Digital Commons Network^™

Genes Differentially Expressed At 1 Day, 6 Weeks, And 6 Months Of Age In Aortas Of Spontaneously Atherosclerotic White Carneau Pigeons, Suzanne Lee Pearlman

Master's Theses and Capstones

Genetics is reported to be the primary causative factor for individuals diagnosed with atherosclerosis, in the absence of known risk factors. The development of atherosclerosis in White Carneau (WC) pigeons is of genetic origin, making it an excellent model to study genetic factors.

Representational Difference Analysis (RDA) was used to determine genes differentially upregulated between three ages, at the celiac bifurcation of the aorta in WC pigeons. Genes responsible for spontaneous initiation of atherosclerosis were hypothesized as being differentially expressed at 1 day, while those differentially expressed at 6 weeks and 6 months were related to progression.

Multiple candidate genes …

Child Fatalities In Tennessee 2009, Tennessee. Department Of Health.

Child Fatalities in Tennessee Report

No abstract provided.

Rate-Limiting Step Of Cone Phototransduction Recovery And Oguchi Disease Mechanisms, Frank Chen

Theses and Dissertations

ABSTRACT RATE-LIMITING STEP OF CONE PHOTOTRANSDUCTION RECOVERY AND OGUCHI DISEASE MECHANISMS By Frank Sungping Chen Advisor: Ching-Kang Jason Chen, Ph.D. Retinal photoreceptors provide the first gateway in which light information from the environment is transformed into neuronal signals. The cone and rod photoreceptors are responsible for day and night vision, respectively. Understanding rod and cone phototransduction is to figure out how these cells differ in their temporal and spatial sensitivities to allow perception of a broad dynamic range of stimuli. Phototransduction is mediated through a Gprotein signaling cascade. Light absorption by visual pigment triggers the isomerization of 11- cis-retinal covalently …

Hiv Protease Inhibitors Trigger Lipid Metabolism Dysregulation Through Endoplasmic Reticulum Stress And Autophagy, Beth Shoshana Zha

Theses and Dissertations

HIV protease inhibitors (PI) are core components of Highly Active Antiretroviral Therapy (HAART). HIV PIs are extremely effective at suppressing viral load, but have been linked to lipodystrophy and dyslipidemia, which are major risk factors for cardiovascular disease. Recent studies indicate that activation of endoplasmic reticulum (ER) stress is an important cellular mechanism underlying HIV PI-induced dysregulation of lipid metabolism. However, the exact role of ER stress in HIV PI-associated lipodystrophy and dyslipidemia remains to be identified. Hepatocytes and adipocytes are important players in regulating lipid metabolism and the inflammatory state. Dysfunction of these two cell types is closely linked …

Synthesis, Screening And Cocrystallization Of Adenosine Based Inhibitors With Methyltransferases, Ermc' And Ksga, Matthew Baker

Theses and Dissertations

Antibiotic resistance threatens to throw mankind back into an era when infectious disease was the predominant cause of death. In an effort to mitigate this danger, we targeted ErmC’ and KsgA. Both methylate N6-adenosine of ribosomal RNA, though each serve different roles in their bacterial host. ErmC’ dimethylates A2058 on 23S rRNA, conferring resistance to MLSB antibiotics (macrolides, lincosamides, streptogramin B). KsgA aids in ribosome assembly, binding inactive 30S until dimethylating A1518/A1519 of 16S rRNA. Like most methyltransferases, ErmC’ and KsgA use cofactor S-adenosylmethionine (SAM) as their methyl source, which binds adjacent to their specific adenosine substrate. ErmC’ inhibitors could …

Biobehavioral Relationships And Health Related Quality Of Life In Persons With End Stage Renal Disease On Hemodialysis, Avis Allen

Theses and Dissertations

The study of immune status and biobehavioral measures is limited in professional nursing. The purpose of the pre-pilot study was to describe levels of cytokines prior to, during, and after dialysis, examine changes in cytokine levels from immediate pre-dialysis to immediate post-dialysis, and to compare cytokine patterns prior to and after dialysis. A within subject descriptive study was conducted as part of a larger pilot study to describe levels of cytokines prior to, during, and after dialysis, examine changes in cytokine levels from immediate pre-dialysis to immediate post-dialysis, and to compare cytokine patterns prior to and after dialysis. Serum cytokine …

