Digital Commons Network^™

Paclitaxel Induces Thrombomodulin Downregulation In Human Aortic Endothelial Cells, Huang-Joe Wang, Te-Ling Lu, Haimei Huang, Huey-Chun Huang

The Texas Heart Institute Journal

Patients with paclitaxel-eluting stents are at risk of developing stent thrombosis upon premature discontinuation of dual antiplatelet therapy. In this study, we set out to clarify whether paclitaxel can modulate thrombomodulin expression in human aortic endothelial cells. Human aortic endothelial cells were stimulated with paclitaxel. Methoxyphenyl tetrazolium inner salt cell viability assay, Western blot analysis, real-time polymerase chain reaction, and immunohistochemical assay were performed. In human aortic endothelial cells, paclitaxel (10(-5) to 10(-9) mol/L) treatment for 13 hours caused significant cytotoxicity at drug concentrations greater than 10(-7) mol/L. Paclitaxel (10(-5) to 10(-9) mol/L) treatment for 5 hours downregulated thrombomodulin expression …

A Dosing Study Of Bone Marrow Mononuclear Cells For Transendocardial Injection In A Pig Model Of Chronic Ischemic Heart Disease, Guilherme V Silva, Marlos R Fernandes, Cristiano O Cardoso, Ricardo R Sanz, Edie M Oliveira, Pilar Jimenez-Quevedo, Javier Lopez, Franca S Angeli, Yi Zheng, James T Willerson, Emerson C Perin

The Texas Heart Institute Journal

We studied the effect of the dose of bone marrow mononuclear cells, delivered via transendocardial injection, upon capillary density and fibrosis in pigs with chronic ischemic heart disease.

Pigs (n = 16) that had undergone ameroid constrictor placement (left circumflex coronary artery) to induce chronic ischemia were divided equally into 4 groups on the basis of bone marrow mononuclear cell dose: control (saline injection) and 50, 100, or 200 × 106 bone marrow mononuclear cells. Thirty days after ameroid placement, each pig received 13 transendocardial NOGA-guided injections. An implantable loop recorder monitored possible arrhythmias caused by cell transplantation. Thirty days …

Rosuvastatin Therapy Does Not Affect Serum Mmp-13 Or Timp-1 Levels In Hypercholesterolemic Patients, Cihan Cevik, Kenneth Nugent, Gary Meyerrose, Mohammad Otahbachi, Cemil Izgi, Mark Lyte, R David Fish

The Texas Heart Institute Journal

Matrix metalloproteinases degrade the collagen content of atherosclerotic plaque and reduce plaque stability. In tissue sections of atherosclerotic plaque, the expression of matrix metalloproteinases is increased. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) decrease the tissue expression of matrix metalloproteinases-1, -2, -3, and -9 in atheromatous plaque by attenuating the inflammatory process that leads to increased expression. However, it is not known whether statins decrease levels of matrix metalloproteinase-13—an enzyme crucial to the initiation of collagen degradation—as part of their plaque-stabilizing effect.

We prospectively examined the effect of statin therapy on serum levels of matrix metalloproteinase-13, tissue inhibitor of metalloproteinase-1, and …

Internal Medicine Problems As They Present To The Cardiologist, Ira Martin Grais

The Texas Heart Institute Journal

No abstract provided.

Troubleshooting Implantable Cardioverter-Defibrillators: An Overview For Physicians Who Are Not Electrophysiologists, Mohammad Saeed

The Texas Heart Institute Journal

No abstract provided.

Micro-Ultrasonographic Imaging Of Atherosclerotic Progression And Correlation With Inflammatory Markers In Apolipoprotein-E Knockout Mice, Rong-Juan Li, Ya Yang, Yan-Hong Wang, Jin-Jie Xie, Li Song, Zheng Wang, Yao-Zhong Zhang, Yan-Wen Qin, Zhi-An Li, Xiao-Shan Zhang

The Texas Heart Institute Journal

We studied prospectively whether atherosclerotic progression in apolipoprotein-E knockout mice could be noninvasively and accurately measured by use of high-resolution ultrasonographic biomicroscopy. We examined the correlation between the ultrasonographic characterization of ascending aortic atherosclerotic plaque and plasma C-reactive protein, interleukin-1, and interleukin-6 levels in these mice.

