Digital Commons Network^™

Permutation-Based Pathway Testing Using The Super Learner Algorithm, Paul Chaffee, Alan E. Hubbard, Mark L. Van Der Laan

U.C. Berkeley Division of Biostatistics Working Paper Series

Many diseases and other important phenotypic outcomes are the result of a combination of factors. For example, expression levels of genes have been used as input to various statistical methods for predicting phenotypic outcomes. One particular popular variety is the so-called gene set enrichment analysis (GSEA). This paper discusses an augmentation to an existing strategy to estimate the significance of an associations between a disease outcome and a predetermined combination of biological factors, based on a specific data adaptive regression method (the "Super Learner," van der Laan et al., 2007). The procedure uses an aggressive search procedure, potentially resulting in …

Poles Apart: The ‘‘Bipolar’’ Pteropod Species Limacina Helicina Is Genetically Distinct Between The Arctic And Antarctic Oceans, Brian Hunt, Jan Strugnell, Nina Bednarsek, Katrin Linse, R. John Nelson, Evgeny Pakhomov, Brad A. Seibel, Dirk Steinke, Laura Würzberg

Biological Sciences Faculty Publications

The shelled pteropod (sea butterfly) Limacina helicina is currently recognised as a species complex comprising two sub-species and at least five “forma”. However, at the species level it is considered to be bipolar, occurring in both the Arctic and Antarctic oceans. Due to its aragonite shell and polar distribution L. helicina is particularly vulnerable to ocean acidification. As a key indicator of the acidification process, and a major component of polar ecosystems, L. helicina has become a focus for acidification research. New observations that taxonomic groups may respond quite differently to acidification prompted us to reassess the taxonomic status of …

Adhesin-Specific Nanoparticles And Process For Using Same, Fred J. Stutzenberger, Robert A. Latour, Ya-Ping Sun, Tzuen R. Tzeng

Clemson Patents

The present invention is generally directed to compositions useful in preventing and/or treating disease due to infection by any of a variety of biologically active pathogenic microorganisms. The compositions include nanoparticles formed of a hydrophobic polymeric core, hydrophilic linking agents bound to the core, and biofunctional materials bound to the linking agents. The biofunctional materials are functionally identical to receptors on host cell surfaces that can be recognized and bound by adhesins on the surface of the targeted pathogenic adhesin-bearing microorganisms. In one embodiment, the binding action between the nanoparticles and the microorganisms can lead to the formation of large …

Report: The Illinois State University Faculty-Staff Newsletter, March 23, 2010, Illinois State University

Illinois State University Report (1966-2012)

Illinois State University bi-weekly employee newsletter.

Ballistic Tongue Projection In Chameleons Maintains High Performance At Low Temperature, Christopher V. Anderson, Stephen M. Deban

Integrative Biology Faculty and Staff Publications

Environmental temperature impacts the physical activity and ecology of ectothermic animals through its effects on muscle contractile physiology. Sprinting, swimming, and jumping performance of ectotherms decreases by at least 33% over a 10 °C drop, accompanied by a similar decline in muscle power. We propose that ballistic movements that are powered by recoil of elastic tissues are less thermally dependent than movements that rely on direct muscular power. We found that an elastically powered movement, ballistic tongue projection in chameleons, maintains high performance over a 20 °C range. Peak velocity and power decline by only 10%–19% with a 10 °C …

03-23-2010 Saskatchewan Professor And Oklahoma Native To Speak At Swosu Physics Banquet, Southwestern Oklahoma State University

THE BARK ARCHIVE 2010

Dr. L Dean Chapman of the University of Saskatchewan will be guest speaker at this year's 2010 Physics Spring Alumni Banquet scheduled Saturday, April 10, at Southwestern Oklahoma State University in Weatherford.

Bulletin, Dmacc Marketing

Bulletin

No abstract provided.

