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2011

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Articles 13471 - 13500 of 16826

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Substituted Coumarin Derivatives: Synthesis And Evaluation Of Antiproliferative And Src Kinase Inhibitory Activities, Abha Kathuria, Sarah Jalal, Rakesh Tiwari, Amir Nasrolahi Shirazi, Shilpi Gupta, Shiv Kumar, Keykavous Parang, Sunil K. Sharma Jan 2011

Substituted Coumarin Derivatives: Synthesis And Evaluation Of Antiproliferative And Src Kinase Inhibitory Activities, Abha Kathuria, Sarah Jalal, Rakesh Tiwari, Amir Nasrolahi Shirazi, Shilpi Gupta, Shiv Kumar, Keykavous Parang, Sunil K. Sharma

Pharmacy Faculty Articles and Research

Six classes of coumarin derivatives (i.e. 3-alkyl-4-methylcoumarins, pyranocoumarins, coumarin carboxamides, quaternary ammonium coumarins, 7-aminocoumarins, and 4-aminocoumarins) were synthesized and evaluated for inhibition of cell proliferation of colon adenocarcinoma (HT-29), breast carcinoma (MDA-MB-468 or MCF-7), and human ovarian adenocarcinoma (SK-OV-3) cells. C-3-Alkyl substituted analogs of 4-methylcoumarins and pyranocoumarins, 5 and 6, inhibited the cell proliferation of MDA-MB-468 and SK-OV-3 cells by 53-74%, while 3-decyl substituted pyranocoumarin 10 and triethyl substituted quaternary ammonium coumarin derivative 29 inhibited the cell proliferation of HT-29 and SK-OV-3 cells by 63-72% at a concentration of 50 μM. Among all the compounds studied, C-3 decyl substituted quaternary …

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Morphology And Microanatomy Of Harbor Porpoise (Phocoena Phocoena ) Dorsal Fin Tubercles, Carly C. Ginter, S. Anne Boettger, Frank E. Fish Jan 2011

Morphology And Microanatomy Of Harbor Porpoise (Phocoena Phocoena ) Dorsal Fin Tubercles, Carly C. Ginter, S. Anne Boettger, Frank E. Fish

Biology Faculty Publications

No abstract provided.

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Late Devonian Paleontology And Paleoenvironments At Red Hill And Other Fossil Sites In The Catskill Formation Of North-Central Pennsylvania, Edward B. Daeschler, Walter L. Cressler Iii Jan 2011

Late Devonian Paleontology And Paleoenvironments At Red Hill And Other Fossil Sites In The Catskill Formation Of North-Central Pennsylvania, Edward B. Daeschler, Walter L. Cressler Iii

Earth & Space Sciences Faculty Publications

No abstract provided.

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The Green Legacy Project: Evaluating Campus Tree Benefits, Joy Fritschle, Gary Coutu, Joan Welch, Gerard Hertel Jan 2011

The Green Legacy Project: Evaluating Campus Tree Benefits, Joy Fritschle, Gary Coutu, Joan Welch, Gerard Hertel

Geography & Planning Faculty Publications

No abstract provided.

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Art In The Light Of Knowing A Cognitive Approach To The Creative Process, Victor M. Knoe Jan 2011

Art In The Light Of Knowing A Cognitive Approach To The Creative Process, Victor M. Knoe

HIM 1990-2015

Art can be an elusive concept. Neither an outsider nor a professional artist is immune to abstractions in the attempt to describe it. Every individual must necessarily come from their own, unique perspective. The obstacles that we experience in defining the essence of art can be better understood if we see them as a gauge for our historical period. Given the limits of our contemporary conditions, it seems impossible that we may ever overcome the vast chasms that imprison us. We are discouraged to build bridges, at almost every turn, by the suggestive hopelessness of the abysmal distances between us. …

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Crmp5 Regulates Generation And Survival Of Newborn Neurons In Olfactory And Hippocampal Neurogenic Areas Of The Adult Mouse Brain, Alexandra Veyrac, Sophie Reibel, Joelle Sacquet, Mireille Mutin, Jean-Philippe Camdessanche, Pappachan Kolattukudy, Jerome Honnorat, Francois Jourdan Jan 2011

