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Identification Of Functional Elements And Regulatory Circuits By Drosophila Modencode, Sushmita Roy, Jason Ernst, Peter Kharchenko, Pouya Kheradpour, Nicolas Negre, Matthew Eaton, Jane Landolin, Christopher Bristow, Lijia Ma, Michael Lin, Stefan Washietl, Bradley Arshinoff, Ferhat Ay, Patrick Meyer, Nicolas Robine, Nicole Washington, Luisa Di Stefano, Eugene Berezikov, Christopher Brown, Rogerio Candeias, Joseph Carlson, Adrian Carr, Irwin Jungreis, Daniel Marbach, Rachel Sealfon, Michael Tolstorukov, Sebastian Will, Artyom Alekseyenko, Carlo Artieri, Benjamin Booth, Angela Brooks, Qi Dai, Carrie Davis, Michael Duff, Xin Feng, Andrey Gorchakov, Tingting Gu, Jorja Henikoff, Philipp Kapranov, Renhua Li, Heather Macalpine, John Malone, Aki Minoda, Jared Nordman, Katsutomo Okamura, Marc Perry, Sara Powell, Nicole Riddle, Akiko Sakai, Anastasia Samsonova, Jeremy Sandler, Yuri Schwartz, Noa Sher, Rebecca Spokony, David Sturgill, Marijke Van Baren, Kenneth Wan, Li Yang, Charles Yu, Elise Feingold, Peter Good, Mark Guyer, Rebecca Lowdon, Kami Ahmad, Justen Andrews, Bonnie Berger, Steven Brenner, Michael R. Brent, Lucy Cherbas, Sarah C.R. Elgin, Thomas Gingeras, Robert Grossman, Roger Hoskins, Thomas Kaufman, William Kent, Mitzi Kuroda, Terry Orr-Weaver, Norbert Perrimon, Vincenzo Pirrotta, James Posakony, Bing Ren, Steven Russell, Peter Cherbas, Brenton Graveley, Suzanna Lewis, Gos Micklem, Brian Oliver, Peter Park, Susan Celniker, Steven Henikoff, Gary Karpen, Eric Lai, David Macalpine, Lincoln Stein, Kevin White, Manolis Kellis

Biology Faculty Research

To gain insight into how genomic information is translated into cellular and developmental programs, the Drosophila model organism Encyclopedia of DNA Elements (modENCODE) project is comprehensively mapping transcripts, histone modifications, chromosomal proteins, transcription factors, replication proteins and intermediates, and nucleosome properties across a developmental time course and in multiple cell lines. We have generated more than 700 data sets and discovered protein-coding, noncoding, RNA regulatory, replication, and chromatin elements, more than tripling the annotated portion of the Drosophila genome. Correlated activity patterns of these elements reveal a functional regulatory network, which predicts putative new functions for genes, reveals stage- and …

Investigation Whether The German Credit Financial Market Is Promising For Consulting Fees As An Alternative To Traditional Commission Banking., Alexandra Antonia Behrens 1979-

Electronic Theses and Dissertations

This thesis is written to investigate if and how far the German credit financial market could be promising for consulting fees in the field of mortgage loan banking. The problem identified is an extensively discussed issue in the German credit financial sector. In solving the problem the author made some literature research and points out different modes of determining consulting fees. The author faces the challenge that, up to now, there is hardly any literature on the application of mortgage loan consulting fees in Germany. Secondly, a form concerning mortgage loan related business in conjunction with customers' attitudes towards consulting …

The Deidentification Dilemma: A Legislative And Contractual Proposal, Robert Gellman

Fordham Intellectual Property, Media and Entertainment Law Journal

No abstract provided.

Written Description: Protecting The Quid Pro Quo Since 1793, Jacob Adam Schroeder

Fordham Intellectual Property, Media and Entertainment Law Journal

No abstract provided.

