Digital Commons Network^™

Suffolk Journal, Vol. 72, No. 12, 12/7/2011, Suffolk Journal

Suffolk Journal

No abstract provided.

Chloroform Fraction Of Centratherum Anthelminticum (L.) Seed Inhibits Tumor Necrosis Factor Alpha And Exhibits Pleotropic Bioactivities: Inhibitory Role In Human Tumor Cells, A. Arya, M. Achoui, S. C. Cheah, S. I. Abdelwahab, P. Narrima, S. Mohan, Mohd Rais Mustafa, M. A. Mohd

Research Publications (2011 to 2015)

We investigated the antioxidant potential, cytotoxic effect, and TNF-α inhibition activity with NF-κB activation response in a chloroformfraction of Centratherum anthelminticum seeds (CACF). The antioxidant property of CACF was evaluated with DPPH, ORAC, and FRAP assays, which demonstrated significant antioxidant activity. The cytotoxicity of CACF was tested using theMTT assay; CACF effective inhibitory concentrations (IC50) for A549, PC-3, MCF-7, and WRL-68 cells were 31.42 ± 5.4, 22.61 ± 1.7, 8.1±0.9, and 54.93±8.3 μg/mL, respectively. CACF effectively and dose-dependently inhibited TNF-α release, in vitro and in vivo. CACF inhibited TNF-α secretion in stimulated RAW264.7macrophage supernatants with an IC50 of 0.012 μg/mL, …

The Aporphine Alkaloid Boldine Improves Endothelial Function In Spontaneously Hypertensive Rats, Yeh-Siang Lau, A. Machha, F.I. Achike, Mohd Rais Mustafa, D. Murugan

Research Publications (2011 to 2015)

Boldine, a major aporphine alkaloid found in Chilean boldo tree, is a potent antioxidant. Oxidative stress plays a detrimentalrole in the pathogenesis of endothelial dysfunction in hypertension. In the present study, we investigated the effects of boldine on endothelial dysfunction in hypertension using spontaneously hypertensive rats (SHR), the most studied animal model of hypertension. SHR and their age-matched normotensive Wistar-Kyoto (WKY) rats were treated with boldine (20 mg/kg perday) or its vehicle, which served as control, for seven days. Control SHR displayed higher systolic blood pressure (SBP), reduced endothelium-dependent aortic relaxation to acetylcholine (ACh), marginally attenuated endothelium-independent aortic relaxation to …

Jean-Martin Charcot - Neurologist By Avocation, Nephrologist By Yearning, Gary Eknoyan

Houston History of Medicine Lectures (2006-2012)

In an age of medical advances and specialization, Jean-Martin Charcot (1825-1893) helped found the discipline of neurology and in 1882 was appointed the first professor of Diseases of the Nervous System in France. As an investigator with broad interests and vast knowledge Charcot contributed to several other disciplines. An early mentor and dominant figure in Charcot's formative years was Pierre Rayer (1793-1867), famous for his seminal contributions to the study of the kidney, who gifted Charcot with his passion for clinical pathological correlations and likely a yearning for the study of kidney diseases. Famous for the clarity and incisiveness of …

State V. Crawford Appellant's Brief Dckt. 38587

Not Reported

No abstract provided.

The Bg News December 7, 2011, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. December 7, 2011. Volume 102-Issue 49.

The Colby Echo (2011-12-07), Colby College

The Colby Echo

Published by the students of Colby College since 1877, The Colby Echo is the weekly, editorially independent student-run newspaper of Colby College in Waterville, Maine. Published monthly, 1877-1886; semi-monthly, 1886-1897; and weekly, during the academic year, 1898-present.

Predator Mediated Selection And The Impact Of Developmental Stage On Viability In Wood Frog Tadpoles (Rana Sylvatica), Ryan Calsbeek, Shawn Kuchta

Dartmouth Scholarship

Complex life histories require adaptation of a single organism for multiple ecological niches. Transitions between life stages, however, may expose individuals to an increased risk of mortality, as the process of metamorphosis typically includes developmental stages that function relatively poorly in both the pre- and post-metamorphic habitat. We studied predator-mediated selection on tadpoles of the wood frog, Rana sylvatica, to identify this hypothesized period of differential predation risk and estimate its ontogenetic onset. We reared tadpoles in replicated mesocosms in the presence of the larval odonate Anax junius, a known tadpole predator.