Morphometric And Genetic Variation Among Populations Of The Southern Short-Tailed Shrew, Blarina Carolinensis, Located Along The Coastal Plain Of Virginia, Devon Kersten

Theses and Dissertations

The distribution of short-tailed shrews, Blarina carolinensis and B. brevicauda, demonstrates contiguous allopatry in peninsular situations in the Coastal Plain of Virginia, and in other areas. The distribution of these two species is unusual in that they do not exhibit syntopy except within a narrow corridor along the borders of their ranges. Interestingly, along the Coastal Plain of Virginia, B. carolinensis is generally found only at the distal ends of the peninsular areas, existing as local populations that appear to be isolated from each other and from the primary population that exists in south-central Virginia. It is thought that the …

The Synergy Of Visual Projections And Contemporary Dance, Hannah Molly Timbrell

Theses : Honours

Projections are becoming an increasingly common part of contemporary dance performance, however, I believe that choreographers do not always integrate the media to form a dependent synergy. My research addresses the principal question: What are the factors that indicate that there is a critical relationship (synergy) between projection, including art work, moving images or light and the dancer in a contemporary dance performance? A brief history explains the background and development of lighting technology, through to film and more recently motion capture technology. Through sources of pre-existing literature and my interpretation of video excerpts of contemporary dance, I explore various …

Transdermal And Oral Dl-Methylphenidate-Ethanol Interactions In C57bl/6j Mice, Guinevere Hannah Bell

MUSC Theses and Dissertations

The persistence of attention-deficit/hyperactivity disorder (ADHO) into adulthood has been increasingly recognized over the past few decades and the stimulant drug dl-methylphenidate (MPH) has remained a first-line pharmacotherapeutic agent in the treatment of ADHD. Many adult ADHD patients who are prescribed MPH report concomitant use with ethanol. In humans, coadministration of dl-MPH and ethanol results in pharmacokinetic and pharmacodynamic drug - drug interactions. Ethanol elevates biological concentrations of the pharmacologically active d-MPH isomer and yields the metabolic transesterification product ethylphenidate (EPH). EPH appears to be formed through the actions of carboxylesterase 1 (CES1) which exhibits I-MPH substrate enantioselectivity in both …

Consulting The Architect When Problems Arise – The Divine Law, Brian Mccall

Faculty Articles

In The Architecture of Law: Building Law on a Solid Foundation- The Eternal and Natural Law, I began laying the foundation for a particular form of legal architecture. Taking inspiration from St. Thomas Aquinas’ description of God as the artificer or architect, I argued that the Law is a multi storied edifice comprised of different types of law. I explored the nature of the foundational law, the Eternal Law and its relationship to justice. I considered how the frame of Natural Law is erected upon or participates in the foundation of Eternal Law. Finally, I discussed some of the most …

The Wonderful World Of Disney Visas, Kit Johnson

Faculty Articles

International workers play an important role in perpetuating the carefully crafted fantasy that to visit the Walt Disney World Resort in Orlando, Florida is to be transported to far-off destinations around the globe. This Article examines how Disney has filled its need for these workers in two ways. For one, Disney has used a blend of chutzpah and ingenuity to forge new federal law establishing the Q visa. Additionally, Disney has dexterously used the existing J visa, along with an on-resort academic program, to bring international workers to Florida as students. An examination of Disney’s immigration practices offers insight into …

Assessing The Impact Of Learning Communities As An Alternative Delivery Model For The Public Speaking Course, Katherine N. Kinnick, Emily Holler, Marla Bell

Basic Communication Course Annual

This study provides empirical evidence of the impact of learning communities on outcomes for public speaking students, including grades, speaking anxiety, and student and instructor perceptions. Subjects (n = 236, half of whom took the course in freshman learning communities and half in traditional sections) perceived the learning community as the preferable environment for public speaking, and students with greater speaking anxiety were more likely to self-select into learning communities. Perception, however, was not reality: Participation in a learning community made no measurable difference in terms of course outcomes of grades or decline in speaking anxiety.