Crmp5 Regulates Generation And Survival Of Newborn Neurons In Olfactory And Hippocampal Neurogenic Areas Of The Adult Mouse Brain, Alexandra Veyrac, Sophie Reibel, Joelle Sacquet, Mireille Mutin, Jean-Philippe Camdessanche, Pappachan Kolattukudy, Jerome Honnorat, Francois Jourdan

Faculty Bibliography 2010s

The Collapsin Response Mediator Proteins (CRMPs) are highly expressed in the developing brain, and in adult brain areas that retain neurogenesis, ie: the olfactory bulb (OB) and the dentate gyrus (DG). During brain development, CRMPs are essentially involved in signaling of axon guidance and neurite outgrowth, but their functions in the adult brain remain largely unknown. CRMP5 has been initially identified as the target of auto-antibodies involved in paraneoplasic neurological diseases and further implicated in a neurite outgrowth inhibition mediated by tubulin binding. Interestingly, CRMP5 is also highly expressed in adult brain neurogenic areas where its functions have not yet …

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Social Implications From Agricultural Taskscapes In The Southwestern Amazon, John H. Walker Jan 2011

Social Implications From Agricultural Taskscapes In The Southwestern Amazon, John H. Walker

Faculty Bibliography 2010s

Across the Americas, but particularly in the Amazon Basin, precolumbian farmers invested their labor in features such as canals, causeways, and raised fields, creating agricultural landscapes. These landscapes required organized action in order to build and maintain them. Such actions can be usefully described as "tasks" to draw specific connections between communal work and landscape features (Ingold 1993). Using two parallel examples front the precolumbian Bolivian Amazon, this article presents landscape features as correlates of the variety and scale of tasks that compose the processes of creating and managing them. Data come from remote sensing and pedestrian survey. The execution …

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Direct Patterning Of Coplanar Polyethylene Glycol Alkylsilane Monolayers By Deep-Ultraviolet Photolithography As A General Method For High Fidelity, Long-Term Cell Patterning And Culture, Kerry Wilson, Maria Stancescu, Mainak Das, John Rumsey, James Hickman Jan 2011

Direct Patterning Of Coplanar Polyethylene Glycol Alkylsilane Monolayers By Deep-Ultraviolet Photolithography As A General Method For High Fidelity, Long-Term Cell Patterning And Culture, Kerry Wilson, Maria Stancescu, Mainak Das, John Rumsey, James Hickman

Faculty Bibliography 2010s

This manuscript details a general method for patterning coplanar alkylsilane monolayers using deep-ultraviolet photolithography that has broad application for high fidelity patterning of cells of varying phenotype in long-term cultures. A polyethylene glycol monolayer was formed on a silica substrate and then patterned using 193 nm light from an ArF excimer laser. The regions of photoablation were then rederivatized with (3-trimethoxysilyl propyl) diethyltriamine (DETA), yielding high contrast cytophilic islands that promoted cell adhesion and growth. Rat hippocampal neurons, motoneurons, and myoblasts were then cultured in a defined, serum-free medium on the patterned surfaces for periods in excess of 40 days. …

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The Accuracy Of Climate Models' Simulated Season Lengths And The Effectiveness Of Grid Scale Correction Factors, Wade E. Winterhalter Jan 2011

The Accuracy Of Climate Models' Simulated Season Lengths And The Effectiveness Of Grid Scale Correction Factors, Wade E. Winterhalter

Faculty Bibliography 2010s

Global climate change is expected to impact biological populations through a variety of mechanisms including increases in the length of their growing season. Climate models are useful tools for predicting how season length might change in the future. However, the accuracy of these models tends to be rather low at regional geographic scales. Here, I determined the ability of several atmosphere and ocean general circulating models (AOGCMs) to accurately simulate historical season lengths for a temperate ectotherm across the continental United States. I also evaluated the effectiveness of regional-scale correction factors to improve the accuracy of these models. I found …

