Digital Commons Network^™

Cyclic Elongation And Pull Out Of Unicortical And Bicortical Suture Anchor Designs, Richard Justin Lesley

All ETDs from UAB

CYCLIC ELONGATION AND PULL OUT OF UNICORTICAL AND BICORTICAL SUTURE ANCHOR DESIGNS JUSTIN LESLEY BIOMEDICAL ENGINEERING ABSTRACT A novel suture anchor design was introduced and biomechanically tested. The novel design involved lengthening a standard metal screw type anchor so as to achieve greater fixation in bone. Along with utilizing a greater amount of trabecular bone, this design also allows a second layer of cortical bone to be involved in order to further enhance fixation. This "bicortcal" design is intended to be used under unique clinical circumstances. Such circumstances may include RC repair in patients with extreme osteoporosis, in cases where …

Characterization Of Tbx20 Isoforms And Protein Interactions In Heart Development, Paige Debenedittis

All ETDs from UAB

Proper cardiogenesis is critical for the development of vertebrates. Abnormalities in cardiogenesis can lead to congenital heart defects (CHDs), which occur in approximately 1% of live births. The cardiac transcription factor network contains different transcription factor families which direct the expression of critical cardiac genes. Determining how the cardiac transcription factors are regulated will provide insight in the mechanisms of cardiogenesis and CHDs. The T-box (TBX) transcription factor family is an ancient gene family important for development. Several TBX genes are expressed within the developing heart and play critical roles in differentiation, proliferation, and morphogenesis. One important TBX protein is …

Health Status And Health Behavior As Factors Predicting Online Health Seeking, Timothy Hale

All ETDs from UAB

The purpose of this dissertation is to examine why people use the Internet for health-related purposes and whether this usage is part of larger pattern of health-promoting behaviors, or health lifestyle. Pierre Bourdieu's concept of habitus provides the key theoretical concept that links health lifestyle theory and the digital inequality framework to explain how socioeconomic status and level of Internet access may contribute to status-specific attitudes and behaviors, or lifestyles. Two dependent variables are used to measure online health behavior: (1) online health information seeking, and (2) an index constructed from six types of online health-related activities. Path analysis is …

Determining The Functional Role Of Trem-Like Transcript 2 In The Innate Immune Response, Matthew Martin Halpert

All ETDs from UAB

TLT2 is one of four receptors conserved between mouse and human within the TREM locus, and is expressed on B cells, macrophages, and neutrophils. TLT2 ligation on murine macrophages induces the production of chemokines and growth factors, as evidenced by ex vivo treatment with anti-TLT2 mAbs. This treatment did not lead to the upregulation of activation markers such as CD69 or costimulatory molecules such as CD80 and CD86, indicating a specific response following TLT2 ligation. This is recapitulated in vivo following injection of anti-TLT2 mAbs resulting in the production of chemokines and growth factors, which ultimately lead to enhanced neutrophil …

Dreams Of A Far Away Land: Japanese Immigration To Peru, 1899-1950, Cheyenne Nicole Haney

All ETDs from UAB

The purpose of this research is to address the Japanese immigration to Peru and Japanese cultural traditions within Peru. It is necessary to note the reasons for emigration and effects of the conditions in Peru. Through the use of various sources, I will study the transition of culture and history of the Japanese community in Peru. Diplomatic relations between Japan and Peru began in 1872 after tensions surrounding the Maria Luz incident. It was not until 1899 that the two countries established a formal relationship. The Peruvians viewed the Japanese as a source of cheap labor. Ergo, an immigration policy, …

Ampa Receptor Trafficking In Schizophrenia, John Hammond

All ETDs from UAB

The glutamate hypothesis of schizophrenia is based primarily on NMDA receptor dysfunction. Recent studies have led to an expansion of this hypothesis to include AMPA receptors which are essential for neurotransmission through NMDA receptors. Examination of total AMPA receptor protein expression in schizophrenia has been inconsistent and led to examination of AMPA receptor interacting proteins and trafficking and subcellular localization of the receptors. AMPA receptors are highly trafficked from the endoplasmic reticulum to the synapse and in a complex system of endosomes. Alterations in the subcellular localization of these receptors may be a part of the underlying pathophysiology of schizophrenia. …