In 4 age groups (8, 16, 24, and 32 wk) of 8 male knockout mice each (atherosclerotic groups) and age-matched male C57BL/6 mice (control groups), we used ultrasonographic biomicroscopy to measure maximal plaque thickness or intima-media thickness in the ascending aorta. We compared the findings with corresponding histologic measurements, and we measured plasma C-reactive …

Cardiac Surgery: A Century Of Progress, Allen B Weisse

The Texas Heart Institute Journal

Well into the first decades of the 20th century, medical opinion held that any surgical attempts to treat heart disease were not only misguided, but unethical. Despite such reservations, innovative surgeons showed that heart wounds could be successfully repaired. Then, extracardiac procedures were performed to correct patent ductus arteriosus, coarctation of the aorta, and tetralogy of Fallot. Direct surgery on the heart was accomplished with closed commissurotomy for mitral stenosis. The introduction of the heart-lung machine and cardiopulmonary bypass enabled the surgical treatment of other congenital and acquired heart diseases. Advances in aortic surgery paralleled these successes. The development of …

Cd34-Positive Stem Cells In The Treatment Of Heart And Vascular Disease In Human Beings, Alexander R Mackie, Douglas W Losordo

The Texas Heart Institute Journal

Bone marrow-derived CD34(+) cells are a well-characterized population of stem cells that have traditionally been used clinically to reconstitute the hematopoietic system after radiation or chemotherapy. More recently, CD34(+) cells have also been shown to induce therapeutic angiogenesis in animal models of myocardial, peripheral, and cerebral ischemia. The mechanism by which CD34(+) cells promote therapeutic angiogenesis is not completely understood, although evidence supports both direct incorporation of the cells into the expanding vasculature and paracrine secretion of angiogenic growth factors that support the developing microvasculature. Phase I and phase II clinical trials have explored the usefulness of CD34(+) cells in …

Prehypertension: A Meta-Analysis Of The Epidemiology, Risk Factors, And Predictors Of Progression, Xiaofan Guo, Liling Zou, Xingang Zhang, Jue Li, Liqiang Zheng, Zhaoqing Sun, Jian Hu, Nathan D Wong, Yingxian Sun

The Texas Heart Institute Journal

We investigated the prevalence and risk factors of prehypertension, as well as the predictors of progression from prehypertension to hypertension. To do this, we performed a systematic review and meta-analysis of cross-sectional and longitudinal studies, after unrestricted searches of PubMed and The Cochrane Library through September 2010. In addition, we reviewed references, major textbooks, and review articles. Pooled prevalence, standardized mean differences, and odds ratios were estimated by using a random-effects model.

Twenty-six articles met our inclusion criteria; these included 20 cross-sectional and 6 longitudinal studies, with a total sample of 250,741 individuals. The overall pooled prevalence of prehypertension was …

Interposition Grafting Of Large Extracranial Carotid Aneurysm, Marlous Huyzer, Michel M P J Reijnen, Johannes E M Sybrandy, Jacob Buth, Clark J Zeebregts

The Texas Heart Institute Journal

Extracranial carotid aneurysms are a rare entity and carry an inherent risk of thromboembolic complications. Treatment options consist of endovascular and conventional surgical techniques. We describe the cases of 3 patients who were treated with an interposition graft for a large extracranial carotid aneurysm.

The patients had presented with an extracranial carotid aneurysm with a diameter of 30 to 43 mm. In all cases, the aneurysm was excluded by means of an interposition graft, without major perioperative complications. There was 1 case of temporary paresis of the facial nerve and another of temporary paresis of the vocal cord. After a …

Nafta, Cafta And The Environment: The Role Of Institutions, Sherrie Baver

Publications and Research

This essay examines the institutionalization of environmental concerns, primarily focusing on NAFTA, and argues that the 1994 agreement should be seen as a positive first attempt to raise the profile of environmental concerns within discussions of expanding global trade. More specifically, NAFTA and subsequent U.S. FTAs have contributed to the growth of procedural environmental rights that have the potential to deepen democracy in the wider political system. Given that free trade agreements represent the U.S. approach to world trade at present, this paper takes the practical position that building on NAFTA’s foundation, opportunities exist to continue promoting environmental sustainability within …

Growing Up Policed In The Age Of Aggressive Policing Policies, Brett G. Stoudt, Michelle Fine, Madeline Fox

Publications and Research

Spray-painted atop an old tenement building in the East Village of Manhattan is a large fossilized graffiti image of a tyrannosaurus rex that reads: “NYC EATS ITS YOUNG.” With its ribs exposed and mouth open, this image represents symbolically what many young people in the neighborhood already know intimately and have experienced: New York City (NYC) is not an easy place to grow up. Their social safety nets are being dismantled and the public institutions they rely on every day often fail them. In NYC, public school budgets are being slashed each year even though the high school dropout/push-out rates …

Critical Teaching In The Library, Alycia Sellie

Publications and Research

No abstract provided.

War Don Don And Fambol Tok, Polly Thistlethwaite

Publications and Research

Reviews two documentary films about the aftermath and reconciliation of the Sierra Leone Civil War 1991-2002.

