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Articles 15871 - 15900 of 16819
Full-Text Articles in Entire DC Network
Out-Of-Frame T Cell Receptor Beta Transcripts Are Eliminated By Multiple Pathways In Vivo, Grace K. Mahowald, Michael A. Mahowald, Clara Moon, Bernard Khor, Barry P. Sleckman
Out-Of-Frame T Cell Receptor Beta Transcripts Are Eliminated By Multiple Pathways In Vivo, Grace K. Mahowald, Michael A. Mahowald, Clara Moon, Bernard Khor, Barry P. Sleckman
Open Access Publications
No abstract provided.
Isg15 Is Critical In The Control Of Chikungunya Virus Infection Independent Of Ube1l Mediated Conjugation, Scott W. Werneke, Clementine Schilte, Anjali Rohatgi, Kristen J. Monte, Alain Michault, Fernando Arenzana-Seisdedos, Dana L. Vanlandingham, Stephen Higgs, Arnaud Fontanet, Matthew L. Albert, Deborah J. Lenschow
Isg15 Is Critical In The Control Of Chikungunya Virus Infection Independent Of Ube1l Mediated Conjugation, Scott W. Werneke, Clementine Schilte, Anjali Rohatgi, Kristen J. Monte, Alain Michault, Fernando Arenzana-Seisdedos, Dana L. Vanlandingham, Stephen Higgs, Arnaud Fontanet, Matthew L. Albert, Deborah J. Lenschow
Open Access Publications
No abstract provided.
Ancestral Genes Can Control The Ability Of Horizontally Acquired Loci To Confer New Traits, H. Deborah Chen, Mollie W. Jewett, Eduardo A. Groisman
Ancestral Genes Can Control The Ability Of Horizontally Acquired Loci To Confer New Traits, H. Deborah Chen, Mollie W. Jewett, Eduardo A. Groisman
Open Access Publications
No abstract provided.
Targeting Protein-Protein Interactions For Parasite Control, Christina M. Taylor, Kerstin Fischer, Sahar Abubucker, Zhengyuan Wang, John Martin, Daojun Jiang, Marc Magliano, Marie-Noelle Rosso, Ben-Wen Li, Peter U. Fischer, Makedonka Mitreva
Targeting Protein-Protein Interactions For Parasite Control, Christina M. Taylor, Kerstin Fischer, Sahar Abubucker, Zhengyuan Wang, John Martin, Daojun Jiang, Marc Magliano, Marie-Noelle Rosso, Ben-Wen Li, Peter U. Fischer, Makedonka Mitreva
Open Access Publications
No abstract provided.
Rna Interference In Marine And Freshwater Sponges: Actin Knockdown In Tethya Wilhelma And Ephydatia Muelleri By Ingested Dsrna Expressing Bacteria, Ajna S. Rivera, Jorg U. Hammel, Karri M. Haen, Elizabeth S. Danka, Brandon Cieniewicz, Ian P. Winters, Dora Posfai, Gert Worheide, Dennis V. Lavrov, Scott W. Knight, Malcolm S. Hill, April L. Hill, Michael Nickel
Rna Interference In Marine And Freshwater Sponges: Actin Knockdown In Tethya Wilhelma And Ephydatia Muelleri By Ingested Dsrna Expressing Bacteria, Ajna S. Rivera, Jorg U. Hammel, Karri M. Haen, Elizabeth S. Danka, Brandon Cieniewicz, Ian P. Winters, Dora Posfai, Gert Worheide, Dennis V. Lavrov, Scott W. Knight, Malcolm S. Hill, April L. Hill, Michael Nickel
Open Access Publications
No abstract provided.
Pdfr And Cry Signaling Converge In A Subset Of Clock Neurons To Modulate The Amplitude And Phase Of Circadian Behavior In Drosophila, Seol Hee Im, Weihua Li, Paul H. Taghert
Pdfr And Cry Signaling Converge In A Subset Of Clock Neurons To Modulate The Amplitude And Phase Of Circadian Behavior In Drosophila, Seol Hee Im, Weihua Li, Paul H. Taghert
Open Access Publications
No abstract provided.