Measurement Of Γ-Emission Branching Ratios For 154,156,158Gd Compound Nuclei: Tests Of Surrogate Nuclear Reaction Approximations For (N,Γ) Cross Sections, N. D. Scielzo

Physics Faculty Publications

The surrogate nuclear reaction method can be used to determine neutron-induced reaction cross sections from measured decay properties of a compound nucleus created using a different reaction and calculated formation cross sections. The reliability of (n,γ) cross sections determined using the Weisskopf-Ewing and ratio approximations are explored for the ^{155, 157}Gd(n,γ) reactions. Enriched gadolinium targets were bombarded with 22-MeV protons and γ rays were detected in coincidence with scattered protons using the Silicon Telescope Array for Reaction Studies/Livermore-Berkeley Array for Collaborative Experiments (STARS/LiBerACE) silicon and germanium detector arrays. The γ-emission probabilities for the ^{154, 156, …}

Distribution Of Allatostatin C-Like Immunoreactivity In The Central Nervous System Of The Copepod Crustacean Calanus Finmarchicus, Caroline H. Wilson, Andrew E. Christie

Health Sciences and Kinesiology Faculty Articles

The C-type allatostatins (C-ASTs) are a family of highly pleiotropic arthropod neuropeptides. In crustaceans, transcriptomic/mass spectral studies have identified C-ASTs in the nervous systems of many species; the cellular distributions of these peptides remain unknown. Here, the distribution of C-AST was mapped in the nervous system of the copepod Calanus finmarchicus, the major contributor to the North Atlantic’s zooplanktonic biomass; C-AST-immunopositive neurons were identified in the protocerebrum, in several peripheral ganglia associated with feeding appendages, and in the ganglia controlling the swimming legs, with immunopositive axons present throughout the ventral nerve cord. In addition, axons innervating the dorsal longitudinal …

Differentiation Of Labor-Related Activity By Means Of Musculoskeletal Markers, Annette Doying

USF Tampa Graduate Theses and Dissertations

This study tests whether musculoskeletal markers are attributable to occupational categories. It is hypothesized that individuals over the age of 30 years with a lifetime occupation as a laborer will demonstrate a significantly different pattern of activity markers from individuals in the white collar classifications. A sample of n=69 from the Maxwell Museum's Documented Skeletal Collection are investigated.

Upper and lower extremities were scored for MSM type (robusticity, stress lesions, and ossification exostoses) and severity (grades 0 - 3) following Hawkey and Merbs (1995) visual reference system. To evaluate methodological approaches to MSM scoring, ossification exostoses and stress lesions were …

Improved Methodologies For Modeling Storage And Water Level Behavior In Wetlands, Kenneth Allan Nilsson

USF Tampa Graduate Theses and Dissertations

Wetlands are important elements of watersheds that influence water storage, surface water runoff, groundwater recharge/discharge processes, and evapotranspiration. To understand the cumulative effect wetlands have on a watershed, one must have a good understanding of the water-level fluctuations and the storage characteristics associated with multiple wetlands across a region. An improved analytical method is presented to describe the storage characteristics of wetlands in the absence of detailed hydrologic and bathymetric data. Also, a probabilistic approach based on frequency analysis is developed to provide insight into surface and groundwater interactions associated with isolated wetlands. The results of the work include: 1) …

Spartan Daily March 23, 2010, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily (School of Journalism and Mass Communications)

Volume 134, Issue 29

Preliminary Results Of Combining Low Frequency Low Intensity Ultrasound And Liposomal Drug Delivery To Treat Tumors In Rats, William G. Pitt, Ghaleb A. Husseini, Beverly L. Roeder, David Dickinson, David Warden, Jonathan Hartley, Peter Jones

Faculty Publications

Ultrasound is a convenient trigger for site-specific drug delivery in cancer therapy. Nanosized liposomes formulated from soy phosphatidyl choline, cholesterol, 1,2-distearoyl-sn-glycero3-phosphoethanolamine-N-[carboxy(polyethylene glycol)-2000] and alpha-tocopherol were loaded with Doxorubicin (Dox)using a pH gradient. The liposomal suspension was infused through the tail vein of BDIX rats possessing bilateral intradermal DHD/K12 tumors on their hind legs. Then 20-kHz ultrasound was applied to only one of the tumors for 15 minutes. This therapy was repeated weekly for 4 weeks. The results showed that in five of sixrats, the tumors regressed to non-measurable size within 4 weeks. A paired comparison of the normalized size of …

