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2011

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Characterization Of The Mechanism Of Pparγ-Mediated Neointima Formation In Rodents, Ryoko Tsukahara Dec 2011

Characterization Of The Mechanism Of Pparγ-Mediated Neointima Formation In Rodents, Ryoko Tsukahara

Theses and Dissertations (ETD)

Lysophosphatidic acid (LPA) and its ether analog alkyl glycerophosphate (AGP) elicit arterial wall remodeling when applied intralumenally into the uninjured carotid artery. LPA is the ligand of eight GPCRs and the peroxisome proliferator-activated receptor γ (PPARγ). We pursued a gene knockout strategy to identify the LPA receptor subtypes necessary for the neointimal response in a non-injury model of carotid remodeling and also compared the effects of AGP and the PPARγ agonist rosiglitazone (ROSI) on balloon injury-elicited neointima development. In the balloon injury model AGP significantly increased neointima; however, rosiglitazone application attenuated it. AGP and ROSI were also applied intralumenally for …

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Compound 49b: A Novel Beta-Adrenergic Receptor Agonist In The Treatment Of Diabetic Retinopathy, Kimberly Williams-Guy Dec 2011

Compound 49b: A Novel Beta-Adrenergic Receptor Agonist In The Treatment Of Diabetic Retinopathy, Kimberly Williams-Guy

Theses and Dissertations (ETD)

Diabetic retinopathy is the leading cause of blindness in working Americans. While there are therapeutic regimens for the disease, more effective methods are needed. We have previously shown that a non-specific beta-adrenergic receptor agonist, isoproterenol, was effective in preventing functional and morphological changes associated with diabetic retinopathy in the rat. Isoproterenol also produced left ventricle remodeling suggesting it entered the systemic circulation. We therefore synthesized various novel beta-adrenergic receptor compounds and screened these compounds in vitro for their ability to reduce markers of inflammation and apoptosis. Of the various compounds tested, Compound 49b was able to reduce both inflammation and …

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Characterization Of The Key Mouse Cochlear Developmental Genes For Auditory Hair Cell Regeneration, Zhiyong Liu Dec 2011

Characterization Of The Key Mouse Cochlear Developmental Genes For Auditory Hair Cell Regeneration, Zhiyong Liu

Theses and Dissertations (ETD)

Mammalian inner ear cochlear auditory hair cells (HCs) and adjacent supporting cells (SCs) are believed to derive from the same progenitors during development. However, unlike SCs of nonmammalian vertebrates, mammalian cochlear SCs cannot be converted into functional hair cells (HCs) after damage, thus leading to permanent deafness. To entitle mammals with the ability to restore hearing capacity after HC damage, we first achieved proliferation of SCs by acute ablation of p27 or Sox2. Secondly, we overactivated Notch1 signaling in the mouse inner ear at different developmental stages, and found that the ability of Notch signaling in generating new HCs declines …

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Autoimmune Consequences Of Histone Deimination During Neutrophil Activation, Nishant Dwivedi Dec 2011

Autoimmune Consequences Of Histone Deimination During Neutrophil Activation, Nishant Dwivedi

Theses and Dissertations (ETD)

Tolerance blocks the expression of autoantibodies, whereas autoimmunity promotes it. How tolerance breaks and autoantibody production begins, thus, are crucial questions for the understanding and treatment of autoimmune diseases. Evidence implicates cell death and autoantigen modifications in the initiation of autoimmune reactions. One form of neutrophil cell death deserves attention because it occurs as a consequence of neutrophil activation, requires the post-translational modification of histones and results in the extracellular release of chromatin. The extracellular chromatin incorporates histones in which arginines have been converted to citrullines by peptidylarginine deiminase IV (PAD4) creating structures that capture or "trap" bacterial pathogens. Neutrophil …

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Toxic Marine Microalgae And Shellfish Poisoning In The British Isles: History, Review Of Epidemiology, And Future Implications, Sl Hinder, Gc Hays, Cj Brooks, Ap Davies, Et Al Dec 2011