Application Of Differential Transform Method To The Generalized Burgers–Huxley Equation, J. Biazar, F. Mohammadi

Applications and Applied Mathematics: An International Journal (AAM)

In this paper, the differential transform method (DTM) will be applied to the generalized Burgers-Huxley equation, and some special cases of the equation, say, Huxley equation and Fitzhugh-Nagoma equation. The DTM produces an approximate solution for the equation, with few and easy computations. Numerical comparison between differential transform method, Adomian decomposition method and Variational iteration method for Burgers-Huxley, Huxley equation and Fitzhugh-Nagoma equation reveal that differential transform method is simple, accurate and efficient.

Particulate Suspension Blood Flow Through A Stenosed Catheterized Artery, V. P. Srivastava, Rochana Vishnoi, Poonam Sinha

Applications and Applied Mathematics: An International Journal (AAM)

The flow of blood through a narrow catheterized artery with an overlapping stenosis has been investigated. To account for the presence of red cells, blood has been represented by a macroscopic two-phase model (i.e., a suspension of erythrocytes in plasma). The expression for the flow characteristics-the flow rate, the impedance (resistance to flow), the wall shear stress in the stenotic region, the shear stresses at the stenosis two throats and at critical height of the stenosis, has been derived. It is found that the impedance increases with the catheter size, with the hematocrit and also with the stenosis size (height …

Differential Transform Method For Nonlinear Parabolic-Hyperbolic Partial Differential Equations, J. Biazar, M. Eslami, M. R. Islam

Applications and Applied Mathematics: An International Journal (AAM)

In the present paper an analytic solution of non-linear parabolic-hyperbolic equations is deduced with the help of the powerful differential transform method (DTM). To illustrate the capability and efficiency of the method four examples for different cases of the equation are solved. The method can easily be applied to many problems and is capable of reducing the size of computational work.

An Analytical Technique For Solving Nonlinear Heat Transfer Equations, Hossein Aminikhah, Milad Hemmatnezhad

Applications and Applied Mathematics: An International Journal (AAM)

In this paper, an analytic technique, namely the New Homotopy Perturbation Method (NHPM) is applied for solving the nonlinear differential equations arising in the field of heat transfer. In this method, the solution is considered as an infinite series expansion where converges rapidly to the exact solution. The nonlinear convective–radioactive cooling equation and nonlinear equation of conduction heat transfer with the variable physical properties are chosen as illustrative examples and the exact solutions have been found for each case.

Duality In Fuzzy Linear Programming With Symmetric Trapezoidal Numbers, S. H. Nasseri, E. Ebrahimnejad, S. Mizuno

Applications and Applied Mathematics: An International Journal (AAM)

Linear programming problems with trapezoidal fuzzy numbers have recently attracted much interest. Various methods have been developed for solving these types of problems. Here, following the work of Ganesan and Veeramani and using the recent approach of Mahdavi-Amiri and Nasseri, we introduce the dual of the linear programming problem with symmetric trapezoidal fuzzy numbers and establish some duality results. The results will be useful for post optimality analysis.

Rmi1 Is Essential For Early Embryonic Development And Attenuation Of Tumor Development, Haoyi Chen

Dissertations and Theses (Open Access)

RMI1 (BLM-Associated Protein 75 or Blap75) is highly conserved from yeast to human. Previous studies have shown that hRMI1 is required for BLM/TopoIIIα/RMI1 complex stability and function. However, in vivo functions of RMI1 remain elusive. To address this question, I generated RMI1 knockout mice by homologous replacement targeting. While RMI1+/- mice showed no obvious phenotype, deletion of both RMI1 alleles leads to early embryonic lethality before implantation. I then generated RMI1/p53 double knockout mice. After ionizing radiation treatment at 4Gy, RMI1/p53 double-heterzygous mice showed shortened tumor latency and aggressive tumor types when comparing with wild type, RMI1+/- and p53+/- control …

New To Ols For Monitoring Gamma Camera Uniformity, Brad K. Lofton

Dissertations and Theses (Open Access)

Detector uniformity is a fundamental performance characteristic of all modern gamma camera systems, and ensuring a stable, uniform detector response is critical for maintaining clinical images that are free of artifact. For these reasons, the assessment of detector uniformity is one of the most common activities associated with a successful clinical quality assurance program in gamma camera imaging. The evaluation of this parameter, however, is often unclear because it is highly dependent upon acquisition conditions, reviewer expertise, and the application of somewhat arbitrary limits that do not characterize the spatial location of the non-uniformities. Furthermore, as the goal of any …

