Digital Commons Network^™

T Cell Receptor Signal Strength In Treg And Inkt Cell Development As Revealed By A Novel Fluorescent Reporter Mouse, Amy E. Moran, Keli L. Holzapfel, Nicole R. Cunningham, Jennifer Punt

Biology Faculty Scholarship

No abstract provided.

Molecular-Genetic Mapping Of Zebrafish Mutants With Variable Phenotypic Penetrance, Roshan A. Jain, Marc A. Wolman, Lauren A. Schmidt

Biology Faculty Scholarship

No abstract provided.

Reading Charles Black Writing: "The Lawfulness Of The Segregation Decisions" Revisited, Kendall Thomas

Faculty Scholarship

The year 2010 marked the fiftieth anniversary of the publication of Charles L. Black, Jr.'s "The Lawfulness of the Segregation Decisions." Professor Black's magisterial essay on the Supreme Court's 1954-1955 decisions in Brown v. Board of Education and its companion cases is, by any account, a foundational text in the scholarly literature on race and law in the United States. Black's short but searing defense of Brown introduced ideas and arguments about race, about law, and about the law of race that transformed the field. I can think of no better way to celebrate this inaugural issue of the Columbia …

The Uniform Law Commission And Cooperative Federalism: Implementing Private International Law Conventions Through Uniform State Laws, William H. Henning

Faculty Scholarship

The Uniform Law Commission (ULC) is a non-partisan, nonprofit, unincorporated association comprised of commissions formed in each state of the United States and also the District of Columbia, Puerto Rico, and the U.S. Virgin Islands. Its mission is "to promote uniformity in the law among the several States on subjects as to which uniformity is desirable and practicable." In the 117 years of its existence, the ULC has produced hundreds of uniform laws and forwarded them to the legislatures of its member jurisdictions for enactment, often with striking and sometimes with universal success. Its premier product, produced in partnership with …

The Incidence Of Type-1 Diabetes In Nod Mice Is Modulated By Restricted Flora Not Germ-Free Conditions., Cecile King, Nora Sarvetnick

Journal Articles: Regenerative Medicine

In the NOD mouse, the incidence of type-1 diabetes is thought to be influenced by the degree of cleanliness of the mouse colony. Studies collectively demonstrate that exposure to bacterial antigen or infection in the neonatal period prevents diabetes [1], [2], [3], [4], [5], [6], [7], [8], [9], [10], supporting the notion that immunostimulation can benefit the maturation of the postnatal immune system [11]. A widely accepted extrapolation from this data has been the notion that NOD mice maintained under germ-free conditions have an increased incidence of diabetes. However, evidence supporting this influential concept is surprisingly limited [12]. In this …

Two Years After The Pennsylvania Supreme Court's Decision In Belden & Blake Corp. V. Commonwealth Department Of Conservation & Natural Resources: The Commonwealth's Struggle To Protect State Lands, Gina S. Warren, Krista M. Baron

Faculty Scholarship

The Marcellus Shale is by far the largest natural gas shale play in the United States' and the largest known shale deposit in the world.

Located beneath a large part of the Appalachian basin, it extends north into upstate New York, south into West Virginia and Virginia, and west into Ohio, and geologists estimate that it may contain as much as 489 trillion cubic feet of recoverable natural gas. The Commonwealth of Pennsylvania currently owns 117 parks and three conservation areas in Pennsylvania, making up 2.4 million acres of land - approximately 1.5 million of which are above the Marcellus …

Building Bridges, Building Peace: The Life And Work Of Claudette Werleigh Of Haiti, Bijoyeta Das

Kroc IPJ Research and Resources

In the following pages, you will find narrative stories about a Woman PeaceMaker, along with additional information to provide a deep understanding of a contemporary conflict and one person’s journey within it. These complementary components include a brief biography of the peacemaker, a historical summary of the conflict, a timeline integrating political developments in the country with personal history of the peacemaker, a question-and-answer transcript of select interviews, and a table of best practices in peacebuilding as demonstrated and reflected on by the peacemaker during her time at the Joan B. Kroc Institute for Peace & Justice.