Moving Pictures Of The Human Microbiome, J Gregory Caporaso, Christian L. Lauber, Elizabeth K. Costello, Donna Berg-Lyons, Antonio Gonzalez, Jesse Stombaugh, Dan Knights, Pawel Gajer, Jacques Ravel, Noah Fierer, Jeffrey I. Gordon, Rob Knight
Moving Pictures Of The Human Microbiome, J Gregory Caporaso, Christian L. Lauber, Elizabeth K. Costello, Donna Berg-Lyons, Antonio Gonzalez, Jesse Stombaugh, Dan Knights, Pawel Gajer, Jacques Ravel, Noah Fierer, Jeffrey I. Gordon, Rob Knight
Open Access Publications
No abstract provided.
Rna Binding Protein Cugbp2/Celf2 Mediates Curcumin- Induced Mitotic Catastrophe Of Pancreatic Cancer Cells, Dharmalingam Subramaniam, Satish Ramalingam, David C. Linehan, Brian K. Dieckgraefe, Russell G. Postier, Courtney W. Houchen, Roy A. Jensen, Shrikant Anant
Rna Binding Protein Cugbp2/Celf2 Mediates Curcumin- Induced Mitotic Catastrophe Of Pancreatic Cancer Cells, Dharmalingam Subramaniam, Satish Ramalingam, David C. Linehan, Brian K. Dieckgraefe, Russell G. Postier, Courtney W. Houchen, Roy A. Jensen, Shrikant Anant
Open Access Publications
No abstract provided.
A Knock-In Mouse Model For The R120g Mutation Of Alphabcrystallin Recapitulates Human Hereditary Myopathy And Cataracts, Usha P. Andley, Paul D. Hamilton, Nathan Ravi, Conrad C. Weihl
A Knock-In Mouse Model For The R120g Mutation Of Alphabcrystallin Recapitulates Human Hereditary Myopathy And Cataracts, Usha P. Andley, Paul D. Hamilton, Nathan Ravi, Conrad C. Weihl
Open Access Publications
No abstract provided.
Mixed Infection With Caga Positive And Caga Negative Strains Of Helicobacter Pylori Lowers Disease Burden In The Gambia, Ousman Secka, Martin Antonio, Douglas E. Berg, Mary Tapgun, Christian Bottomley, Vivat Thomas, Robert Walton, Tumani Corrah, Julian E. Thomas, Richard A. Adegbola
Mixed Infection With Caga Positive And Caga Negative Strains Of Helicobacter Pylori Lowers Disease Burden In The Gambia, Ousman Secka, Martin Antonio, Douglas E. Berg, Mary Tapgun, Christian Bottomley, Vivat Thomas, Robert Walton, Tumani Corrah, Julian E. Thomas, Richard A. Adegbola
Open Access Publications
No abstract provided.
Raw Sewage Harbors Diverse Viral Populations, Paul G. Cantalupo, Byron Calgua, Guoyan Zhao, Ayalkibet Hundesa, Adam D. Wier, Josh P. Katz, Michael Grabe, Roger W. Hendrix, Rosina Girones, David Wang, James M. Pipas
Raw Sewage Harbors Diverse Viral Populations, Paul G. Cantalupo, Byron Calgua, Guoyan Zhao, Ayalkibet Hundesa, Adam D. Wier, Josh P. Katz, Michael Grabe, Roger W. Hendrix, Rosina Girones, David Wang, James M. Pipas
Open Access Publications
No abstract provided.
A Monomorphic Haplotype Of Chromosome Ia Is Associated With Widespread Success In Clonal And Nonclonal Populations Of Toxoplasma Gondii, Asis Khan, Natalie Miller, David S. Roos, J P. Dubey, Daniel Ajzenberg, Marie Laure Darde, James W. Ajioka, Benjamin Rosenthal, L. David Sibley
A Monomorphic Haplotype Of Chromosome Ia Is Associated With Widespread Success In Clonal And Nonclonal Populations Of Toxoplasma Gondii, Asis Khan, Natalie Miller, David S. Roos, J P. Dubey, Daniel Ajzenberg, Marie Laure Darde, James W. Ajioka, Benjamin Rosenthal, L. David Sibley
Open Access Publications
No abstract provided.
Molecular Characterization Of The North American Lung Fluke Paragonimus Kellicotti In Missouri And Its Development In Mongolian Gerbils, Peter U. Fischer, Kurt C. Curtis, Luis A. Marcos, Gary J. Weil
Molecular Characterization Of The North American Lung Fluke Paragonimus Kellicotti In Missouri And Its Development In Mongolian Gerbils, Peter U. Fischer, Kurt C. Curtis, Luis A. Marcos, Gary J. Weil
Open Access Publications
No abstract provided.
