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Unilateral Thalamic Infarction Presenting As Vertical Gaze Palsy: A Case Report, Muhib Khan, Christos Sidiropoulos, Panayiotis Mitsias

Wayne State University Associated BioMed Central Scholarship

Abstract

Introduction

Vertical gaze palsy is a recognized manifestation of midbrain lesions. It rarely is a consequence of unilateral thalamic infarction.

Case presentation

We report the case of a 48-year-old African-American woman who presented to our facility with vertical gaze palsy and evidence of left medial thalamic infarct on diffusion-weighted imaging without coexisting midbrain ischemia. The etiology of infarct was determined to be small vessel disease after extensive investigation.

Conclusions

This report suggests a possible role of the thalamus as a vertical gaze control center. Clinicoradiological studies are needed to further define the role of the thalamus in vertical gaze …

Lack Of An Association Of Mir-938 Snp In Iddm10 With Human Type 1 Diabetes, Xiaofan Mi, Hongzhi He, Yangxin Deng, Abert M. Levin, Jin-Xiong She, Qing-Sheng Mi, Li Zhou

Wayne State University Associated BioMed Central Scholarship

Abstract

MicroRNAs (miRNAs) are a newly discovered type of small non-protein coding RNA that function in the inhibition of effective mRNA translation, and may serve as susceptibility genes for various disease developments. The SNP rs12416605, located in human type 1 diabetes IDDM10 locus, changes the seeding sequence (UGU[G/A]CCC) of miRNA miR-938 and potentially alters miR-938 targets, including IL-16 and IL-17A. In an attempt to test whether miR-938 may be a susceptibility gene for IDDM10, we assessed the possible association of the miR-938 SNP with T1D in an American Caucasian cohort of 622 patients and 723 healthy controls by TaqMan assay. …

Inhibition Of Cathepsin B Activity Attenuates Extracellular Matrix Degradation And Inflammatory Breast Cancer Invasion, Bernadette C. Victor, Arulselvi Anbalagan, Mona M. Mohamed, Bonnie F. Sloane, Dora Cavallo-Medved

Wayne State University Associated BioMed Central Scholarship

Abstract

Introduction

Inflammatory breast cancer (IBC) is an aggressive, metastatic and highly angiogenic form of locally advanced breast cancer with a relatively poor three-year survival rate. Breast cancer invasion has been linked to proteolytic activity at the tumor cell surface. Here we explored a role for active cathepsin B on the cell surface in the invasiveness of IBC.

Methods

We examined expression of the cysteine protease cathepsin B and the serine protease urokinase plasminogen activator (uPA), its receptor uPAR and caveolin-1 in two IBC cell lines: SUM149 and SUM190. We utilized a live cell proteolysis assay to localize in real …

Brain Candy: Wayne State University School Of Medicine Journal Of Art And Literature, 3rd Edition, Wayne State University School Of Medicine Writing Workshop, Wayne State University School Of Medicine Gold Humanism Honor Society

Gold Humanism Honor Society

Brain Candy collects poetry, nonfiction essays, short fiction, photographs, and drawings to shed light on the creative process in medicine, the city of Detroit, and the experiences of health care providers. Features submissions from the School of Medicine (including the Writing Workshop), the WSU Department of English, and the WSU Department of Fine Arts. It also reintroduces the creative efforts of Detroit’s "Future Docs," children ages 6 through 12 with a curiosity for the field of medicine.

The Potential Role Of Innate Immunity In The Pathogenesis Of Post-Operative Adhesions, Jennell White

Wayne State University Dissertations

Post-operative adhesion development occurs in the vast majority of patients following abdominal surgery and is a natural occurrence of peritoneal-wound healing. These fibrous bands may form within the first 5-7 days post-surgery and have the ability to cause a distortion in the normal anatomical positioning of abdominal organs. Consequently, adhesions are major contributors to small bowel obstruction, infertility, and severe pelvic and abdominal pain. Physiological processes responsible for adhesion formation remain obscure though it is believed to involve cell migration, proliferation, and differentiation of several cell types including mesothelial cells, fibroblasts, and inflammatory and immune cells. Substances released from these …

Intellectual Property, Innovation, And The Future: Toward A Better Model For Educating Leaders In Intellectual Property Law, Robert W. Gomulkiewicz

SMU Law Review

No abstract provided.

