Digital Commons Network^™

The Effects Of Pten Deletion On Cell Size And Plasticity In The Hippocampus, Margaret Sperow

Theses and Dissertations (ETD)

The tumor suppressor phosphatase and tensin homolog (PTEN) is the central negative regulator of the phosphatidylinositol 3-kinase (PI3K) -signaling pathway, which mediates diverse processes in various tissues. In the nervous system, the PI3K pathway modulates proliferation, migration, cellular size and synaptic transmission and plasticity. Neurologic abnormalities such as autism, seizures, and ataxia are associated with inherited PTEN mutations. Yet, how PTEN loss contributes to neurologic dysfunction remains unknown. PTEN loss during early development is associated with extensive deficits in neuronal migration and substantial hypotrophy of neurons and synaptic densities. However, whether its effect on synaptic transmission and plasticity is direct …

Development And Evaluation Of Nano‑Scale Systems For Targeted Delivery To Treat Liver Fibrosis, Ningning Yang

Theses and Dissertations (ETD)

Excessive deposition of ECM is the common characteristic of liver fibrosis. During hepatic fibrosis, various inflammatory cytokines are released and trigger the activation of quiescent HSCs. The activated HSCs play the major role in producing extra amount collagen. It becomes very crucial to focus on HSCs to find out therapeutics, such as inhibiting collagen synthesis, inhibiting activation to myofibroblasts, or controlling inflammation.

To control excessive collagen synthesis, one triplex forming oligonucleotides (TFO), was systemically administrated to prevent type I collagen mRNA transcription. To enhance circulation time and targeted delivery efficiency, TFO was conjugated to M6P‑HPMA and showed efficient targeted delivery …

Preclinical Pharmacology Of The Mdm2 Antagonist Nutlin-3a, Fan Zhang

Theses and Dissertations (ETD)

Nutlin-3a is an MDM2-p53 interaction antagonist that is under investigation in preclinical models for a variety of pediatric malignancies, including neuroblastoma, retinoblastoma, leukemia, and rhabdomyosarcoma. In the current research, we conducted preclinical pharmacology studies of nutlin-3a to evaluate the synergistic effect of the nutlin-3a and topotecan combination on neuroblastoma cell growth, to assess the effect of nutlin-3a on breast cancer resistance protein (BCRP), and to characterize the disposition of nutlin-3a in the mouse plasma and multiple tissues.

Activating the p53 pathway might offer a new therapy for neuroblastoma. In the first part of the study, we assessed the effect of …

Effect Of Gender On The Association Of Single-Nucleotide Polymorphisms With Bipolar Disorder, Jerald Eric Mullersman

Electronic Theses and Dissertations

Bipolar disorder is a relatively common form of mental illness that depends strongly on genetic inheritance for expression. The author of this study has sought to evaluate whether the gender of subjects influences which genetic variants are associated with the disease. A portion of the cases from a previously published study were analyzed using PLINK software and the association of single-nucleotide polymorphisms was evaluated separately for all cases, for female subjects alone, and for male subjects alone. The results obtained for male subjects alone reached higher levels of statistical significance than when both genders were evaluated together or when female …

Feeding Practices Of Mothers In The Gobi Desert Of Mongolia, Julie F. Tate

Electronic Theses and Dissertations

The diets of Mongolia infants are deficient in vitamins and minerals and complementary foods are introduced too early. Breastfeeding is the best source of nutrition for infants until 6 months of age. A survey of 50 Mongolian mothers with children under the age of 5 in the town of Sainshand, Dornogobi, was conducted in July 2011. Mongolian infants are among the highest percent of infants in the world who are exclusively breastfed for the first 6 months of their lives, thus providing them with excellent nutrition. However, complementary feedings and supplements are not appropriately used or understood. Therefore, the diets …

Organizational Change In The Russian Airborne Forces: The Lessons Of The Georgian Conflict, Rod Thornton Dr.