A Recurrent Missense Mutation In Gja3 Associated With Autosomal Dominant Cataract Linked To Chromosome 13q, Thomas M. Bennett, Alan Shiels
A Recurrent Missense Mutation In Gja3 Associated With Autosomal Dominant Cataract Linked To Chromosome 13q, Thomas M. Bennett, Alan Shiels
Open Access Publications
No abstract provided.
Digital Gene Expression For Non-Model Organisms, Lewis Z. Hong, Jun Li, Anne Schmidt-Küntzel, Wesley C. Warren, Gregory S. Barsh
Digital Gene Expression For Non-Model Organisms, Lewis Z. Hong, Jun Li, Anne Schmidt-Küntzel, Wesley C. Warren, Gregory S. Barsh
Open Access Publications
No abstract provided.
Plasticity In Patterns Of Histone Modifications And Chromosomal Proteins In Drosophila Heterochromatin, Nicole C. Riddle, Sarah C.R. Elgin, Et Al
Plasticity In Patterns Of Histone Modifications And Chromosomal Proteins In Drosophila Heterochromatin, Nicole C. Riddle, Sarah C.R. Elgin, Et Al
Open Access Publications
No abstract provided.
Genomic And Metabolic Profiling Of Nonulosonic Acids In Vibrionaceae Reveal Biochemical Phenotypes Of Allelic Divergence In Vibrio Vulnificus, Amanda L. Lewis, Jean-Bernard Lubin, Shilpa Argade, Natasha Naidu, Biswa Choudhury, E. Fidelma Boyd
Genomic And Metabolic Profiling Of Nonulosonic Acids In Vibrionaceae Reveal Biochemical Phenotypes Of Allelic Divergence In Vibrio Vulnificus, Amanda L. Lewis, Jean-Bernard Lubin, Shilpa Argade, Natasha Naidu, Biswa Choudhury, E. Fidelma Boyd
Open Access Publications
No abstract provided.
Expression During Host Infection And Localization Of Yersinia Pestis Autotransporter Proteins, Jonathan D. Lenz, Matthew B. Lawrenz, David G. Cotter, M. Chelsea Lane, Rodrigo J. Gonzalez, Michelle Palacios, Virginia L. Miller
Expression During Host Infection And Localization Of Yersinia Pestis Autotransporter Proteins, Jonathan D. Lenz, Matthew B. Lawrenz, David G. Cotter, M. Chelsea Lane, Rodrigo J. Gonzalez, Michelle Palacios, Virginia L. Miller
Open Access Publications
No abstract provided.
Efficacy Of The Egfr Inhibitor Iressa On Development Of Chemically-Induced Urinary Bladder Cancers: Dose Dependency And Modulation Of Biomarkers, Ronald A. Lubet, Yan Lu, Ann M. Bode, Ming You, Zoe M. Verney, Vernon E. Steele, Reid Townsend, M. Margaret Juliana, Clinton J. Grubbs
Efficacy Of The Egfr Inhibitor Iressa On Development Of Chemically-Induced Urinary Bladder Cancers: Dose Dependency And Modulation Of Biomarkers, Ronald A. Lubet, Yan Lu, Ann M. Bode, Ming You, Zoe M. Verney, Vernon E. Steele, Reid Townsend, M. Margaret Juliana, Clinton J. Grubbs
Open Access Publications
No abstract provided.
Epidemiological Model For Clostridium Difficile Transmission In Healthcare Settings, Cristina Lanzas, Erik R. Dubberke, Z Lu, Kimberly Ann Reske, Y T. Grohn
Epidemiological Model For Clostridium Difficile Transmission In Healthcare Settings, Cristina Lanzas, Erik R. Dubberke, Z Lu, Kimberly Ann Reske, Y T. Grohn
Open Access Publications
No abstract provided.
Xenotransplantation Of Embryonic Pig Kidney Or Pancreas To Replace The Function Of Mature Organs, Marc R. Hammerman
Xenotransplantation Of Embryonic Pig Kidney Or Pancreas To Replace The Function Of Mature Organs, Marc R. Hammerman
Open Access Publications
No abstract provided.