Toxic Marine Microalgae And Shellfish Poisoning In The British Isles: History, Review Of Epidemiology, And Future Implications, Sl Hinder, Gc Hays, Cj Brooks, Ap Davies, Et Al

School of Biological and Marine Sciences

The relationship between toxic marine microalgae species and climate change has become a high profile and well discussed topic in recent years, with research focusing on the possible future impacts of changing hydrological conditions on Harmful Algal Bloom (HAB) species around the world. However, there is very little literature concerning the epidemiology of these species on marine organisms and human health. Here, we examine the current state of toxic microalgae species around the UK, in two ways: first we describe the key toxic syndromes and gather together the disparate reported data on their epidemiology from UK records and monitoring procedures. …

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Characterization Of M-Cadherin's Role In Regulating Apoptosis And Myogenic Differentiation Of Myoblasts By Interacting With Key Components Of Canonical Wnt Signaling, Yan Wang Dec 2011

Characterization Of M-Cadherin's Role In Regulating Apoptosis And Myogenic Differentiation Of Myoblasts By Interacting With Key Components Of Canonical Wnt Signaling, Yan Wang

Graduate Theses, Dissertations, and Problem Reports (ETD)

Activation, proliferation, and differentiation of satellite cells are the basic means for adult muscle regeneration. Apoptosis is concurrent to differentiation of satellite cells and dysregulated apoptosis contributes to the occurrence and progression of certain muscular dystrophies. This study investigated the role of M-cadherin-mediated signaling in regulating apoptosis versus survival of myoblasts during the process of myogenic differentiation. Inhibition of M-cadherin expression by RNAi (RNA interference) in confluent C2C12 myoblasts sensitized the cells to mitochondria-associated intrinsic apoptosis induced by either cell confluence or serum starvation. Manipulation of M-cadherin signaling regulated the Glycogen Synthase Kinase-3beta (GSK-3beta) activity via phosphoinositide-3 kinase (PI3K)/Akt pathway. …

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Liability Issues And Agritourism Development, Steven Burr Dec 2011

Liability Issues And Agritourism Development, Steven Burr

All Current Publications

According to the Utah Farm Bureau, agritourism is “any activity that allows members of the general public, for recreational, entertainment, or educational purposes, to view or enjoy agricultural related activities.”

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Black Bear Conflicts And Safety And Utah Campgrounds, Barrie Gilbert Dec 2011

Black Bear Conflicts And Safety And Utah Campgrounds, Barrie Gilbert

All Current Publications

Utah had its first black bear attack in June of 1992 when a young girl was dragged from a camper at Strawberry campground.

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Effects Of Delay Order And D-Amphetamine On Delay Discounting In Rats, Shana R. Bailey Dec 2011

Effects Of Delay Order And D-Amphetamine On Delay Discounting In Rats, Shana R. Bailey

Graduate Theses, Dissertations, and Problem Reports (ETD)

Impulsive choice is defined as choice for a smaller, more immediate reinforcer over a larger, more delayed reinforcer, whereas self-controlled choice is defined as choice for a larger, more delayed reinforcer over a smaller, more immediate reinforcer. Determinants of impulsive and self-controlled choices may be studied by employing delay-discounting procedures. When using a discrete-trials delay-discounting procedure, a difference in delay discounting as a function of order of presentation of delays to larger-reinforcer delivery was reported by one previous study, whereas another study reported no differences. In both studies, subjects had a history of exposure to both ascending and descending order …

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Chinches De Cama (Bed Bugs): Para Profesionales En El Control De Pestes, Ryan S. Davis Dec 2011

Chinches De Cama (Bed Bugs): Para Profesionales En El Control De Pestes, Ryan S. Davis

All Current Publications

En la última década, reportes de infestaciones de chinches de cama (Cimicidae: Cimex lectularius) han estado en aumento en todo Norte América y en otros países. De acuerdo con esto, las presentaciones de chinches de cama al Utah Plant Pest Diagnostic Lab también han aumentado. Esta hoja de datos ha sido diseñada para informar a los profesionales en el control de pestes de las complejidades involucradas en la erradicación de chinches de cama.