Bone Morphogenetic Protein Signaling Pathways During Mouse Heart Development: Roles For Chd7 And Mycn, Cristina Harmelink

All ETDs from UAB

Bone Morphogenetic Protein (BMP) signaling pathways are imperative for proper heart development. BMP ligands bind serine threonine kinase receptors, which activate intracellular receptor-regulated SMAD proteins. SMAD1, SMAD5, and SMAD8 transduce BMP signals from the cytoplasm to the nucleus, where they regulate transcription. We have investigated two aspects of BMP signaling during mouse cardiogenesis: identifying SMAD1-interacting proteins and exploring the roles of a known BMP target, Mycn, in the developing myocardium. Chromodomain helicase DNA binding protein 7 (CHD7) is a highly conserved transcription factor that promotes protein synthesis, proliferation, and differentiation. Haploinsufficiency for CHD7 causes CHARGE syndrome, a developmental disorder characterized …

The Role Of Mitochondrial Oxidative Stress In Cardiovascular Disease Development, Corey Michael Harrison

All ETDs from UAB

An estimated 70 million Americans have one or more types of cardiovascular disease (CVD). Although the sequence of events leading to CVD are still controversial, there is a general consensus that atherosclerotic lesions result from oxidative stress associated with risk factor. For this study, it was hypothesized that endogenous mitochondrial oxidative stress would influence susceptibility to atherogenesis and mitochondrial damage mediated by CVD risk factor exposure. To test this hypothesis, atherosclerotic lesion formation, oxidant stress, and mitochondrial DNA damage were assessed in hypercholestoremic mice (apolipoprotein E null - apoE -/- SOD2 +/+) and mice with significantly decreased levels of the …

The Role Of Ll-37 In Prostate Cancer And Its Potential As A Therapeutic Target, Jonathan Adam Hensel

All ETDs from UAB

LL-37 is the only cathelicidin-derived anti-microbial peptide in humans and has been shown to stimulate proliferation, angiogenesis, cellular migration and inhibit apoptosis, in addition to serving as a chemoattractant for leukocytes. It is produced primarily by epithelial cells and leukocytes, and has recently been discovered to be over-expressed in breast, ovarian and lung cancers. Based on these findings, we compared levels of LL-37 expression in benign and cancerous human prostate tissues. Results of this investigation demonstrated that LL-37 is increasingly over-expressed in primary prostate tumors in a grade dependent manner and in metastatic lesions. Since the physiological mechanisms of LL-37 …

Protein Modifications And The Response To Oxidized Lipids In Cardiovascular Cells, Ashlee Higdon

All ETDs from UAB

Free radical catalyzed oxidation of polyunsaturated fatty acids (PUFAs) such as arachidonic acid is increased in cardiovascular disease states, including atherosclerosis and heart failure. Oxidized lipids have been extensively studied and found to recapitulate several key steps in atherogenesis. However, clinical trials with antioxidants such as alpha-tocopherol have been less promising than originally predicted. Now appreciated as more than just biomarkers of disease, lipid peroxidation products have been shown to have roles in pathogenesis as well as physiology. Of particular interest are reactive lipid species that possess electrophilic carbonyls enabling them to act in a receptor-independent manner. To date, the …

Reconstructing The Southern Populists: Alabama Farmers Before Political Revolt, 1874-1889, Joshua Hodge