Books, Monographs & Collaborative Studies

This monograph considers the recent history of organizational change in the Russian Airborne Forces (VDV). In particular, it looks at how the VDV has changed since the end of Russia’s conflict with Georgia in 2008. The VDV, a force much admired in Russian media and society has, in fact, escaped fairly lightly during the comprehensive reform of the Russian Army more generally over the last few years. In large part this has been down to the personality of the current head of the VDV, Lieutenant-General Vladimir Shamanov. Close to Prime Minister Vladimir Putin, Shamanov--a "maverick"--has used his political connections to …

Salud Y Saludos: The E-News Of The College Of Health Sciences, College Of Health Sciences

College of Health Sciences

Monthly e-news of the College of Health Sciences

Morphine Potentiates Neuropathogenesis Of Siv Infection In Rhesus Macaques, Sirosh M. Bokhari, Ramakrishna Hedge, Shannon Callen, Honghong Yao, Istvan Adany, Qingsheng Li, Zhuang Li, David Pinson, Hung-Wen Yeh, Paul D. Cheney, Shilpa Buch

Qingsheng Li Publications

Despite the advent of antiretroviral therapy, complications of HIV-1 infection with concurrent drug abuse are an emerging problem. Opiates are well-known to modulate immune responses by preventing the development of cell-mediated immune responses. Their effect on the pathogenesis of HIV-1 infection however, remains controversial. Using the Simian Immunodeficiency Virus/ macaque model of HIV pathogenesis, we sought to explore the impact of morphine on disease progression and pathogenesis. Sixteen Rhesus macaques were divided into 2 groups; 4 were administered saline and twelve others morphine routinely. Both groups of animals were then inoculated with SIVmacR71/17E and followed longitudinally for disease pathogenesis. The …

Cancer Stem Cells. From Characterization To Therapeutic Implications., Nehad M. Alajez

Saudi Medical Journal

The cancer stem cell (CSC), or alternatively referred to as the tumor initiating cell (TIC) model, proposes that human cancers are organized in a hierarchical structure with the CSC at the apex. Cancer stem cells are functionally defined by their ability to self-renew, and to recapitulate the hierarchy of the original tumor from which they were derived. Emerging data from the literature suggest that CSCs might be the fraction within the tumor that resists conventional therapies; hence, the CSC paradigm provides new insight into tumor progression and relapse. Herein, we provide literature review of the CSC model, with emphasis on …

Expression Of Alkaline Phosphatase In Immortalized Murine Cementoblasts In Response To Compression-Force., Ye Tian, Lan Huang, Yong-Wen Guo, Li Cao, Ya-Ting Wang, Hui Xu, Ding Bai

Saudi Medical Journal

OBJECTIVES: To determine the effect of compression-force on the expression of alkaline phosphatase (ALP), and ALP activity in cementoblasts. METHODS: We performed this study in the State Key Laboratory of Oral Diseases, West China Stomatology Hospital, Sichuan University, Chengdu, Sichuan, China from October to December 2010. We exposed murine immortalized cementoblasts (OCCM-30) to 2000-ustrain compression-force at a frequency of 0.5 Hz for 1, 3, 6, 12, and 24 hours. We assayed the cellular ALP activity after the treatments. We used real-time polymerase chain reaction (RT-PCR) and western blot to examine the gene and protein expression of ALP in the OCCM-30 …

Serum Hyaluronic Acid Level Does Not Reliably Differentiate Minimal And Significant Liver Disease In Chronic Hepatitis C., Shoukat A. Arain, Sultan A. Meo, Qamar Jamal

Saudi Medical Journal

OBJECTIVES: To evaluate the predictive value of hyaluronic acid (HA) for the assessment of liver fibrosis and inflammation in chronic hepatitis C (CHC). METHODS: This cross-sectional study was conducted at Ziauddin University, Karachi, Pakistan from June 2006 to July 2010. Ninety-eight CHC patients, 52 (53%) males, and 46 (47%) females, with an age range of 20-60 years (mean 36.0±10.5) were recruited. Liver fibrosis was staged on a 5-point scale, F0 to F4, and inflammation was graded on a 4-point scale, A0 to A3. Patients were divided into minimal (F<2 and A<2) and significant (F>/=2 or A>/=2) overall disease groups. The HA was measured …

Plasma Total Antioxidant Capacity And Its Related Factors In Iranian Pregnant Women., Zatollah Asemi, Shima Jazayeri, Mohammad Najafi, Mansoreh Samimi, Zohreh Tabasi, Farzad Shidfar, Abbas Rahimi-Foroushani, Vahid Mofid