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Evaluation Of Biolistic Gene Transfer Methods In Vivo Using Non-Invasive Bioluminescent Imaging Techniques, Jixiang Xia, Angela Martinez, Henry Daniell, Steven N. Ebert Jan 2011

Evaluation Of Biolistic Gene Transfer Methods In Vivo Using Non-Invasive Bioluminescent Imaging Techniques, Jixiang Xia, Angela Martinez, Henry Daniell, Steven N. Ebert

Faculty Bibliography 2010s

Background: Gene therapy continues to hold great potential for treating many different types of disease and dysfunction. Safe and efficient techniques for gene transfer and expression in vivo are needed to enable gene therapeutic strategies to be effective in patients. Currently, the most commonly used methods employ replication-defective viral vectors for gene transfer, while physical gene transfer methods such as biolistic-mediated ("genegun") delivery to target tissues have not been as extensively explored. In the present study, we evaluated the efficacy of biolistic gene transfer techniques in vivo using non-invasive bioluminescent imaging (BLI) methods. Results: Plasmid DNA carrying the firefly luciferase …

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Crmp5 (Collapsin Response Mediator Protein 5) Regulates Dendritic Development And Synaptic Plasticity In The Cerebellar Purkinje Cells, Naoya Yamashita, Bedrich Mosinger, Arpita Roy, Mari Miyazaki, Kozue Ugajin, Fumio Nakamura, Yukio Sasaki, Kazuhiko Yamaguchi, Pappachan Kolattukudy, Yoshio Goshima Jan 2011

Crmp5 (Collapsin Response Mediator Protein 5) Regulates Dendritic Development And Synaptic Plasticity In The Cerebellar Purkinje Cells, Naoya Yamashita, Bedrich Mosinger, Arpita Roy, Mari Miyazaki, Kozue Ugajin, Fumio Nakamura, Yukio Sasaki, Kazuhiko Yamaguchi, Pappachan Kolattukudy, Yoshio Goshima

Faculty Bibliography 2010s

Collapsin response mediator protein 5 (CRMP5) is one of the CRMP members that expresses abundantly in the developing brain. To examine the in vivo function of CRMP5, we generated crmp5-deficient (crmp5(-/-)) mice. Anti-calbindin immunofluorescence studies of crmp5(-/-) mice revealed aberrant dendrite morphology; specifically, a decrease in the size of soma and diameter of primary dendrite of the cerebellar Purkinje cells at postnatal day 21 (P21) and P28, but not at P14. Coincidentally, CRMP5 is detected in Purkinje cells at P21 and P28 from crmp5(+/-) mice. In cerebellar slices of crmp5(-/-) mice, the induction of long-term depression of excitatory synaptic transmission …

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Expression And Characterization Of Antimicrobial Peptides Retrocyclin-101 And Protegrin-1 In Chloroplasts To Control Viral And Bacterial Infections, Seung-Bum Lee, Baichuan Li, Shuangxia Jin, Henry Daniell Jan 2011

Expression And Characterization Of Antimicrobial Peptides Retrocyclin-101 And Protegrin-1 In Chloroplasts To Control Viral And Bacterial Infections, Seung-Bum Lee, Baichuan Li, Shuangxia Jin, Henry Daniell

Faculty Bibliography 2010s

Retrocyclin-101 (RC101) and Protegrin-1 (PG1) are two important antimicrobial peptides that can be used as therapeutic agents against bacterial and/or viral infections, especially those caused by the HIV-1 or sexually transmitted bacteria. Because of their antimicrobial activity and complex secondary structures, they have not yet been produced in microbial systems and their chemical synthesis is prohibitively expensive. Therefore, we created chloroplast transformation vectors with the RC101 or PG1 coding sequence, fused with GFP to confer stability, furin or Factor Xa cleavage site to liberate the mature peptide from their fusion proteins and a His-tag to aid in their purification. Stable …

