a higher peak stress.

Experimentation has shown that triple junctions are preferred nucleation …


Matlab/Simulink Implementation And Analysis Of Three Pulse-Width-Modulation (Pwm) Techniques, Phuong Hue Tran Dec 2011

Matlab/Simulink Implementation And Analysis Of Three Pulse-Width-Modulation (Pwm) Techniques, Phuong Hue Tran

Boise State University Theses and Dissertations

With advances in solid-state power electronic devices and microprocessors, various pulse-width-modulation (PWM) techniques have been developed for industrial applications. For example, PWM-based three-phase voltage source inverters (VSI) convert DC power to AC power with variable voltage magnitude and variable frequency.

This thesis discusses the advantages and drawbacks of three different PWM techniques: the sinusoidalPWM(SPWM) technique, the third-harmonic-injection PWM(THIPWM) technique, and the space-vector PWM (SVPWM) technique. These three methods are compared by discussing their ease of implementation and by analyzing the output harmonic spectra of various output voltages (poles voltages, line-to-neutral voltages, and line-to-line voltages) and their total harmonic distortion (THD). …


Historic Calculator Project, Will Harris, Dan Marioni, Kevin Webb, Chad Williams Dec 2011

Historic Calculator Project, Will Harris, Dan Marioni, Kevin Webb, Chad Williams

Mechanical Engineering

The Deutsches Museum of Munich, Germany requested add-on components to their mechanical calculator exhibit. The end-goal is to produce an interactive 3D model in software to demonstrate the functions of the Braun-Vayringe Machine (BVM). There will be four students working on this project at California Polytechnic State University, San Luis Obispo: two mechanical engineers (Dan Marioni and Will Harris) and two computer engineers (Chad Williams and Kevin Webb).This project involves the coordination of three facilities; the Deutsches Museum, and the Mechanical and Computer Science Departments of Cal Poly. The name of the project is known as the Historic Calculator Project …


Current Status And Long-Term Trends In Water Quality And Living Resources In The Virginia Tributaries And Chesapeake Bay Mainstem From 1985 Through 2010, Daniel M. Dauer, Harold G. Marshall, John R. Donat, Michael F. Lane, Suzanne C. Doughten, Frederick A. Hoffman, Raghavendra Kurada Dec 2011

Current Status And Long-Term Trends In Water Quality And Living Resources In The Virginia Tributaries And Chesapeake Bay Mainstem From 1985 Through 2010, Daniel M. Dauer, Harold G. Marshall, John R. Donat, Michael F. Lane, Suzanne C. Doughten, Frederick A. Hoffman, Raghavendra Kurada

Status and Trends for Virginia Chesapeake Bay

The period prior to the implementation of the Chesapeake Bay Monitoring Program was characterized by a marked decline in the water quality of the Chesapeake Bay. The disappearance of submerged aquatic vegetation in certain regions of the Bay, declines in the abundance of some commercially and recreationally important species, increases in the incidence of low dissolved oxygen events, changes in the Bay's food web, and other ecological problems have been related to the deteriorating water quality (e.g. USEPA, 1982,1983;Officer et al.,1984; Orth and Moore, 1984). The results of concentrated research efforts in the late 1970s and early 1980s stimulated the …


Preliminary Evaluations Of Secondary Productivity Estimates As Indicators Of The Ecological Value Of The Benthos To Higher Trophic Levels In Chesapeake Bay, Daniel M. Dauer, Michael F. Lane, Roberto J. Llansó, Robert Diaz Dec 2011

Preliminary Evaluations Of Secondary Productivity Estimates As Indicators Of The Ecological Value Of The Benthos To Higher Trophic Levels In Chesapeake Bay, Daniel M. Dauer, Michael F. Lane, Roberto J. Llansó, Robert Diaz

Benthic Applications

The primary objective of this project was to develop an analytical tool that management could use to assess the ecological value of the benthos for higher trophic levels. Ideally any tool developed should be simple to implement, adaptable to both fixed and probability monitoring programs and applicable across multiple spatial and temporal scales. Direct evaluations of secondary productivity involve time-consuming cohort or size-based methods that require multiple measurements of the populations in question over time (Dolbeth et al., 2005; Cusson and Bourget, 2005). However, empirical regression models have been developed that provide reasonable alternatives to these techniques when direct measurements …


Integrating Physical Activity Data Technologies Into Elementary School Classrooms, Victor R. Lee, Jonathan M. Thomas Dec 2011

Integrating Physical Activity Data Technologies Into Elementary School Classrooms, Victor R. Lee, Jonathan M. Thomas

Instructional Technology and Learning Sciences Faculty Publications

This paper describes an iteration of a design-based research project that involved integrating commercial physical activity data (PAD) sensors, such as heart rate monitors and pedometers, as technologies that could be used in two fifth-grade classrooms. Design-based research involves the development, implementation and study of new learning interventions in real-world contexts with the goal of elaborating principles or guidelines relevant to the design of new technologies and learning experiences. The current project involved the implementation of PAD technology-supported learning activities in two fifth-grade classrooms where students pursued investigations related to the distances that they walk, the relationship between heights and …