Technology Convergence And Federalism: Who Should Decide The Future Of Telecommunications Regulation?, Daniel A. Lyons

University of Michigan Journal of Law Reform

This Article critically examines the division of regulatory jurisdiction over telecommunications issues between the federal government and the states. Currently, the line between federal and state jurisdiction varies depending on the service at issue. This compartmentalization might have made sense fifteen years ago, but the advent of technology convergence has largely rendered this model obsolete. Yesterday's telephone and cable companies now compete head-to-head to offer consumers the vaunted "triple play" of voice, video, and internet services. But these telecommunications companies are finding it increasingly difficult to fit new operations into arcane, rigid regulatory compartments. Moreover, services that consumers view as …

Exhausted Or Unlicensed: Can Field-Of-Use Restrictions In Biotech License Agreements Still Prevent Off-Label Use Promotion After Quanta Computer?, Kristal M. Wicks

The University of New Hampshire Law Review

[Excerpt] “In the biotechnology (biotech) industry, companies must be increasingly aware of their intellectual property and how their licensing strategies can impact their rights. When licensing patented technology, it is common practice for biotech companies to include restricted field-of-use provisions in their license agreements. Such provisions permit a licensee to only use licensed technology in a defined field and restrict use or development in another field. This licensing strategy plays an important role within the biotech industry because it allows companies to more effectively control their intellectual property and to more efficiently research and develop pharmaceutical products.

A problem that …

Effect Of Core Strength On The Measure Of Power In The Extremities, Justin Shinkle

All-Inclusive List of Electronic Theses and Dissertations

The purpose of this study was to determine the effects of core strength on the transfer and production of forces in the extremities. Twenty-five division 1 collegiate football players performed a series of medicine ball throws in the forward, reverse, right and left directions in a static and dynamic position. The results of the medicine ball throws were compared to several athletic performance measurements including: push press power, 1RM squat, 1RM bench press, countermovement vertical jump, broad jump, 40 yard dash, 20 yard dash, pro agility to the right and left, and the L drill. Several strong correlations were found …

The Current Situation Of Supply Chain Management And Technology Structure At Al-Hassan Industrial Estate In Jordan, Mahmoud Alodeh

All-Inclusive List of Electronic Theses and Dissertations

Introduction: countries all over the world have competed to develop their economies through different methods. One of the ways is enhancing Logistics and Supply Chain Management (LSCM). The Jordanian government is one of the governments that found out that if it needs to improve the Jordanian economy it has to improve the supply chain management (SCM) in almost every aspect of life. Problem: The current status of the use of information systems for LSCM at Al-Hassan Industrial Estate (AIE), and the current enterprises’ policies for LSCM were not known. Purpose: The study aimed to answer the following questions: What are …

Impacts Of Low-Speed Vehicles On Transportation Infrastructure And Safety, Katharine M. Hunter-Zaworski, Linda Cornell

TREC Final Reports

There are increasing numbers of low-speed electric vehicles (LSVs) on public roadways. These vehicles are designed to be used within protected environments and on roadways with a maximum posted speed of 25 mph. Currently these vehicles are not subject to the same federal requirements for occupant protection as passenger cars. This research project investigated safety standards, operating regulations, and LSV manufacturer materials from sources around the world. The purpose of the research was to determine positive and negative impacts that LSVs, including Neighborhood Electric Vehicles (NEVs) and Medium Speed Electric Vehicles (MSEVs), are likely to have for the Oregon Department …

Performance Enhancement Of Bridge Bracing Under Service And Extreme Loads, Peter Dusicka, Max Taylor Stephens, Kate Fox-Lent

TREC Final Reports

As truck loads continue to get bigger, the demand on many aging bridges increases. Slender steel structural elements widely used in bridge superstructures and braced substructures to resist these loads are built primarily for tension, however, and can buckle under compressive loads. Portland State University associate professor Peter Dusicka set out to develop and demonstrate the concept of retrofitting bridge brace elements with fiber reinforced composites in order to provide restraint against buckling. The advanced materials consisted of a combination of fiber reinforced polymer (FRP) composite pultruded sections and wet lay-up wraps intended to be applied in the field. This …