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Cognitive Agendas And Legal Epistemology, Danny Marrero Dec 2011

Cognitive Agendas And Legal Epistemology, Danny Marrero

Graduate Theses and Dissertations

The domain of legal epistemology is defined from two alternative perspectives: individual epistemology and Social epistemology. Since these perspectives have different objects of evaluation, their judgments privilege and exclude different sets of information. While methodological individualism is concerned with justified beliefs of individual knowers, the Social angle focuses on the institutional conditions of knowledge. I will show that the information that is respectively excluded by both the individual and the Social concepts of legal epistemology weaken their respective evaluations. With this in mind, I will explore one new option of defining legal epistemology. This alternative is more comprehensive, in the …

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The Ins And Outs Of Prostitution: A Moral Analysis, Kathryn Alice Zawisza Dec 2011

The Ins And Outs Of Prostitution: A Moral Analysis, Kathryn Alice Zawisza

Graduate Theses and Dissertations

Prostitution is illegal in almost all parts of the United States. Regardless of whether one considers this to be positive or negative, prostitution is still a booming business and thrives despite the legal ramifications of the practice. The pervasiveness of prostitution despite its prohibition may lead one to question the point of the legislation if enforcement is so costly and ineffective. Is prostitution illegal because it harms the well being of society as a whole and the prostitute in particular? Or perhaps it is simply distasteful or worse, immoral and must be forbidden by the law. This, however, leads to …

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Army Transformation: What Does It Mean?, David Jerome Dec 2011

Army Transformation: What Does It Mean?, David Jerome

Graduate Theses and Dissertations

The way in which senior U.S. Army leaders such as the chiefs of staff define transformative change is important, especially if the meaning of that term is to be interpreted as originally intended by Army field grade officers. An Army chief of staff is responsible for creating a vision and establishing goals for the future, and field grade officers are responsible for pursuing that vision and those goals by implementing objectives that endeavor to arrive at the desired ends. By using both qualitative and quantitative methods, this research analyzes what each of the three chiefs of staff, who have served …

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The Incidence Of Plexiform Lesion Formation In Lines Divergently Selected For Ascites, James Grant Mason Dec 2011

The Incidence Of Plexiform Lesion Formation In Lines Divergently Selected For Ascites, James Grant Mason

Graduate Theses and Dissertations

Complex Vascular Lesions, (CVL) are a common vascular change associated with idiopathicpulmonary arterial hypertension (IPAH). CVL have been characterized in studies using animal models involving, but not limited to, Sprague-Dawley rats and poultry (Abe et al., 2010; Wideman et al., 2011).IPAH has been documented in poultry although no connection has been made with CVLs. The current study characterizes CVL in the lungs from broilers derived from lines divergently selected for 15 generations for ascites susceptibility under conditions of simulated high altitude. The ascites RES and SUS lines were sampled for CVL incidence over time. Both lines were reared in a …

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Protein Utilization And Requirements In Broiler Breeders, Ricardo David Ekmay Dec 2011

Protein Utilization And Requirements In Broiler Breeders, Ricardo David Ekmay

Graduate Theses and Dissertations

Advances in the genetics of poultry have created unintended consequences to the broiler breeder industry. Excessive weight has been shown to have many negative effects, including double hierarchies, multiple ovulations, and fatty liver. In an effort to curb excessive body weight gain, both the protein requirements and feeding strategies of broiler breeders are being revisited. A series of studies were conducted to determine the protein and amino acid requirements of broiler breeders during the production phase and to determine the interrelationship between protein turnover and egg formation. In the first trial, a 2x3x3 factorial study was conducted to determine the …

