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2011

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Body Surface Potentials Generated By The Heart Of Normal Guinea Pigs, Anusak Kijtawornrat, Suwanakiet Sawangkoon, Orlando P. Simonetti, Robert L. Hamlin Dec 2011

Body Surface Potentials Generated By The Heart Of Normal Guinea Pigs, Anusak Kijtawornrat, Suwanakiet Sawangkoon, Orlando P. Simonetti, Robert L. Hamlin

The Thai Journal of Veterinary Medicine

The objectives of this study were to describe (1) the form of body surface potentials for P, QRS and ST-Tcomponents using semiorthogonal ECG leads and vectorcardiograms (VCGs), (2) the instability of the QT usingcoefficient of variation compared with 3 other published methods, and (3) the frequency-domain characteristics of theQRS complex. Electrocardiograms were recorded and VCGs of P, QRS and ST-T loops were generated in frontal (Xaxisversus Y-axis), sagittal (Y-axis versus Z-axis), and horizontal (X-axis versus Z-axis) planes. Frequency-domaincomponents of the QRS complex were calculated using Fast Fourier Transform (FFT) algorithm. One of the 7 guineapigs was placed in sternal recumbency …


Prevalence Of Henneguya Infections On Cage-Reared Channel Catfish Ictalurus Punctatus (Rafinesque) In Mexico, Jaime Luis Rábago-Castro, Ricardo Gomez-Flores, Gabriel Aguirre-Guzmán, Patricia Tamez-Guerra, Carlos Ramírez-Pfeiffer, Jorge Loredo-Osti, Jesús Genaro Sánchez-Martínez Dec 2011

Prevalence Of Henneguya Infections On Cage-Reared Channel Catfish Ictalurus Punctatus (Rafinesque) In Mexico, Jaime Luis Rábago-Castro, Ricardo Gomez-Flores, Gabriel Aguirre-Guzmán, Patricia Tamez-Guerra, Carlos Ramírez-Pfeiffer, Jorge Loredo-Osti, Jesús Genaro Sánchez-Martínez

The Thai Journal of Veterinary Medicine

The aim of the present study was to determine the type of infection, species, the period and annual spatialprevalence, the effect of site, period and host size on prevalence of Henneguya infections in floating cages-raisedchannel catfish. Henneguya infections were detected in gills, fin adipose and skin, with mature spores measuring 58 to66 μm and 16 to 17 μm TL/BL. H. exilis was identified as the causing infection agent based on fresh cyst morphologyand spore measurements. In addition, mature spores measuring from 45 to 60 μm in TL and 14 to 19 μm in BL, wereobserved in the adipose tissue infections; …


Efficacy Of Acetone And Ethanol In Dehydrating Canine Body Sheets :Before And After Resin Coating, Kriengyot Sajjarengpong, Pawana Chuesiri, Pakorn Prachammuang, Panida Phisiriyuenyong Dec 2011

Efficacy Of Acetone And Ethanol In Dehydrating Canine Body Sheets :Before And After Resin Coating, Kriengyot Sajjarengpong, Pawana Chuesiri, Pakorn Prachammuang, Panida Phisiriyuenyong

The Thai Journal of Veterinary Medicine

The aim of this study was to compare the efficacy of ethanol and acetone in dehydration of canine bodysheets before preservation in resin for a 16-week period. A 10-kg male dog which died of the respiratory failure waspreserved in 10% formalin via common carotid artery at room temperature for 7 days prior to being kept in a freezerat -250C for 7 days. The body of the dog was cut into 2.5-cm-thick sheets with a band saw. The body sheets wereseparately dehydrated for 3 days with either acetone or ethanol. In this study, the color of muscles and fat fromacetone-dehydrated sheets …


The Use Of Commercial Soil Nucleic Acid Extraction Kit And Nested Pcr For Detection Of Leptospira In Farm Environment After Flooding In Taiwan, Ying-Bin Fuh, Wei-Yau Shia, Wei-Ming Lee, Ching-Lin Shyu, Chi-Young Wang, Chang-Young Fei Dec 2011