A Community-Based Study Of Factors Associated With Continuing Transmission Of Lymphatic Filariasis In Leogane, Haiti, Alexis Boyd, Kimberly Y. Won, Shannon K. Mcclintock, Catherine V. Donovan, Sandra J. Laney, Steven A. Williams, Nils Pilotte, Thomas G. Streit, Madsen V.E. Beau De Rochars, Patrick J. Lammie

Biological Sciences: Faculty Publications

Seven rounds of mass drug administration (MDA) have been administered in Leogane, Haiti, an area hyperendemic for lymphatic filariasis (LF). Sentinel site surveys showed that the prevalence of microfilaremia was reduced to ,1% from levels as high as 15.5%, suggesting that transmission had been reduced. A separate 30-cluster survey of 2- to 4-year-old children was conducted to determine if MDA interrupted transmission. Antigen and antifilarial antibody prevalence were 14.3% and 19.7%, respectively. Follow-up surveys were done in 6 villages, including those selected for the cluster survey, to assess risk factors related to continued LF transmission and to pinpoint hotspots of …

The Current Volume 20 : Issue 25, Nova Southeastern University

Student Newspapers

No abstract provided.

Renowned Cancer Pathologist To Speak At Uab April 1, Staff

Browse All News

No abstract provided.

Poster Session, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• River Basins of Kentucky, Dan Carey, Kentucky Geological Survey
• An Initial Prioritization Approach for Potential Agricultural Best Management Practice Implementation Based on Subwatershed Indicators and Expert Knowledge, Brian Lee and Corey Wilson, Dept Landscape Architecture, UK
• Locating Karst Conduits in Cane Run Watershed of Central Kentucky Using Electrical Resistivity Methods, Junfeng Zhu and others, Kentucky Geological Survey
• Identification of DNA Biomarkers for Determining Sources of Fecal Pollution in Water, Rick Fowler and others, WATERS Laboratory, WKU
• Integrating Participatory Communication and Structured Public Involvement Processes to Better Address Superfund Issues: The Paducah Gaseous Diffusion Plant Future State …

Session 2c, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• A Field Protocol for Measuring the Hydrogeomorphic Effects of Land-Use Conversion in Northern Kentucky Streams, Robert Hawley, Sustainable Streams, LLC, Louisville
• Subwatershed Clustering Based on Geomorphic and Human Induced Landscape Modifications: The Licking River Basin, Brian Lee and Corey Wilson, Dept Landscape Architecture, UK, and others
• Updating the National Hydrography Dataset in a Dynamic Land Cover Change Environment: The Case of the Elusive Water Bodies in Kentucky’s Eastern Coal Field Region, Demetrio Zourarakis, KY Div of Geographic Info, Frankfort
• Relationships Associated with Land Cover and the Macroinvertebrate Community of Northern Kentucky Watersheds, Matthew Wooten, SD1 and …

Session 2b, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• Outer Scaling Method for Velocity Profile Collapse in Gravel-Bed Rivers, Brian Belcher, Beaver Creek Hydrology, LLC and James Fox, Civil Engineering, UK
• Water Availability Tool for Environmental Resources (WATER), Jeremy Newson, USGS Kentucky Water Science Center
• Methods for Estimating Low-Flow Frequencies of Unregulated Streams in Kentucky, Gary Martin and Leslie Arihood, USGS Kentucky Water Science Center
• Investigation of the Surface Fine Grained Laminae Using a Watershed Scale Sediment Transport Model, Joseph Russo and Jimmy Fox, Dept of Civil Engineering, UK

Biopharmaceutical Development Of Vaccines For Prophylactic And Therapeutic Applications, Isidro Zarraga

Amgen Seminar Series in Chemical Engineering

Advances in biotechnology and immunology in the last two decades have paved the way for novel biologics treatments for cancer such as monoclonal antibodies as well as cancer vaccines in clinical trials. Cell-culture based production (as opposed to egg-based fermentation) has enabled production of vaccines comprised of either purified protein antigens or virus-like particles (VLPs) using recombination of viral genes, at rates capable of meeting surge demands due to a pandemic. This approach also provides a better controlled process and a more purified product which minimizes potential allergies and side effects. Another recent development, the discovery of small molecule immune …