Faculty Senate Monthly Packet December 2010, Portland State University Faculty Senate

Faculty Senate Monthly Packets

The December 2010 Monthly packet includes the December agenda and appendices and the Faculty Senate minutes and attachments from the meeting held November 2010

Ibpi: Bicycle And Pedestrian Education Program, Jennifer Dill, Lynn Weigand, Karen Dixon

Urban Studies and Planning Faculty Publications and Presentations

Since the 1990s, the amount of attention and funding for bicycle and pedestrian infrastructure has increased significantly. This, combined with the role of transportation in public health and environmental concerns, has raised expectations for engineering and planning practitioners to possess more knowledge and skills related to pedestrian and bicycle planning and design. This demand requires more education around these topics but university curriculum doesn?t reflect these important shifts in the field. This project was intended to begin addressing the need for more bicycle and pedestrian curriculum in two ways: (1) Determine the existence of and need for courses and curriculum …

Singular Value Decomposition Metrics Show Limitations Of Detector Design In Diffuse Fluorescence Tomography, Frederic Leblond, Kenneth M. Tichauer, Brian W. Pogue

Dartmouth Scholarship

The spatial resolution and recovered contrast of images reconstructed from diffuse fluorescence tomography data are limited by the high scattering properties of light propagation in biological tissue. As a result, the image reconstruction process can be exceedingly vulnerable to inaccurate prior knowledge of tissue optical properties and stochastic noise. In light of these limitations, the optimal source-detector geometry for a fluorescence tomography system is non-trivial, requiring analytical methods to guide design. Analysis of the singular value decomposition of the matrix to be inverted for image reconstruction is one potential approach, providing key quantitative metrics, such as singular image mode spatial …

Phosphorus Export From A Restored Wetland Ecosystem In Response To Natural And Experimental Hydrologic Fluctuations, Marcelo Ardón, Shaena Montanari, Jennifer L. Morse, Martin W. Doyle, Emily S. Bernhardt

Environmental Science and Management Faculty Publications and Presentations

Wetland restoration is a commonly used approach to reduce nutrient loading to freshwater and coastal ecosystems, with many wetland restoration efforts occurring in former agricultural fields. Restored wetlands are expected to be effective at retaining or removing both nitrogen and phosphorus (P), yet restoring wetland hydrology to former agricultural fields can lead to the release of legacy fertilizer P. Here, we examined P cycling and export following rewetting of the Timberlake Restoration Project, a 440 ha restored riverine wetland complex in the coastal plain of North Carolina. We also compared P cycling within the restored wetland to two minimally disturbed …

A Study On The Diversity Of Cal Poly's Faculty, Suzanne Tack

Social Sciences

No abstract provided.

Hot Air Balloon Navigation, Dustin Blackwell

Aerospace Engineering

This report describes a program used for navigating a hot air balloon.  The program, Balloon_Trip, was written using MATLAB and gives a flight path to follow from a start position to an end position.  Balloon_Trip calculates the flight path by taking in wind conditions and then flying through these different winds so as to steer the hot air balloon.  The program calculates the flight path by taking into consideration at all times how the wind will propel the balloon while it is rising or falling in elevation.  It then takes the most direct and least complicated, if not fastest, …

Hydraulic Conductivity, Infiltration, And Runoff From No-Till And Tilled Cropland, Jessica H. Deck

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

Infiltration and runoff are important processes that affect the efficiency of center pivot irrigation systems. No-till planting systems potentially influence the hydraulic properties of soils and the soil surface conditions. The result of long-term use of no-till could be higher infiltration and lower runoff from rainfall and irrigation.