Saudi Medical Journal

OBJECTIVES: To determine the plasma total antioxidant capacity (TAC) and its related factors in pregnant Iranian women attending maternity clinics. METHODS: In a cross-sectional study carried out in Naghavi Maternity Clinic, Shaheed Beheshti Specialty and Subspecialty Polyclinic and 10 antenatal centers, affiliated to Kashan University of Medical Sciences, Kashan, Iran, we determined the plasma TAC and its related factors including maternal age, weight, and body mass index (BMI) at the beginning, thirteenth, and twenty-first to twenty-fourth weeks of pregnancy, and gestational age at the twenty-first to twenty-fourth weeks of pregnancy in 137 primigravid pregnant women, 18-30 years old from October …

The Burden Of Ischemic Heart Disease At A Major Cardiac Center In Central Saudi Arabia., Ahmed M. Osman, Mohammed S. Alsultan, Meshal A. Al-Mutairi

Saudi Medical Journal

OBJECTIVES: To estimate the direct medical costs associated with ischemic heart disease (IHD) at Prince Sultan Cardiac Center (PSCC) in Riyadh, Saudi Arabia. METHODS: This is a prevalence-based prospective observational cost of illness study conducted in PSCC, Riyadh, Kingdom of Saudi Arabia between April and June 2009. All patients diagnosed or suspected of having IHD at admission were included. They were followed up until discharge, or performing coronary artery bypass graft (CABG), or changing diagnosis. Clinical data were extracted from the patients9 computerized database, and combined with the unit cost of services to calculate costs. RESULTS: A total of 205 …

Assessment Of Quality Of Life In Patients With Type 2 Diabetes Mellitus In Oman., Masoud Y. Al-Maskari, Ali O. Al-Shookri, Samir H. Al-Adawi, Khor G. Lin

Saudi Medical Journal

OBJECTIVES: To measure quality of life of type 2 diabetes patients in Oman, and examine which patients9 socio-demographic and diabetes-related clinical characteristics are associated with better quality of life. METHODS: This cross-sectional study of 200 diabetic subjects was conducted in Sultan Qaboos University Hospital, Al-Khod, Oman between April and September 2009. A short form of the diabetes quality of life questionnaire (DQoL) was used to elicit indices of quality of life on subjects (n=200) seeking consultation at the diabetic outpatient clinic. Socio-demographic variables, body mass index (kg/m) and clinical parameters relevant for the diagnosis of type 2 diabetes, including glycated …

Vitiligo-Epidemiological Study Of 4134 Patients At The National Center For Vitiligo And Psoriasis In Central Saudi Arabia., Ahmed Alissa, Abdulla Al Eisa, Rozeena Huma, Sajeev Mulekar

Saudi Medical Journal

OBJECTIVES: To assess the clinical patterns, epidemiological profile of vitiligo, and its awareness among Saudi nationals. METHODS: A retrospective study was conducted among Saudi nationals with a confirmed diagnosis of vitiligo presenting to the National Center for Vitiligo and Psoriasis, Riyadh, Saudi Arabia, from August 2002 to August 2006 using a retrospective questionnaire based on the history and medical records of patients. RESULTS: Of the 4134 cases, 53.5% were females. The mean age of onset of vitiligo was 17.4 years. Vitiligo vulgaris was the most common type in 42.3% of cases, 90.5% had no associated autoimmune conditions. The family history …

Research Productivity Among Faculty Members At Medical And Health Schools In Saudi Arabia. Prevalence, Obstacles, And Associated Factors., Saad A. Alghanim, Rashid M. Alhamali

Saudi Medical Journal

OBJECTIVES: To identify the prevalence, factors and obstacles affecting research productivity among academic staff at medical and health colleges in the Kingdom of Saudi Arabia. METHODS: This cross-sectional survey employed self-administered questionnaires to collect data on faculty members9 profile, research activities, and obstacles impeding research productivity. The questionnaires were distributed randomly to 500 faculty members, of which 389 (77.8%) completed the questionnaire at 10 medical and health colleges during January to April 2011. The data were analyzed and presented in a descriptive fashion. RESULTS: Only 150 (38.6%) respondents reported published work in the past 2 years. Of these, 80% indicated …

Genotoxicity And Cytotoxicity Of Ovine Collagen On Human Dermal Fibroblasts., Fauzi M. Busra, Shiplu R. Chowdhury, Aminuddin B. Saim, Ruszymah B. Idrus

Saudi Medical Journal

No abstract provided.