Achieving Real Development Impact Among Pastoralists: Lessons From Ethiopia, D. Layne Coppock

Environment and Society Faculty Publications

No abstract provided.

Linkages To Public Land Framework: Toward Embedding Humans In Ecosystem Analyses By Using “Inside-Out Social Assessment", Joanna Endter-Wada, D. J. Blahna

Environment and Society Faculty Publications

This article presents the ‘‘Linkages to Public Land’’ (LPL) Framework, a general but comprehensive data-gathering and analysis approach aimed at informing citizen and agency decision making about the social environment of public land. This social assessment and planning approach identifies and categorizes various types of linkages that people have to public land and guides the tasks of finding and using information on people in those linkages. Linkages are defined as the ‘‘coupling mechanisms’’ that explain how and why humans interact with ecosystems, while linkage analyses are empirical investigations contextualized both temporally and geographically. The conceptual, legal, and theoretical underpinnings of …

Defining International Law Librarianship In An Age Of Multiplicity, Knowledge, And Open Access To Law, Richard A. Danner

Faculty Scholarship

Many law librarians are experts in international law and legal research. The concept of ‘international law librarianship’, however, encompasses something more than a field of study in which a group of experts practise their profession. In the broader sense, the idea suggests a common calling, similar interests, and goals shared by librarians with a range of specialties beyond international law, working in all types of law libraries. What commonalities create and sustain the concept of international law librarianship? This paper suggests that they can be found in: law librarians’ common need to respond to the ‘multiplicity’ of information sources facing …

Lessons From The Financial Crisis: Report Of The Asian Financial Regulatory Committee, Jeremy Choo Yong Goh, Sri Adiningsih, Maria S. Gochoco-Bautista

Research Collection Lee Kong Chian School Of Business

No abstract provided.

Autonomy In The Workplace: An Essential Ingredient To Employee Engagement And Well-Being In Every Culture, Marylène Gagne, Devasheesh P. Bhave

Research Collection Lee Kong Chian School Of Business

The nature of organizational life requires questioning the role of worker autonomy. An impressive amount of management research has been devoted to autonomy issues in organizations. Autonomy is at the forefront of research on job design and the management of employees. Therefore, we review evidence in the area of job design and management practices that deeply affect worker autonomy. Throughout this discussion, we evaluate the cross-cultural applicability of research and practice and offer future directions based on self-determination theory.

The Impact Of Underemployment On Individual And Organizational Performance, Michael Ramsay Bashshur, Ana Hernández, José María Peiró

Research Collection Lee Kong Chian School Of Business

The issue of underemployment is one of increasing concern for countries across the globe. For example, in the USA estimates have put the number of underemployed as high as 20.3%, while in Europe the number of overqualified workers (just one dimension of underemployment) has been estimated at 21.5% (Groot & Maassen van den Brink, 2000). Unfortunately, given the current global economic crisis, this situation can only be expected to worsen in the near future. The international labor pool is becoming more educated and qualified (Peiró, Agut, & Grau, 2010) while organizations worldwide are seeking the minimum effective level of human …

Overuse Of Antibiotics In Children For Upper Respiratory Infections (Uris): A Dilemma, Malika Taufiq, Rukhsana Wamiq Zuberi

Department for Educational Development

No abstract provided.

Consultation Etiquette In General Practice: A Qualitative Study Of What Makes It Different For Lay Cancer Caregivers, Geoffry K. Mitchell, Moyez Jiwa, Afaf Girgis

Medical Papers and Journal Articles

Background: It is commonplace for lay caregivers to overlook their own health concerns when supporting someone with advanced cancer. During this time, caregivers’ needs as patients are often marginalised by health professionals, including General Practitioners (GPs), who may miss the breadth of caregivers’ needs by focusing on the practicalities of caregiving. GPs traditionally rely on patients to raise their concerns, and then respond to these concerns, but caregivers as patients may be disinclined to cue their GP. The norms of engagement when caregivers consult their GP are less defined, and how they interact with their GP regarding their own health …