From literacy education …

Broken Can Heal: The Life And Work Of Manjula Pradeep Of India, Amy S. Choi

Kroc IPJ Research and Resources

In the following pages, you will find narrative stories about a Woman PeaceMaker, along with additional information to provide a deep understanding of a contemporary conflict and one person’s journey within it. These complementary components include a brief biography of the peacemaker, a historical summary of the conflict, a timeline integrating political developments in the country with personal history of the peacemaker, a question-and-answer transcript of select interviews, and a table of best practices in peacebuilding as demonstrated and reflected on by the peacemaker during her time at the Joan B. Kroc Institute for Peace & Justice.

A brazen human …

Politics Of Beauty, Ken-Ichi Sasaki

Contemporary Aesthetics (Journal Archive)

I look back at the history of modern aesthetics to grasp its current situation and to propose its possibilities for the future. The early modern period, during which aesthetics came into being, was a great historical turning point for civilization. Our contemporary period shares this character, and it is worthwhile for us to consult its history in order to reflect on our civilization. Aesthetics began with Baumgarten’s proposal, which consisted in a triple subject: sensibility, beauty, and art. His idea was accepted because it responded to the fundamental problems of the period. Sensibility was the only form of cognition of …

Bulletin Of The University Of San Diego School Of Law 2011-2013, University Of San Diego. School Of Law

School of Law Course Catalogs (1954-2013)

72 pages : illustrations, photographs ; 18.5 x 28 cm

Property Rights In Land, Agricultural Capitalism, And The Relative Decline Of Pre-Industrial China, Taisu Zhang

Faculty Scholarship

No abstract provided.

Reasoning About The Irrational: The Roberts Court And The Future Of Constitutional Law, H. Jefferson Powell

Faculty Scholarship

Commentary on the future direction of the Roberts Court generally falls along lines that correlate with the commentators' political views on the desirability of the Court's recent decisions. A more informative approach is to look for opinions suggesting changes in the presuppositions with which the Justices approach constitutional decision making. In footnote 27 in his opinion for the Court in the District of Columbia v. Heller Second Amendment decision, Justice Scalia suggested a fundamental revision of the Court's assumptions about the role of judicial doctrine, and the concept of rationality, in constitutional law. Justice Scalia would eliminate the normative aspects …

Causation In The Fiduciary Realm, Deborah A. Demott

Faculty Scholarship

No abstract provided.

Financing Direct Democracy: Revisiting The Research On Campaign Spending And Citizen Initiatives, John M. De Figueiredo, Chang Ho Ji, Thad Kousser

Faculty Scholarship

The conventional view in the direct democracy literature is that spending against a measure is more effective than spending in favor of a measure, but the empirical results underlying this conclusion have been questioned by recent research. We argue that the conventional finding is driven by the endogenous nature of campaign spending: initiative proponents spend more when their ballot measure is likely to fail. We address this endogeneity by using an instrumental variables approach to analyze a comprehensive dataset of ballot propositions in California from 1976 to 2004. We find that both support and opposition spending on citizen initiatives have …

The Law And Policy Of Judicial Retirement, Mitu Gulati, Stephen J. Choi, Eric A. Posner

Faculty Scholarship

Lifetime tenure maximizes judicial independence by shielding judges from political pressures, but it creates problems of its own. As is widely known, judges with judicial independence may implement their political preferences or shirk in other ways. Less attention has been given to another problem: that judges will remain in office after their abilities degrade as a result of old age. The U.S. federal system addresses these problems in an indirect way. When judges’ pensions vest, they receive a full salary regardless of whether they work or not; thus, the effective compensation for judicial work falls to zero. Judges can retire, …

The Federal Common Law Crime Of Corruption, Lisa Kern Griffin

Faculty Scholarship

This contribution to the North Carolina Law Review’s 2010 symposium, Adaptation and Resiliency in Legal Systems, considers the compatibility between the common law nature of honest services fraud and the dynamic quality of public integrity offenses. Corruption enforcement became a focal point of recent debates about over- criminalization because it typifies expansive legislative mandates for prosecutors and implicit delegations to courts. Federal prosecutions of political corruption have relied primarily on an open-textured provision: 18 U.S.C. § 1346, the honest services extension of the mail fraud statute. Section 1346 raises notice concerns because it contains few self-limiting terms, but it has …