The Use Of Commercial Soil Nucleic Acid Extraction Kit And Nested Pcr For Detection Of Leptospira In Farm Environment After Flooding In Taiwan, Ying-Bin Fuh, Wei-Yau Shia, Wei-Ming Lee, Ching-Lin Shyu, Chi-Young Wang, Chang-Young Fei

The Thai Journal of Veterinary Medicine

Leptospirosis is a rapidly transmitted and flood-related disease. The number of cases usually increase in thecountries of Southeast Asia after flood damage during typhoon seasons. This disease also poses a potential threat toTaiwan due to its geographic characteristics. Therefore, it is necessary to establish a practical technique for anestimation of the distribution of Leptospira in natural environment, especially after flood damage. The aim of thisstudy was to demonstrate the use of commercial soil nucleic acid extraction kits with nested PCR in the detection ofLeptospira spp. in the farm environment. The detection limit for Leptospira DNA was 24.24 pg. A total …


Ejaculate Characteristics Of Captive Malayan Tapirs (Tapirus Indicus), Wanlaya Tipkantha, Budhan Pukazhenthi, Boripat Siriaroonrat, Ampika Thongphakdee, Umaporn Maikaew, Warisara Thomas, Daraka Tongthainan, Jessada Thaeonoen, Sumate Kamolnorranath, Mitchell Bush, Sitthawee Thongtipsiridech Dec 2011

Ejaculate Characteristics Of Captive Malayan Tapirs (Tapirus Indicus), Wanlaya Tipkantha, Budhan Pukazhenthi, Boripat Siriaroonrat, Ampika Thongphakdee, Umaporn Maikaew, Warisara Thomas, Daraka Tongthainan, Jessada Thaeonoen, Sumate Kamolnorranath, Mitchell Bush, Sitthawee Thongtipsiridech

The Thai Journal of Veterinary Medicine

The aims of this study were to optimize semen collection by electroejaculation and characterize ejaculatecharacteristics in Malayan tapir (Tapirus indicus). Eight adult males (4-20 years of age) were anesthetized using acombination of medetomidine HCl (0.012-0.018 mg/kg), butorphanol tartrate (0.012-0.018 mg/kg),and ketamine HCl(5-7 mg/kg) administered intramuscularly via a dart and subjected to electroejaculation. Ejaculates (milky-white toyellowish color) were successfully collected from all males. Averages (Mean±SD) of the seminal traits (volume, pH,osmolality, sperm concentration, total sperm motility, and viability) were 10.3±9.4 ml, 7.4±3.4, 278.6±13.3 mOsm,206.2±185.4x106 spermatozoa/ml , 24±15.4%, and 35.1±6.5%, respectively. Morphological analysis showed lowpercentage of normal spermatozoa 6.7±2.6 % with 39.2±8.5% …


Association Of Filaggrin (Flg) Gene Polymorphism With Canine Atopic Dermatitis In Small Breed Dogs, Gunnaporn Suriyaphol, Prapat Suriyaphol, Meena Sarikaputi, Sirin Theerawatanasirikul, Achariya Sailasuta Dec 2011

Association Of Filaggrin (Flg) Gene Polymorphism With Canine Atopic Dermatitis In Small Breed Dogs, Gunnaporn Suriyaphol, Prapat Suriyaphol, Meena Sarikaputi, Sirin Theerawatanasirikul, Achariya Sailasuta

The Thai Journal of Veterinary Medicine

As a cornified envelope protein, filaggrin (FLG) is involved in the formation and support of the skin barrier.FLG single nucleotide polymorphism (SNP) at the position 64,297,022 (rs22588227) on canine chromosome 17 hasinitially been described as being associated with canine atopic dermatitis (CAD) in Labrador Retrievers in UK. In thisstudy, we have examined whether the mentioned FLG SNP is associated with a susceptibility to CAD in small breeddogs, comprising 21 Poodles, 17 Shih tzus and 3 Pugs. Twelve of these subjects were dogs with atopy and wereassigned to the experiment group and the remaining 39 samples were healthy controls. The results …