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Determination Of Poultry Litter's Nitrogen-Fertilizer Value For Winter Wheat Production, Brett Lee Gordon Dec 2011

Determination Of Poultry Litter's Nitrogen-Fertilizer Value For Winter Wheat Production, Brett Lee Gordon

Graduate Theses and Dissertations

Nitrogen (N) availability in poultry litter (PL) applied in the fall as a nutrient source for winter wheat (Triticum aestivum L.) has not been adequately characterized. Our objective was to determine a potentially available N (PAN) coefficient based on the inorganic-N fertilizer equivalence (FEQ) of fall-applied PL to winter wheat via field and laboratory research. Wheat grown at six site-years received 0, 84 and 168 kg N ha-1 as PL applied preplant and/or at-planting. The FEQ of PL-N was based on growth and yield responses of wheat fertilized with 22 to 191 kg N ha-1 applied in late winter as …

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2011 December, Office Of Communications & Marketing, Morehead State University. Dec 2011

2011 December, Office Of Communications & Marketing, Morehead State University.

Morehead State Press Release Archive, 1961 to the Present

Press releases for December of 2011.

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Trajectories Of Psychological Distress Among Low-Income, Female Survivors Of Hurricane Katrina, Sarah Ryan Lowe Dec 2011

Trajectories Of Psychological Distress Among Low-Income, Female Survivors Of Hurricane Katrina, Sarah Ryan Lowe

Graduate Doctoral Dissertations

The purpose of this study was to investigate trajectories of psychological distress among low-income women, primarily unmarried and African American, who survived Hurricane Katrina (N = 386). Data were collected in the year prior to the hurricane, as well as approximately one and three years thereafter. Using Latent Class Growth Analysis (LCGA), we detected six distinct trajectory groups. Over half of participants fit into a trajectory consistent with resilience; that is, they maintained low levels of psychological distress over the course of the study, but experienced an elevation in symptoms at the first pre-disaster time point, followed by a return …

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Specters In The Archive: Faculty Digital Image Collections And The Problems Of Invisibility, Joan E. Beaudoin Dec 2011

Specters In The Archive: Faculty Digital Image Collections And The Problems Of Invisibility, Joan E. Beaudoin

School of Information Sciences Faculty Research Publications

This paper argues that the devaluation of visual information in favor of textual information will result in a loss of visual information in a digital form that has personal, institutional and cultural ramifications. Framing this discussion is a study of the digital preservation practices among two faculty user groups, archaeologists and art historians. The study examined the faculty users’ knowledge, perception, emotions and processes surrounding the digital images they had created and, or collected to support their professional activities. What was discovered is a worrisome situation where an important part of the cultural record is at serious risk of being …

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Probabilistic Framework For Image Understanding Applications Using Bayesian Networks, Mustafa Jaber Dec 2011

Probabilistic Framework For Image Understanding Applications Using Bayesian Networks, Mustafa Jaber

Theses

Machine learning algorithms have been successfully utilized in various systems/devices. They have the ability to improve the usability/quality of such systems in terms of intelligent user interface, fast performance, and more importantly, high accuracy. In this research, machine learning techniques are used in the field of image understanding, which is a common research area between image analysis and computer vision, to involve higher processing level of a target image to "make sense" of the scene captured in it. A general probabilistic framework for image understanding where topics associated with (i) collection of images to generate a comprehensive and valid database, …

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Optimal Economic Planning And Control For The Management Of Ecosystems, Kevin Macksamie Dec 2011

Optimal Economic Planning And Control For The Management Of Ecosystems, Kevin Macksamie

Theses

In recent years the interest on sustainable systems has increased significantly. Among the many interested problems, creating and restoring sustainable ecosystems is a challenging and complex problem. One of the fundamental problems within this area is the imbalance between species that have a predator-prey relationship. Solutions involving management have become an integral player in many environments. Management systems typically use ad hoc methods to develop harvesting policies to control the populations of species to desired numbers. In order to amalgamate intelligence and structure, ecological systems require a diverse research effort from three primary fields: ecology, economics, and control theory. In …