The Development And Characterization Of A 60k Snp Chip For Chicken, Martin Am Groenen, Hendrik-Jan Megens, Yalda Zare, Wesley C. Warren, Ladeana W. Hillier, Richard Pma Crooijmans, Addie Vereijken, Ron Okimoto, Williams M. Muir, Hans H. Cheng
The Development And Characterization Of A 60k Snp Chip For Chicken, Martin Am Groenen, Hendrik-Jan Megens, Yalda Zare, Wesley C. Warren, Ladeana W. Hillier, Richard Pma Crooijmans, Addie Vereijken, Ron Okimoto, Williams M. Muir, Hans H. Cheng
Open Access Publications
No abstract provided.
Lineage-Specific Evolution Of The Vertebrate Otopetrin Gene Family Revealed By Comparative Genomic Analyses, Belen Hurle, Tomas Marques-Bonet, Francesca Antonacci, Inna Hughes, Joseph F. Ryan, Nisc Comparative Sequencing Program, Evan E. Eichler, David M. Ornitz, Eric D. Green
Lineage-Specific Evolution Of The Vertebrate Otopetrin Gene Family Revealed By Comparative Genomic Analyses, Belen Hurle, Tomas Marques-Bonet, Francesca Antonacci, Inna Hughes, Joseph F. Ryan, Nisc Comparative Sequencing Program, Evan E. Eichler, David M. Ornitz, Eric D. Green
Open Access Publications
No abstract provided.
Genome-Wide Identification Of Allele-Specific Expression (Ase) In Response To Marek’S Disease Virus Infection Using Next Generation Sequencing, Sean Maceachern, William M. Muir, Seth Crosby, Hans H. Cheng
Genome-Wide Identification Of Allele-Specific Expression (Ase) In Response To Marek’S Disease Virus Infection Using Next Generation Sequencing, Sean Maceachern, William M. Muir, Seth Crosby, Hans H. Cheng
Open Access Publications
No abstract provided.
Autophagy In Antigen-Presenting Cells Results In Presentation Of Citrullinated Peptides To Cd4 T Cells, Jamie M. Ireland, Emil R. Unanue
Autophagy In Antigen-Presenting Cells Results In Presentation Of Citrullinated Peptides To Cd4 T Cells, Jamie M. Ireland, Emil R. Unanue
Open Access Publications
Antibody responses to citrullinated self-proteins are found in autoimmunities, particularly in rheumatoid arthritis, where they serve as a diagnostic indicator. We show here that processing of the protein hen egg-white lysozyme (HEL) resulted in citrullination of peptides presented on class II MHC molecules by antigen-presenting cells. The presentation of the citrullinated peptides but not of the unmodified peptides was associated with autophagy. Dendritic cells (DCs), macrophages, and thymic DCs presented citrullinated peptides constitutively. Their treatment with 3-methyladenine (3MA) blocked presentation of citrullinated HEL peptides, but presentation of unmodified peptides was not affected. Presentation of citrullinated peptides was not detected on …
Type I Interferon Is Selectively Required By Dendritic Cells For Immune Rejection Of Tumors, Mark S. Diamond, Michelle Kinder, Hirokazu Matsushita, Mona Mashayekhi, Gavin P. Dunn, Jessica M. Archambault, Hsiaoju Lee, Cora D. Arthur, J Michael White, Ulrich Kalinke, Kenneth M. Murphy, Robert D. Schreiber
Type I Interferon Is Selectively Required By Dendritic Cells For Immune Rejection Of Tumors, Mark S. Diamond, Michelle Kinder, Hirokazu Matsushita, Mona Mashayekhi, Gavin P. Dunn, Jessica M. Archambault, Hsiaoju Lee, Cora D. Arthur, J Michael White, Ulrich Kalinke, Kenneth M. Murphy, Robert D. Schreiber
Open Access Publications
Cancer immunoediting is the process whereby the immune system suppresses neoplastic growth and shapes tumor immunogenicity. We previously reported that type I interferon (IFN-α/β) plays a central role in this process and that hematopoietic cells represent critical targets of type I IFN's actions. However, the specific cells affected by IFN-α/β and the functional processes that type I IFN induces remain undefined. Herein, we show that type I IFN is required to initiate the antitumor response and that its actions are temporally distinct from IFN-γ during cancer immunoediting. Using mixed bone marrow chimeric mice, we demonstrate that type I IFN sensitivity …