Antimicrobial Sensitivity Of Avian Pathogenic Escherichia Coli (Apec) Isolated From Chickens During 2007-2010, Niwat Chansiripornchai, Sarawoot Mooljuntee, Pongthai Boonkhum Dec 2011

Antimicrobial Sensitivity Of Avian Pathogenic Escherichia Coli (Apec) Isolated From Chickens During 2007-2010, Niwat Chansiripornchai, Sarawoot Mooljuntee, Pongthai Boonkhum

The Thai Journal of Veterinary Medicine

Fifty isolates of Avian pathogenic Escherichia coli (APEC) isolated from chickens during 2007-2010 were invitro tested to 21 antimicrobial discs. The highest sensitivity of APEC was to fosfomycin (84%). The second sensitivityagainst enrofloxacin and norfloxacin was 70%. The antimicrobial sensitivity to colistin, gentamicin, kanamycin,sulfametroxazole+trimethoprim, amoxicillin+clavulanic acid and doxycycline were 66, 64, 62, 60, 58 and 52%,respectively. The antimicrobial resistance of APEC to tylosin, tilmicosin, tiamulin, lincomycin, amoxicillin, ampicillin,erythromycin, cephalexin and neomycin were 100, 100, 100, 94, 86, 82, 80, 72 and 62%, respectively.


Expression Of Aheabc Efflux System And Plasmid Profile Of Aeromonas Hydrophila Isolates From Farmed Nile Tilapia (Oreochromis Niloticus) Mintra, Mintra Lukkana, Janenut Wongtavatchai, Rungtip Chuanchuen Dec 2011

Expression Of Aheabc Efflux System And Plasmid Profile Of Aeromonas Hydrophila Isolates From Farmed Nile Tilapia (Oreochromis Niloticus) Mintra, Mintra Lukkana, Janenut Wongtavatchai, Rungtip Chuanchuen

The Thai Journal of Veterinary Medicine

Fifty Aeromonas hydrophila isolates from farmed Nile Tilapia were characterized for expression of AheABCmultidrug efflux system and plasmid profile. Thirty nine isolates (78%) expressed AheABC with production of 1.7 to221.3 folds more than AheB of A. hydrophila ATCC35654, the reference. This suggests that the AheABC efflux systemis not always constitutively expressed in the A. hydrophila clinical isolates. The isolates with less AheB expressionwere more resistant to antibiotics than those with high AheB expression. Seventeen isolates were found to carryplasmids that were arranged into 11 plasmid profiles. This is the first study of the AheABC efflux system in A.hydrophila isolates from …


Ecg Quiz, Chollada Buranakarl, Winai Chansaisakorn Dec 2011

Ecg Quiz, Chollada Buranakarl, Winai Chansaisakorn

The Thai Journal of Veterinary Medicine

No abstract provided.


What Is Your Diagnosis, Pranee Tuntivanich, Suwicha Chuthatep Dec 2011

What Is Your Diagnosis, Pranee Tuntivanich, Suwicha Chuthatep

The Thai Journal of Veterinary Medicine

No abstract provided.


It's Not So Simple: Understanding Participant Involvement In The Design, Implementation, And Improvement Of Cash & Counseling Programs, Erin E. Mcgaffigan Dec 2011

It's Not So Simple: Understanding Participant Involvement In The Design, Implementation, And Improvement Of Cash & Counseling Programs, Erin E. Mcgaffigan

Graduate Doctoral Dissertations

For more than three decades, the United States federal government and the states have worked to restructure the long-term care system to be more community based and responsive to personal preferences. Some argue that those who seek such services should be actively engaged in their design (Morris, 2008; Priester, Hewitt, & Kane, 2006). While many who design and implement home and community-based services may believe that participant engagement could be beneficial, most plans move forward with little to no provision for such engagement. The existing literature provides very little insight into the implications of such decisions.