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Production And Fate Of Transparent Exopolymer Particles In The Ocean, Oliver Wurl, Lisa Miller, Svein Vagle Dec 2011

Production And Fate Of Transparent Exopolymer Particles In The Ocean, Oliver Wurl, Lisa Miller, Svein Vagle

OES Faculty Publications

The production and fate of transparent exopolymer particles (TEP) have been investigated in various oceanic regions (tropical, temperate, and polar), from the sea surface microlayer (SML) to the deep ocean. Accumulation of TEP within the mixed layer was observed even in the absence of phytoplankton blooms, indicating abiotic processes are important in TEP production. The abiotic TEP aggregation rates measured in the tropical and temperate North Pacific and the Arctic Ocean averaged between 8 and 12 μmol C L-1 d-1. Depth profiles from under sea ice in the Arctic revealed the highest TEP concentrations, potentially released by …

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The Inkwell, Armstrong Atlantic State University Dec 2011

The Inkwell, Armstrong Atlantic State University

The Inkwell

No abstract provided.

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Genetic Influence On The Working Memory Circuitry: Behavior, Structure, Function And Extensions To Illness, Katherine H. Karlsgodt, Peter Bachman, Anderson M. Winkler, Carrie E. Bearden, David C. Glahn Dec 2011

Genetic Influence On The Working Memory Circuitry: Behavior, Structure, Function And Extensions To Illness, Katherine H. Karlsgodt, Peter Bachman, Anderson M. Winkler, Carrie E. Bearden, David C. Glahn

School of Medicine Publications

Working memory is a highly heritable complex cognitive trait that is critical for a number of higher-level functions. However, the neural substrates of this behavioral phenotype are intricate and it is unknown through what precise biological mechanism variation in working memory is transmitted. In this review we explore different functional and structural components of the working memory circuitry, and the degree to which each of them is contributed to by genetic factors. Specifically, we consider dopaminergic function, glutamatergic function, white matter integrity and gray matter structure all of which provide potential mechanisms for the inheritance of working memory deficits. In …

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Culture And Regulation: Examining Collectivism And Individualism As Predictors Of Self-Control, Michael B. Pyle Dec 2011

Culture And Regulation: Examining Collectivism And Individualism As Predictors Of Self-Control, Michael B. Pyle

College of Graduate Studies: Theses & Dissertations

Self-control is the capacity to alter one's intended or instinctual behavior in order to align with societal and cultural standards. It has been suggested that the ability to exert self-control has developed evolutionarily in order to increase the odds of one and one's family's survival through participating in a society. A prediction resulting from this is that horizontal collectivism, in which individuals consider themselves as equals acting toward a shared goal, should predict self control, because a focus on one's ties to others will requires a greater development for restraining one's self. Conversely, vertical individualism, in which individuals are considered …

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The Effects Of Simulation On Junior Level Baccalaureate Nursing Students' Self-Efficacy And Intrinsic Motivation, Michelle E. Dykes Dec 2011

The Effects Of Simulation On Junior Level Baccalaureate Nursing Students' Self-Efficacy And Intrinsic Motivation, Michelle E. Dykes

College of Graduate Studies: Theses & Dissertations

Nursing education is experiencing a generational phenomenon with student enrollment spanning three generations. Classrooms cultures are changing today and include some Baby Boomers and large numbers of Generation X, Generation Y, and second-degree seeking students. These culturally diverse groups of students have unique sets of learning characteristics. Given the current challenges of growing student diversity, balancing budgets, and meeting faculty shortages, nursing schools are pressed to find alternative teaching methods that are not only cost and labor saving but also effective and equitable for the diverse student groups. This quantitative, experimental research design study explored the effects of the alternative …