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Participation Of Mcp-Induced Protein 1 In Lipopolysaccharide Preconditioning-Induced Ischemic Stroke Tolerance By Regulating The Expression Of Proinflammatory Cytokines, Jian Liang, Jing Wang, Yasser Saad, Logan Warble, Edilu Becerra, Pappachan E. Kolattukudy Jan 2011

Participation Of Mcp-Induced Protein 1 In Lipopolysaccharide Preconditioning-Induced Ischemic Stroke Tolerance By Regulating The Expression Of Proinflammatory Cytokines, Jian Liang, Jing Wang, Yasser Saad, Logan Warble, Edilu Becerra, Pappachan E. Kolattukudy

Faculty Bibliography 2010s

Background: Lipopolysaccharide (LPS) preconditioning-induced neuroprotection is known to be related to suppression of the inflammatory response in the ischemic area. This study seeks to determine if monocyte chemotactic protein-induced protein 1 (MCPIP1), a recently identified CCCH Zn finger-containing protein, plays a role in focal brain ischemia and to elucidate the mechanisms of LPS-induced ischemic brain tolerance. Methods: Transcription and expression of MCPIP1 gene was monitored by qRT-PCR and Western blot. Mouse microglia was prepared from cortices of C57BL/6 mouse brain and primary human microglia was acquired from Clonexpress, Inc. Wild type and MCPIP1 knockout mice were treated with LPS (0.2 …

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Post-Transcriptional Regulation Of Igf1r By Key Micrornas In Long-Lived Mutant Mice, Ruqiang Liang, Amit Khanna, Senthilkumar Muthusamy, Na Li, Harshini Sarojini, John J. Kopchick, Michal M. Masternak, Andrzej Bartke, Eugenia Wang Jan 2011

Post-Transcriptional Regulation Of Igf1r By Key Micrornas In Long-Lived Mutant Mice, Ruqiang Liang, Amit Khanna, Senthilkumar Muthusamy, Na Li, Harshini Sarojini, John J. Kopchick, Michal M. Masternak, Andrzej Bartke, Eugenia Wang

Faculty Bibliography 2010s

Long-lived mutant mice, both Ames dwarf and growth hormone receptor genedisrupted or knockout strains, exhibit heightened cognitive robustness and altered IGF1 signaling in the brain. Here, we report, in both these long-lived mice, that three up-regulated lead microRNAs, miR-470, miR-669b, and miR-681, are involved in posttranscriptional regulation of genes pertinent to growth hormone/IGF1 signaling. All three are most prominently localized in the hippocampus and correspond to reduced expression of key IGF1 signaling genes: IGF1, IGF1R, and PI3 kinase. The decline in these genes expression translates into decreased phosphorylation of downstream molecules AKT and FoxO3a. Cultures transfected with either miR-470, miR-669b, …

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Portable And Airborne Small Footprint Lidar: Forest Canopy Structure Estimation Of Fire Managed Plots, Claudia M. C. S. Listopad, Jason B. Drake, Ron E. Masters, John F. Weishampel Jan 2011

Portable And Airborne Small Footprint Lidar: Forest Canopy Structure Estimation Of Fire Managed Plots, Claudia M. C. S. Listopad, Jason B. Drake, Ron E. Masters, John F. Weishampel

Faculty Bibliography 2010s

This study used an affordable ground-based portable LiDAR system to provide an understanding of the structural differences between old-growth and secondary-growth Southeastern pine. It provided insight into the strengths and weaknesses in the structural determination of portable systems in contrast to airborne LiDAR systems. Portable LiDAR height profiles and derived metrics and indices (e. g., canopy cover, canopy height) were compared among plots with different fire frequency and fire season treatments within secondary forest and old growth plots. The treatments consisted of transitional season fire with four different return intervals: 1-yr, 2-yr, 3-yr fire return intervals, and fire suppressed plots. …

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On Apteronotus Magdalenensis (Miles, 1945) (Gymnotiformes: Apteronotidae): A Poorly Known Species Endemic To The Rio Magdalena Basin, Colombia, Javier A. Maldonado-Ocampo, Carlos David De Santana, William G. R. Crampton Jan 2011