Working Memory In Simultaneous Interpreters: Effects Of Task And Age, Teresa Signorelli, Henk Haarmann, Loraine Obler

Publications and Research

This study examines whether interpreters have better working memory (WM) than noninterpreters, taking into account different WM components and the potential modulatory influence of age. Younger and older interpreters and non-interpreters were tested on reading span, nonword repetition, and order- and category-cued recall, using English, second-language materials. Articulation rate was also assessed. Interpreters outperformed non-interpreters in reading span and nonword repetition, but not cued recall and articulation rate. These results suggest that interpreters have better ability to manipulate information in working memory and process or store sub-lexical phonological representations, but have no advantage in short-term retention of words and their …

Política Del Lenguaje Y Geopolítica: España, La Rae Y La Población Latina De Estados Unidos, José Del Valle

Publications and Research

The status of Spanish in the US is discussed through a focus on the coexistence of monoglossic and heteroglossic ideologies as well as on the institutionalized discourses on Spanish in the US.

Review Of Branded To Kill, Michael Adams

Publications and Research

Review of Seijun Suzuki's 1967 crime film.

Review Of Zazie Dans Le Metro, Michael Adams

Publications and Research

Review of Louis Malle's 1960 French New Wave film.

Review Of The Killing, Michael Adams

Publications and Research

Review of Stanley Kubrick's The Killing: http://www.media-party.com/discland/2011/10/the-killing-blu-ray.html

Review Of Last Tango In Paris, Michael Adams

Publications and Research

Review of Bernardo Bertolucci's Last Tango in Paris: http://www.media-party.com/discland/2011/03/last-tango-in-paris-blu-ray.html

Review Of Lolita, Michael Adams

Publications and Research

Review of Stanley Kubrick's Lolita: http://www.media-party.com/discland/2011/06/lolita-1962-blu-ray.html

Italian Militants And Migrants And The Language Of Solidarity In The Early- Twentieth-Century Western Coalfields, Stephen Brier, Ferdinando Fasce

Publications and Research

This article uses the life and experiences of an Italian immigrant and labor militant, Carlo Demolli, to examine a range of issues, including: the intersection of ethnic and national identity and labor militancy and solidarity in the organizing efforts of the United Mine Workers of America (UMWA) among the ethnically diverse workforce of coal miners in the American West at the turn of the 20th century; the role of a "language of solidarity" as expressed in an Italian language version of the UMW Journal, Il Lavoratore Italiano, in sustaining a militant Italian immigrant workforce in the coal mines; and the …

Between "Voluntary Migrants" And War Refugees: The Health Of The Shan Burmese Migrant Workers In Northern Thailand, Nishant Verma, Celina Su, Coralie Chan, Peter Muennig

Publications and Research

The Shan are a large migrant group from Burma (Myanmar) found within Thailand. While some Shan migrate to escape the civil war within Burma, others migrate for economic opportunity. Despite the size of this population, little is known about their health. Our study highlights the need for expanded access to primary care among this Shan population. Despite the arduous and trying journeys of these Shan migrants, they do not display the level of health sometimes attributed to health selection among immigrant groups.

Freedom Of Expression Under The California Constitution, Joseph R. Grodin

Faculty Scholarship

No abstract provided.

Floorplan Design And Yield Enhancement Of 3-D Integrated Circuits, Rajeev Kumar Nain

Dissertations and Theses

We have developed a placement-aware 3-D floorplanning algorithm that enables additional wirelength reduction by planning for 3-D placement of logic gates in selected circuit modules during the floorplanning stage. Thus it also bridges the existing gap between 3-D floorplanning and 3-D placement. To reduce the solution space of 3-D floorplanning which is known to be an NP-hard problem, we derive a set of feasibility conditions on the topological representation of a floorplan. In addition, we have designed a fast module packing algorithm that satisfies a set of constraints for placement-aware 3-D floorplanning. Furthermore, we have designed an efficient evolutionary algorithm …

Foreign Official Immunity After Samantar, Chimene Keitner

Faculty Scholarship

No abstract provided.

Framing Constitutional Rights, Chimene Keitner

Faculty Scholarship

No abstract provided.

Pathos, Winter 2011, Portland State University. Student Publications Board

Pathos

Editor: Joel Eisenhower

Issue 14

Past Tense, 2011, Retired Association Of Portland State

Past Tense columns of the RAPS Sheet

January, 2011 "Pres. Ramaley champions redesign of seal"

February, 2011 "A walk through the PSU Park Blocks: Past and Present"

March, 2011 "Remembering Sharkey Nelson"

April, 2011 "Name that PSU person"

May, 2011 "From Ugly Duckling to Beautiful Swan"

September, 2011 "1976: Keith Larson garners Partners Award for PSU"

October, 2011 "The Vanguard: then and now"

November, 2011 "SBA students join the PC revolution 1981 BC (Before Computers)"

December, 2011 "Protests at PSU: Big, Small, Imaginary"

Portland State Magazine, Portland State University. Office Of University Communications

Portland State Magazine

PSU’s alumni magazine, published 2-3 times a year. In this issue: As new electric vehicles come to market, Portland State is helping pave the way; a generous new GI Bill is persuading some veterans to get their college degree; Lincoln Hall gets a new look; Oregon’s public universities are asking the state for more control over their finances and future; and more.