Four Constitutional Limits That The Minimum Coverage Provision Respects, Neil S. Siegel

Faculty Scholarship

Opponents of the minimum coverage provision in the Affordable Care Act charge that if Congress can require most people to obtain health insurance or pay a certain amount of money, then Congress can impose whatever mandates it wishes—or, at least, whatever purchase mandates it wishes. This Essay refutes that claim by identifying four limits on the Commerce Clause that the minimum coverage provision honors. Congress may not use its commerce power: (1) to regulate noneconomic subject matter; (2) to impose a regulation that violates constitutional rights, including the right to bodily integrity; (3) to regulate at all, including by imposing …

A Once And Future Gulf Of Mexico Ecosystem: Restoration Recommendations Of An Expert Working Group, Charles H. Peterson, Felicia C. Coleman, Jeremy B.C. Jackson, R. Eugene Turner, Gilbert T. Rowe, Richard T. Barber, Karen A. Bjorndal, Robert S. Carney, Robert K. Cowen, Jonathan M. Hoekstra, James T. Hollibaugh, Shirley B. Laska, Richard A. Luettich Jr., Craig W. Osenberg, Stephen E. Roady, Stanley Senner, John M. Teal, Ping Wang

Faculty Scholarship

The Deepwater Horizon (DWH) well blowout released more petroleum hydrocarbons into the marine environment than any previous U.S. oil spill (4.9 million barrels), fouling marine life, damaging deep sea and shoreline habitats and causing closures of economically valuable fisheries in the Gulf of Mexico. A suite of pollutants — liquid and gaseous petroleum compounds plus chemical dispersants — poured into ecosystems that had already been stressed by overfishing, development and global climate change. Beyond the direct effects that were captured in dramatic photographs of oiled birds in the media, it is likely that there are subtle, delayed, indirect and potentially …

Proposition 26: The Cost To All Women, Emma S. Ketteringham, Allison Korn, Lynn M. Paltrow

Faculty Scholarship

No abstract provided.

Federal Rule Of Evidence 502: Has It Lived Up To Its Potential?, Paul W. Grimm, Lisa Yurwit Bergstrom, Matthew P. Kraeuter

Faculty Scholarship

No abstract provided.

Picturing Flag Violence In Civil War Sheet Music: The Case Of “Down With The Traitors’ Serpent Flag”, Kenneth Hartvigsen

Faculty Publications

Published in Chicago in 1861, “Down with the Traitors’ Serpent Flag” is one of thousands of political parlor songs from the American Civil War. Many of these songs are unremarkable musically and were preserved in homes, archives, and museum collections largely for their vibrant illustrations. In my presentation I examine this song’s lithographic cover illustration—a Union soldier grinding a Confederate flag into the dust—within a broader discourse of Civil War flag imagery taken from songs, political cartoons, and cartes-de-visite.

Compelling secrets exist within this colorful image that may not first meet the eye; to uncover these meanings along with the …

Insight Into The Cellular Alterations Required For Establishing Opportunistic Pseudomonas Aeruginosa Infections, Dacie R. Bridge

Graduate Theses, Dissertations, and Problem Reports (ETD)

The Gram-negative, opportunistic pathogen Pseudomonas aeruginosa (Pa) is responsible for causing disease of high morbidity and mortality in individuals who are immunocompromised, suffer from damaged epithelial barriers, and who have cystic fibrosis. However, the underlying host cell compromise that allows the establishment of Pa infections remains unknown and is of importance to the development of novel strategies that interrupt Pa infections. The type III secretion system (T3S) allows the direct translocation of bacterial effectors into the host cell cytosol, and in this study was used first, to identify host cell properties involved in the initiation of Pa infections, and then …

New Methodologies For In Vitro Analysis Of Binding And Functional Activity Of Sigma Receptor Ligands, James A. Fishback

Graduate Theses, Dissertations, and Problem Reports (ETD)

Sigma receptors represent a promising drug development target for a number of therapeutic indications including cancer, depression, psychostimulant abuse and stroke. To date, two subtypes of sigma receptors have been identified; sigma1 and sigma2. Their respective roles in normal physiology and in disease processes are a subject of ongoing studies. Consequently, the discovery and development of subtype specific agonist and antagonist ligands remains a key research goal. To date, no in vitro functional assay suitable for routine screening of putative sigma ligands has been reported. As a result, radioligand binding assays are used as a primary screen. Therefore, to support …