The Cash & Counseling …


Review: "Sin In The Suburbs: Nevada's Changing Brothel Industry": The State Of Sex: Tourism, Sex And Sin In The New American Heartland, Greggor Mattson Dec 2011

Review: "Sin In The Suburbs: Nevada's Changing Brothel Industry": The State Of Sex: Tourism, Sex And Sin In The New American Heartland, Greggor Mattson

Faculty & Staff Scholarship

No abstract provided.


Nuevas Narrativas: Translation Of Family History, Migel A. Delgado Dec 2011

Nuevas Narrativas: Translation Of Family History, Migel A. Delgado

Boise State University Theses and Dissertations

Family histories are hard to pass on when the native language of one's culture is no longer passed on to the next generation. Growing up between two cultures has created a void that is considerably complex. Nuevas Narrativas: Translation of Family History represents the dynamics involved with deciphering my grandfather's migration story. This investigation within family narratives illustrates the dynamics within reception, translation, and transcription of traditional narratives.

In this installation, I engage the reception of my grandfather's migration story as a way of addressing how foreign languages and historical narratives create displacement through time. The context for this work …


The Metroburb: American Values In Facebook Culture, Heather Marie Carlson Dec 2011

The Metroburb: American Values In Facebook Culture, Heather Marie Carlson

Boise State University Theses and Dissertations

Using critical discourse analysis, fantasy themes were extracted from user profiles and postings to examine American values found in Facebook culture.

Core values found on Facebook worked to create not only socially recognizable identities enacted and communicated through the participants, but also a particular culture to which participants both reflected and contributed in Facebook. Themes and values extracted from findings indicate that Facebook users should be casual, technologically-aware, social, respectful and fair to others, “good little copers,” financially savvy while at the same time valuing higher education, a healthy lifestyle, family and travel.

Because Facebook is an interestingly fluid cultural …


Anaesthetic Management Of Abdominal Hysterectomy In Patient With Congenital Sinus Node Dysfunction, Dileep Kumar, Faisal Shamim Dec 2011

Anaesthetic Management Of Abdominal Hysterectomy In Patient With Congenital Sinus Node Dysfunction, Dileep Kumar, Faisal Shamim

Department of Anaesthesia

A 45 years old woman having dysfunctional uterine bleeding was scheduled for total abdominal hysterectomy with bilateral salpingo-oophorectomy under general anaesthesia. On pre-operative anaesthesia assessment, she was found to have junctional rhythm at rate of 44 beats/minute with bigeminies and pre-mature ventricular contractions on ECG. On further evaluation, she was diagnosed as having congenital sinus node dysfunction on the basis of 24 hours Holter monitoring. She was asymptomatic, no prior comorbidity and belonged to functional class one. General anaesthesia was successfully managed by vigilance, invasive monitoring, standby transcutaneous and transvenous pacemakers; use of cardiostable and vagolytic anaesthetic agents like Etomidate, …


Magnesium, A Drug Of Diverse Use, Mohammad Irfan Akhtar, Hameed Ullah, Mohammad Hamid Dec 2011

Magnesium, A Drug Of Diverse Use, Mohammad Irfan Akhtar, Hameed Ullah, Mohammad Hamid

Department of Anaesthesia

Magnesium has evolved as a drug with diverse clinical applications. Mg++ is an important caution and its homeostasis is very important for normal body functioning. The physiological role of Mg is due to its calcium channel blocking properties at smooth muscle, skeletal muscle and conduction system levels. The analgesic properties are due to NMDA receptor blocking action. Mg++ is beneficial in acute Myocardial Infarction, protection during open heart surgery and treatment and prevention of heart rhythm disturbances. Mg has an established role in the management of preeclampsia and eclampsia. Magnesium prevents or controls convulsions by blocking neuromuscular transmission and decreasing …


The Impact Of Regulating Social Science Research With Biomedical Regulations, Brenda Braxton Durosinmi Dec 2011

The Impact Of Regulating Social Science Research With Biomedical Regulations, Brenda Braxton Durosinmi