The findings challenge assumptions …

Technology Corner: Virtual Crime Scene Reconstruction: The Basics Of 3d Modeling, Nick V. Flor

Journal of Digital Forensics, Security and Law

Digital crime scenes take place in the context of physical crime scenes. Virtual crime scene reconstruction is an activity where investigators create a 3- dimensional (3-D) model of an actual crime scene for the purpose of determining the events that lead to the crime. While virtual crime scene reconstruction is currently used for analyzing physical scenes, it can also help investigators visualize and explore ways digital media could have been used to perpetrate a crime. In this technology corner we explore one of the technologies underlying virtual crime scene reconstruction: 3-D modeling.

Analogous Mechanisms Of Resistance To Benzothiazinones And Dinitrobenzamides In Mycobacterium Smegmatis, Ana Luisa Ribeiro, Giulia Degiacomi, Fanny Ewann, Silvia Buroni, Maria Loreto Incandela, Laurent R. Chiarelli, Giorgia Mori, Jaeseung Kim, Monica Contreras-Dominguez, Young-Sam Park, Sung-Jun Han, Priscille Brodin, Giovanna Valentini, Menico Rizzi, Giovanna Riccardi, Maria Rosalia Pasca

Faculty and Staff Publications

Tuberculosis is still a leading cause of death worldwide. The selection and spread of Mycobacterium tuberculosis multidrug-resistant (MDR-TB) and extensively drug-resistant strains (XDR-TB) is a severe public health problem. Recently, two different classes of chemical series, the benzothiazinones (BTZ) and the dinitrobenzamide (DNB) derivatives have been found to be highly active against M. tuberculosis, including XDR-TB strains. The target of BTZs is DprE1 protein which works in concert with DprE2 to form the heteromeric decaprenylphosphoryl-β-D-ribose 2'-epimerase, involved in Decaprenyl-Phospho-Arabinose (DPA) biosynthesis. Interestingly, it has been shown that the DNBs block the same pathway thus suggesting that both drugs could share …

The Tea Party Movement And The Perils Of Popular Originalism, Jared A. Goldstein

Law Faculty Scholarship

The Tea Party movement presents something of a curiosity for constitutional theory because it combines originalist ideology and popular constitutionalist methods. Like minotaurs, werewolves, and other half-man, half-animal hybrids of myth and legend, the Tea Party's hybrid of originalism and popular constitutionalism serves to expose the limitations of both sources upon which it draws. Although originalists assert that interpreting the Constitution according to its original meaning would take politics out of constitutional law, the Tea Party movement shows that originalism also provides a powerful political rhetoric. Moreover, while popular constitutionalists assert that democracy would be advanced by empowering the people …

Soil Fertility And Crop Yields In Long-Term Organic And Conventional Cropping Systems In Eastern Nebraska, Samuel E. Wortman, Tomie D. Galusha, Stephen C. Mason, Charles A. Francis

Department of Agronomy and Horticulture: Faculty Publications

Organic agriculture aims to build soil quality and provide long-term benefits to people and the environment; however, organic practices may reduce crop yields. This long-term study near Mead, NE was conducted to determine differences in soil fertility and crop yields among conventional and organic cropping systems between 1996 and 2007. The conventional system (CR) consisted of corn (Zea mays L.) or sorghum (Sorghum bicolor (L.) Moench)–soybean (Glycine max (L.) Merr.)–sorghum or corn–soybean, whereas the diversified conventional system (DIR) consisted of corn or sorghum– sorghum or corn–soybean–winter wheat (wheat, Triticum aestivum L.). The animal manure-based organic system (OAM) …

Moving Micronutrients From The Soil To The Seeds: Genes And Physiological Processes From A Biofortification Perspective, Brian M. Waters, Renuka P. Sankaran

Department of Agronomy and Horticulture: Faculty Publications

The micronutrients iron (Fe), zinc (Zn), and copper (Cu) are essential for plants and the humans and animals that consume plants. Increasing the micronutrient density of staple crops, or biofortification, will greatly improve human nutrition on a global scale. This review discusses the processes and genes needed to translocate micronutrients through the plant to the developing seeds, and potential strategies for developing biofortified crops.