All ETDs from UAB

The traditional story of the Populist movement begins in 1887 where by the leadership of the Farmers' Alliance, agricultural organizations combined to initiate formal political action on behalf of farmers and laborers alike. But proper understanding of the Populists, this study suggests, must begin earlier, in the fluid era of Reconstruction when farmers first began to articulate their concerns and grapple with possible solutions. This study explores earlier manifestations of farmer solidarity, describing the community of like-minded farmers that organized into agricultural groups in the immediate post-Civil War period. Well before the political revolt of the 1890s, southern farmers participated …

Pax5 Controls B Lineage Specific Gene Expression Program Through Association With The Nuclear Matrix, Sang Yong Hong

All ETDs from UAB

Pax5 is an essential regulator for B lineage cell development and controls hundreds of positive and negative target genes. The nuclear matrix (NM) has long been proposed to provide a dynamic structural support for biological reactions inside of the nucleus, including DNA replication, RNA transcription, and RNA splicing. Although Pax5 binding sites have been identified in numerous Pax5 target genes, it is not clear how Pax5 controls so many target genes. In this dissertation, I demonstrate that Pax5 association with the NM is essential for regulation of the B lineage specific gene expression program. In part I, I found that …

Efficacy Of Sterisil In The Treatment Of Dental Unit Waterlines, Don Schmidtke

All ETDs from UAB

Introduction: Dental unit waterlines (DUWL) are an ideal home for bacterial microorganisms to grow, multiply, and develop complex living colonies commonly known as "biofilm." The American Dental Association (ADA) and the Centers for Disease Control and Prevention (CDC) have recommendations to maintain DUWL heterotrophic plate count bacteria levels below 500 colony forming units per milliliter (CFU/ml) of water. The aim of this study is to determine whether Sterisil PureTube is able to control the bacterial load in the orthodontic clinic to recommended levels. Methods: Waterline samples from the twelve dental chairs in the orthodontic clinic were used in this study. …

The Role Of Cd19 In Follicular Dendritic Cell Activation, Riley Croom Myers

All ETDs from UAB

Germinal Centers (GC) are organized foci in secondary lymphoid organs of birds and mammals and are the principle sites of memory B cell generation and plasma cell formation. GC concentrate antigen within follicles to facilitate recognition by responding B cells to promote somatic hypermutation and affinity maturation. Follicular dendritic cells (FDC) reside within the light zones of GC and serve to facilitate B cell interactions with antigen, as well as B cell selection, proliferation, and survival. The work contained within this dissertation addresses the collaborative interactions between B cells and FDC. FDC within an active, GC-containing follicle express an array …

Section 2259 Restitution Claims And Child Pornography Possession, Dina Mcleod

Michigan Law Review

In 2009, a child pornography victim brought a criminal restitution claim against a defendant who possessed images of her abuse. The statutory provision authorizing restitution, 18 U.S.C. § 2259, had never before been used to bring a claim against a defendant who had only possessed, rather than produced or distributed, child pornography ("child pornography possession defendants"). The federal courts have not developed a consistent approach to resolving Section 2259 claims involving such defendants. This Note argues that two conceptions of traditional proximate cause doctrine can provide a framework for analyzing such claims. It examines Section 2259 claims using both a …

Responding To Our Own Transgressions: An Experimental Writing Study Of Repentance, Offense Rumination, Self-Justification, And Distraction, Charlotte Witvliet, Nova G. Hinman, Julie J. Exline, Timothy Brandt

Faculty Scholarship

This between-subjects experiment focused on offender responses to their past interpersonal transgressions in self-identified Christian undergraduates (55 M, 85 F). Participants completed pre-post measures for one of four randomly assigned 20-minute writing conditions: repentance (i.e., writing about constructive sorrow, apology, restitution, behavior change), offense rumination (i.e., negative wallowing), self-justification (i.e., externalizing blame, minimizing costs), or distraction (i.e., daily details). Offense rumination and repentance writing included the most cost-oriented language; rumination had the most negative emotion language. Mixed within (pre vs. post) X between group ANOVA interactions yielded theoretically meaningful results. Repentance reduced self-condemnation and regret while increasing conciliatory motivations toward …

2011-2012 Risd Course Announcement, Risd Registrar's Office, Risd Archives

RISD Course Catalogs / Announcements

No abstract provided.