UNLV Theses, Dissertations, Professional Papers, and Capstones

The Impact of Regulating Social Science Research with Biomedical Regulations Since 1974 Federal regulations have governed the use of human subjects in biomedical and social science research. The regulations are known as the Federal Policy for the Protection of Human Subjects, and often referred to as the "Common Rule" because 18 Federal agencies follow some form of the policy. The Common Rule defines basic policies for conducting biomedical and social science research. Almost from the inception of the Common Rule social scientists have expressed concerns of the policy's medical framework of regulations having its applicability also to human research in …


School Counselor Assignment In Secondary Schools: Replication And Extension, Jennifer L. Williamson Dec 2011

School Counselor Assignment In Secondary Schools: Replication And Extension, Jennifer L. Williamson

UNLV Theses, Dissertations, Professional Papers, and Capstones

Before school counselors can carry out the duties and responsibilities outlined as part of a comprehensive school counseling program, they must know which students they are responsible for helping. The topic of assigning students to school counselors has only recently been seen in the educational research arena in a study by Akos, Schuldt, and Walendin (2009). The current study attempts to replicate and extend the findings of Akos, Schuldt, and Walendin by addressing the questions of how secondary school counselors are assigned and what are their perceptions of their assignment. In addition, the study attempts to determine whether a particular …


Being Outside Learning About Science Is Amazing: A Mixed Methods Study, Michelle L. Weibel Dec 2011

Being Outside Learning About Science Is Amazing: A Mixed Methods Study, Michelle L. Weibel

UNLV Theses, Dissertations, Professional Papers, and Capstones

This study used a convergent parallel mixed methods design to examine teachers' environmental attitudes and concerns about an outdoor educational field trip. Converging both quantitative data (Environmental Attitudes Scale and teacher demographics) and qualitative data (Open-Ended Statements of Concern and interviews) facilitated interpretation. Research has shown that adults' attitudes toward the environment strongly influence children's attitudes regarding the environment. Science teachers' attitudes toward nature and attitudes toward children's field experiences influence the number and types of field trips teachers take. Measuring teacher attitudes is a way to assess teacher beliefs.

The one day outdoor field trip had significant outcomes for …


A Brief Content Analysis Of Attachment And Sexual Relationships In Sex Therapy And Research Journals, Kathryn Zambrano Devis Dec 2011

A Brief Content Analysis Of Attachment And Sexual Relationships In Sex Therapy And Research Journals, Kathryn Zambrano Devis

UNLV Theses, Dissertations, Professional Papers, and Capstones

A surge of scholarly publications on attachment within couple relationships prompted this content analysis of attachment articles published in six sex therapy and sex research journals. This study investigates the extent to which these journals attend to attachment in the context of adult sexual relationships. The researcher found 2257 articles published within these journals; 64 of which attend to attachment and 9 of which attend to attachment and sex. Implications for couples therapy in the field of sex therapy and future directions are discussed.


Optimizing Heart Dose Reduction For Deep Inspiration Left Breast Radiotherapy, Ronald James Harder Dec 2011

Optimizing Heart Dose Reduction For Deep Inspiration Left Breast Radiotherapy, Ronald James Harder

UNLV Theses, Dissertations, Professional Papers, and Capstones

Multiple studies have shown that an increased risk of late injury cardiac abnormalities including congestive heart failure (CHF), ischemia, and coronary artery disease (CAD) can be associated with common left breast radiation therapy (RT) techniques. Many radiation therapy clinics have adopted the Deep Inspiration Breath Hold (DIBH) technique for the treatment of the left breast with external beam therapy based on studies showing a decrease in the dose received by the heart. A common technology used to monitor inhalation during DIBH is the Real-Time Position Management (RPM) system (Varian Medical Systems, Palo Alto, CA). This study analyzes if there is …


Factors Which Influence The Use Of Active Learning Strategies By Nursing Faculty, Deborah Lowell Shindell Dec 2011

Factors Which Influence The Use Of Active Learning Strategies By Nursing Faculty, Deborah Lowell Shindell

UNLV Theses, Dissertations, Professional Papers, and Capstones

Nursing education is facing a crisis. Anachronistic teaching methods are no longer keeping up with the needs of new graduates entering practice. Despite a body of knowledge which supports the use of active learning in higher education, nursing faculty continue to rely on lecture as their primary pedagogical approach. Previous study of the use of research products in clinical nursing practice identified systematic factors such as characteristics of the communication of research findings and characteristics of the organization form the greatest barrier to use. This study discovers if these same barriers face nursing educators.