On Apteronotus Magdalenensis (Miles, 1945) (Gymnotiformes: Apteronotidae): A Poorly Known Species Endemic To The Rio Magdalena Basin, Colombia, Javier A. Maldonado-Ocampo, Carlos David De Santana, William G. R. Crampton

Faculty Bibliography 2010s

Based on the examination of the two available paratypes and recently collected material, we present new data and information on the electric knifefish Apteronotus magdalenensis, a species endemic to the rio Magdalena-Cauca basin in Colombia. Since Miles' description in 1945, this species was not collected until recent field work at the Torrents of Honda and additional localities. We present data on the external morphology, morphometrics, pigmentation and electric organ discharges (EODs), of A. magdalenensis. We also review its distribution, ecology and conservation status.

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Hiv-1 Enhancing Effect Of Prostatic Acid Phosphatase Peptides Is Reduced In Human Seminal Plasma, Julie A. Martellini, Amy L. Cole, Pavel Svoboda, Olga Stuchlik, Li-Mei Chen, Karl X. Chai, Bhushan K. Gangrade, Ole E. Sorensne, Jan Pohl, Alexander M. Cole Jan 2011

Hiv-1 Enhancing Effect Of Prostatic Acid Phosphatase Peptides Is Reduced In Human Seminal Plasma, Julie A. Martellini, Amy L. Cole, Pavel Svoboda, Olga Stuchlik, Li-Mei Chen, Karl X. Chai, Bhushan K. Gangrade, Ole E. Sorensne, Jan Pohl, Alexander M. Cole

Faculty Bibliography 2010s

We recently reported that HIV-1 infection can be inhibited by innate antimicrobial components of human seminal plasma (SP). Conversely, naturally occurring peptidic fragments from the SP-derived prostatic acid phosphatase ( PAP) have been reported to form amyloid fibrils called "SEVI'' and enhance HIV-1 infection in vitro. In order to understand the biological consequence of this proviral effect, we extended these studies in the presence of human SP. PAP-derived peptides were agitated to form SEVI and incubated in the presence or absence of SP. While PAP-derived peptides and SEVI alone were proviral, the presence of 1% SP ablated their proviral activity …

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Learning Objects As Tools For Teaching Information Literacy Online: A Survey Of Librarian Usage, Lori S. Mestre, Lisa Baures, Mona Niedbala, Corinne Bishop, Sarah Cantrell, Alice Perez, Kate Silfen Jan 2011

Learning Objects As Tools For Teaching Information Literacy Online: A Survey Of Librarian Usage, Lori S. Mestre, Lisa Baures, Mona Niedbala, Corinne Bishop, Sarah Cantrell, Alice Perez, Kate Silfen

Faculty Bibliography 2010s

Based on information gathered from two discussion sessions moderated by members of the Education and Behavioral Sciences Section's Online Learning Research Committee a survey was conducted to identify how librarians use course/learning management systems and learning objects to deliver instruction. Objectives of the study were to identify the experiences of librarians who are using course/learning management systems; in what context learning objects are being developed and used; and the pedagogical considerations by librarians when creating online learning materials. In addition to discussing the results of the survey, a description of a "Toolkit for Online Learning" created by the Online Learning …

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Reproductive Regulators In Decapod Crustaceans: An Overview, Ganji Purna Chandra Nagaraju Jan 2011

Reproductive Regulators In Decapod Crustaceans: An Overview, Ganji Purna Chandra Nagaraju

Faculty Bibliography 2010s

Control of reproductive development in crustaceans requires neuropeptides, ecdysone and methyl farnesoate (MF). A major source of neuropeptides is the X-organ-sinus gland (XO-SG) complex located in the eyestalk ganglia of crustaceans. The other regulatory factors (either peptides or neuromodulators) are produced in the brain and thoracic ganglia (TG). Two other regulatory non-peptide compounds, the steroid ecdysone and the sesquiterpene MF, are produced by the Y-organs and the mandibular organs, respectively. In the current review, I have tried to recapitulate recent studies on the role of gonadal regulatory factors in regulating crustacean reproduction.