This potential was investigated in Nebraska on two center pivot irrigated sites; Fillmore County and Phelps County, one furrow irrigated site; South Central Agriculture Laboratory (SCAL), and one dryland site; Rogers Farm. Paired treatments were used at each location, one that was no-till planted and one that used two to three operations …

Mercury Removal From Coal By Leaching With Sulfur Dioxide, Poornima Chateker

Graduate Theses, Dissertations, and Problem Reports (ETD)

Mercury from coal-fired utilities has been identified as one of the most hazardous air pollutants and the greatest potential public health concern. Furthermore, it has a tendency to bio-accumulate in the food chain. Mercury is present in coal in concentration well below 1 ppm; however, the large tonnages of coal consumed for electric power generation represent a significant source of mercury vapor entering the environment. There are various technologies available to control the emission of mercury from coal-fired power plants. Among them activated carbon injection into the flue gas stream has been studied for many years and is considered to …

A Field Evaluation Of Dust Palliatives In West Virginia, Kevin A. Butler

Graduate Theses, Dissertations, and Problem Reports (ETD)

It is estimated that a vehicle making a single pass on one mile of untreated, unpaved road every day can generate one ton of dust per year. This dust constitutes fine materials which act as a binder to the larger coarse aggregates within surface gravel. As these fines are removed, the surface deteriorates and expensive aggregate ends up along the roadside in ditches and culverts. The surface continually deteriorates until the road must be reconstructed. Furthermore, airborne dust presents serious safety concerns to traveling motorists and health concerns associated with respiratory illnesses. At the West Virginia Division of Highway's current …

Pot Heat Balance Analysis In Continuous Galvanizing Lines, Quang Minh Phuong

Graduate Theses, Dissertations, and Problem Reports (ETD)

Galvanizing is an energy intensive industry. Knowing how much energy is consumed when producing a certain product will help the company in determining which products can be produced to maximize profits. E-GEPDSS was built to explore the potential of saving energy in galvanizing lines by utilizing heat balance analysis. Heat transfer mechanisms of the heat losses for the pot presented in the heat balance are basic heat transfer concepts (i.e. radiation, convection, conduction, and specific heat.;The pot heat balance model was built and applied using the data collected from a host company during the plant visit. Sensitivity analyses were done …

Developing A Cellular Assay For Screening Inhibitors Of Stat4 Phosphorylation, Vivian Marcela Suarez

Graduate Theses, Dissertations, and Problem Reports (ETD)

In order to design better therapeutic strategies, scientists work on understanding the interactions that take place at cell level and have an effect on the immune system. In order to identify a few possible inhibitors that may be up-regulated in tumor environment and that may affect T-cell action, a cellular assay was designed. An Interleukin-12 (IL-12)-responsive murine Th1 cell clone called 2D6 was used as cellular model to study the effects of transforming growth factor-beta (TGF-beta), insulin, and interleukin-6 (IL-6) on the phosphorylation of Signal transducer and activator of transcription 4 (STAT4), a key element in IL-12 signaling. Cells were …

Nanofabrication Of Optofluidic Photonic Crystal Resonators For Biosensing, Henry Bolivar Andagana Junta

Graduate Theses, Dissertations, and Problem Reports (ETD)

Advances in nanofabrication have made possible the development of novel nanophotonics based on Photonic Crystal (PhC) structures. Different types of biosensors have been proposed to take advantage of the unique optical properties of PhCs, which, when combined with microfluidics, provide an enabling approach for biomolecule analysis. In this thesis, nanofabrication of a new biosensor structure integrating a 2D PhC nanocavity resonator with an optofluidic channel is described. The recipes for e-beam lithography of PhC and PhC nanocavity patterns were optimized by carefully tuning the e-beam dose as well as control of the resist baking and development conditions. Two PhC fabrication …

Evaluating The Effects Of The Blennerhassett Island Bridge Crossing (Ohio River) On Soil, Vegetation, And Wildlife, Joshua Allen Vance

Graduate Theses, Dissertations, and Problem Reports (ETD)

Corridor D was one of the original 23 highway corridors selected by the Appalachian Highway Development System in 1965 and stretches from Bridgeport, West Virginia to Cincinnati, Ohio. The last piece of Corridor D to be completed was the Blennerhassett Island Bridge which crosses over the Ohio River and Blennerhassett Island near Parkersburg, West Virginia and Belpre, Ohio. The Blennerhassett Island Bridge is a tied-arch style bridge about 1,220 m in length and 24 m above the ground and water surface. Construction of the bridge began in March 2005 and the bridge was opened to the public in June 2008. …