Using Roger‟s Theory of Diffusion of …


Practicing Orthodontists' Use And Perceived Efficacy Of Self-Ligating Brackets, John-David Beuhler Dec 2011

Practicing Orthodontists' Use And Perceived Efficacy Of Self-Ligating Brackets, John-David Beuhler

UNLV Theses, Dissertations, Professional Papers, and Capstones

Introduction.

The purpose of this study was to compare perceptions of efficacy and efficiency of Self-Ligating Brackets vs. conventional brackets between practicing Orthodontists and Orthodontic Residents.

Methods.

Cross-sectional survey research using a three-wave emailing of addresses from the current American Association of Orthodontists directory. The directors of all orthodontic residency programs in the US were asked to also distribute to all residents. The survey included five sections: (1) respondents' experience, (2) factors that influence, (3) positive or negative factors, (4) the perceived efficiency/efficacy, and (5) demographics. A 39% response rate (N=707) was obtained.

Results.

Over half (51.8%) …


Pain Tolerance And Thresholds In Women With Dyspareunia: Do Pain And Sex Primes Have Differential Effects?, Lea Thaler Dec 2011

Pain Tolerance And Thresholds In Women With Dyspareunia: Do Pain And Sex Primes Have Differential Effects?, Lea Thaler

UNLV Theses, Dissertations, Professional Papers, and Capstones

Dyspareunia, defined as recurrent pain in the genital/pelvic region during sexual intercourse, is one of the most common types of female sexual dysfunction, affecting approximately 15% of women between the ages of 18 and 24. Women with dyspareunia display similar cognitive and emotional styles evidenced in other chronic pain conditions (e.g. hypervigilance for pain information, catastrophization, and negative affect); however, dyspareunia is a unique pain disorder in that it directly involves sexual functioning. This pairing of pain and sex raises the issue of conditioning. Is it possible that because intercourse is painful for women with dyspareunia, the presentation of any …


The Effect Of Pre-Collaborative Activity Instruction On Self-Efficacy, Robert Ray Mattson Dec 2011

The Effect Of Pre-Collaborative Activity Instruction On Self-Efficacy, Robert Ray Mattson

UNLV Theses, Dissertations, Professional Papers, and Capstones

Collaborative learning is increasing in popularity in education. This collaborative pedagogy is based on a significant body of research that shows positive learning gains. Additionally, given the nature of much of the information-age work, it is thought that such collaborative activity in school helps develop knowledge, skills and attitudes that will be beneficial to students in their post-college lives.

In spite of collaborative learning's increasing use and popularity, there is only limited research on how students feel about such methods and their level of confidence in their collaborative knowledge, skills and attitudes. Based on the current theories about self-efficacy, delineated …


Visual Attention To Erotic Stimuli In Androphilic Male-To-Female Transsexuals, Sarah A. Akhter Dec 2011

Visual Attention To Erotic Stimuli In Androphilic Male-To-Female Transsexuals, Sarah A. Akhter

UNLV Theses, Dissertations, Professional Papers, and Capstones

The present study investigated sex differences in visual attention to erotic stimuli by comparing three groups of individuals: heterosexual men, heterosexual women, and androphilic MtF transsexuals. Twenty men, 20 women and 13 MtF transsexuals were shown 10 split-screen slides, each featuring one nude erotic photo of a man shown on half of the screen and one nude erotic photo of a woman shown on the other half of the screen. Eye movements were tracked as participants viewed the slides. All participants were heterosexual (Kinsey 0-1) relative to gender identity, thus erotic targets for natal men were nude women in the …