Opposing Actions Of Extracellular Signal-Regulated Kinase (Erk) And Signal Transducer And Activator Of Transcription 3 (Stat3) In Regulating Microtubule Stabilization During Cardiac Hypertrophy, D Ng, I Ng, B Badrian, T Tsoutsman, J Mcmullen, C Semsarian, M Bogoyevitch

Medical Papers and Journal Articles

Excessive proliferation and stabilization of the microtubule (MT) array in cardiac myocytes can accompany pathological cardiac hypertrophy, but the molecular control of these changes remains poorly characterized. In this study, we examined MT stabilization in two independent murine models of heart failure and revealed increases in the levels of post-translationally modified stable MTs, which were closely associated with STAT3 activation. To explore the molecular signaling events contributing to control of the cardiac MT network, we stimulated cardiac myocytes with an a-adrenergic agonist phenylephrine (PE), and observed increased tubulin content without changes in detyrosinated (glutubulin) stable MT’s. In contrast, the hypertrophic …

Do Individual Differences In Perceiving Situational Demands Moderate The Relationship Between Personality And Assessment Center Dimension Ratings?, Anne Jansen, Filip Lievens, Martin Kleinmann

Research Collection Lee Kong Chian School Of Business

This study contributes to research on assessment centers' (AC) external construct-related validity by investigating a potential moderator of the relationship between personality and AC dimension ratings. On the basis of recent insights in person-situation contingencies we hypothesized that individual differences in people's perception of situational demands moderate the relationship between personality and conceptually related AC dimension ratings. The hypotheses were tested with 108 individuals in two leaderless group discussion exercises. Results confirmed the hypotheses for two of the three traits (i.e., Agreeableness and Conscientiousness). In particular, people high on these traits who identified the situational demands received higher AC dimension …

State Of The Fisheries And Aquatic Resources Report 2010/11, W.J Fletcher, K. Santoro

Status Reports of the Fisheries and Aquatic Resources

This is the second edition of the newly named State of the Fisheries and Aquatic Resources Report. Each year this report provides the public with an update on the status of all the fish and fisheries resources of Western Australia that are managed by the Department. The report outlines the current risk status for the ecological resources (assets) within each of WA‘s six Bioregions by taking a bioregional, Ecosystem-Based Fisheries Management (EBFM) approach.

Lifestyle And Demographic Correlates Of Poor Mental Health In Early Adolescence, Monique Robinson, Garth Kendall, Peter Jacoby, Beth P. Hands, Lawrence Beilin, Sven Silburn, Steve Zubrick, Wendy Oddy

Health Sciences Papers and Journal Articles

Aim: To determine the constellation of lifestyle and demographic factors that are associated with poor mental health in an adolescent population.

Methods: The Raine Study 14-year follow-up involved primary care givers and their adolescent children (n = 1860). The Child Behaviour Checklist (CBCL) was used to assess adolescent mental health. We examined diet, socio-demographic data, family functioning, physical activity, screen use and risk-taking behaviours with mental health outcomes using linear regression.

Results: Adolescents with higher intakes of meat and meat alternatives and ‘extras’ foods had poorer mental health status. Adverse socioeconomic conditions, higher hours of screen use and ever partaking …

Visualizing The Role Of Cbl-B In Control Of Islet-Reactive Cd4 T Cells And Susceptibility To Type 1 Diabetes, Gerard F. Hoyne, Eleanor Flening, Mehmet Yabas, Charis Teh, John A. Altin, Katrina Randall, Christine B F Thien, Wallace Y. Langdon, Christopher C. Goodnow

Health Sciences Papers and Journal Articles

The E3 ubiquitin ligase Cbl-b regulates T cell activation thresholds and has been associated with protecting against Type 1 diabetes, but its in vivo role in the process of self-tolerance has not been examined at the level of potentially auto-aggressive CD4+ T cells. Here we visualize the consequences of Cbl-b deficiency on self-tolerance to lysozyme antigen expressed in transgenic mice under control of the insulin promoter (insHEL). By tracing the fate of pancreatic islet-reactive CD4+ T cells in pre-diabetic 3A9-TCR x insHEL double-transgenic mice, we find that Cbl-b deficiency contrasts with AIRE or IL-2 deficiency because it does not affect …