Involuntary Servitude, Public Accommodations Laws, And The Legacy Of Heart Of Atlanta Hotel, Inc. V. United States, Linda C. Mcclain

Faculty Scholarship

In Heart of Atlanta Motel v. United States (1964), the U.S. Supreme Court unanimously affirmed Congress’s power under the Commerce Clause to pass Title II, the public accommodations component of the Civil Rights Act of 1964 (CRA). The Johnson Administration expressed hope that this unanimous decision would aid the “reasonable and responsible acceptance” of the CRA. A less familiar legacy of this case is the role played by the Thirteenth Amendment and its declaration that “neither slavery and involuntary servitude . . . shall exist within the United States.” The owner of the Heart of Atlanta Motel unsuccessfully invoked this …

Afro-Derived Amazonian Populations: Inferring Continental Ancestry And Population Substructure, Luana Gomes Lopes Maciel, Elzemar Martins Ribeiro-Rodrigues, Ney Pereira Cameiro Dos Santos, Ândrea K. C. Ribeiro Dos Santos, João Farias Guerreiro, Sidney Emanuel Batista Dos Santos

Human Biology

A panel of Ancestry Informative Markers (AIMs) was used to identify population substructure and estimate individual and overall interethnic admixture in 294 individuals from seven African-derived communities of the Brazilian Amazon. A panel of 48 biallelic markers, representing the insertion (IN) or the deletion (DEL) of small DNA fragments, was employed for this purpose. Overall interethnic admixture estimates showed high miscegenation with other ethnic groups in all populations (between 46% and 64%). The proportion of ancestral genes varied significantly among individuals of the sample: the contribution of African genes varied between 12% and 75%; of European genes between 10% and …

Chronic Hindlimb Ischemia Impairs Functional Vasodilation And Vascular Reactivity In Mouse Feed Arteries, Trevor R. Cardinal, Kyle R. Struthers, Thomas J. Kesler, Matthew D. Yocum, David T. Kurjiaka, James B. Hoying

Peer Reviewed Articles

Vasodilation of lower leg arterioles is impaired in animal models of chronic peripheral ischemia. In addition to arterioles, feed arteries are a critical component of the vascular resistance network, accounting for as much as 50% of the pressure drop across the arterial circulation. Despite the critical importance of feed arteries in blood flow control, the impact of ischemia on feed artery vascular reactivity is unknown. At 14 days following unilateral resection of the femoral–saphenous artery–vein pair, functional vasodilation of the profunda femoris artery was severely impaired, 11 ± 9 versus 152 ± 22%. Although endothelial and smooth muscle-dependent vasodilation were …

Spartan Daily December 6, 2011, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily (School of Journalism and Mass Communications)

Volume 137, Issue 51

Public Interest Analysis Of The Us Tpp Proposal For An Ip Chapter, Sean Flynn, Margot E. Kaminski, Brook K. Baker, Jimmy H. Koo

Joint PIJIP/TLS Research Paper Series

This briefing paper provides preliminary analysis of two leaked U.S. proposals for an intellectual property chapter in the Trans Pacific Partnership (TPP) agreement. The U.S. proposal, if adopted, would create the highest intellectual property protection and enforcement standards in any free trade agreement to date. Its provisions are primarily based on, and frequently go beyond, the maximalist and controversial standards of the Korea-US Free Trade Agreement (KORUS), the Anti-Counterfeiting Trade Agreement (ACTA) and US law, while negating the development-oriented flexibilities required by the 2007 New Trade Deal for developing countries and included in the US-Peru Free Trade Agreement. If adopted, …

Independent - Dec. 6, 2011, Janean L Watkins

The Independent (1988-present)

No abstract provided.

Using Design Layers Model To Develop Computer-Based Training For The Center For Teaching And Learning's Usability Center, Matthew B. Guinn

Theses and Dissertations

The Usability Center training course is an instructional resource for BYU faculty, employees, and students to prepare them to effectively use the BYU Usability Center. This document describes the process and results of analyzing, designing, developing, implementing, and evaluating the Usability Center training course. By taking this course, participants learn the basics of planning, piloting, executing, and reporting their usability activities and the skills prerequisite to using BYU's Usability Center.

The Current Volume 22 : Issue 15, Nova Southeastern University

Student Newspapers

No abstract provided.

The George-Anne, Georgia Southern University

The George-Anne

• Pi Kappa Phi Faces Hazing Allegations
• Views
• Arts
• Classifieds
• Puzzles/ Comics
• Sports

The Dutch Connection: The European Court Of Human Rights And The Pursuit Of Global Citizenship In The Netherlands, Patrick Schmidt, Erik Larson

Macalester International

No abstract provided.

Spinoza, Locke, And The Limits Of Dutch Toleration, Geoffrey A. Gorham

Macalester International

No abstract provided.