Review: Lipid Addition To Corn Finishing Diets, Virgil R. Bremer, Galen Erickson, Terry Klopfenstein Klopfenstein

Nebraska Beef Cattle Reports

The fat content of distillers grains with solubles (DGS) partially accounts for DGS feeding value being greater than corn. Finishing diets containing DGS to supply up to 8% of diet DM as fat may be fed without depressing cattle performance. However, feeding diets containing 8% diet fat with corn oil depresses cattle performance. The difference in rumen metabolism of these two fats is due to physical protection of DGS fat from interaction with rumen microbes. Due to an unknown mechanism, condensed corn distillers solubles, a liquid fat source, does not limit ruminal metabolism like corn oil. Optimum dietary fat level …

Meta-Analysis Of Feeding Calf-Feds Or Yearlings Wet Distillers Grains With Different Corn Processing Types, Virgil R. Bremer, Kathryn J. Hanford, Galen Erickson Erickson, Terry Klopfenstein

Nebraska Beef Cattle Reports

Meta-analyses of University of Nebraska–Lincoln feedlot research feeding wet corn distillers grains plus solubles (WDGS) with dry-rolled corn (DRC) and high moisture corn (HMC) to either calf-feds or yearlings was conducted to calculate the feeding values of WDGS relative to corn. The feeding valueof wet distillers grains plus solubles (WDGS) was superior to dry-rolled corn (DRC) and high moisture corn (HMC). The feeding value of WDGS was greater for yearlings than for calf-feds. The combination of WDGS and HMC provided cattle performance superior to DRC with or without WDGS.

Relationship Between Morbidity And Performance In Feedlot Cattle, Galen Erickson, Virgil R. Bremer, Terry Klopfenstein Klopfenstein, David R. Smith, Kathryn J. Hanford, Robert E. Peterson, Luis O. Burciaga-Robles, Dan B. Faulkner, Clint R. Krehbiel

Nebraska Beef Cattle Reports

Five datasets from Canada, Oklahoma, Illinois, and Nebraska were used to determine the impact of bovine respiratory disease (BRD) on performance, with emphasis on dry matter intake (DMI) and feed to gain ratio (F:G). Data included pens and individually fed cattle. In general, cattle treated for BRD had lower DMI and average daily gain (ADG) with little to no effect on F:G. When BRD occured early in the feeding period (days), little change in performance was observed.

Effects Of Glycerin In Steam Flaked Corn Feedlot Diets, Justin P. Moore, Stephanie A. Furman, Galen Erickson Erickson, Judson Vasconcelos, William A. Griffin, Todd Milton

Nebraska Beef Cattle Reports

Glycerin was fed at 0%, 3%, 6%, and 9% (DM basis) in a steam-flaked, corn-based (SFC) diet to determine the effects on performance and carcass characteristics. Glycerin linearly increased (P = 0.02) final BW, ADG linearly increased (P = 0.02), and F:G linearly decreased (P < 0.01) by 7.1%. The data  suggests glycerin can be added up to 9% inclusion to improve performance.

Economic Impact Of Sulfur Levels In Distillers Grains Diets Fed To Beef Cattle, Jhones O. Sarturi, Darrell Mark, Galen Erickson Erickson, Terry Klopfenstein, Judson Vasconcelos, Virgil R. Bremer

Nebraska Beef Cattle Reports

An economic evaluation of a growth performance study (2011 Nebraska Beef Cattle Report, pp. 62-64) comparing wet or dry distillers grains with solubles (DGS) containing varying levels of sulfur was conducted. Diets containing DGS were more profitable than the control diets containing no co-product (Control). Wet DGS showed greater profitability than Control and dry DGS diets. Sulfur content in dry DGS did not affect profitability. Profits were lowest for Control and greatest for wet DGS (0.82% S) at 30% inclusion. Low sulfur concentration in wet DGS allows shipment to feedlots further away.

Effects Of Sulfur Concentration In Distillers Grains With Solubles In Finishing Cattle Diets, Jhones O. Sarturi, Galen Erickson, Terry Klopfenstein Klopfenstein, Judson Vasconcelos, Joshua R. Benton, William A. Griffin

Nebraska Beef Cattle Reports

Effect of dietary sulfur on beef cattle fed diets containing wet or dry distillers grains with solubles (DGS) was evaluated. Sulfur concentration in DGS was either 0.82 or 1.16%. Steers (n = 120; IBW = 761 ± 75 lb) were individually fed ad libitum. Intake decreased when wet and dry 1.16% S DGS were fed. Gain decreased as wet DGS that was 1.16% S increased in the diet to 40%. Feeding wet DGS improved F:G, regardless of sulfur content. Fat thickness and HCW decreased as wet and dry 1.16% S DGS increased in the diet. High sulfur DGS reduced DMI …