Human Health And The Environment Can't Wait For Reform: Current Opportunities For The Federal Government And States To Address Chemical Risks Under The Toxic Substances Control Act, Lauren Trevisan Dec 2011

Human Health And The Environment Can't Wait For Reform: Current Opportunities For The Federal Government And States To Address Chemical Risks Under The Toxic Substances Control Act, Lauren Trevisan

American University Law Review

Expressing its concern about growing rates of cancer and other diseases, coupled with the lack of data about the effect of the thousands of chemicals used in U.S. society, in 1976 Congress enacted the Toxic Substances Control Act (TSCA). Congress intended for TSCA to shed new light on chemical risks and provide the U.S. Environmental Protection Agency (EPA) with a set of tools to address those risks and protect human health and the environment. In the years since TSCA’s passage, the procedural hurdles and the difficult-to-meet legal standards built into the statute, along with a court decision rejecting EPA’s use …


Development Of A State Of The Art Traffic Microsimulation Model For Nebraska, Justice Appiah, Bhaven Naik, Laurence Rilett, Yifeng Chen, Seung-Jun Kim Dec 2011

Development Of A State Of The Art Traffic Microsimulation Model For Nebraska, Justice Appiah, Bhaven Naik, Laurence Rilett, Yifeng Chen, Seung-Jun Kim

Nebraska Department of Transportation: Research Reports

No abstract provided.


School Leaders' Effect On Technology, Irene Amos Causey Dec 2011

School Leaders' Effect On Technology, Irene Amos Causey

Dissertations

Because of increasing heavy investments in technology during an era of accountability within K-12 public schools, school leaders are expected to be flexible and innovative in order to produce the most effective and efficient use of technology. School leaders in this research study included principals, assistant principals, and technology coordinators from intercoastal elementary, middle, and high public schools in South Mississippi. This causal comparative study examined whether or not a correlation existed among school leaders’ attitude toward technology use and years of technology training, confidence and comfort using technology and school accreditation level, school leaders’ preparation for technology use and …


Performance Analysis And Fitness Of Gpgpu And Multicore Architectures For Scientific Applications, Mohammad Bhuiyan Dec 2011

Performance Analysis And Fitness Of Gpgpu And Multicore Architectures For Scientific Applications, Mohammad Bhuiyan

All Dissertations

Recent trends in computing architecture development have focused on exploiting task- and data-level parallelism from applications. Major hardware vendors are experimenting with novel parallel architectures, such as the Many Integrated Core (MIC) from Intel that integrates 50 or more x86 processors on a single chip, the Accelerated Processing Unit from AMD that integrates a multicore x86 processor with a graphical processing unit (GPU), and many other initiatives from other hardware vendors that are underway.
Therefore, various types of architectures are available to developers for accelerating an application. A performance model that predicts the suitability of the architecture for accelerating an …


The Update, December 2011, University Of Northern Iowa. College Of Humanities, Arts And Sciences. Dec 2011

The Update, December 2011, University Of Northern Iowa. College Of Humanities, Arts And Sciences.

Update

Inside this issue:

-- Two UNI Alums to Graduate with Doctoral Degrees
-- Department News
-- UNI Department of Theatre: Guernica Re-Cap
-- Art High School Scholarship Day
-- Faculty member Awarded Fellowship
-- School of Music Events
-- Student Spotlight: Department of Art: Erlinda Babauta
-- Military Veteran and UNI Alumnus Joins the Center for Teaching and Learning Mathematics
-- UNI Geology Students Explore Heavy Metal: Learning How to Rock!
-- Modern Motives: Influences in Today's Art
-- New U.S.-Brazil Program in Communication Disorders
-- Student Spotlight: Department of Math: Nathan Bradfield


A Framework For Developing And Integrating Effective Routing Strategies Within The Emergency Decision Support System, Joseph W. Yu Dec 2011

A Framework For Developing And Integrating Effective Routing Strategies Within The Emergency Decision Support System, Joseph W. Yu

Master's Theses

In recent years transportation professionals have shown increasing interest in evacuation planning. With the advances in computing technologies it is possible to simulate urban transportation networks with great detail. These details from the traffic simulation model can be used for devising strategies for evacuation and emergency response in case of a disaster.

This thesis describes the modeling, calibration, and validation of the VISSIM traffic simulation model coded for downtown San Jose. The network is then used to test various evacuation scenarios to assess evacuation strategies that would be effective in case of a human-caused disaster.