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Cellular Infiltration And Cytokine Expression Correlate With Fistulizing State In Crohn's Disease, Saleh A. Naser, Claudia Romero, Princess Urbina, Najih Naser, John Valentine Jan 2011

Cellular Infiltration And Cytokine Expression Correlate With Fistulizing State In Crohn's Disease, Saleh A. Naser, Claudia Romero, Princess Urbina, Najih Naser, John Valentine

Faculty Bibliography 2010s

The purpose of this study was to determine the degree of infiltration of different cell subpopulations (tissue dendritic macrophages, T-helper cells, cytotoxic T lymphocytes, monocytes, neutrophils, and B cells) and the expression of the cytokines interleukin-12 (IL-12) and tumor necrosis factor alpha (TNF-alpha) in inflamed and noninflamed resected tissues from Crohn's disease (CD) and non-CD patients. Twenty-one resected full-thickness intestinal tissue specimens representing 13 subjects (8 CD and 5 non-CD patients) were included in this study. Sections of 20 mu m in thickness were cut and then stained using immunohistochemistry. The sections were analyzed using confocal laser scanning microscopy (CLSM). …

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Seed Bank Changes With Time-Since-Fire In Florida Rosemary Scrub, Jennifer J. Navarra, Nancy Kohfeldt, Eric S. Menges, Pedro F. Quintana-Ascencio Jan 2011

Seed Bank Changes With Time-Since-Fire In Florida Rosemary Scrub, Jennifer J. Navarra, Nancy Kohfeldt, Eric S. Menges, Pedro F. Quintana-Ascencio

Faculty Bibliography 2010s

The soil seed bank plays a central role in the regeneration of obligate seeding species in fire-prone habitats. We evaluated how seed density and species composition changed with time-since-fire in the Florida, USA, rosemary scrub community. Because fire affects habitat availability and plant demographic variation, we predicted that soil seed density would be low in recently burned and long-unburned stands and high at intermediate time-since-fire. Seed bank soil samples were collected from a chronosequence of time-since-fire composited from two trials conducted in 1992-1993 and 2008-2009: two sites each of 3, 6, 10, and 24 years post-fire, and 3 long-unburned (similar …

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Distinctive Left-Sided Distribution Of Adrenergic-Derived Cells In The Adult Mouse Heart, Kingsley Osuala, Kathleen Telusma, Saad M. Khan, Shandong Wu, Mubarak Shah, Candice Baker, Sabikha Alam, Ibrahim Abukenda, Aura Fuentes, Hani B. Seifein, Steven N. Ebert Jan 2011

Distinctive Left-Sided Distribution Of Adrenergic-Derived Cells In The Adult Mouse Heart, Kingsley Osuala, Kathleen Telusma, Saad M. Khan, Shandong Wu, Mubarak Shah, Candice Baker, Sabikha Alam, Ibrahim Abukenda, Aura Fuentes, Hani B. Seifein, Steven N. Ebert

Faculty Bibliography 2010s

Adrenaline and noradrenaline are produced within the heart from neuronal and non-neuronal sources. These adrenergic hormones have profound effects on cardiovascular development and function, yet relatively little information is available about the specific tissue distribution of adrenergic cells within the adult heart. The purpose of the present study was to define the anatomical localization of cells derived from an adrenergic lineage within the adult heart. To accomplish this, we performed genetic fate-mapping experiments where mice with the cre-recombinase (Cre) gene inserted into the phenylethanolamine-n-methyltransferase (Pnmt) locus were cross-mated with homozygous Rosa26 reporter (R26R) mice. Because Pnmt serves as a marker …

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Morphologies From Slippery Ballistic Deposition Model: A Bottom-Up Approach For Nanofabrication, Anthony Robledo, Christopher N. Grabill, Stephen M. Kuebler, Aniruddha Dutta, Helge Heinrich, Aniket Bhattacharya Jan 2011

Morphologies From Slippery Ballistic Deposition Model: A Bottom-Up Approach For Nanofabrication, Anthony Robledo, Christopher N. Grabill, Stephen M. Kuebler, Aniruddha Dutta, Helge Heinrich, Aniket Bhattacharya