Bacillus Calmette-Guerins Vaccination At Birth Causing Tuberculous Granulomatous Lymphadenitis, Mahmood D. Al-Mendalawi

Saudi Medical Journal

No abstract provided.

Drug Susceptibility Pattern Of Mycobacterium Tuberculosis Isolates Against Conventional Anti-Tuberculosis Drugs In Dhaka, Bangladesh., Mahmood D. Al-Mendalawi, Murad Hossain

Saudi Medical Journal

No abstract provided.

Borderplex Economic Outlook: 2011-2013, Thomas M. Fullerton Jr., Adam G. Walke

Border Region Modeling Project

No abstract provided.

Impact Of Computerized “Sounding Out” On Spelling Performance Of A Child Who Uses Aac: A Preliminary Report, Jillian H Mccarthy, David R. Beukelman, Tiffany Hogan

Department of Special Education and Communication Disorders: Faculty Publications

Spelling is a vital skill for people who rely on augmentative and alternative communication (AAC). The ability to spell words provides an opportunity to create novel and spontaneous communication and increases educational, social, and employment opportunities for children and adults. However, many children and youth who rely on AAC struggle to gain functional spelling skills and written language. The purpose of this preliminary investigation was to develop a strategy to provide auditory letter-sounds using commercially available computer equipment and to evaluate how such a computerized “sounding out” strategy influences spelling accuracy for one child who required AAC support. The spelling …

Development Of A Flow-Based Ultrafast Immunoextraction And Reverse Displacement Immunoassay: Analysis Of Free Drug Fractions, John E. Schiel, Zenghan Tong, Chainarong Sakulthaew, David S. Hage

David Hage Publications

A flow-based method employing a reverse displacement immunoassay was combined with ultrafast immunoextraction and near-infrared fluorescence detection for the analysis of free drug fractions, using phenytoin as a model analyte. Factors considered in the design of this method included the sample application conditions, the design of the immobilized drug analog column, the utilization of antibodies or F_ab fragments as labeled binding agents, and the label application and column regeneration conditions. In the final method, sample injections led to the displacement of labeled binding agents from an immobilized phenytoin analog column. This displacement peak appeared within 20–30 s of sample …

Race-Ethnicity And Medical Services For Infertility: Stratified Reproduction In A Population-Based Sample Of U.S. Women, Arthur L. Greil, Julia Mcquillan, Karina M. Shreffler, Katherine M. Johnson, Kathleen S. Slauson-Blevins

Department of Sociology: Faculty Publications

Evidence of group differences in reproductive control and access to reproductive health care suggests the continued existence of “stratified reproduction” in the United States. Women of color are overrepresented among people with infertility but are underrepresented among those who receive medical services. The authors employ path analysis to uncover mechanisms accounting for these differences among black, Hispanic, Asian, and non-Hispanic white women using a probability-based sample of 2,162 U.S. women. Black and Hispanic women are less likely to receive services than other women. The enabling conditions of income, education, and private insurance partially mediate the relationship between race-ethnicity and receipt …

Childhood Maltreatment, Parental Monitoring, And Self-Control Among Homeless Young Adults: Consequences For Negative Social Outcomes, Lisa A. Kort-Butler, Kimberly A. Tyler, Lisa A. Melander

Department of Sociology: Faculty Publications

Although parenting factors have been found to contribute to self-control, little is understood about how experiences of maltreatment affect the development of self-control and whether self-control mediates the relationship between maltreatment and negative social outcomes, especially among homeless individuals. This study examined whether lower parental monitoring, physical abuse, and neglect affected the development of self-control and if self-control mediated the relationship between parenting factors and negative social outcomes among a sample of homeless young adults. Results from path analyses indicated that lower parental monitoring and earlier age at first abuse contributed to less cognitive self-control. The effect of monitoring on …

State Super-Maximum Security Policies: An Examination Of Admission Characteristics, Classification Reviews, Mental Health Amenities, And Inmate Privileges, Harry Daniel Butler

Master's Theses

Super-maximum security prisons have flourished within a political environment that endorses tougher criminal sanctions. This punitive evolution has created new problems for correctional agencies attempting to control the “worst of the worst” inmates. Federal courts and researchers have examined the detrimental effects supermax isolation has on inmates’ mental health. This analysis examines forty-two state supermax policies to determine how states admit inmates to supermax custody, the classification review process, the management of inmates with mental illnesses, and the availability of privileges for supermax inmates. Drawing on the concept of the McDonaldization of Justice (Ritzer, 1993), particular attention is given to …