Phylogeographic Structure Of Teretrius Nigrescens (Coleoptera: Histeridae) Predator Of The Invasive Post Harvest Pest Prostephanus Truncatus (Coleoptera: Bostrichidae)., B. A. Omondi, J. Van Den Berg, D. Masiga, F. Schulthess

All Peer-Reviewed Publications

The invasive larger grain borer Prostephanus truncatus (Horn) is the most important pest of farm-stored maize in Africa. It was introduced into the continent from Mesoamerica in the late 1970s and by 2008 had spread to at least 18 countries. Classical biological control using two populations of the predator Teretrius nigrescens Lewis achieved long-term and cost effective control in warm-humid areas, but not in cool and hot-dry zones. The present study investigated the phylogenetic relationships between geographical populations of the predator. Ten populations of T. nigrescens were studied using randomly amplified polymorphic DNA polymerase chain reaction (RAPD-PCR), sequence analysis of …

Flexible Use Of Anti-Predator Defences, Ximena J. Nelson, Robert R. Jackson

All Peer-Reviewed Publications

Belonging to a size category that makes them vulnerable to a wide variety of predators, spiders have evolved a bewildering array of anti-predator adaptations, which can be clustered under two broad categories, primary and secondary defence. Primary defences are ploys by which the spider avoids provoking pursuit by, and interaction with, the predator. Camouflage and masquerade are especially common examples. Secondary defences come into play once an interaction with a predator is under way, and these are the defences that have been most thoroughly studied. However, elements of anti-predator defence may often be integrated into other aspects of the spider's …

Parasitism Of Lepidopterous Stem Borers In Cultivated And Natural Habitats, Duna Madu Mailafiya, Bruno Pierre Le Ru, Eunice Waitherero Kairu, Stéphane Dupas, Paul-André Calatayud

All Peer-Reviewed Publications

Plant infestation, stem borer density, parasitism, and parasitoid abundance were assessed during two years in two host plants, Zea mays (L.) (Cyperales: Poaceae) and Sorghum bicolor (L.) (Cyperales: Poaceae), in cultivated habitats. The four major host plants (Cyperus spp., Panicum spp., Pennisetum spp., and Sorghum spp.) found in natural habitats were also assessed, and both the cultivated and natural habitat species occurred in four agroecological zones in Kenya. Across habitats, plant infestation (23.2%), stem borer density (2.2 per plant), and larval parasitism (15.0%) were highest in maize in cultivated habitats. Pupal parasitism was not higher than 4.7% in both habitats, …

Probing The Mechanical Properties Of Tnf-A Stimulated Endothelial Cell With Atomic Force Microscopy, Sei-Young Lee, Ana-Maria Zaske, Tommaso Novellino, Delia Danila, Mauro Ferrari, Jodie Conyers, Paolo Decuzzi

Faculty, Staff and Student Publications

TNF-α (tumor necrosis factor-α) is a potent pro-inflammatory cytokine that regulates the permeability of blood and lymphatic vessels. The plasma concentration of TNF-α is elevated (> 1 pg/mL) in several pathologies, including rheumatoid arthritis, atherosclerosis, cancer, pre-eclampsia; in obese individuals; and in trauma patients. To test whether circulating TNF-α could induce similar alterations in different districts along the vascular system, three endothelial cell lines, namely HUVEC, HPMEC, and HCAEC, were characterized in terms of 1) mechanical properties, employing atomic force microscopy; 2) cytoskeletal organization, through fluorescence microscopy; and 3) membrane overexpression of adhesion molecules, employing ELISA and immunostaining. Upon stimulation …

Re: Sleep And The Family Doctor: Time To Lead, D. Bluestein, A. C. Healey, C. M. Rutledge

Ellmer School of Nursing Faculty Publications

No abstract provided.