Faculty Bibliography 2010s

We report pattern formation using a slippery ballistic deposition (SBD) model where growth germinates from a single site or from sites distributed periodically on a lattice. By changing the sticking probability p(s) and choosing systems with different lattice constants and symmetries, we demonstrate that a variety of patterns can be generated. These patterns can be further used as scaffolds for nanofabrication. We also demonstrate that by choosing a lateral sticking probability p(l) at the base that is different than p(s), one can control both the early and late time morphologies originating from a seed. Furthermore, we indicate a possible generalization …

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Formulation Development Of Retrocyclin 1 Analog Rc-101 As An Anti-Hiv Vaginal Microbicide Product, A. B. Sassi, M. R. Cost, A. L. Cole, A. M. Cole, D. L. Patton, P. Gupta, L. C. Rohan Jan 2011

Formulation Development Of Retrocyclin 1 Analog Rc-101 As An Anti-Hiv Vaginal Microbicide Product, A. B. Sassi, M. R. Cost, A. L. Cole, A. M. Cole, D. L. Patton, P. Gupta, L. C. Rohan

Faculty Bibliography 2010s

RC-101 is a synthetic microbicide analog of retrocyclin, which has shown in vitro activity against X4 and R5 HIV-1. In an effort to develop a safe and effective RC-101 vaginal microbicide product, we assessed safety in ex vivo macaque and human models and efficacy using in vitro and ex vivo models. A polyvinyl-alcohol vaginal film containing RC-101 (100 mu g/film) was developed. Formulation assessment was conducted by evaluating disintegration, drug content, mechanical properties, and stability. Efficacy was evaluated by in vitro peripheral blood mononuclear cells (PBMC) assay and ex vivo human ectocervical tissue explant model. Ex vivo safety studies were …

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Transcriptomic Analysis Of The Zebrafish Inner Ear Points To Growth Hormone Mediated Regeneration Following Acoustic Trauma, Julie B. Schuck, Huifang Sun, W. Todd Penberthy, Nigel G. F. Cooper, Xiaohong Li, Michael E. Smith Jan 2011

Transcriptomic Analysis Of The Zebrafish Inner Ear Points To Growth Hormone Mediated Regeneration Following Acoustic Trauma, Julie B. Schuck, Huifang Sun, W. Todd Penberthy, Nigel G. F. Cooper, Xiaohong Li, Michael E. Smith

Faculty Bibliography 2010s

Background: Unlike mammals, teleost fishes are capable of regenerating sensory inner ear hair cells that have been lost following acoustic or ototoxic trauma. Previous work indicated that immediately following sound exposure, zebrafish saccules exhibit significant hair cell loss that recovers to pre-treatment levels within 14 days. Following acoustic trauma in the zebrafish inner ear, we used microarray analysis to identify genes involved in inner ear repair following acoustic exposure. Additionally, we investigated the effect of growth hormone (GH) on cell proliferation in control zebrafish utricles and saccules, since GH was significantly up-regulated following acoustic trauma. Results: Microarray analysis, validated with …

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Picbreeder: A Case Study In Collaborative Evolutionary Exploration Of Design Space, Jimmy Secretan, Nicholas Beato, David B. D'Ambrosio, Adelein Rodriguez, Adam Campbell, Jeremiah T. Folsom-Kovarik, Kenneth O. Stanley Jan 2011

Picbreeder: A Case Study In Collaborative Evolutionary Exploration Of Design Space, Jimmy Secretan, Nicholas Beato, David B. D'Ambrosio, Adelein Rodriguez, Adam Campbell, Jeremiah T. Folsom-Kovarik, Kenneth O. Stanley

Faculty Bibliography 2010s

For domains in which fitness is subjective or difficult to express formally, interactive evolutionary computation (IEC) is a natural choice. It is possible that a collaborative process combining feedback from multiple users can improve the quality and quantity of generated artifacts. Picbreeder, a large-scale online experiment in collaborative interactive evolution (CIE), explores this potential. Picbreeder is an online community in which users can evolve and share images, and most importantly, continue evolving others' images. Through this process of branching from other images, and through continually increasing image complexity made possible by the underlying neuroevolution of augmenting topologies (NEAT) algorithm, evolved …