Consequences Of Contact: An Evaluation Of Childhood Health Patterns Using Enamel Hypoplasias Among The Colonial Maya Of Tipu, Amanda R. Harvey

Master's Theses

Located in western Belize, Tipu was occupied from 1541-1704. This Colonial Maya population from a Spanish visita mission church was analyzed to investigate health disturbances associated with European contact. Dental defect called enamel hypoplasias were scored to assess childhood health. Standard methods of scoring (Buikstra and Ubelaker 1994) were employed to assess frequency, severity, and type of episode in the permanent anterior dentition. For analysis, 325 individuals were placed into age groups of subadults (6-17 years), younger adults (18-35 years), and older adults (36-50+ years). The population was also considered for differences by sex and tooth type.

Results showed a …

Chemical, Biological, And Preliminary In Vitro Studies Of Novel Vanadium(Iv) Complexes With Schiff Bases And Thiosemicarbazone Ligands, Nerissa Abigail Lewis

Master's Theses

9-Anthraldehyde-N(4)-methylthiosemicarbazone (MeATSC), potassium (E)-2-(2-hydroxybenzylideneamino)-3-(1H-indol-3-yl)propanoate (K[(Sal-L-tryp)] and 2-(2-hydroxybenzylamino)-3-(1H-indol-3-yl)propanoic acid (the reduced Schiff base) were prepared using known synthetic procedures. Two novel thiosemicarbazone ligands, (E)-N-ethyl-2-(4-hydroxy-3-methoxybenzylidene)hydrazinecarbothioamide (N-Ethhymethohcarbthio) and (E)-N-ethyl-2-(1-(thiazol-2-yl)ethylidene)hydrazinecarbothioamide (acetylethTSC), were also prepared. All ligands were characterized by FT IR and electrochemistry. N-Ethhymethohcarbthio were characterized by elemental analysis whereas the reduced Schiff base and K[(Sal-L-tryp)] were characterized by ESI MS. X-ray crystallography was also used to characterize acetylethTSC. The ligands were then reacted with [VO(Sal-L-tryp)(H2O)] (1) (Sal-L-tryp = N-salicylidene-L-tryptophanate) to produce the …

Measuring Physical Activity In Youth Settings: Considerations For Instrument Selection, Benjamin Hickerson

Journal of Youth Development

Increasing physical activity participation has become one of the primary strategies for prevention of early-onset health conditions including obesity and Type II diabetes. Youth programs including summer camps and after-school programs are premium providers of physical activity opportunities, but researchers and administrators of these programs must be able to effectively collect and interpret physical activity data to make program adjustments and communicate results. This article reviews existing methods for physical activity measurement including self-reports and objective instruments and makes suggestions for their applicability. Pedometers are covered in-depth as they may be the method of choice in many youth settings. These …

A Study Of The Early American Author Judith Sargent Murray, Her Role In Early American Print Culture And Her Misappropriation By Twentieth-Century Feminism, Robert Allen Fowler

Master's Theses

In 1798, Judith Sargent Murray published a three-volume collection of one hundred miscellaneous essays on topics ranging from social politesse to women’s education to international politics. Her diligence, forethought and manipulation of pseudonyms in the print-hungry post-Revolutionary America create a unique place for her in the history of American letters. However, in the twentieth century, modern feminism has attempted to claim Murray as one of their own, choosing between one and four examples of her work as proof of her forward-looking philosophy, while ignoring significant pieces of those same works as well as much of her oeuvre as a whole …

Motivating Factors Influencing Spectator Attendance At Professional Soccer Events In Brazil, Rafael Andreis

Master's Theses

In Brazil, soccer is regarded so highly that Brazilians often refer to their country as o pais do futebol, or the country of football ("Natal Brazil", 2006). Brazil national soccer teams won five of the nineteen World Cup tournaments, a record that is so far unmatched by any other country. Brazil boasts 102 million soccer fans who attend games in the country's 300 soccer stadiums, which, combined, have more than five million seats (Helal et al., 2006; Fifa.com, 2010). However, while the importance of soccer in Brazil is unquestionable, the monetization of professional soccer in Brazil is currently far from …