Educating Advanced Practice Nurses In Using Social Media In Rural Health Care, Carolyn M. Rutledge, Michelle Renaud, Laurel Shephard, Michele Bordelon, Tina Haney, Donna Gregory, Paula Ayers

Ellmer School of Nursing Faculty Publications

Health care in the United States is facing a crisis in providing access to quality care for those in underserved and rural regions. Advanced practice nurses are at the forefront of addressing such issues, through modalities such as health care technology. Many nursing education programs are seeking strategies for better educating students on technology utilization. Health care technology includes electronic health records, telemedicine, and clinical decision support systems. However, little focus has been placed on the role of social media in health care. This paper describes an educational workshop using standardized patients and hands-on experiences to introduce advanced practice nurses …

Educating Advanced Practice Nurses In Using Social Media In Rural Health Care, Carolyn M. Rutledge, Michelle Renaud, Laurel Shepherd, Michele Bordelon, Tina Haney, Donna Gregory, Paula Ayers

Ellmer School of Nursing Faculty Publications

Health care in the United States is facing a crisis in providing access to quality care for those in underserved and rural regions. Advanced practice nurses are at the forefront of addressing such issues, through modalities such as health care technology. Many nursing education programs are seeking strategies for better educating students on technology utilization. Health care technology includes electronic health records, telemedicine, and clinical decision support systems. However, little focus has been placed on the role of social media in health care. This paper describes an educational workshop using standardized patients and hands-on experiences to introduce advanced practice nurses …

Coping Strategies Of Family Members Of Hospitalized Psychiatric Patients, Phyllis M. Eaton, Bertha L. Davis, Pamela V. Hammond, Esther H. Condon, Zina T. Mcgee

Ellmer School of Nursing Faculty Publications

This exploratory research paper investigated the coping strategies of families of hospitalized psychiatric patients and identified their positive and negative coping strategies. In this paper, the coping strategies of 45 family members were examined using a descriptive, correlational, mixed method research approach. Guided by the Neuman Systems Model and using the Family Crisis Oriented Personal Evaluation Scales and semistructured interviews, this paper found that these family members used more emotion-focused coping strategies than problem-focused coping strategies. The common coping strategies used by family members were communicating with immediate family, acceptance of their situation, passive appraisal, avoidance, and spirituality. The …

Addressing The Fertility Needs Of Hiv-Seropositive Males, Brian A. Levine, Sahadat K. Nurudeen, Jennifer T. Gosselin, Mark V. Sauer

Psychology Faculty Publications

An increasing number of serodiscordant couples are utilizing advanced reproductive technologies to address their reproductive needs. Recent literature has demonstrated that it is not only technically possible but also safe to utilize sperm-washing techniques to allow for the creation of embryos, thereby preventing both horizontal and vertical transmission of HIV. This article addresses the strengths and weakness of various reproductive techniques and discusses our experience at Columbia University (NY, USA), the location of the largest HIV-focused fertility program in the USA.

Editing Sophia Peabody Hawthorne’S Travel Writing And The Conundrum Of Copies, Patricia Dunlavy Valenti

Documentary Editing: Journal of the Association for Documentary Editing (1979–2011)

For Sophia Peabody Hawthorne, living and writing were virtually synonymous. An inveterate letter-writer and journal-keeper, she was among the first American women to document her travels abroad. In December of 1833, Sophia Peabody departed for Cuba; she spent the next eighteen months on a coffee plantation, where her older sister Mary was a governess. In 1853, Sophia Hawthorne left the United States again, this time with her husband, Nathaniel Hawthorne, who assumed the post of United States Consul at Liverpool. During the subsequent seven years, Sophia traveled throughout England and Scotland. She and her daughters, Una and Rose, also journeyed …

The Lion In Winter : Review Of Collected Works Of Ralph Waldo Emerson, Volume Viii: Letters And Social Aims Edited By Ronald A. Bosco, Glen M. Johnson, And Joel Myerson., Richard Deming

Documentary Editing: Journal of the Association for Documentary Editing (1979–2011)

The recent publication by Harvard University Press of Ralph Waldo Emerson’s Letters and Social Aims, Volume VIII of the Collected Works, is in many ways the most important contribution of this ongoing project, which presents scholarly editions of one of America’s most central literary and philosophical figures. Among all of Emerson’s books, Letters and Social Aims is without a doubt the most vexed in terms of textual questions, coming as it did so late in his life and at the dimming of his powers. However, the volume also represents some of the finest, most necessary thinking of this shaper of …