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Density, Shell Use And Species Composition Of Juvenile Fiddler Crabs (Uca Spp.) At Low And High Impact Salt Marshes On Georgia Barrier Islands, Michelle D. Carlson Dec 2011

Density, Shell Use And Species Composition Of Juvenile Fiddler Crabs (Uca Spp.) At Low And High Impact Salt Marshes On Georgia Barrier Islands, Michelle D. Carlson

College of Graduate Studies: Theses & Dissertations

Coastal wetlands offer refuge for juveniles of many species, with protection often coming in the form of dense vegetation. Human impacts have led to a 67% loss of coastal wetlands worldwide in the past 300 years, thus decreasing available refuges. There are no studies that show what affect this has on fiddler crabs (Uca spp.), a key species in salt marsh habitats. The present study looks at how human impacts are affecting juvenile fiddler crab densities, shell use, and species compositions. This study was conducted at 3 low and 3 high impact sites on Tybee and Skidaway Island, Georgia. Six …

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Evaluating Restoration Potential Of An Endangered Legume, Baptisia Arachnifera: Shade & Litter Effects On Early Life Stages, Timothy John Estep Dec 2011

Evaluating Restoration Potential Of An Endangered Legume, Baptisia Arachnifera: Shade & Litter Effects On Early Life Stages, Timothy John Estep

College of Graduate Studies: Theses & Dissertations

Baptisia arachnifera, hairy rattleweed, is a federally endangered, herbaceous, legume endemic to Wayne and Brantley Counties in Georgia. The species has declined by 89% in the past 20 years. Therefore I examined the early life stages of the species for weevil predation, fungus infection, and germination; information used to help prevent the species extinction. Seed pods of Baptisia arachnifera from six sites were examined for weevil predation and fungal infestation. Germination was examined under greenhouse conditions. One site had intense weevil predation, fungal infection, and reduced germination compared to other sites. Over 62% of seeds germinated within the greenhouse. To …

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Investigations Of The Tribological Effects Of Engine Oil Dilution By Vegetable And Animal Fat Feedstock Biodiesel On Selected Surfaces, Sultana Mahbuba Shanta Dec 2011

Investigations Of The Tribological Effects Of Engine Oil Dilution By Vegetable And Animal Fat Feedstock Biodiesel On Selected Surfaces, Sultana Mahbuba Shanta

College of Graduate Studies: Theses & Dissertations

Biodiesels have become attractive alternative fuel to replace traditional fossil fuels. Biodiesels can be used in diesel engines with no major modification, but its use leads to some degree of engine oil dilution because of biodiesel leaking and scrapping to engine oil pan. Biodiesels can be made from vegetable and animal fat feedstocks. Therefore, the fatty acid methyl ester components of biodiesel may vary upon these sources of feedstock. In this thesis work, engine oil is diluted with vegetable (canola oil, peanut oil and soybean oil biodiesel) and animal (chicken fat) feedstock biodiesels at known percentages and these mixtures are …

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Modeling 3d Articulated Motions With Conformal Geometry Videos (Cgvs), Dao T. P. Quynh, Ying He, Xiaoming Chen, Jiazhi Xia, Qian Sun, Steven C. H. Hoi Dec 2011

Modeling 3d Articulated Motions With Conformal Geometry Videos (Cgvs), Dao T. P. Quynh, Ying He, Xiaoming Chen, Jiazhi Xia, Qian Sun, Steven C. H. Hoi

Research Collection School Of Computing and Information Systems

3D articulated motions are widely used in entertainment, sports, military, and medical applications. Among various techniques for modeling 3D motions, geometry videos (GVs) are a compact representation in that each frame is parameterized to a 2D domain, which captures the 3D geometry (x, y, z) to a pixel (r, g, b) in the image domain. As a result, the widely studied image/video processing techniques can be directly borrowed for 3D motion. This paper presents conformal geometry videos (CGVs), a novel extension of the traditional geometry videos by taking into the consideration of the isometric nature of 3D articulated motions. We …

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