Cd103+ Pulmonary Dendritic Cells Preferentially Acquire And Present Apoptotic Cell-Associated Antigen, A Nicole Desch, Gwendalyn J. Randolph, Kenneth Murphy, Emmanuel L. Gautier, Ross M. Kedl, Mireille H. Lahoud, Irina Caminschi, Ken Shortman, Peter M. Henson, Claudia V. Jakubzick
Cd103+ Pulmonary Dendritic Cells Preferentially Acquire And Present Apoptotic Cell-Associated Antigen, A Nicole Desch, Gwendalyn J. Randolph, Kenneth Murphy, Emmanuel L. Gautier, Ross M. Kedl, Mireille H. Lahoud, Irina Caminschi, Ken Shortman, Peter M. Henson, Claudia V. Jakubzick
Open Access Publications
Cells undergoing programmed cell death (apoptosis) are removed in situ by macrophages and dendritic cells (DCs) through a specialized form of phagocytosis (efferocytosis). In the lung, there are two primary DC subsets with the potential to migrate to the local lymph nodes (LNs) and initiate adaptive immune responses. In this study, we show that only CD103(+) DCs were able to acquire and transport apoptotic cells to the draining LNs and cross present apoptotic cell-associated antigen to CD8 T cells. In contrast, both the CD11b(hi) and the CD103(+) DCs were able to ingest and traffic latex beads or soluble antigen. CD103(+) …
Innate And Cytokine-Driven Signals, Rather Than Microbial Antigens, Dominate In Natural Killer T Cell Activation During Microbial Infection, Manfred Brigl, Raju V.V. Tatituri, Gerald F.M. Watts, Veemal Bhowruth, Elizabeth A. Leadbetter, Nathaniel Barton, Nadia R. Cohen, Fong-Fu Hsu, Gurdyal S. Besra, Michael B. Brenner
Innate And Cytokine-Driven Signals, Rather Than Microbial Antigens, Dominate In Natural Killer T Cell Activation During Microbial Infection, Manfred Brigl, Raju V.V. Tatituri, Gerald F.M. Watts, Veemal Bhowruth, Elizabeth A. Leadbetter, Nathaniel Barton, Nadia R. Cohen, Fong-Fu Hsu, Gurdyal S. Besra, Michael B. Brenner
Open Access Publications
Invariant natural killer T cells (iNKT cells) are critical for host defense against a variety of microbial pathogens. However, the central question of how iNKT cells are activated by microbes has not been fully explained. The example of adaptive MHC-restricted T cells, studies using synthetic pharmacological α-galactosylceramides, and the recent discovery of microbial iNKT cell ligands have all suggested that recognition of foreign lipid antigens is the main driver for iNKT cell activation during infection. However, when we compared the role of microbial antigens versus innate cytokine-driven mechanisms, we found that iNKT cell interferon-γ production after in vitro stimulation or …
Barth Syndrome Mutations That Cause Tafazzin Complex Lability, Steven M. Claypool, Kevin Whited, Santi Srijumnong, Xianlin Han, Carla M. Koehler
Barth Syndrome Mutations That Cause Tafazzin Complex Lability, Steven M. Claypool, Kevin Whited, Santi Srijumnong, Xianlin Han, Carla M. Koehler
Open Access Publications
Deficits in mitochondrial function result in many human diseases. The X-linked disease Barth syndrome (BTHS) is caused by mutations in the tafazzin gene TAZ1. Its product, Taz1p, participates in the metabolism of cardiolipin, the signature phospholipid of mitochondria. In this paper, a yeast BTHS mutant tafazzin panel is established, and 18 of the 21 tested BTHS missense mutations cannot functionally replace endogenous tafazzin. Four BTHS mutant tafazzins expressed at low levels are degraded by the intermembrane space AAA (i-AAA) protease, suggesting misfolding of the mutant polypeptides. Paradoxically, each of these mutant tafazzins assembles in normal protein complexes. Furthermore, in the …
Genome-Wide Identification And Quantification Of Cis- And Trans-Regulated Genes Responding To Marek’S Disease Virus Infection Via Analysis Of Allele-Specific Expression, Sean Maceachern, William M. Muir, Seth D. Crosby, Hans H. Cheng
Genome-Wide Identification And Quantification Of Cis- And Trans-Regulated Genes Responding To Marek’S Disease Virus Infection Via Analysis Of Allele-Specific Expression, Sean Maceachern, William M. Muir, Seth D. Crosby, Hans H. Cheng
Open Access Publications
No abstract provided.