The Garden State Just Got Greener: New Jersey Is The Fourteenth State In The Nation To Legalize Medical Marijuana, Melissa Brown

Seton Hall Law Review

No abstract provided.

Rethinking The Indefinite Detention Of Sex Offenders, Fredrick E. Vars

Articles

Thousands of sex offenders in the United States are being held indefinitely under civil commitment programs The analysis in this Article suggests that none or precious few belong there Specifically in a large dataset an instrument as good as the one most widely used by experts the "Static99" could not identify even one sex offender who met the legal standards for commitment Supplementing such instruments with additional information appears not to improve matters so the failure of the instrument is profoundly disturbingThere are three possible responses 1 improve instruments to meet existing standards 2 lower the standards and 3 abandon …

Milton Three Ponds, Cooperative Extension

UNH Cooperative Extension

No abstract provided.

Influence Of The Hip On Patients With Patellofemoral Pain Syndrome: A Systematic Review, Erik P. Meira, Jason Brumitt

Faculty Publications - College of Physical Therapy

Context: Patellofemoral pain syndrome (PFPS) is one of the most common conditions limiting athletes. There is a growing body of evidence suggesting that dysfunction at the hip may be a contributing factor in PFPS.

Data Sources: MEDLINE (1950–September 2010), CINAHL (1982–September 2010), and SPORTDiscus (1830–September 2010) were searched to identify relevant research to this report. Study Selection: Studies were included assessing hip strength, lower extremity kinematics, or both in relation to PFPS were included.

Data Extraction: Studies included randomized controlled trials, quasi-experimental designs, prospective epidemiology, case-control epidemiology, and cross-sectional descriptive epidemiology in a scientific peer-reviewed journal.

Results: PFPS is associated …

The Relationship Of Self-Care To Burnout Among Social Workers In Health Care Settings, Jennifer D. Weekes

Walden Dissertations and Doctoral Studies

Self-care is critical in minimizing the symptoms of burnout among human services professionals, but specific information on the role of self-care among social workers in healthcare settings is limited. This correlational study was designed provide a fuller understanding of this relationship. Orem's theory of self-care and the theory of reasoned action and planned behavior served as the theoretical foundations of this study. The sample included 185 members of the National Association of Social Workers, who volunteered to participate in this study. Participants completed online versions of the Maslach Burnout Inventory and Self-Care Assessment Work Sheet. Correlation and analysis of variance …

Patellofemoral Pain Syndrome Alters Neuromuscular Control And Kinetics During Stair Ambulation, Naoko Aminaka, Brian G. Pietrosimone, Charles W. Armstrong, Andrew Mezsaros, Phillip A. Gribble

Faculty Publications - College of Physical Therapy

The aim of the study was to investigate differences in frontal plane knee kinetics, onset timing and dura-tion of the gluteus medius (GMed), adductor longus (AL), and vastus medialis oblique (VMO) during stair ambulation between those with and without patellofemoral pain syndrome (PFPS). Twenty PFPS patients and twenty healthy participants completed stair ambulation while surface electromyography (EMG), video, and ground reaction forces were collected. PFPS patients had a higher peak internal knee abduction moment during stair ascent, and a higher internal knee abduction impulse for both ascent and descent. During stair ascent, PFPS patients displayed earlier onset of the AL …

Musculoskeletal Healthcare For Latino Migrant Farmworkers: Interprofessional Collaboration To Provide Service And Educate Future Health Care Providers, Jason Brumitt, Leda Garside, Rebecca Reisch, Talina Marshall, Hu En Gilpin, Jessica Kinsey, Kelsey Imondi