Session 2a, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• Millcreek Elementary Stream & Wetlands Restoration Project & Outdoor Classroom, Carol Hanley, Tracy Farmer Institute for Sustainability & the Environment, UK
• Southern Region 4-H₂O Ambassador Program, Ashley Osborne, Cooperative Extension Service, UK
• Oldham County Fiscal Court Leads Watershed Planning Effort, Beth Stuber and others, Oldham County Fiscal Court
• Update on Lexington’s Consent Decree, Richard Walker and others, Tetra Tech

Session 1c, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• Quantifying the Soil Carbon Uptake Rate in Reclaimed Appalachia Mine Soil, Peter Acton and others, Dept of Civil Engineering, UK
• Modeling of CO₂-Water-Rock Interactions in Mississippian Sandstone and Carbonate Reservoirs of Kentucky, Anne Schumacher and others, Dept Earth and Environmental Sciences, UK
• Brine Chemistry in the Illinois and Appalachian Basins of Kentucky – Implications for Geologic Carbon Sequestration, Marty Parris and others, KGS
• Reconnaissance of Selenium Occurrence and Bioaccumulation in the Eastern Kentucky Coal Field, Alex Fogle, KGS

Plenary Session, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• Evaluating the Impact of Hemlock Woolly Adelgid Invasion on Headwater Streams, Joshua Adkins and Lynne Reiske-Kinney, Dept of Entomology, UK
• Effects of Roundup^® Exposure on Behavior and Reproductive Function in a Pond-Breeding Salamander, Catherine Aubee and Howard Whiteman, Dept of Biological Sciences, Murray State University

Proceedings Of 2010 Kentucky Water Resources Annual Symposium, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

This conference was planned and conducted as part of the state water resources research annual program with the support and collaboration of the Department of the Interior, U.S. Geological Survey and the University of Kentucky Research Foundation, under Grant Agreement Number 06HQGR0087.

The views and conclusions contained in this document and presented at the symposium are those of the abstract authors and presenters and should not be interpreted as necessarily representing the official policies, either expressed or implied, of the U.S. Government or other symposium organizers and sponsors.

The Ticker, March 22, 2010

The Ticker

The Ticker is the student newspaper of Baruch College. It has been published continuously since 1932, when the Baruch College campus was the School of Business and Civic Administration of the City College of New York.

03-22-2010 Swosu's 97th Annual Interscholastic Meet (Swim) This Thursday, Southwestern Oklahoma State University

THE BARK ARCHIVE 2010

Southwestern Oklahoma State University's annual interscholastic meet (SWIM) is this Thursday, March 25, on the Weatherford campus, and 71 schools from around the state will be sending students to the contest.

The Utah Statesman, March 22, 2010, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

March 22, 2010, James Madison University

The Breeze, 2010-2019

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Artificial Intelligence: Soon To Be The World’S Greatest Intelligence, Or Just A Wild Dream?, Edward R. Kollett

Academic Symposium of Undergraduate Scholarship

The purpose of the paper was to examine the field of artificial intelligence. In particular, the paper focused on what has been accomplished towards the goal of making a machine that can think like a human, and the hardships that researchers in the field has faced. It also touched upon the potential outcomes of success. Why is this paper important? As computers become more powerful, the common conception is that they are becoming more intelligent. As computers become more integrated with society and more connected with each other, people again believe they are becoming smarter. Therefore, it is important that …

Rbc And Wbc Fatty Acid Composition Following Consumption Of An Omega 3 Supplement: Lessons For Future Clinical Trials, Theodore R. Witte, Alexander J. Salazar, Oscar F. Ballester, W. Elaine Hardman

Biochemistry and Microbiology

Background: Results from increasing numbers of in vitro and in vivo studies have demonstrated that omega 3 fatty acids incorporated in cell culture media or in the diet of the animals can suppress the growth of cancers. When human clinical trials are initiated to determine the ability of omega 3 fatty acids to alter growth or response to chemotherapeutic interventions of cancers, it will be essential to determine the omega 3 intake of individuals in the trial to determine compliance with consumption of the supplement and to correlate with endpoints of efficacy. We wondered if the fatty acid composition of …