Effects Of The Synthetic Antioxidants On Shelf Life Of M. Psoas Major And M. Triceps Brachii Muscles From Beef Fed Wet Distillers Grains, Lasika S. Senaratne, Chris Calkins, Judson Vasconcelos Vasconcelos, Amilton S. De Mello, M. A. Andersen, Stephanie A. Furman, Siroj Pokharel

Nebraska Beef Cattle Reports

Feedlot finishing steers (n = 483) were randomly allotted to four dry-rolled corn based diets containing 0 or 30% wet distillers grains with or without the synthetic antioxidants supplementation (ethoxyquin and tertiary butyl hydroquinone in AGRADO®PLUS). This study intended to minimize detrimental effects of feeding wet distillers grains on color and lipidoxidation of beef tenderloin and clod heart muscles during retail display by feeding a synthetic antioxidant mixture. Feeding AGRADO®PLUS significantly reduced meat discoloration and lipid oxidation.

Economic Analysis Of Supplementing Ddgs To Grazing Steers, Andrea K. Watson, Terry Klopfenstein, Galen Erickson Erickson, Darrell Mark, Walter H. Schacht

Nebraska Beef Cattle Reports

A five-year study from 2005-2009 was conducted to evaluate differences in three grazing management strategies for backgrounding calves on smooth bromegrass pastures. Economic budgets were used to calculate profit differences. Steers supplemented an average of 5.3 lb/day of distillers grains were 90 lb heavier than either of the unsupplemented groups, which resulted in increased revenue of $49.38 for supplemented steers. Land costs were the same per AUM for all treatments but were decreased on a per head basis for pastures with supplemented cattle because cattle were stocked at higher rates than the control. Profit was greatest for the supplemented steers, …

Supplementing Ddgs To Steers Grazing Smooth Bromegrass Pastures, Andrea K. Watson, William A. Griffin, Terry Klopfenstein Klopfenstein, Galen Erickson, Kelly R. Brink, Walter H. Schacht

Nebraska Beef Cattle Reports

Five years of data were summarized to evaluate cattle and pasture performance when smooth bromegrass pastures were fertilized or cattle were supplemented daily with dried distillers grains with solubles (DDGS) on nonfertilized pastures. Cattle were supplemented at 0.6% of BW for an average of 158 days. Supplemented cattle gained 0.59 lb/day more than unsupplemented cattle. As forage quality declined over the grazing season, ADG also declined but the cattle’s response to DDGS supplementation increased. Each 1 lb of DDGS supplement replaced approximately 1 lb of forage intake. Pastures with supplemented cattle had increased forage production compared to control pastures but …

Investigating Modern Communication Technologies: The Effect Of Internet-Based Communication Technologies On The Investigation Process, Matthew Simon, Jill Slay

Journal of Digital Forensics, Security and Law

Communication technologies are commonplace in modern society. For many years there were only a handful of communication technologies provided by large companies, namely the Public Switched Telephone Network (PSTN) and mobile telephony; these can be referred to as traditional communication technologies. Over the lifetime of traditional communication technologies has been little technological evolution and as such, law enforcement developed sound methods for investigating targets using them. With the advent of communication technologies that use the Internet – Internet-based or contemporary communication technologies – law enforcement are faced with many challenges. This paper discusses these challenges and their potential impact. It …

Blowout: The Legal Legacy Of The Deepwater Horizon Catastrophe. Background Document On Natural Resource Damages, Nicholas Paine

Sea Grant Law Fellow Publications

No abstract provided.

Massachusetts Town Bylaws As They Relate To Restricting Or Conditioning Human Activities In And Around Eelgrass Beds, Benjamin J. Goetsch

Sea Grant Law Fellow Publications

No abstract provided.

Legal Considerations For Possible Noise Ordinances For Newport Harbor, Kristen Bonjour

Sea Grant Law Fellow Publications

In this report prepared for the Newport Waterfront Commission by the Marine Affairs Institute at the Roger Williams University School of Law, current and prospective noise ordinances in the city of Newport, RI are examined, and the legal precedents and management tools to create harbor-specific noise ordinances are discussed.