Faculty Publications - College of Physical Therapy

The inability to access health care services is a significant issue in the United States (US). The US Census Bureau reports that as of 2009 over 50 million individuals (16.7% of the population) lacked health insurance. The number of people who became uninsured has also increased over time. One segment of the US population that is particularly vulnerable to health care inequities is Latinos. Failure to access timely primary medical services may increase the risk of disease transmission, morbidity, and mortality. In addition, failing to address health care needs at the primary provider level may contribute to an overutilization of …

A Phenomenological Approach To Examining Perceptions Of Middle School Students And Their Educators About Their Service-Learning Experiences, Mccafferty, Anita J. Stewart Mccafferty

Walden Dissertations and Doctoral Studies

A primary purpose of public education is to ensure that all citizens have the knowledge, skills, and dispositions to participate in a democracy. Service learning is a democratic, constructivist, instructional strategy that connects academic learning with community needs. This phenomenological study described: (a) how youth, their educators, and community partners who experience service learning perceive its effects on themselves, their schools, and their community lives and (b) how professional-development opportunities need to be structured in order to encourage high quality civics education instruction. The problem this study addressed was how to solve youth civic and political disengagement. This study relied …

Effects Of Neurofeedback On Neuropsychological Functioning In An Adult With Autism, Michael J. Lucido

Walden Dissertations and Doctoral Studies

Autism spectrum condition (ASC) is a complex neurodevelopmental disorder that impacts physiological processes, cognition, functional behaviors, social-communication, and often has comorbidities. One approach gaining empirical support for ASC treatment is neurofeedback. Neurofeedback uses operant conditioning to normalize cerebral activity through auditory and visual reinforcement. Live Z-score Training (LZT) has become the latest advancement in neurofeedback. There is no published research to date on LZT neurofeedback in adulthood ASC. The purpose of this study was to evaluate LZT's impact on neuropsychological measures in an adult with ASC. A multiple baseline single-case research design was used with a convenience sample of one …

Transforming Students, Transforming Self: The Power Of Teaching Social Justice Struggles In Context, Raquel Aldana

McGeorge School of Law Scholarly Articles

No abstract provided.

Rosenberg Institute For East Asian Studies At Suffolk University Annual Report For 2011-2012, Rosenberg Institute

Rosenberg Institute Annual Reports

These reports summarize the activities of the Rosenberg Institute during the academic year, including information related to public programming, visiting scholars, cooperation with the Asian Studies program at Suffolk College of Arts & Sciences, promotion of Suffolk's Asia-related activities, community outreach, and funding. Most reports also contain photographs of scholars, staff, and events.

The Role Of Acculturation In Adolescent Mental Health And Academic Achievement: Mediational Pathways, Ariz Rojas

USF Tampa Graduate Theses and Dissertations

This study investigated the different pathways by which acculturation may influence Hispanic adolescents' psychological functioning and academic achievement. Proposed mediational pathways included adolescent perceptions of mothers' and fathers' parenting practices, acculturative stress, self-esteem, academic support, and academic motivation. Participants included 116 9^th and 10^th grade students recruited from high schools and a parent for each student. Parents completed a measure of acculturation and rated their adolescents' psychological symptomology. Adolescents completed measures of perceived parenting (mother and father), a self-report of psychological symptoms, a measure of acculturation and acculturative stress, as well as ratings of academic support and motivation. …

Effects Of Solids Loadings And Particle Size Distribution On Siphon Ceramic Candle Filters, Danielle Renzi

USF Tampa Graduate Theses and Dissertations

In the rural areas of Madagascar only 29% of the population has access to clean water and 10% has access to improved sanitation. It has been estimated that environmental risk factors, such as inadequate access to clean drinking water and proper sanitation, are responsible for 94% of the diarrheal disease burden. This study was focused on testing a point-of-use technology called the Tulip filter, which is a siphon ceramic candle filter impregnated with silver. The purpose is to assess its feasibility for implementation in rural regions of Madagascar through a laboratory study performed at the University of South Florida.

The …