The network modeled in the …


Digitally-Controlled Deep Brain Stimulation Lead Implant System, Matthew Joseph Phillips Dec 2011

Digitally-Controlled Deep Brain Stimulation Lead Implant System, Matthew Joseph Phillips

Master's Theses

Deep brain stimulation, the treatment of disorders by applying electrical stimulation to brain tissue, is a relatively new field of medicine with great potential to provide cures for neurological disorders. It utilizes a system very similar to a cardiac pacemaker and lead to electrically stimulate brain tissue. This electrical stimulation is programmed to disrupt or mask aberrant brain signals while not impeding the normal function of the brain. The advances in implantable pulse generators designed for deep brain stimulation have been remarkable, and the applications for deep brain stimulation continue to grow including multiple sclerosis (Berk, et al. 2002), severe …


Analysis Of Volatile Organic Compounds In Virgin Coconut Oil And Their Sensory Attibutes, Fabian M. Dayrit, Jaclyn Elizabeth R. Santos, Bianca J. Villarino, Anthony R. Zosa Dec 2011

Analysis Of Volatile Organic Compounds In Virgin Coconut Oil And Their Sensory Attibutes, Fabian M. Dayrit, Jaclyn Elizabeth R. Santos, Bianca J. Villarino, Anthony R. Zosa

Chemistry Faculty Publications

The volatile compounds in the headspace of twenty-four commercial virgin coconut oil (VCO) samples prepared by different methods (i.e. expeller, centrifugation, and fermentation with and without heat) were analyzed by solid phase microextraction-gas chromatography mass spectrometry (SPME-GCMS). The following volatile organic compounds (VOCs) were identified: ethyl acetate, acetic acid, 2-pentanone, hexanal, n-octane, 2-heptanone, limonene, nonanal, octanoic acid, ethyl octanoate, δ-octalactone, ethyl decanoate, δ-decalactone, and dodecanoic acid. Fermentation-produced samples were found to have higher levels of acetic acid and free fatty acids in the headspace compared to VCO produced using the centrifuge and expeller methods. Descriptive sensory analysis of the VCO …


Opacity Of P(Mma-Maa)-Pmma Composite Latex System With Varying Maa Concentration, Gilbert U. Yu, Jerry T. Dy, Erwin P. Enriquez Dec 2011

Opacity Of P(Mma-Maa)-Pmma Composite Latex System With Varying Maa Concentration, Gilbert U. Yu, Jerry T. Dy, Erwin P. Enriquez

Chemistry Faculty Publications

Polymer composites of core-shell morphology are commonly used in the paint industry as opacity enhancer. These are usually made of block copolymer systems wherein the core is formed from a polymer that swells in the presence of a solvent and surrounded by a high glass transition polymeric shell. Thus, upon drying, the swollen regions turn into voids while leaving a hard shell. Here, composites based on poly(methyl methacrylate-butyl acrylate) [P(MMA-BuA)] (seed stage), poly(methyl methacrylate-methacrylic acid) [P(MMA-MAA)] (second stage), and poly(methyl methacrylate) [PMMA] (third stage) were synthesized through a multistage sequential emulsion polymerization and their opacity was investigated. The second stage …


Identifying Polyglutamine Protein Species In Situ That Best Predict Neurodegeneration, Jason Miller, Montserrat Arrasate, Elizabeth Brooks, Clare Peter Libeu, Justin Legleiter, Danny Hatters, Jessica Curtis, Kenneth Cheung, Preethi Krishnan, Siddhartha Mitra, Kartika Widjaja, Benjamin A. Shaby, Gregor P. Lotz, Yvonne Newhouse, Emily M. Sontag, Alex Osmand, Michelle Gray, Vanitha Thulasiramin, Frederic Saudou, Mark Segal, X William Yang, Eliezer Masliah, Leslie M. Thompson, Paul J. Muchowski, Karl H. Weisgraber, Steven Finkbeiner Dec 2011

Identifying Polyglutamine Protein Species In Situ That Best Predict Neurodegeneration, Jason Miller, Montserrat Arrasate, Elizabeth Brooks, Clare Peter Libeu, Justin Legleiter, Danny Hatters, Jessica Curtis, Kenneth Cheung, Preethi Krishnan, Siddhartha Mitra, Kartika Widjaja, Benjamin A. Shaby, Gregor P. Lotz, Yvonne Newhouse, Emily M. Sontag, Alex Osmand, Michelle Gray, Vanitha Thulasiramin, Frederic Saudou, Mark Segal, X William Yang, Eliezer Masliah, Leslie M. Thompson, Paul J. Muchowski, Karl H. Weisgraber, Steven Finkbeiner

Biological Sciences Faculty Research and Publications

Polyglutamine (polyQ) stretches exceeding a threshold length confer a toxic function to proteins that contain them and cause at least nine neurological disorders. The basis for this toxicity threshold is unclear. Although polyQ expansions render proteins prone to aggregate into inclusion bodies, this may be a neuronal coping response to more toxic forms of polyQ. The exact structure of these more toxic forms is unknown. Here we show that the monoclonal antibody 3B5H10 recognizes a species of polyQ protein in situ that strongly predicts neuronal death. The epitope selectively appears among some of the many low-molecular-weight conformational states assumed by …


Majority-Minority Voting Rights: Is Cumulative Voting A Valid Remedy For Violations Of The Voting Rights Act Or An Impermissible Tactic To Advance Racial Politics., Erica Lynne Mirehouse Dec 2011

Majority-Minority Voting Rights: Is Cumulative Voting A Valid Remedy For Violations Of The Voting Rights Act Or An Impermissible Tactic To Advance Racial Politics., Erica Lynne Mirehouse

The Scholar: St. Mary's Law Review on Race and Social Justice

Abstract Forthcoming.