Bioscience Laboratory: Online And Face-To-Face Laboratory Experiences In Requisite Biosciences For Nursing At A Community College, Deborah K. Folger

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of this study was to analyze student perceptions of the online and face-to-face bioscience laboratory experiences in Anatomy and Physiology and Microbiology. The study took place at a community college in a rural geographic area and data were collected from associate degree seeking first and second year nursing students via a survey questionnaire and student focus groups in addition to archival enrollment and graduate data. The research study was guided by the following questions: What are nursing student perceptions concerning the impact of Anatomy and Physiology and Microbiology bioscience laboratory experiences on the transfer of knowledge to nursing …

Procurement Risk Management In Beef Supply Chains, Onur Boyabatli, Paul R. Kleindorfer, Steve R. Koontz

Research Collection Lee Kong Chian School Of Business

This chapter develops the theoretical model and provides the optimal solution for the procurement portfolio of the packer. It describes the computational results for the above model based on data for the U.S. beef industry described in the GIPSA Report, and complemented by industry demand and supply studies. The chapter determines the impact on the optimal procurement portfolio of spot price and demand uncertainty, the degree of substitution between products in final markets, as well as the cost characteristics of the packer and the nature of quality and cost differences in the contract and spot markets. It provides insights about …

A Different Way To Think About Creativity: The Case Of Autism And Outsider Art, Rk Mckenzie

Plymouth Institute of Education

No abstract provided.

Insights Into A Multidrug Resistant Escherichia Coli Pathogen Of The Globally Disseminated St131 Lineage: Genome Analysis And Virulence Mechanisms, Makrina Totsika, Scott A. Beatson, Sohinee Sarkar, P Minh-Duy, Nicola K. Petty, Nathan Bachmann, Marek Szubert, Hanna E. Sidjabat, David L. Paterson, Mathew Upton, Mark A. Schembri

School of Biomedical Sciences

No abstract provided.

A Replicating Cytomegalovirus-Based Vaccine Encoding A Single Ebola Virus Nucleoprotein Ctl Epitope Confers Protection Against Ebola Virus, Yoshimi Tsuda, Patrizia Caposio, Christopher J. Parkins, Sara Botto, Ilhem Messaoudi, Luka Cicin-Sain, Heinz Feldmann, Michael A. Jarvis

School of Biomedical Sciences

No abstract provided.

White Body: Animating Feminine Pleasure, K Parker

School of Art, Design and Architecture

Following Luce Irigaray’s perspective that “femininity’ ... may be recovered only in secret, in hiding’ (1985a: 30), my paper investigates the relationship between the moving image screen, feminine pleasure and the body, through critical reflection as an artist film-maker on the plasticine animation White Body (2009): in this practice-as-research film, I manipulate plasticine, sugar and dust with my fingers under the animation rostrum camera to explore my early childhood memories of secret, transgressive play; seeking to liberate a cascading feminine sensibility through the creative process of working ‘intuitively’ frame-by-frame with materiality and digital technologies.

Phytoestrogens Directly Inhibit Tnf-Α-Induced Bone Resorption In Raw264.7 Cells By Suppressing C-Fos-Induced Nfatc1 Expression., S Karieb, Sw Fox

School of Biomedical Sciences

TNF-α-induced osteoclastogenesis is central to post-menopausal and inflammatory bone loss, however, the effect of phytoestrogens on TNF-α-induced bone resorption has not been studied. The phytoestrogens genistein, daidzein, and coumestrol directly suppressed TNF-α-induced osteoclastogenesis and bone resorption. TRAP positive osteoclast formation and resorption area were significantly reduced by genistein (10(-7)  M), daidzein (10(-5)  M), and coumestrol (10(-7)  M), which was prevented by the estrogen antagonist ICI 182,780. TRAP expression in mature TNF-α-induced osteoclasts was also significantly reduced by these phytoestrogen concentrations. In addition, in the presence of ICI 182,780 genistein and coumestrol (10(-5) -10(-6)  M) augmented TNF-α-induced osteoclast formation and resorption. …