Switches, Excitable Responses And Oscillations In The Ring1b/Bmi1 Ubiquitination System., Lan K Nguyen, Javier Muñoz-García, Helene Maccario, Aaron Ciechanover, Walter Kolch, Boris N Kholodenko Dec 2011

Switches, Excitable Responses And Oscillations In The Ring1b/Bmi1 Ubiquitination System., Lan K Nguyen, Javier Muñoz-García, Helene Maccario, Aaron Ciechanover, Walter Kolch, Boris N Kholodenko

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

In an active, self-ubiquitinated state, the Ring1B ligase monoubiquitinates histone H2A playing a critical role in Polycomb-mediated gene silencing. Following ubiquitination by external ligases, Ring1B is targeted for proteosomal degradation. Using biochemical data and computational modeling, we show that the Ring1B ligase can exhibit abrupt switches, overshoot transitions and self-perpetuating oscillations between its distinct ubiquitination and activity states. These different Ring1B states display canonical or multiply branched, atypical polyubiquitin chains and involve association with the Polycomb-group protein Bmi1. Bistable switches and oscillations may lead to all-or-none histone H2A monoubiquitination rates and result in discrete periods of gene (in)activity. Switches, overshoots …


Switches, Excitable Responses And Oscillations In The Ring1b/Bmi1 Ubiquitination System., Lan K Nguyen, Javier Muñoz-García, Helene Maccario, Aaron Ciechanover, Walter Kolch, Boris N Kholodenko Dec 2011

Switches, Excitable Responses And Oscillations In The Ring1b/Bmi1 Ubiquitination System., Lan K Nguyen, Javier Muñoz-García, Helene Maccario, Aaron Ciechanover, Walter Kolch, Boris N Kholodenko

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

In an active, self-ubiquitinated state, the Ring1B ligase monoubiquitinates histone H2A playing a critical role in Polycomb-mediated gene silencing. Following ubiquitination by external ligases, Ring1B is targeted for proteosomal degradation. Using biochemical data and computational modeling, we show that the Ring1B ligase can exhibit abrupt switches, overshoot transitions and self-perpetuating oscillations between its distinct ubiquitination and activity states. These different Ring1B states display canonical or multiply branched, atypical polyubiquitin chains and involve association with the Polycomb-group protein Bmi1. Bistable switches and oscillations may lead to all-or-none histone H2A monoubiquitination rates and result in discrete periods of gene (in)activity. Switches, overshoots …


Sources Of Funds In Academic Libraries In Delta State, Nigeria, Janet Onomeh Ubogu, Rose B. Okiy Dec 2011

Sources Of Funds In Academic Libraries In Delta State, Nigeria, Janet Onomeh Ubogu, Rose B. Okiy

Library Philosophy and Practice (e-journal)

Academic libraries are those attached to universities, polytechnics, college of education and other similar institutions of higher learning. The importance of funding in providing quality library service cannot be overemphasized. It is the glue that holds the building, collection and staff together and allows the library to attain its goals. As such, money can be considered the soul of the library. Inadequate funds impede the effectiveness of any library (Anafulu, 1997).

It is absolutely essential for a library to posses the resources that will enable it meet its goals. Beautiful building, well trained staff and modern information storage and retrieval …


Education For Information Professionals In Bangladesh: A Case Study Of The University Of Dhaka, A.I.M. Jakaria Rahman, Momena Khatun, Dr. Mohammed Mezbah-Ul-Islam Dec 2011

Education For Information Professionals In Bangladesh: A Case Study Of The University Of Dhaka, A.I.M. Jakaria Rahman, Momena Khatun, Dr. Mohammed Mezbah-Ul-Islam

Library Philosophy and Practice (e-journal)

Professional competence is achieved through University education. University is the place where the root of knowledge in a field of study is fabricated. It is also the forum where research and professional queries begin. As such, the curriculum is not only for the forming of knowledge but also for the forming of attitudes, academic and professional approaches. The impact of a departmental curriculum is far greater than the mere transfer of knowledge. Syllabus or courses of studies are one-dimensional document that embody the subjects and contents outline with broad time allocation. Curriculum is three-dimensional, and takes into account the needs …