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Inactivation And Reactivation Of The Mitochondrial Alpha-Ketoglutarate Dehydrogenase Complex, Qingli Shi, Hui Xu, Haiqiang Yu, Nawei Zhang, Yaozu Ye, Alvaro G. Estevez, Haiteng Deng, Gary E. Gibson Jan 2011

Inactivation And Reactivation Of The Mitochondrial Alpha-Ketoglutarate Dehydrogenase Complex, Qingli Shi, Hui Xu, Haiqiang Yu, Nawei Zhang, Yaozu Ye, Alvaro G. Estevez, Haiteng Deng, Gary E. Gibson

Faculty Bibliography 2010s

Reduced brain metabolism is an invariant feature of Alzheimer Disease (AD) that is highly correlated to the decline in brain functions. Decreased activities of key tricarboxylic acid cycle (TCA) cycle enzymes may underlie this abnormality and are highly correlated to the clinical state of the patient. The activity of the alpha-ketoglutarate dehydrogenase complex (KGDHC), an arguably rate-limiting enzyme of the TCA cycle, declines with AD, but the mechanism of inactivation and whether it can be reversed remains unknown. KGDHC consists of multiple copies of three subunits. KGDHC is sensitive to oxidative stress, which is pervasive in AD brain. The present …

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A Therapeutic Chemical Chaperone Inhibits Cholera Intoxication And Unfolding/Translocation Of The Cholera Toxin A1 Subunit, Michael Taylor, Tuhina Banerjee, Fernando Navarro-Garcia, Jazmin Huerta, Shane Massey, Mansfield Burlingame, Abhay H. Pande, Suren A. Tatulian, Ken Teter Jan 2011

A Therapeutic Chemical Chaperone Inhibits Cholera Intoxication And Unfolding/Translocation Of The Cholera Toxin A1 Subunit, Michael Taylor, Tuhina Banerjee, Fernando Navarro-Garcia, Jazmin Huerta, Shane Massey, Mansfield Burlingame, Abhay H. Pande, Suren A. Tatulian, Ken Teter

Faculty Bibliography 2010s

Cholera toxin (CT) travels as an intact AB(5) protein toxin from the cell surface to the endoplasmic reticulum (ER) of an intoxicated cell. In the ER, the catalytic A1 subunit dissociates from the rest of the toxin. Translocation of CTA1 from the ER to the cytosol is then facilitated by the quality control mechanism of ER-associated degradation (ERAD). Thermal instability in the isolated CTA1 subunit generates an unfolded toxin conformation that acts as the trigger for ERAD-mediated translocation to the cytosol. In this work, we show by circular dichroism and fluorescence spectroscopy that exposure to 4-phenylbutyric acid (PBA) inhibited the …

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Interpretations Of Pre-Hispanic Ritual Violence At Tucume, Peru, From Cut Mark Analysis, J. Marla Toyne Jan 2011

Interpretations Of Pre-Hispanic Ritual Violence At Tucume, Peru, From Cut Mark Analysis, J. Marla Toyne

Faculty Bibliography 2010s

Archaeological residues of ritual are often ephemeral, and reconstructing the dynamics of performed actions that create deposits can be difficult. Rituals associated with the dead are common across many cultures since all human,groups have specific means of disposing of corpses. Evidence of peri- and postmortem manipulation of human remains,such as cutting. dismemberment, or disarticulation can provide details of the sequence of actions performed related to the circumstances surrounding death and the possible social meaning of those behaviors. Cur marks observed on the upper chest and throat of 93 percent of 117 children and men found interred at the Temple oldie …

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Fibergramme Vol.34 No. 1, Weavers Of Orlando Jan 2011

Fibergramme Vol.34 No. 1, Weavers Of Orlando

Text Materials of Central Florida

FIBERGRAMME is published in September, November, January, March and May.

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