Memory And Urbanism In The Constitution Of Global Citizenship: Heritage, Preservation, And Tourism In Amsterdam And Rotterdam, Ernesto Capello

Macalester International

No abstract provided.

The Dutch Golden Age And Globalization: History And Heritage, Legacies And Contestations, Joop De Jong

Macalester International

No abstract provided.

Queers And Muslims: The Dutch Case, Gert Hekma

Macalester International

No abstract provided.

The Influence Of Oxytocin On Adipose Tissue, Inflammation And Atherosclerosis, Maria Agustina Rossetti

Open Access Theses

Purpose: The present study investigates the potential anti-inflammatory effects of in vivo oxytocin (OT) infusion on adipose tissue inflammation in the Watanabe Heritable Hyperlipidimic Rabbits (WHHL). Methods: Twenty-eight 3-month-old WHHL were surgically implanted with osmotic minipumps containing OT (n = 14, infusion rate 250 ng/kg/hr) or vehicle (n = 14). Blood samples were taken at baseline, midpoint, and endpoint for lipids and C-reactive protein (CRP). After 16 weeks, animals were sacrificed and samples of adipose tissue (epididiymal, retroperitoneal, mesenteric, pericardial, and subcutanous) were collected and analyzed for pro-inflammatory cytokine (IL-6, TNF-α, and MCP-1) and anti- inflammatory adipokine (adiponectin and IL-10) …

Operant Conditioning Of Tibialis Anterior And Soleus H-Reflex Improves Spinal Reflex Modulation And Walking Function In Individuals With Motor-Incomplete Spinal Cord Injury, Kathleen Joy Manella

Open Access Dissertations

Spinal cord injury (SCI) manifests signs of spasticity, plantar flexor (PF) hyperreflexia and ankle clonus, and deficits in motor function. In individuals with motor-incomplete SCI (MISCI), ankle clonus may limit independent walking function. Ankle clonus is attributed to enhanced soleus stretch reflex (SSR) excitability due to decreased supraspinal input and maladaptive reorganization of spinal reflex circuitry. We explored these questions: 1. What are the biomechanical, clinical, and neurophysiologic correlates of ankle clonus? 2. Does locomotor training improve ankle clonus and walking function? 3. Will operant conditioning-based interventions that increase tibialis anterior activation or decrease soleus reflex excitability improve ankle motor …

P27 And Metastatic Progression: Molecular Mechanisms Underlying Bone Metastasis, Seth A. Wander

Open Access Dissertations

The complex PI3K/mTOR pathway regulates tumor progression via effects on cellular proliferation, apoptosis, autophagy, and motility. New drugs that inhibit the catalytic site of both PI3K and mTOR have shown promise in clinical trials. Here, we report the first use of a novel, dual PI3K/mTOR catalytic site inhibitor (PF-04691502, PF1502) in a xenograft model of breast cancer metastasis to bone. Metastatic MDA-MB-1833 cells showed PI3K/mTOR activation relative to parental MDA-MB-231. Low-dose PF1502 significantly impaired tumor cell motility and invasion in vitro without causing cell cycle arrest, apoptosis, or reduced proliferation. Pre-treatment of tumor cells at this dose reduced bone metastatic …

December 5, 2011: Why Do We Mourn?, Bruce Ledewitz

Hallowed Secularism

Blog post, “Why Do We Mourn?“ discusses politics, theology and the law in relation to religion and public life in the democratic United States of America.

Current, December 05, 2011, University Of Missouri-St. Louis

Current (2010s)

No abstract provided.

Effect Of Education Tablet Applications On Beginning Reading Skills Of Students With Autism, Jillian Ratliff

Theses & Honors Papers

The purpose of this study was to explore the relationship between the effect of tablet computer applications and the reading skills of students with autism. Two subjects diagnosed with autism selected by using a convenient sampling method participated in this study. A single subject ABA design was used for collecting data regarding phonemic identification, letter identification, letter discrimination, ap.d sight word identification. Following the collection of baseline data, interventions in the form of different iPad applications were used in individual tutoring sessions and data were collected on the percent of correct responses given per trial. At the completion of a …

Columbia Chronicle (12/05/2011), Columbia College Chicago

Columbia Chronicle

Student newspaper from December 5, 2011 entitled The Columbia Chronicle. This issue is 44 pages and is listed as Volume 47, Number 14. Cover story: "Top dogs make top dollars" Editor-in-Chief: Brianna Wellen

Cseas Weekly Bulletin (December 5, 2011), Center For Southeast Asian Studies

CSEAS Bulletin

No abstract provided.